Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
221981
Gene name Gene Name - the full gene name approved by the HGNC.
Thrombospondin type 1 domain containing 7A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
THSD7A
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p21.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT612374 hsa-miR-3074-5p HITS-CLIP 19536157
MIRT612373 hsa-miR-7152-5p HITS-CLIP 19536157
MIRT616414 hsa-miR-532-5p HITS-CLIP 19536157
MIRT709128 hsa-miR-153-5p HITS-CLIP 19536157
MIRT709127 hsa-miR-4297 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane IDA 27214550
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612249 22207 ENSG00000005108
Protein
UniProt ID Q9UPZ6
Protein name Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]
Protein function [Thrombospondin type-1 domain-containing protein 7A]: Plays a role in actin cytoskeleton rearrangement. ; [Thrombospondin type-1 domain-containing protein 7A, soluble form]: The soluble form promotes endot
PDB 8OXR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF19030 TSP1_ADAMTS 61 115 Domain
PF19028 TSP1_spondin 195 246 Spondin-like TSP1 domain Domain
PF00090 TSP_1 364 416 Thrombospondin type 1 domain Domain
PF19028 TSP1_spondin 635 694 Spondin-like TSP1 domain Domain
PF00090 TSP_1 775 830 Thrombospondin type 1 domain Domain
PF00090 TSP_1 910 960 Thrombospondin type 1 domain Domain
PF00090 TSP_1 1039 1093 Thrombospondin type 1 domain Domain
PF19030 TSP1_ADAMTS 1099 1162 Domain
PF00090 TSP_1 1169 1219 Thrombospondin type 1 domain Domain
PF19028 TSP1_spondin 1287 1340 Spondin-like TSP1 domain Domain
PF00090 TSP_1 1344 1392 Thrombospondin type 1 domain Domain
PF19028 TSP1_spondin 1415 1474 Spondin-like TSP1 domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected on kidney podocytes along the glomerular capillary wall (at protein level). {ECO:0000269|PubMed:25394321}.
Sequence
MGLQARRWASGSRGAAGPRRGVLQLLPLPLPLPLLLLLLLRPGAGRAAAQGEAEAPTLYL
WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKE
LYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPK
PLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQV
CQSSPC
EAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELI
KKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKE
CQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVV
PCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTH
KNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKL
RKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQE
VVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQI
RARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC
TVYHWQTGPWGQCIEDTSVSSFNTTT
TWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDW
TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQAC
QSYRWKTHKW
RRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQ
IPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDK
YNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNS
HGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVN
QAQVYEVVPCHSD
CNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH
VEDYLCDPEEMPLGSRVCKLPC
PEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADE
GRSCPNAVEKEPCNLNKNC
YHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVD
LKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQG
DGRPCPSLMDQSKPCPVKPC
YRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFS
KVVDEEFCADIE
LIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGG
IQVRSRPVIIQELENQHLCPEQMLETKSCYDGQC
YEYKWMASAWKGSSRTVWCQRSDGIN
VTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVV
LPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLI
FIVSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADM
Sequence length 1657
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 29472232
Glaucoma Glaucoma, Glaucoma, Open-Angle rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328
View all (29 more)
30054594, 29891935
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Unknown
Disease term Disease name Evidence References Source
Tourette Syndrome Tourette Syndrome GWAS
Anorexia Anorexia GWAS
Neuroticism Neuroticism GWAS
Bipolar Disorder Bipolar Disorder GWAS
Associations from Text Mining
Disease Name Relationship Type References
Autoimmune Diseases Associate 30520531
Bipolar Disorder Associate 32627186, 40562893
Breast Neoplasms Stimulate 31443644
Carcinoma Ovarian Epithelial Associate 30898391
Carcinoma Squamous Cell Associate 37445817
Colorectal Neoplasms Stimulate 31443644
Colorectal Neoplasms Associate 40098080
Drug Hypersensitivity Associate 30868298
Endometrial Neoplasms Associate 27436855
Eosinophilia Associate 31705303