UNC5CL (unc-5 family C-terminal like)

Gene

• Entrez ID: 222643
• Gene name: Unc-5 family C-terminal like
• Gene symbol: UNC5CL
• Synonyms (NCBI Gene): MUXA, ZUD
• Chromosome: 6
• Chromosome location: 6p21.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018350	hsa-miR-335-5p	Microarray	18185580
MIRT1475571	hsa-miR-1291	CLIP-seq
MIRT1475572	hsa-miR-3131	CLIP-seq
MIRT1475573	hsa-miR-3647-3p	CLIP-seq
MIRT1475574	hsa-miR-4767	CLIP-seq
MIRT1475575	hsa-miR-494	CLIP-seq
MIRT1475576	hsa-miR-552	CLIP-seq
MIRT1475577	hsa-miR-611	CLIP-seq
MIRT1475578	hsa-miR-764	CLIP-seq
MIRT1921021	hsa-miR-376a	CLIP-seq
MIRT1921022	hsa-miR-376b	CLIP-seq
MIRT1921021	hsa-miR-376a	CLIP-seq
MIRT1921022	hsa-miR-376b	CLIP-seq
MIRT1921021	hsa-miR-376a	CLIP-seq
MIRT1921022	hsa-miR-376b	CLIP-seq
MIRT2143331	hsa-miR-140-3p	CLIP-seq
MIRT2143332	hsa-miR-3136-5p	CLIP-seq
MIRT2143333	hsa-miR-4427	CLIP-seq
MIRT2143334	hsa-miR-4439	CLIP-seq
MIRT2143335	hsa-miR-4513	CLIP-seq
MIRT2143336	hsa-miR-4686	CLIP-seq
MIRT2143337	hsa-miR-4789-3p	CLIP-seq
MIRT2143338	hsa-miR-628-5p	CLIP-seq
MIRT2363579	hsa-miR-302a	CLIP-seq
MIRT2363580	hsa-miR-302b	CLIP-seq
MIRT2363581	hsa-miR-302c	CLIP-seq
MIRT2363582	hsa-miR-302d	CLIP-seq
MIRT2363583	hsa-miR-302e	CLIP-seq
MIRT1475573	hsa-miR-3647-3p	CLIP-seq
MIRT2363584	hsa-miR-372	CLIP-seq
MIRT2363585	hsa-miR-373	CLIP-seq
MIRT2143333	hsa-miR-4427	CLIP-seq
MIRT2143337	hsa-miR-4789-3p	CLIP-seq
MIRT2363586	hsa-miR-520a-3p	CLIP-seq
MIRT2363587	hsa-miR-520b	CLIP-seq
MIRT2363588	hsa-miR-520c-3p	CLIP-seq
MIRT2363589	hsa-miR-520d-3p	CLIP-seq
MIRT2363590	hsa-miR-520e	CLIP-seq
MIRT1475572	hsa-miR-3131	CLIP-seq
MIRT1475574	hsa-miR-4767	CLIP-seq
MIRT2462932	hsa-miR-485-5p	CLIP-seq
MIRT1475577	hsa-miR-611	CLIP-seq
MIRT1475572	hsa-miR-3131	CLIP-seq
MIRT1475574	hsa-miR-4767	CLIP-seq
MIRT2462932	hsa-miR-485-5p	CLIP-seq
MIRT1475577	hsa-miR-611	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005042	Function	Netrin receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IDA	22158417
GO:0016020	Component	Membrane	IDA	22158417
GO:0016021	Component	Integral component of membrane	IEA
GO:0038007	Process	Netrin-activated signaling pathway	IEA
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	22158417
GO:0046330	Process	Positive regulation of JNK cascade	IBA	21873635
GO:0046330	Process	Positive regulation of JNK cascade	IDA	22158417

Other IDs

• MIM: 617464
• HGNC: 21203
• e!Ensembl: ENSG00000124602

Protein

• UniProt ID: Q8IV45
• Protein name: UNC5C-like protein (Protein unc-5 homolog C-like) (ZU5 and death domain-containing protein)
• Protein function: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00791	ZU5	103 → 197	ZU5 domain	Family
  PF17217	UPA	243 → 372	UPA domain	Domain
  PF00531	Death	413 → 491	Death domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in pancreas, liver and kidney. {ECO:0000269|PubMed:14769797}.
• Sequence:

  MCPQESSFQPSQFLLLVGVPVASVLLLAQCLRWHCPRRLLGACWTLNGQEEPVSQPTPQL
  ENEVSRQHLPATLPEMVAFYQELHTPTQGQTMVRQLMHKLLVFSAREVDHRGGCLMLQDT
  GISLLIPPGAVAVGRQERVSLILVWDLSDAPSLSQAQGLVSPVVACGPHGASFLKPCTLT
  FKHCAEQPSHARTYSSNTTLLDAKVWRPLGRPGAHASRDECRIHLSHFSLYTCVLEAPVG
  REARKWLQLAVFCSPLVPGQSHLQLRIYFLNNTPCALQWALTNEQPHGGRLRGPCQLFDF
  NGARGDQCLKLTYISEGWENVDDSSCQLVPHLHIWHGKCPFRSFCFRRKAADENEDCSAL
  TNEIIVTMHTFQDGLETKYMEILRFQASEEESWAAPPPVSQPPPCNRLPPELFEQLRMLL
  EPNSITGNDWRRLASHLGLCGMKIRFLSCQRSPAAAILELFEEQNGSLQELHYLMTVMER
  LDCASAIQNYLSGTHGGSPGPERGGARDNQGLELDEKL

• Sequence length: 518

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Schizophrenia	Schizophrenia			GWAS
Alzheimer disease	Alzheimer disease			GWAS
Diabetes	Diabetes			GWAS
Oligodendroglioma	Oligodendroglioma			GWAS
Insomnia	Insomnia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Esophageal Squamous Cell Carcinoma	Associate	22865593
Neoplasms	Associate	26129866
Stomach Neoplasms	Associate	26129866