FDPS (farnesyl diphosphate synthase)

Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2224
Gene name Gene Name - the full gene name approved by the HGNC.
Farnesyl diphosphate synthase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FDPS
Synonyms (NCBI Gene) Gene synonyms aliases
FPPS, FPS, POROK9
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q22
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholester
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs2297480 T>A,G Drug-response Intron variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT051567 hsa-let-7e-5p CLASH 23622248
MIRT038702 hsa-miR-30c-2-3p CLASH 23622248
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(4)
Transcription factor Regulation Reference
NFYC Unknown 20450493
SREBF1 Unknown 8798690
SREBF2 Unknown 20450493
YY1 Unknown 10318878
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(31)
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0004161 Function Dimethylallyltranstransferase activity IBA
GO:0004161 Function Dimethylallyltranstransferase activity IEA
GO:0004337 Function (2E,6E)-farnesyl diphosphate synthase activity IBA
GO:0004337 Function (2E,6E)-farnesyl diphosphate synthase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
134629 3631 ENSG00000160752
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P14324
Protein name Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)
Protein function Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate
PDB 1YQ7 , 1YV5 , 1ZW5 , 2F7M , 2F89 , 2F8C , 2F8Z , 2F92 , 2F94 , 2F9K , 2OPM , 2OPN , 2QIS , 2RAH , 2VF6 , 3B7L , 3CP6 , 3N1V , 3N1W , 3N3L , 3N45 , 3N46 , 3N49 , 3N5H , 3N5J , 3N6K , 3RYE , 3S4J , 4DEM , 4GA3 , 4H5C , 4H5D , 4H5E , 4JVJ , 4KFA , 4KPD , 4KPJ , 4KQ5 , 4KQS , 4KQU , 4L2X , 4LFV , 4LPG , 4LPH , 4N1Z , 4N9U , 4NFI , 4NFJ , 4NFK , 4NG6 , 4NKE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00348 polyprenyl_synt 108 → 374 Polyprenyl synthetase Domain
Sequence
Sequence length 419
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Terpenoid backbone biosynthesis
Metabolic pathways
Influenza A
Human T-cell leukemia virus 1 infection 		  Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Porokeratosis porokeratosis 9, multiple types rs863225241, rs769193201 N/A
Show/Hide Unknown Diseases (4)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast Cancer Breast cancer N/A N/A GWAS
Carpal Tunnel Syndrome Carpal tunnel syndrome N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Disseminated Superficial Actinic Porokeratosis disseminated superficial actinic porokeratosis N/A N/A GenCC
Show/Hide Text Mining Associations (25)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 17387528
Bisphosphonate Associated Osteonecrosis of the Jaw Associate 21196316
Bone Diseases Associate 16698791
Brain Neoplasms Associate 28419419
Breast Neoplasms Associate 36634566, 37190091
Calcinosis Inhibit 39289624
Carcinoma Hepatocellular Associate 12824919
Carcinoma Renal Cell Associate 34513998
Cardiomyopathies Associate 34783037
Cardiomyopathy Dilated Associate 34783037