SRRM3 (serine/arginine repetitive matrix 3)

Gene

• Entrez ID: 222183
• Gene name: Serine/arginine repetitive matrix 3
• Gene symbol: SRRM3
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7q11.23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017701	hsa-miR-335-5p	Microarray	18185580
MIRT1389887	hsa-miR-1184	CLIP-seq
MIRT1389888	hsa-miR-1193	CLIP-seq
MIRT1389889	hsa-miR-1197	CLIP-seq
MIRT1389890	hsa-miR-1263	CLIP-seq
MIRT1389891	hsa-miR-1293	CLIP-seq
MIRT1389892	hsa-miR-1301	CLIP-seq
MIRT1389893	hsa-miR-1343	CLIP-seq
MIRT1389894	hsa-miR-1470	CLIP-seq
MIRT1389895	hsa-miR-18a	CLIP-seq
MIRT1389896	hsa-miR-18b	CLIP-seq
MIRT1389897	hsa-miR-1915	CLIP-seq
MIRT1389898	hsa-miR-1976	CLIP-seq
MIRT1389899	hsa-miR-214	CLIP-seq
MIRT1389900	hsa-miR-2278	CLIP-seq
MIRT1389901	hsa-miR-2355-5p	CLIP-seq
MIRT1389902	hsa-miR-2681	CLIP-seq
MIRT1389903	hsa-miR-3138	CLIP-seq
MIRT1389904	hsa-miR-3150a-3p	CLIP-seq
MIRT1389905	hsa-miR-3175	CLIP-seq
MIRT1389906	hsa-miR-3179	CLIP-seq
MIRT1389907	hsa-miR-3202	CLIP-seq
MIRT1389908	hsa-miR-342-5p	CLIP-seq
MIRT1389909	hsa-miR-3616-5p	CLIP-seq
MIRT1389910	hsa-miR-3619-5p	CLIP-seq
MIRT1389911	hsa-miR-3647-5p	CLIP-seq
MIRT1389912	hsa-miR-3689d	CLIP-seq
MIRT1389913	hsa-miR-371b-5p	CLIP-seq
MIRT1389914	hsa-miR-4264	CLIP-seq
MIRT1389915	hsa-miR-4267	CLIP-seq
MIRT1389916	hsa-miR-4274	CLIP-seq
MIRT1389917	hsa-miR-4276	CLIP-seq
MIRT1389918	hsa-miR-4291	CLIP-seq
MIRT1389919	hsa-miR-4292	CLIP-seq
MIRT1389920	hsa-miR-4308	CLIP-seq
MIRT1389921	hsa-miR-4453	CLIP-seq
MIRT1389922	hsa-miR-4459	CLIP-seq
MIRT1389923	hsa-miR-4468	CLIP-seq
MIRT1389924	hsa-miR-4469	CLIP-seq
MIRT1389925	hsa-miR-4476	CLIP-seq
MIRT1389926	hsa-miR-4483	CLIP-seq
MIRT1389927	hsa-miR-4488	CLIP-seq
MIRT1389928	hsa-miR-4489	CLIP-seq
MIRT1389929	hsa-miR-4490	CLIP-seq
MIRT1389930	hsa-miR-4520a-3p	CLIP-seq
MIRT1389931	hsa-miR-4522	CLIP-seq
MIRT1389932	hsa-miR-4525	CLIP-seq
MIRT1389933	hsa-miR-4538	CLIP-seq
MIRT1389934	hsa-miR-4660	CLIP-seq
MIRT1389935	hsa-miR-4664-5p	CLIP-seq
MIRT1389936	hsa-miR-4667-3p	CLIP-seq
MIRT1389937	hsa-miR-4697-3p	CLIP-seq
MIRT1389938	hsa-miR-4697-5p	CLIP-seq
MIRT1389939	hsa-miR-4704-3p	CLIP-seq
MIRT1389940	hsa-miR-4711-5p	CLIP-seq
MIRT1389941	hsa-miR-4716-3p	CLIP-seq
MIRT1389942	hsa-miR-4735-3p	CLIP-seq
MIRT1389943	hsa-miR-4774-5p	CLIP-seq
MIRT1389944	hsa-miR-4795-5p	CLIP-seq
MIRT1389945	hsa-miR-483-3p	CLIP-seq
MIRT1389946	hsa-miR-490-5p	CLIP-seq
MIRT1389947	hsa-miR-5047	CLIP-seq
MIRT1389948	hsa-miR-510	CLIP-seq
MIRT1389949	hsa-miR-512-5p	CLIP-seq
MIRT1389950	hsa-miR-542-3p	CLIP-seq
MIRT1389951	hsa-miR-573	CLIP-seq
MIRT1389952	hsa-miR-610	CLIP-seq
MIRT1389953	hsa-miR-637	CLIP-seq
MIRT1389954	hsa-miR-761	CLIP-seq
MIRT1389955	hsa-miR-765	CLIP-seq
MIRT1389956	hsa-miR-767-5p	CLIP-seq
MIRT1389957	hsa-miR-922	CLIP-seq
MIRT1389958	hsa-miR-939	CLIP-seq
MIRT2116798	hsa-miR-1254	CLIP-seq
MIRT2116799	hsa-miR-1262	CLIP-seq
MIRT2116800	hsa-miR-128	CLIP-seq
MIRT1389891	hsa-miR-1293	CLIP-seq
MIRT2116801	hsa-miR-1321	CLIP-seq
MIRT2116802	hsa-miR-3116	CLIP-seq
MIRT2116803	hsa-miR-3123	CLIP-seq
MIRT1389903	hsa-miR-3138	CLIP-seq
MIRT2116804	hsa-miR-3616-3p	CLIP-seq
MIRT2116805	hsa-miR-376c	CLIP-seq
MIRT2116806	hsa-miR-3925-5p	CLIP-seq
MIRT2116807	hsa-miR-3976	CLIP-seq
MIRT2116808	hsa-miR-4290	CLIP-seq
MIRT2116809	hsa-miR-4419a	CLIP-seq
MIRT1389922	hsa-miR-4459	CLIP-seq
MIRT1389926	hsa-miR-4483	CLIP-seq
MIRT2116810	hsa-miR-4510	CLIP-seq
MIRT1389930	hsa-miR-4520a-3p	CLIP-seq
MIRT1389931	hsa-miR-4522	CLIP-seq
MIRT2116811	hsa-miR-4640-5p	CLIP-seq
MIRT1389936	hsa-miR-4667-3p	CLIP-seq
MIRT2116812	hsa-miR-4701-3p	CLIP-seq
MIRT2116813	hsa-miR-4707-5p	CLIP-seq
MIRT2116814	hsa-miR-4721	CLIP-seq
MIRT2116815	hsa-miR-4726-5p	CLIP-seq
MIRT2116816	hsa-miR-4728-5p	CLIP-seq
MIRT2116817	hsa-miR-4739	CLIP-seq
MIRT2116818	hsa-miR-4756-5p	CLIP-seq
MIRT2116819	hsa-miR-583	CLIP-seq
MIRT2116820	hsa-miR-635	CLIP-seq
MIRT1389955	hsa-miR-765	CLIP-seq
MIRT2339199	hsa-miR-105	CLIP-seq
MIRT2339200	hsa-miR-1266	CLIP-seq
MIRT1389898	hsa-miR-1976	CLIP-seq
MIRT2339201	hsa-miR-3150a-5p	CLIP-seq
MIRT2339202	hsa-miR-3150b-5p	CLIP-seq
MIRT1389922	hsa-miR-4459	CLIP-seq
MIRT2339203	hsa-miR-4518	CLIP-seq
MIRT2116799	hsa-miR-1262	CLIP-seq
MIRT1389891	hsa-miR-1293	CLIP-seq
MIRT2395177	hsa-miR-3151	CLIP-seq
MIRT2395178	hsa-miR-4283	CLIP-seq
MIRT1389926	hsa-miR-4483	CLIP-seq
MIRT1389927	hsa-miR-4488	CLIP-seq
MIRT1389928	hsa-miR-4489	CLIP-seq
MIRT2395179	hsa-miR-4492	CLIP-seq
MIRT2395180	hsa-miR-4498	CLIP-seq
MIRT2395181	hsa-miR-4505	CLIP-seq
MIRT1389938	hsa-miR-4697-5p	CLIP-seq
MIRT2116812	hsa-miR-4701-3p	CLIP-seq
MIRT2395182	hsa-miR-4731-5p	CLIP-seq
MIRT1389953	hsa-miR-637	CLIP-seq
MIRT2395183	hsa-miR-762	CLIP-seq
MIRT2116799	hsa-miR-1262	CLIP-seq
MIRT1389891	hsa-miR-1293	CLIP-seq
MIRT2395177	hsa-miR-3151	CLIP-seq
MIRT2395178	hsa-miR-4283	CLIP-seq
MIRT1389926	hsa-miR-4483	CLIP-seq
MIRT1389927	hsa-miR-4488	CLIP-seq
MIRT1389928	hsa-miR-4489	CLIP-seq
MIRT2395179	hsa-miR-4492	CLIP-seq
MIRT2395180	hsa-miR-4498	CLIP-seq
MIRT2395181	hsa-miR-4505	CLIP-seq
MIRT1389938	hsa-miR-4697-5p	CLIP-seq
MIRT2116812	hsa-miR-4701-3p	CLIP-seq
MIRT2395182	hsa-miR-4731-5p	CLIP-seq
MIRT2116820	hsa-miR-635	CLIP-seq
MIRT1389953	hsa-miR-637	CLIP-seq
MIRT2395183	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003729	Function	MRNA binding	IBA
GO:0005634	Component	Nucleus	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: A6NNA2
• Protein name: Serine/arginine repetitive matrix protein 3
• Protein function: May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08312	cwf21	55 → 98	cwf21 domain	Domain
  PF15230	SRRM_C	522 → 582	Serine/arginine repetitive matrix protein C-terminus	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in breast cancer cell lines. {ECO:0000269|PubMed:26053433}.
• Sequence:

  MSSTVNNGAASMQSTPDAANGFPQPSSSSGTWPRAEEELRAAEPGLVKRAHREILDHERK
  RRVELKCMELQEMMEEQGYSEEEIRQKVGTFRQMLMEKEGVLTREDRPGGHIVAETPRLT
  EGAEPGLEYAPFDDDDGPVDCDCPASCYRGHRGYRTKHWSSSSASPPPKKKKKKKGGHRR
  SRKKRRLESECSCGSSSPLRKKKKSVKKHRRDRSDSGSRRKRRHRSRSSKCKRKEKNKEK
  KRPHTESPGRRSHRHSSGSSHSPSLSSHYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSP
  SPSGGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARG
  KESPSPRSAPSSQGRGGRAAGGAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSS
  RSLSRARSSSDSGSGRGAPGPGPEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRR
  GGPEGKSSSRSPGPHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRA
  RHSEAEATRARRRSRSYSPIRKRRRDSPSFMEPRRITSAASVLFHTTGPAPLPPPAA

• Sequence length: 597

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Neoplasms	Associate	34312180	★☆☆☆☆ Found in Text Mining only
Periodontitis	Associate	35397550	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	34312180	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms Castration Resistant	Associate	34312180	★☆☆☆☆ Found in Text Mining only