Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2220
Gene name	Ficolin 2
Gene symbol	FCN2
Synonyms (NCBI Gene)	EBP-37FCNLP35ficolin-2
Chromosome	9
Chromosome location	9q34.3
Summary	The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is pre

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029624	hsa-miR-26b-5p	Microarray	19088304
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT614115	hsa-miR-764	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT614114	hsa-miR-3665	HITS-CLIP	23824327
MIRT610902	hsa-miR-8485	HITS-CLIP	23824327
MIRT610901	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT610900	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT610899	hsa-miR-8064	HITS-CLIP	23824327
MIRT610898	hsa-miR-5589-3p	HITS-CLIP	23824327

Show/Hide all (44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001867	Process	Complement activation, lectin pathway	IBA
GO:0001867	Process	Complement activation, lectin pathway	IDA	18204047, 22691502, 23386610
GO:0001867	Process	Complement activation, lectin pathway	IDA	10679061, 14707097, 15804047
GO:0001867	Process	Complement activation, lectin pathway	IEA
GO:0001905	Process	Activation of membrane attack complex	IDA	18204047
GO:0002376	Process	Immune system process	IEA
GO:0002752	Process	Cell surface pattern recognition receptor signaling pathway	NAS	17215869
GO:0003823	Function	Antigen binding	IBA
GO:0003823	Function	Antigen binding	IDA	8576206
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	19632990, 19939495, 21054788, 21490156, 23460739, 23785123, 27141819, 32094208
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005581	Component	Collagen trimer	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	NAS	10679061
GO:0006508	Process	Proteolysis	IDA	10679061
GO:0006956	Process	Complement activation	IDA	26841934, 30111885, 37852260
GO:0008228	Process	Opsonization	IDA	3897448, 8538770
GO:0008228	Process	Opsonization	IDA	8576206
GO:0009897	Component	External side of plasma membrane	NAS	10679061
GO:0030246	Function	Carbohydrate binding	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0031638	Process	Zymogen activation	IDA	22691502, 23386610
GO:0031640	Process	Killing of cells of another organism	IDA	30552328
GO:0038187	Function	Pattern recognition receptor activity	IDA	8576206, 25344472
GO:0042802	Function	Identical protein binding	IPI	19109177
GO:0043394	Function	Proteoglycan binding	IDA	8576206
GO:0043654	Process	Recognition of apoptotic cell	IDA	15804047
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048306	Function	Calcium-dependent protein binding	IPI	12421953
GO:0050829	Process	Defense response to Gram-negative bacterium	IDA	8576206
GO:0050830	Process	Defense response to Gram-positive bacterium	IDA	14707097
GO:0051604	Process	Protein maturation	IDA	6906228, 18204047, 22691502
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070892	Function	Lipoteichoic acid immune receptor activity	IDA	14707097
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0097367	Function	Carbohydrate derivative binding	IBA
GO:0097367	Function	Carbohydrate derivative binding	IDA	8576206
GO:0106139	Component	Symbiont cell surface	IDA	25344472
GO:1903028	Process	Positive regulation of opsonization	IDA	10679061
GO:1905370	Component	Serine-type endopeptidase complex	IDA	10679061
GO:2001065	Function	Mannan binding	IDA	8576206

MIM	HGNC	e!Ensembl
601624	3624	ENSG00000160339

Q15485

Protein name

Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35)

Protein function

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. {ECO:0

PDB

2J0G , 2J0H , 2J0Y , 2J1G , 2J2P , 2J3F , 2J3G , 2J3O , 2J3U , 2J61 , 4NYT , 4R9J , 4R9T

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01391	Collagen	39 → 98	Collagen triple helix repeat (20 copies)	Repeat
PF00147	Fibrinogen_C	101 → 313	Fibrinogen beta and gamma chains, C-terminal globular domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.

Sequence

MELDRAVGVLGAATLLLSFLGMAWALQAADTCPEVKMVGLEGSDKLTILRGCPGLPGAPG
PKGEAGTNGKRGERGPPGPPGKAGPPGPNGAPGEPQPCLTGPRTCKDLLDRGHFLSGWHT
IYLPDCRPLTVLCDMDTDGGGWTVFQRRVDGSVDFYRDWATYKQGFGSRLGEFWLGNDNI
HALTAQGTSELRVDLVDFEDNYQFAKYRSFKVADEAEKYNLVLGAFVEGSAGDSLTFHNN
QSFSTKDQDNDLNTGNCAVMFQGAWWYKNCHVSNLNGRYLRGTHGSFANGINWKSGKGYN
YSYKVSEMKVRPA

Sequence length

313

Interactions

View interactions

	Reactome
			Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Clear cell carcinoma of kidney	Benign	rs147936623	RCV005927623
FCN2-related disorder	Benign; Likely benign	rs17549193, rs147940112, rs7851696	RCV003977273 RCV003934701 RCV003981931

Show/Hide Text Mining Associations (43)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	39390580
Atherosclerosis	Associate	32641418
Bronchiectasis	Associate	25251245
Carcinoma Hepatocellular	Associate	22140517
Carcinoma Hepatocellular	Inhibit	26220728
Carcinoma Squamous Cell	Inhibit	39390580
Cerebral Infarction	Associate	32641418
Common Variable Immunodeficiency	Associate	25251245
Communicable Diseases	Associate	22140517, 27576476, 34777352
digital ulcers	Associate	30885245
Drug Related Side Effects and Adverse Reactions	Stimulate	27576476
Fibrosis	Inhibit	26220728
Hepatic Veno Occlusive Disease	Associate	26172478
Hepatitis B	Associate	22140517, 26220728
Hepatitis B Chronic	Stimulate	26220728
HIV Infections	Inhibit	27576476
Infections	Associate	26220728, 34777352
Infections	Inhibit	27576476
Kidney Failure Chronic	Associate	30967869
Liver Diseases	Associate	26220728
Liver Failure Acute	Associate	22140517
Lung Diseases Interstitial	Associate	30885245
Lung Neoplasms	Associate	39390580
Lymphoma	Associate	32047495
Multiple Myeloma	Associate	32047495
Multiple Sclerosis	Associate	37903821
Myocardial Infarction	Associate	32736138
Neoplasms	Stimulate	23744477
Non ST Elevated Myocardial Infarction	Associate	32736138
Ovarian Neoplasms	Inhibit	23744477
Parkinson Disease	Associate	39739972
Pneumonia	Associate	28032346, 34777352
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	32601370
Respiratory Distress Syndrome	Associate	36733481
Respiratory Tract Infections	Associate	17680820
Rheumatic Fever	Associate	19664148
Rheumatic Heart Disease	Associate	19664148
Scleroderma Systemic	Associate	30885245
Squamous Cell Carcinoma of Head and Neck	Associate	20957082
Tonsillitis	Associate	36833169
Tuberculosis	Associate	26379154
Tuberculosis Pulmonary	Associate	26379154
Virus Diseases	Inhibit	27576476

FCN2 (ficolin 2)