Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	221472
Gene name Gene Name - the full gene name approved by the HGNC.	FYVE, RhoGEF and PH domain containing 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FGD2
Synonyms (NCBI Gene) Gene synonyms aliases	ZFYVE4
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocyt

Show/Hide all(153)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017089	hsa-miR-335-5p	Microarray	18185580
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT995193	hsa-miR-142-3p	CLIP-seq
MIRT995194	hsa-miR-2113	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT995199	hsa-miR-3174	CLIP-seq
MIRT995200	hsa-miR-3197	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT995209	hsa-miR-3940-3p	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995211	hsa-miR-4432	CLIP-seq
MIRT995212	hsa-miR-4453	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT995216	hsa-miR-4538	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT995218	hsa-miR-4716-5p	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995220	hsa-miR-4797-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT995223	hsa-miR-499-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT995225	hsa-miR-921	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995090	hsa-miR-24	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995200	hsa-miR-3197	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT1995097	hsa-miR-3929	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT1995099	hsa-miR-4284	CLIP-seq
MIRT1995100	hsa-miR-4419b	CLIP-seq
MIRT1995101	hsa-miR-4478	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT1995103	hsa-miR-4649-3p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT1995105	hsa-miR-890	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT2229194	hsa-miR-4786-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT2229195	hsa-miR-769-5p	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT2449656	hsa-miR-3667-5p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT2449656	hsa-miR-3667-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT2532804	hsa-miR-4300	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT2532805	hsa-miR-920	CLIP-seq
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT2532804	hsa-miR-4300	CLIP-seq
MIRT995211	hsa-miR-4432	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995220	hsa-miR-4797-5p	CLIP-seq
MIRT995223	hsa-miR-499-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT2532805	hsa-miR-920	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	ISS
GO:0005794	Component	Golgi apparatus	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0007010	Process	Cytoskeleton organization	IBA	21873635
GO:0007010	Process	Cytoskeleton organization	ISS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008360	Process	Regulation of cell shape	ISS
GO:0030027	Component	Lamellipodium	ISS
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0031267	Function	Small GTPase binding	ISS
GO:0031901	Component	Early endosome membrane	IEA
GO:0032587	Component	Ruffle membrane	IEA
GO:0043065	Process	Positive regulation of apoptotic process	TAS
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0043507	Process	Positive regulation of JUN kinase activity	IEA
GO:0046847	Process	Filopodium assembly	IBA	21873635
GO:0046847	Process	Filopodium assembly	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:1901981	Function	Phosphatidylinositol phosphate binding	IEA

MIM	HGNC	e!Ensembl
605091	3664	ENSG00000146192

Protein

UniProt ID

Q7Z6J4

Protein name

FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)

Protein function

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, pho

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00621	RhoGEF	106 → 288	RhoGEF domain	Domain
PF00169	PH	320 → 418	PH domain	Domain
PF01363	FYVE	453 → 518	FYVE zinc finger	Domain
PF00169	PH	528 → 641	PH domain	Domain

Sequence

MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEA
VGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVAR
LHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANP
RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQH
HMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDL
WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA
QFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQI
EKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHH
CRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSA
TPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVT
VGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD

Sequence length

655

Interactions

View interactions

	Reactome
			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912 View all (22 more)	30595370

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Eczema	Eczema		GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Obesity	Associate	30397228

FGD2 (FYVE, RhoGEF and PH domain containing 2)