Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
222537
Gene name Gene Name - the full gene name approved by the HGNC.
Heparan sulfate-glucosamine 3-sulfotransferase 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HS3ST5
Synonyms (NCBI Gene) Gene synonyms aliases
3-OST-5, 3OST5, HS3OST5, NBLA04021
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q21-q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM,
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT623650 hsa-miR-548c-3p HITS-CLIP 23824327
MIRT623649 hsa-miR-4668-3p HITS-CLIP 23824327
MIRT623648 hsa-miR-7151-5p HITS-CLIP 23824327
MIRT623647 hsa-miR-539-5p HITS-CLIP 23824327
MIRT623646 hsa-miR-4668-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0005515 Function Protein binding IPI 12138164
GO:0006024 Process Glycosaminoglycan biosynthetic process TAS
GO:0006477 Process Protein sulfation IDA 12138164
GO:0008467 Function [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609407 19419 ENSG00000249853
Protein
UniProt ID Q8IZT8
Protein name Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (3-OST-5) (Heparan sulfate 3-O-sulfotransferase 5) (h3-OST-5)
Protein function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). Thi
PDB 3BD9 , 7SCD , 7SCE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00685 Sulfotransfer_1 90 339 Sulfotransferase domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon. {ECO:0000269|PubMed:12138164, ECO:0000269|PubMed:12740361}.
Sequence
Sequence length 346
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycosaminoglycan biosynthesis - heparan sulfate / heparin   HS-GAG biosynthesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340
View all (64 more)
22535842
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
24086445
Unknown
Disease term Disease name Evidence References Source
Iritis Iritis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Amyotrophic Lateral Sclerosis Associate 37328865
Dementia Associate 37328865