H2AC1 (H2A clustered histone 1)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
221613
Gene name Gene Name - the full gene name approved by the HGNC.
H2A clustered histone 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
H2AC1
Synonyms (NCBI Gene) Gene synonyms aliases
H2AA, H2AFR, HIST1H2AA, HISTH2AA, TH2A, bA317E16.2
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p22.2
Summary Summary of gene provided in NCBI Entrez Gene.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core hi
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
GO ID Ontology Definition Evidence Reference
GO:0000781 Component Chromosome, telomeric region HDA 19135898
GO:0000786 Component Nucleosome IEA
GO:0003677 Function DNA binding IBA 21873635
GO:0005634 Component Nucleus HDA 21630459
GO:0006342 Process Chromatin silencing IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
613499 18729 ENSG00000164508
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q96QV6
Protein name Histone H2A type 1-A (H2A-clustered histone 1) (Histone H2A/r)
Protein function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair,
PDB 5GSU , 5GT0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00125 Histone 2 → 91 Core histone H2A/H2B/H3/H4 Domain
PF16211 Histone_H2A_C 92 → 126 C-terminus of histone H2A Family
Sequence
Sequence length 131
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  ATP-dependent chromatin remodeling
Necroptosis
Neutrophil extracellular trap formation
Alcoholism
Systemic lupus erythematosus 		  HDACs deacetylate histones
HATs acetylate histones
RMTs methylate histone arginines
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
HCMV Early Events
HCMV Late Events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Neuroticism Neuroticism GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA