FCGR3A (Fc gamma receptor IIIa)

Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2214
Gene name Gene Name - the full gene name approved by the HGNC.
Fc gamma receptor IIIa
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FCGR3A
Synonyms (NCBI Gene) Gene synonyms aliases
CD16, CD16-II, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, FcGRIIIA, IGFR3, IMD20
Disease Acronyms (UniProt) Disease acronyms from UniProt database
IMD20
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs396991 A>C,G,T Likely-benign, drug-response Intron variant, coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
miRTarBase ID miRNA Experiments Reference
MIRT993883 hsa-miR-1292 CLIP-seq
MIRT993884 hsa-miR-1294 CLIP-seq
MIRT993885 hsa-miR-1301 CLIP-seq
MIRT993886 hsa-miR-3126-5p CLIP-seq
MIRT993887 hsa-miR-4316 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
GO ID Ontology Definition Evidence Reference
GO:0004888 Function Transmembrane signaling receptor activity IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IBA 21873635
GO:0006955 Process Immune response TAS 2138330
GO:0007166 Process Cell surface receptor signaling pathway IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
146740 3619 ENSG00000203747
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P08637
Protein name Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Protein function Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent
PDB 3AY4 , 3SGJ , 3SGK , 3WN5 , 5BW7 , 5D6D , 5ML9 , 5MN2 , 5VU0 , 5XJE , 5XJF , 5YC5 , 7SEG , 7URU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13895 Ig_2 27 → 104 Immunoglobulin domain Domain
PF13895 Ig_2 108 → 190 Immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in natural killer cells (at protein level) (PubMed:2526846). Expressed in a subset of circulating monocytes (at protein level) (PubMed:27670158). {ECO:0000269|PubMed:2526846, ECO:0000269|PubMed:27670158}.
Sequence
Sequence length 254
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Phagosome
Osteoclast differentiation
Neutrophil extracellular trap formation
Natural killer cell mediated cytotoxicity
Fc gamma R-mediated phagocytosis
Leishmaniasis
Staphylococcus aureus infection
Tuberculosis
Systemic lupus erythematosus 		  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Immunodeficiency IMMUNODEFICIENCY 20 rs1565678077, rs121908002, rs1421444086, rs1565688667, rs944235493, rs121918314, rs587776713, rs137852678, rs587776714, rs128620188, rs2147483647, rs1569556522, rs137853331, rs137853332, rs179363866
View all (256 more)		 23006327, 8608639, 8609432, 8874200
Show/Hide Unknown Diseases (8)
Unknown
Disease term Disease name Evidence References Source
Celiac disease Celiac Disease 30097691 ClinVar
Immunodeficiency with defective spontaneous natural killer cell cytotoxicity Autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity ClinVar
Otitis media Recurrent otitis media ClinVar
Immunodeficiency With Defective Spontaneous Natural Killer Cell Cytotoxicity autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity GenCC
Show/Hide Text Mining Associations (370)
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Stimulate 24807109
Abortion Spontaneous Associate 33103514
Achondroplasia and Swiss type agammaglobulinemia Associate 17900300
Acquired Immunodeficiency Syndrome Associate 10575136, 15767342, 1708784, 2913035
Acute Aortic Syndrome Stimulate 32509885
Acute Disease Associate 10231456
Acute Kidney Injury Associate 35681510
Adenocarcinoma Clear Cell Associate 37064811
Adenocarcinoma of Lung Associate 35836920
Adrenoleukodystrophy Associate 21564078