Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	222537
Gene name Gene Name - the full gene name approved by the HGNC.	Heparan sulfate-glucosamine 3-sulfotransferase 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HS3ST5
Synonyms (NCBI Gene) Gene synonyms aliases	3-OST-5, 3OST5, HS3OST5, NBLA04021
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q21-q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM,

Show/Hide all(147)

miRTarBase ID	miRNA	Experiments	Reference
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT623650	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT623649	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT623648	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT623647	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT623646	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616688	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT611389	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT611388	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT611387	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT1054984	hsa-miR-106a	CLIP-seq
MIRT1054985	hsa-miR-106b	CLIP-seq
MIRT1054986	hsa-miR-1261	CLIP-seq
MIRT1054987	hsa-miR-15a	CLIP-seq
MIRT1054988	hsa-miR-15b	CLIP-seq
MIRT1054989	hsa-miR-16	CLIP-seq
MIRT1054990	hsa-miR-17	CLIP-seq
MIRT1054991	hsa-miR-195	CLIP-seq
MIRT1054992	hsa-miR-20a	CLIP-seq
MIRT1054993	hsa-miR-20b	CLIP-seq
MIRT1054994	hsa-miR-2278	CLIP-seq
MIRT1054995	hsa-miR-296-3p	CLIP-seq
MIRT1054996	hsa-miR-3135	CLIP-seq
MIRT1054997	hsa-miR-3148	CLIP-seq
MIRT1054998	hsa-miR-3194-3p	CLIP-seq
MIRT1054999	hsa-miR-338-5p	CLIP-seq
MIRT1055000	hsa-miR-3662	CLIP-seq
MIRT1055001	hsa-miR-3688-3p	CLIP-seq
MIRT1055002	hsa-miR-369-3p	CLIP-seq
MIRT1055003	hsa-miR-374c	CLIP-seq
MIRT1055004	hsa-miR-424	CLIP-seq
MIRT1055005	hsa-miR-4270	CLIP-seq
MIRT1055006	hsa-miR-4291	CLIP-seq
MIRT1055007	hsa-miR-4310	CLIP-seq
MIRT1055008	hsa-miR-4427	CLIP-seq
MIRT1055009	hsa-miR-4441	CLIP-seq
MIRT1055010	hsa-miR-4496	CLIP-seq
MIRT1055011	hsa-miR-4503	CLIP-seq
MIRT1055012	hsa-miR-4680-3p	CLIP-seq
MIRT1055013	hsa-miR-4699-3p	CLIP-seq
MIRT1055014	hsa-miR-4802-3p	CLIP-seq
MIRT1055015	hsa-miR-497	CLIP-seq
MIRT1055016	hsa-miR-502-5p	CLIP-seq
MIRT1055017	hsa-miR-519a	CLIP-seq
MIRT1055018	hsa-miR-519b-3p	CLIP-seq
MIRT1055019	hsa-miR-519c-3p	CLIP-seq
MIRT1055020	hsa-miR-519d	CLIP-seq
MIRT1055021	hsa-miR-548t	CLIP-seq
MIRT1055022	hsa-miR-593	CLIP-seq
MIRT1055023	hsa-miR-655	CLIP-seq
MIRT1055024	hsa-miR-890	CLIP-seq
MIRT1055025	hsa-miR-93	CLIP-seq
MIRT1055006	hsa-miR-4291	CLIP-seq
MIRT1055007	hsa-miR-4310	CLIP-seq
MIRT1055008	hsa-miR-4427	CLIP-seq
MIRT1055012	hsa-miR-4680-3p	CLIP-seq
MIRT2244833	hsa-miR-139-5p	CLIP-seq
MIRT2244834	hsa-miR-448	CLIP-seq
MIRT2244835	hsa-miR-4700-3p	CLIP-seq
MIRT2244836	hsa-miR-4768-3p	CLIP-seq
MIRT2244837	hsa-miR-4786-3p	CLIP-seq
MIRT2244838	hsa-miR-671-5p	CLIP-seq
MIRT2437645	hsa-miR-4652-3p	CLIP-seq
MIRT2437646	hsa-miR-4778-5p	CLIP-seq
MIRT1055016	hsa-miR-502-5p	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005515	Function	Protein binding	IPI	12138164
GO:0005794	Component	Golgi apparatus	IEA
GO:0006477	Process	Protein sulfation	IDA	12138164
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase activity	IBA
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase activity	IDA	12138164, 12740361
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase activity	IEA
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase activity	TAS
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IDA	12138164
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	TAS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	12138164
GO:0016740	Function	Transferase activity	IEA
GO:0046596	Process	Regulation of viral entry into host cell	IDA	12138164
GO:0050656	Function	3'-phosphoadenosine 5'-phosphosulfate binding	NAS	12138164
GO:0050819	Process	Negative regulation of coagulation	IDA	12138164

MIM	HGNC	e!Ensembl
609407	19419	ENSG00000249853

Protein

UniProt ID

Q8IZT8

Protein name

Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (3-OST-5) (Heparan sulfate 3-O-sulfotransferase 5) (h3-OST-5)

Protein function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). Thi

PDB

3BD9 , 7SCD , 7SCE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00685	Sulfotransfer_1	90 → 339	Sulfotransferase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon. {ECO:0000269|PubMed:12138164, ECO:0000269|PubMed:12740361}.

Sequence

MLFKQQAWLRQKLLVLGSLAVGSLLYLVARVGSLDRLQPICPIEGRLGGARTQAEFPLRA
LQFKRGLLHEFRKGNASKEQVRLHDLVQQLPKAIIIGVRKGGTRALLEMLNLHPAVVKAS
QEIHFFDNDENYGKGIEWYRKKMPFSYPQQITIEKSPAYFITEEVPERIYKMNSSIKLLI
IVREPTTRAISDYTQVLEGKERKNKTYYKFEKLAIDPNTCEVNTKYKAVRTSIYTKHLER
WLKYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQYNLYFNATRGFYCLRFNII
FNKCLAGSKGRIHPEVDPSVITKLRKFFHPFNQKFYQITGRTLNWP

Sequence length

346

Interactions

View interactions

	KEGG		Reactome
	Glycosaminoglycan biosynthesis - heparan sulfate / heparin		HS-GAG biosynthesis

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Iritis	Iritis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Amyotrophic Lateral Sclerosis	Associate	37328865
Dementia	Associate	37328865

HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5)