Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	221656
Gene name Gene Name - the full gene name approved by the HGNC.	Lysine demethylase 1B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KDM1B
Synonyms (NCBI Gene) Gene synonyms aliases	AOF1, C6orf193, LSD2
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p22.3
Summary Summary of gene provided in NCBI Entrez Gene.	Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]

Show/Hide all(161)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019487	hsa-miR-148b-3p	Microarray	17612493
MIRT002552	hsa-miR-373-3p	Microarray	15685193
MIRT026955	hsa-miR-192-5p	Microarray	19074876
MIRT1083980	hsa-miR-1244	CLIP-seq
MIRT1083981	hsa-miR-1258	CLIP-seq
MIRT1083982	hsa-miR-1275	CLIP-seq
MIRT1083983	hsa-miR-129-5p	CLIP-seq
MIRT1083984	hsa-miR-1303	CLIP-seq
MIRT1083985	hsa-miR-1304	CLIP-seq
MIRT1083986	hsa-miR-148a	CLIP-seq
MIRT1083987	hsa-miR-148b	CLIP-seq
MIRT1083988	hsa-miR-152	CLIP-seq
MIRT1083989	hsa-miR-1908	CLIP-seq
MIRT1083990	hsa-miR-199a-3p	CLIP-seq
MIRT1083991	hsa-miR-199b-3p	CLIP-seq
MIRT1083992	hsa-miR-214	CLIP-seq
MIRT1083993	hsa-miR-302a	CLIP-seq
MIRT1083994	hsa-miR-302b	CLIP-seq
MIRT1083995	hsa-miR-302c	CLIP-seq
MIRT1083996	hsa-miR-302d	CLIP-seq
MIRT1083997	hsa-miR-302e	CLIP-seq
MIRT1083998	hsa-miR-3129-5p	CLIP-seq
MIRT1083999	hsa-miR-3140-3p	CLIP-seq
MIRT1084000	hsa-miR-3148	CLIP-seq
MIRT1084001	hsa-miR-3152-3p	CLIP-seq
MIRT1084002	hsa-miR-3180	CLIP-seq
MIRT1084003	hsa-miR-3180-3p	CLIP-seq
MIRT1084004	hsa-miR-3196	CLIP-seq
MIRT1084005	hsa-miR-331-5p	CLIP-seq
MIRT1084006	hsa-miR-338-5p	CLIP-seq
MIRT1084007	hsa-miR-33a	CLIP-seq
MIRT1084008	hsa-miR-33b	CLIP-seq
MIRT1084009	hsa-miR-3619-5p	CLIP-seq
MIRT1084010	hsa-miR-3650	CLIP-seq
MIRT1084011	hsa-miR-3668	CLIP-seq
MIRT1084012	hsa-miR-3688-3p	CLIP-seq
MIRT1084013	hsa-miR-372	CLIP-seq
MIRT1084014	hsa-miR-373	CLIP-seq
MIRT1084015	hsa-miR-4266	CLIP-seq
MIRT1084016	hsa-miR-4291	CLIP-seq
MIRT1084017	hsa-miR-4328	CLIP-seq
MIRT1084018	hsa-miR-4420	CLIP-seq
MIRT1084019	hsa-miR-4464	CLIP-seq
MIRT1084020	hsa-miR-4488	CLIP-seq
MIRT1084021	hsa-miR-4665-5p	CLIP-seq
MIRT1084022	hsa-miR-4678	CLIP-seq
MIRT1084023	hsa-miR-4695-5p	CLIP-seq
MIRT1084024	hsa-miR-4697-3p	CLIP-seq
MIRT1084025	hsa-miR-4697-5p	CLIP-seq
MIRT1084026	hsa-miR-4699-3p	CLIP-seq
MIRT1084027	hsa-miR-4703-3p	CLIP-seq
MIRT1084028	hsa-miR-4711-3p	CLIP-seq
MIRT1084029	hsa-miR-4748	CLIP-seq
MIRT1084030	hsa-miR-4767	CLIP-seq
MIRT1084031	hsa-miR-4779	CLIP-seq
MIRT1084032	hsa-miR-487a	CLIP-seq
MIRT1084033	hsa-miR-494	CLIP-seq
MIRT1084034	hsa-miR-499a-5p	CLIP-seq
MIRT1084035	hsa-miR-509-3p	CLIP-seq
MIRT1084036	hsa-miR-519a	CLIP-seq
MIRT1084037	hsa-miR-519b-3p	CLIP-seq
MIRT1084038	hsa-miR-519c-3p	CLIP-seq
MIRT1084039	hsa-miR-520a-3p	CLIP-seq
MIRT1084040	hsa-miR-520b	CLIP-seq
MIRT1084041	hsa-miR-520c-3p	CLIP-seq
MIRT1084042	hsa-miR-520d-3p	CLIP-seq
MIRT1084043	hsa-miR-520e	CLIP-seq
MIRT1084044	hsa-miR-520f	CLIP-seq
MIRT1084045	hsa-miR-544b	CLIP-seq
MIRT1084046	hsa-miR-663	CLIP-seq
MIRT1084047	hsa-miR-761	CLIP-seq
MIRT1084048	hsa-miR-922	CLIP-seq
MIRT1083980	hsa-miR-1244	CLIP-seq
MIRT1083990	hsa-miR-199a-3p	CLIP-seq
MIRT1083991	hsa-miR-199b-3p	CLIP-seq
MIRT1083992	hsa-miR-214	CLIP-seq
MIRT1083998	hsa-miR-3129-5p	CLIP-seq
MIRT2021261	hsa-miR-3143	CLIP-seq
MIRT1084000	hsa-miR-3148	CLIP-seq
MIRT1084009	hsa-miR-3619-5p	CLIP-seq
MIRT2021262	hsa-miR-3679-3p	CLIP-seq
MIRT1084012	hsa-miR-3688-3p	CLIP-seq
MIRT1084016	hsa-miR-4291	CLIP-seq
MIRT1084018	hsa-miR-4420	CLIP-seq
MIRT2021263	hsa-miR-4422	CLIP-seq
MIRT2021264	hsa-miR-4446-5p	CLIP-seq
MIRT1084019	hsa-miR-4464	CLIP-seq
MIRT1084027	hsa-miR-4703-3p	CLIP-seq
MIRT1084029	hsa-miR-4748	CLIP-seq
MIRT1084034	hsa-miR-499a-5p	CLIP-seq
MIRT2021265	hsa-miR-513a-3p	CLIP-seq
MIRT1084045	hsa-miR-544b	CLIP-seq
MIRT2021266	hsa-miR-607	CLIP-seq
MIRT1084047	hsa-miR-761	CLIP-seq
MIRT1084048	hsa-miR-922	CLIP-seq
MIRT2252792	hsa-miR-1279	CLIP-seq
MIRT2252793	hsa-miR-186	CLIP-seq
MIRT2252794	hsa-miR-2113	CLIP-seq
MIRT2252795	hsa-miR-218	CLIP-seq
MIRT1083993	hsa-miR-302a	CLIP-seq
MIRT1083994	hsa-miR-302b	CLIP-seq
MIRT1083995	hsa-miR-302c	CLIP-seq
MIRT1083996	hsa-miR-302d	CLIP-seq
MIRT1083997	hsa-miR-302e	CLIP-seq
MIRT2252796	hsa-miR-3133	CLIP-seq
MIRT1084000	hsa-miR-3148	CLIP-seq
MIRT1084007	hsa-miR-33a	CLIP-seq
MIRT1084008	hsa-miR-33b	CLIP-seq
MIRT2252797	hsa-miR-34c-3p	CLIP-seq
MIRT2252798	hsa-miR-3607-3p	CLIP-seq
MIRT2252799	hsa-miR-3616-5p	CLIP-seq
MIRT2252800	hsa-miR-3647-5p	CLIP-seq
MIRT1084012	hsa-miR-3688-3p	CLIP-seq
MIRT1084013	hsa-miR-372	CLIP-seq
MIRT1084014	hsa-miR-373	CLIP-seq
MIRT2252801	hsa-miR-4643	CLIP-seq
MIRT2252802	hsa-miR-4653-3p	CLIP-seq
MIRT2252803	hsa-miR-4693-5p	CLIP-seq
MIRT2252804	hsa-miR-4729	CLIP-seq
MIRT2252805	hsa-miR-4753-3p	CLIP-seq
MIRT2252806	hsa-miR-505	CLIP-seq
MIRT1084036	hsa-miR-519a	CLIP-seq
MIRT1084037	hsa-miR-519b-3p	CLIP-seq
MIRT1084038	hsa-miR-519c-3p	CLIP-seq
MIRT1084039	hsa-miR-520a-3p	CLIP-seq
MIRT1084040	hsa-miR-520b	CLIP-seq
MIRT1084041	hsa-miR-520c-3p	CLIP-seq
MIRT1084042	hsa-miR-520d-3p	CLIP-seq
MIRT1084043	hsa-miR-520e	CLIP-seq
MIRT1084044	hsa-miR-520f	CLIP-seq
MIRT2252807	hsa-miR-573	CLIP-seq
MIRT2252808	hsa-miR-626	CLIP-seq
MIRT2438112	hsa-miR-192	CLIP-seq
MIRT2438113	hsa-miR-215	CLIP-seq
MIRT2021265	hsa-miR-513a-3p	CLIP-seq
MIRT1083980	hsa-miR-1244	CLIP-seq
MIRT1083990	hsa-miR-199a-3p	CLIP-seq
MIRT1083991	hsa-miR-199b-3p	CLIP-seq
MIRT1083992	hsa-miR-214	CLIP-seq
MIRT1083998	hsa-miR-3129-5p	CLIP-seq
MIRT1084009	hsa-miR-3619-5p	CLIP-seq
MIRT1084016	hsa-miR-4291	CLIP-seq
MIRT1084027	hsa-miR-4703-3p	CLIP-seq
MIRT1084034	hsa-miR-499a-5p	CLIP-seq
MIRT2452318	hsa-miR-548a-5p	CLIP-seq
MIRT2452319	hsa-miR-548ab	CLIP-seq
MIRT2452320	hsa-miR-548ak	CLIP-seq
MIRT2452321	hsa-miR-548b-5p	CLIP-seq
MIRT2452322	hsa-miR-548c-5p	CLIP-seq
MIRT2452323	hsa-miR-548d-5p	CLIP-seq
MIRT2452324	hsa-miR-548h	CLIP-seq
MIRT2452325	hsa-miR-548i	CLIP-seq
MIRT2452326	hsa-miR-548j	CLIP-seq
MIRT2452327	hsa-miR-548n	CLIP-seq
MIRT2452328	hsa-miR-548t	CLIP-seq
MIRT2452329	hsa-miR-548w	CLIP-seq
MIRT2452330	hsa-miR-548y	CLIP-seq
MIRT2452331	hsa-miR-559	CLIP-seq
MIRT2452332	hsa-miR-577	CLIP-seq
MIRT1084047	hsa-miR-761	CLIP-seq
MIRT1084048	hsa-miR-922	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0000786	Component	Nucleosome	IDA	23260659
GO:0003682	Function	Chromatin binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	23260659
GO:0005634	Component	Nucleus	ISS	19727073
GO:0005654	Component	Nucleoplasm	TAS
GO:0006349	Process	Regulation of gene expression by genetic imprinting	ISS	19727073
GO:0007275	Process	Multicellular organism development	IEA
GO:0008134	Function	Transcription factor binding	IBA	21873635
GO:0008270	Function	Zinc ion binding	IDA	23260659, 23266887
GO:0016491	Function	Oxidoreductase activity	IBA	21873635
GO:0016579	Process	Protein deubiquitination	TAS
GO:0034648	Function	Histone demethylase activity (H3-dimethyl-K4 specific)	IBA	21873635
GO:0034648	Function	Histone demethylase activity (H3-dimethyl-K4 specific)	IDA	23266887
GO:0034648	Function	Histone demethylase activity (H3-dimethyl-K4 specific)	ISS	19727073
GO:0034649	Function	Histone demethylase activity (H3-monomethyl-K4 specific)	IDA	23266887
GO:0034649	Function	Histone demethylase activity (H3-monomethyl-K4 specific)	ISS	19727073
GO:0034720	Process	Histone H3-K4 demethylation	IDA	23266887
GO:0034720	Process	Histone H3-K4 demethylation	ISS	19727073
GO:0042393	Function	Histone binding	IDA	23260659
GO:0044030	Process	Regulation of DNA methylation	ISS	19727073
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA	21873635
GO:0071949	Function	FAD binding	IDA	23260659, 23266887

MIM	HGNC	e!Ensembl
613081	21577	ENSG00000165097

Protein

UniProt ID

Q8NB78

Protein name

Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B)

Protein function

Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by

PDB

4FWE , 4FWF , 4FWJ , 4GU0 , 4GU1 , 4GUR , 4GUS , 4GUT , 4GUU , 4HSU , 6R1U , 6R25 , 7XE1 , 7XE2 , 7XE3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07496	zf-CW	138 → 191	CW-type Zinc Finger	Domain
PF04433	SWIRM	282 → 364	SWIRM domain	Domain
PF01593	Amino_oxidase	392 → 820	Flavin containing amine oxidoreductase	Domain

Sequence

MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTA
TCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYTTWKKIWTSN
GKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLTPQIAKTYRCGMKPNTAIKPE
TSDHCSLPEDLRVLEVSNHWWYSMLILPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTNRA
AATGNASPGKLEHSKAALSVHVPGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEY
SRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKG
LINTGVLSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGR
VWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTID
KRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHL
SNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQC
IDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIE
KIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVAS
VRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD
IIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF

Sequence length

822

Interactions

View interactions

	Reactome
			HDMs demethylate histones UCH proteinases NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	26830138
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	29892015, 30061737

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	29892015	ClinVar
Atrial Fibrillation	Atrial Fibrillation		GWAS

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	36002648
Carcinoma Renal Cell	Associate	31160694
Colorectal Neoplasms	Associate	32726297
Drug Hypersensitivity	Associate	29997151
Lung Neoplasms	Associate	32994395
Neoplasms	Inhibit	26461474
Neoplasms	Associate	36002648
Ovarian Neoplasms	Associate	31108893
Rh Null Regulator Type	Inhibit	31108893
Small Cell Lung Carcinoma	Associate	29845195
Squamous Cell Carcinoma of Head and Neck	Associate	22847005

KDM1B (lysine demethylase 1B)