Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	221472
Gene name	FYVE, RhoGEF and PH domain containing 2
Gene symbol	FGD2
Synonyms (NCBI Gene)	ZFYVE4
Chromosome	6
Chromosome location	6p21.2
Summary	The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocyt

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017089	hsa-miR-335-5p	Microarray	18185580
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT995193	hsa-miR-142-3p	CLIP-seq
MIRT995194	hsa-miR-2113	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT995199	hsa-miR-3174	CLIP-seq
MIRT995200	hsa-miR-3197	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT995209	hsa-miR-3940-3p	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995211	hsa-miR-4432	CLIP-seq
MIRT995212	hsa-miR-4453	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT995216	hsa-miR-4538	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT995218	hsa-miR-4716-5p	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995220	hsa-miR-4797-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT995223	hsa-miR-499-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT995225	hsa-miR-921	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995090	hsa-miR-24	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995200	hsa-miR-3197	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT1995097	hsa-miR-3929	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT1995099	hsa-miR-4284	CLIP-seq
MIRT1995100	hsa-miR-4419b	CLIP-seq
MIRT1995101	hsa-miR-4478	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT1995103	hsa-miR-4649-3p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT1995105	hsa-miR-890	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT2229194	hsa-miR-4786-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT2229195	hsa-miR-769-5p	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT2449656	hsa-miR-3667-5p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT2449656	hsa-miR-3667-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT2532804	hsa-miR-4300	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT2532805	hsa-miR-920	CLIP-seq
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT2532804	hsa-miR-4300	CLIP-seq
MIRT995211	hsa-miR-4432	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995220	hsa-miR-4797-5p	CLIP-seq
MIRT995223	hsa-miR-499-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT2532805	hsa-miR-920	CLIP-seq

Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	IEA
GO:0001726	Component	Ruffle	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005794	Component	Golgi apparatus	ISS
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0007010	Process	Cytoskeleton organization	IBA
GO:0007010	Process	Cytoskeleton organization	ISS
GO:0008270	Function	Zinc ion binding	IEA
GO:0008360	Process	Regulation of cell shape	ISS
GO:0016020	Component	Membrane	IEA
GO:0030027	Component	Lamellipodium	ISS
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0031267	Function	Small GTPase binding	ISS
GO:0031901	Component	Early endosome membrane	IEA
GO:0032587	Component	Ruffle membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0046847	Process	Filopodium assembly	IBA
GO:0046847	Process	Filopodium assembly	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:1901981	Function	Phosphatidylinositol phosphate binding	IEA

MIM	HGNC	e!Ensembl
605091	3664	ENSG00000146192

Q7Z6J4

Protein name

FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)

Protein function

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, pho

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00621	RhoGEF	106 → 288	RhoGEF domain	Domain
PF00169	PH	320 → 418	PH domain	Domain
PF01363	FYVE	453 → 518	FYVE zinc finger	Domain
PF00169	PH	528 → 641	PH domain	Domain

Sequence

MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEA
VGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVAR
LHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANP
RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQH
HMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDL
WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA
QFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQI
EKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHH
CRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSA
TPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVT
VGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD

Sequence length

655

Interactions

View interactions

	Reactome
			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Prostate cancer	Uncertain significance	rs193921018	RCV000149367

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Obesity	Associate	30397228

FGD2 (FYVE, RhoGEF and PH domain containing 2)