Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	222537
Gene name Gene Name - the full gene name approved by the HGNC.	Heparan sulfate-glucosamine 3-sulfotransferase 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HS3ST5
Synonyms (NCBI Gene) Gene synonyms aliases	3-OST-5, 3OST5, HS3OST5, NBLA04021
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q21-q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM,

Show/Hide all(147)

miRTarBase ID	miRNA	Experiments	Reference
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT1054984	hsa-miR-106a	CLIP-seq
MIRT1054985	hsa-miR-106b	CLIP-seq
MIRT1054986	hsa-miR-1261	CLIP-seq
MIRT1054987	hsa-miR-15a	CLIP-seq
MIRT1054988	hsa-miR-15b	CLIP-seq
MIRT1054989	hsa-miR-16	CLIP-seq
MIRT1054990	hsa-miR-17	CLIP-seq
MIRT1054991	hsa-miR-195	CLIP-seq
MIRT1054992	hsa-miR-20a	CLIP-seq
MIRT1054993	hsa-miR-20b	CLIP-seq
MIRT1054994	hsa-miR-2278	CLIP-seq
MIRT1054995	hsa-miR-296-3p	CLIP-seq
MIRT1054996	hsa-miR-3135	CLIP-seq
MIRT1054997	hsa-miR-3148	CLIP-seq
MIRT1054998	hsa-miR-3194-3p	CLIP-seq
MIRT1054999	hsa-miR-338-5p	CLIP-seq
MIRT1055000	hsa-miR-3662	CLIP-seq
MIRT1055001	hsa-miR-3688-3p	CLIP-seq
MIRT1055002	hsa-miR-369-3p	CLIP-seq
MIRT1055003	hsa-miR-374c	CLIP-seq
MIRT1055004	hsa-miR-424	CLIP-seq
MIRT1055005	hsa-miR-4270	CLIP-seq
MIRT1055006	hsa-miR-4291	CLIP-seq
MIRT1055007	hsa-miR-4310	CLIP-seq
MIRT1055008	hsa-miR-4427	CLIP-seq
MIRT1055009	hsa-miR-4441	CLIP-seq
MIRT1055010	hsa-miR-4496	CLIP-seq
MIRT1055011	hsa-miR-4503	CLIP-seq
MIRT1055012	hsa-miR-4680-3p	CLIP-seq
MIRT1055013	hsa-miR-4699-3p	CLIP-seq
MIRT1055014	hsa-miR-4802-3p	CLIP-seq
MIRT1055015	hsa-miR-497	CLIP-seq
MIRT1055016	hsa-miR-502-5p	CLIP-seq
MIRT1055017	hsa-miR-519a	CLIP-seq
MIRT1055018	hsa-miR-519b-3p	CLIP-seq
MIRT1055019	hsa-miR-519c-3p	CLIP-seq
MIRT1055020	hsa-miR-519d	CLIP-seq
MIRT1055021	hsa-miR-548t	CLIP-seq
MIRT1055022	hsa-miR-593	CLIP-seq
MIRT1055023	hsa-miR-655	CLIP-seq
MIRT1055024	hsa-miR-890	CLIP-seq
MIRT1055025	hsa-miR-93	CLIP-seq
MIRT1055006	hsa-miR-4291	CLIP-seq
MIRT1055007	hsa-miR-4310	CLIP-seq
MIRT1055008	hsa-miR-4427	CLIP-seq
MIRT1055012	hsa-miR-4680-3p	CLIP-seq
MIRT2244833	hsa-miR-139-5p	CLIP-seq
MIRT2244834	hsa-miR-448	CLIP-seq
MIRT2244835	hsa-miR-4700-3p	CLIP-seq
MIRT2244836	hsa-miR-4768-3p	CLIP-seq
MIRT2244837	hsa-miR-4786-3p	CLIP-seq
MIRT2244838	hsa-miR-671-5p	CLIP-seq
MIRT2437645	hsa-miR-4652-3p	CLIP-seq
MIRT2437646	hsa-miR-4778-5p	CLIP-seq
MIRT1055016	hsa-miR-502-5p	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0005515	Function	Protein binding	IPI	12138164
GO:0006024	Process	Glycosaminoglycan biosynthetic process	TAS
GO:0006477	Process	Protein sulfation	IDA	12138164
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IBA	21873635
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IDA	12138164, 12740361
GO:0015015	Process	Heparan sulfate proteoglycan biosynthetic process, enzymatic modification	IDA	12138164
GO:0016021	Component	Integral component of membrane	NAS	12138164
GO:0046596	Process	Regulation of viral entry into host cell	IDA	12138164
GO:0050656	Function	3'-phosphoadenosine 5'-phosphosulfate binding	NAS	12138164
GO:0050819	Process	Negative regulation of coagulation	IDA	12138164

MIM	HGNC	e!Ensembl
609407	19419	ENSG00000249853

Protein

UniProt ID

Q8IZT8

Protein name

Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (3-OST-5) (Heparan sulfate 3-O-sulfotransferase 5) (h3-OST-5)

Protein function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). Thi

PDB

3BD9 , 7SCD , 7SCE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00685	Sulfotransfer_1	90 → 339	Sulfotransferase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon. {ECO:0000269|PubMed:12138164, ECO:0000269|PubMed:12740361}.

Sequence

MLFKQQAWLRQKLLVLGSLAVGSLLYLVARVGSLDRLQPICPIEGRLGGARTQAEFPLRA
LQFKRGLLHEFRKGNASKEQVRLHDLVQQLPKAIIIGVRKGGTRALLEMLNLHPAVVKAS
QEIHFFDNDENYGKGIEWYRKKMPFSYPQQITIEKSPAYFITEEVPERIYKMNSSIKLLI
IVREPTTRAISDYTQVLEGKERKNKTYYKFEKLAIDPNTCEVNTKYKAVRTSIYTKHLER
WLKYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQYNLYFNATRGFYCLRFNII
FNKCLAGSKGRIHPEVDPSVITKLRKFFHPFNQKFYQITGRTLNWP

Sequence length

346

Interactions

View interactions

	KEGG		Reactome
	Glycosaminoglycan biosynthesis - heparan sulfate / heparin		HS-GAG biosynthesis

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340 View all (64 more)	22535842
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	24086445

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Iritis	Iritis			GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Amyotrophic Lateral Sclerosis	Associate	37328865
Dementia	Associate	37328865

HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5)