FCGR3A (Fc gamma receptor IIIa)

Gene Gene information from NCBI Gene database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 2214
Gene name Fc gamma receptor IIIa
Gene symbol FCGR3A
Synonyms (NCBI Gene)
CD16CD16-IICD16AFCG3FCGR3FCGRIIIFCR-10FCRIIIFCRIIIAFcGRIIIAIGFR3IMD20
Chromosome 1
Chromosome location 1q23.3
Summary This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody
SNPs SNP information provided by dbSNP.
1
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (1)
SNP ID Visualize variation Clinical significance Consequence
rs396991 A>C,G,T Likely-benign, drug-response Intron variant, coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
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Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT993883 hsa-miR-1292 CLIP-seq
MIRT993884 hsa-miR-1294 CLIP-seq
MIRT993885 hsa-miR-1301 CLIP-seq
MIRT993886 hsa-miR-3126-5p CLIP-seq
MIRT993887 hsa-miR-4316 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001788 Process Antibody-dependent cellular cytotoxicity IBA
GO:0001788 Process Antibody-dependent cellular cytotoxicity IDA 11711607, 27670158, 28652325
GO:0001913 Process T cell mediated cytotoxicity ISS
GO:0002376 Process Immune system process IEA
GO:0005515 Function Protein binding IPI 2532305, 23006327, 23024279, 33961781, 34158475
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
146740 3619 ENSG00000203747
Protein Protein information from UniProt database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P08637
Protein name Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Protein function Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent
PDB 3AY4 , 3SGJ , 3SGK , 3WN5 , 5BW7 , 5D6D , 5ML9 , 5MN2 , 5VU0 , 5XJE , 5XJF , 5YC5 , 7SEG , 7URU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13895 Ig_2 27 → 104 Immunoglobulin domain Domain
PF13895 Ig_2 108 → 190 Immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in natural killer cells (at protein level) (PubMed:2526846). Expressed in a subset of circulating monocytes (at protein level) (PubMed:27670158). {ECO:0000269|PubMed:2526846, ECO:0000269|PubMed:27670158}.
Sequence
Sequence length 254
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Phagosome
Osteoclast differentiation
Neutrophil extracellular trap formation
Natural killer cell mediated cytotoxicity
Fc gamma R-mediated phagocytosis
Leishmaniasis
Staphylococcus aureus infection
Tuberculosis
Systemic lupus erythematosus 		  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity Uncertain significance rs777467556, rs1003462350, rs10127939, rs769001959 RCV001336957
RCV001336960
RCV000015953
RCV000768223
Show/Hide Text Mining Associations (370)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Stimulate 24807109
Abortion Spontaneous Associate 33103514
Achondroplasia and Swiss type agammaglobulinemia Associate 17900300
Acquired Immunodeficiency Syndrome Associate 10575136, 15767342, 1708784, 2913035
Acute Aortic Syndrome Stimulate 32509885
Acute Disease Associate 10231456
Acute Kidney Injury Associate 35681510
Adenocarcinoma Clear Cell Associate 37064811
Adenocarcinoma of Lung Associate 35836920
Adrenoleukodystrophy Associate 21564078