OARD1 (O-acyl-ADP-ribose deacylase 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
221443
Gene name Gene Name - the full gene name approved by the HGNC.
O-acyl-ADP-ribose deacylase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
OARD1
Synonyms (NCBI Gene) Gene synonyms aliases
C6orf130, TARG1, dJ34B21.3
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inh
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(60)
miRTarBase ID miRNA Experiments Reference
MIRT024088 hsa-miR-1-3p Microarray 18668037
MIRT030559 hsa-miR-24-3p Microarray 19748357
MIRT516113 hsa-miR-4524b-3p PAR-CLIP 20371350
MIRT516112 hsa-miR-1182 PAR-CLIP 20371350
MIRT516111 hsa-miR-4524a-3p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(21)
GO ID Ontology Definition Evidence Reference
GO:0001883 Function Purine nucleoside binding IDA 21849506
GO:0005515 Function Protein binding IPI 23481255, 32296183
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IBA
GO:0005654 Component Nucleoplasm IDA 29712969
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
614393 21257 ENSG00000124596
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9Y530
Protein name ADP-ribose glycohydrolase OARD1 (O-acetyl-ADP-ribose deacetylase 1) (EC 3.5.1.-) (Terminal ADP-ribose protein glycohydrolase 1) ([Protein ADP-ribosylglutamate] hydrolase OARD1) (EC 3.2.2.-)
Protein function ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose (PubMed:21849506, PubMed:23474714, PubMed:23481255). Specifically acts as a glutamate
PDB 2EEE , 2L8R , 2LGR , 4J5Q , 4J5R , 4J5S
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01661 Macro 31 → 136 Macro domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:23481255}.
Sequence
Sequence length 152
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Show/Hide Text Mining Associations (6)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 38511601
Glutamyl Ribose 5 Phosphate Storage Disease Associate 23481255
Immunologic Deficiency Syndromes Associate 23481255
Insulin Resistance Associate 29986096
Leukemia Lymphocytic Chronic B Cell Associate 20124481
Neurodegenerative Diseases Associate 23481255