Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
221937
Gene name Gene Name - the full gene name approved by the HGNC.
Forkhead box K1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FOXK1
Synonyms (NCBI Gene) Gene synonyms aliases
FOXK1L
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p22.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020900 hsa-miR-155-5p Proteomics 18668040
MIRT021201 hsa-miR-186-5p Sequencing 20371350
MIRT032384 hsa-let-7b-5p Proteomics 18668040
MIRT046442 hsa-miR-15b-5p CLASH 23622248
MIRT045618 hsa-miR-149-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 17670796, 25402684, 29861159
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616302 23480 ENSG00000164916
Protein
UniProt ID P85037
Protein name Forkhead box protein K1 (Myocyte nuclear factor) (MNF)
Protein function Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can bot
PDB 8BZM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00498 FHA 123 193 FHA domain Family
PF00250 Forkhead 304 390 Forkhead domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed both developing and adult tissues (PubMed:15289879). In adults, significant expression is seen in tumors of the brain, colon and lymph node (PubMed:15289879). {ECO:0000269|PubMed:15289879}.
Sequence
MAEVGEDSGARALLALRSAPCSPVLCAAAAAAAFPAAAPPPAPAQPQPPPGPPPPPPPPL
PPGAIAGAGSSGGSSGVSGDSAVAGAAPALVAAAAASVRQSPGPALARLEGREFEFLMRQ
PSVTIGRNSSQGSVDLSMGLSSFISRRHLQLSFQEPHFYLRCLGKNGVFVDGAFQRRGAP
ALQLPKQCTFRFP
STAIKIQFTSLYHKEEAPASPLRPLYPQISPLKIHIPEPDLRSMVSP
VPSPTGTISVPNSCPASPRGAGSSSYRFVQNVTSDLQLAAEFAAKAASEQQADTSGGDSP
KDESKPPFSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLN
RYFIKVPRSQEEPGKGSFWRIDPASEAKLV
EQAFRKRRQRGVSCFRTPFGPLSSRSAPAS
PTHPGLMSPRSGGLQTPECLSREGSPIPHDPEFGSKLASVPEYRYSQSAPGSPVSAQPVI
MAVPPRPSSLVAKPVAYMPASIVTSQQPAGHAIHVVQQAPTVTMVRVVTTSANSANGYIL
TSQGAAGGSHDAAGAAVLDLGSEARGLEEKPTIAFATIPAAGGVIQTVASQMAPGVPGHT
VTILQPATPVTLGQHHLPVRAVTQNGKHAVPTNSLAGNAYALTSPLQLLATQASSSAPVV
VTRVCEVGPKEPAAAVAATATTTPATATTASASASSTGEPEVKRSRVEEPSGAVTTPAGV
IAAAGPQGPGTGE
Sequence length 733
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Polycomb repressive complex   UCH proteinases
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Hypothyroidism Hypothyroidism rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912
View all (22 more)
30595370
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Astrocytoma Astrocytoma GWAS
Atrial Fibrillation Atrial Fibrillation GWAS
Associations from Text Mining
Disease Name Relationship Type References
Autism Spectrum Disorder Associate 32807774
Autistic Disorder Associate 28171595
Breast Neoplasms Associate 31799667
Carcinoma Hepatocellular Associate 33880589, 36806218
Carcinoma Hepatocellular Stimulate 38302914
Carcinoma Non Small Cell Lung Associate 35166053
Colorectal Neoplasms Associate 28623323, 30562730, 35536149
Esophageal Squamous Cell Carcinoma Stimulate 37173384
Fibrosis Associate 38302914
Klatskin Tumor Associate 33300075