NT5DC1 (5'-nucleotidase domain containing 1)

Gene

• Entrez ID: 221294
• Gene name: 5'-nucleotidase domain containing 1
• Gene symbol: NT5DC1
• Synonyms (NCBI Gene): C6orf200, LP2642, NT5C2L1
• Chromosome: 6
• Chromosome location: 6q22.1
• Summary: While the exact function of the protein encoded by this gene is not known, it belongs to the 5`(3`)-deoxyribonucleotidase family. [provided by RefSeq, May 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003876	hsa-miR-15a-5p	Microarray	18362358
MIRT004370	hsa-miR-16-5p	Microarray	18362358
MIRT047616	hsa-miR-10a-5p	CLASH	23622248
MIRT710876	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT710875	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT710874	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710872	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT710876	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT710875	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT710874	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710873	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT710872	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT663892	hsa-miR-595	HITS-CLIP	21572407
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT517726	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT663895	hsa-miR-548n	HITS-CLIP	23824327
MIRT663894	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT663893	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	23824327
MIRT517729	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT663892	hsa-miR-595	HITS-CLIP	23824327
MIRT517728	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT517726	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT517730	hsa-miR-548at-5p	PAR-CLIP	23446348
MIRT517729	hsa-miR-561-3p	PAR-CLIP	23446348
MIRT517728	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT517727	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT517726	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT517728	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT517728	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT517728	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT517728	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	27418678
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	27418678
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	27418678
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	27418678
MIRT663894	hsa-miR-548az-5p	HITS-CLIP	27418678
MIRT663894	hsa-miR-548az-5p	HITS-CLIP	27418678
MIRT663894	hsa-miR-548az-5p	HITS-CLIP	27418678
MIRT663895	hsa-miR-548n	HITS-CLIP	27418678
MIRT663895	hsa-miR-548n	HITS-CLIP	27418678
MIRT663895	hsa-miR-548n	HITS-CLIP	27418678
MIRT663893	hsa-miR-548t-5p	HITS-CLIP	27418678
MIRT663893	hsa-miR-548t-5p	HITS-CLIP	27418678
MIRT663893	hsa-miR-548t-5p	HITS-CLIP	27418678
MIRT517729	hsa-miR-561-3p	HITS-CLIP	27418678
MIRT517729	hsa-miR-561-3p	HITS-CLIP	27418678
MIRT517729	hsa-miR-561-3p	HITS-CLIP	27418678
MIRT517729	hsa-miR-561-3p	HITS-CLIP	27418678
MIRT517726	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT517726	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT517726	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT517726	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT663892	hsa-miR-595	HITS-CLIP	27418678
MIRT663892	hsa-miR-595	HITS-CLIP	27418678
MIRT663892	hsa-miR-595	HITS-CLIP	27418678
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT710876	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT710875	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT710874	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710872	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT710876	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT710875	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT710874	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710873	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT710872	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT663892	hsa-miR-595	HITS-CLIP	21572407
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT517726	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT663895	hsa-miR-548n	HITS-CLIP	23824327
MIRT663894	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT663893	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	23824327
MIRT517729	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT663892	hsa-miR-595	HITS-CLIP	23824327
MIRT517728	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT517726	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT517730	hsa-miR-548at-5p	PAR-CLIP	23446348
MIRT517729	hsa-miR-561-3p	PAR-CLIP	23446348
MIRT517728	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT517727	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT517726	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT1195750	hsa-miR-101	CLIP-seq
MIRT1195751	hsa-miR-1185	CLIP-seq
MIRT1195752	hsa-miR-125a-3p	CLIP-seq
MIRT740173	hsa-miR-1264	CLIP-seq
MIRT1195753	hsa-miR-129-5p	CLIP-seq
MIRT1195754	hsa-miR-1323	CLIP-seq
MIRT1195755	hsa-miR-144	CLIP-seq
MIRT1195756	hsa-miR-146a	CLIP-seq
MIRT1195757	hsa-miR-146b-5p	CLIP-seq
MIRT1195758	hsa-miR-190	CLIP-seq
MIRT1195759	hsa-miR-190b	CLIP-seq
MIRT1195760	hsa-miR-3201	CLIP-seq
MIRT1195761	hsa-miR-326	CLIP-seq
MIRT1195762	hsa-miR-330-5p	CLIP-seq
MIRT1195763	hsa-miR-34b	CLIP-seq
MIRT1195764	hsa-miR-3654	CLIP-seq
MIRT1195765	hsa-miR-3679-5p	CLIP-seq
MIRT1195766	hsa-miR-3691-3p	CLIP-seq
MIRT1195767	hsa-miR-378	CLIP-seq
MIRT1195768	hsa-miR-378b	CLIP-seq
MIRT1195769	hsa-miR-378c	CLIP-seq
MIRT1195770	hsa-miR-378d	CLIP-seq
MIRT1195771	hsa-miR-378e	CLIP-seq
MIRT1195772	hsa-miR-378f	CLIP-seq
MIRT1195773	hsa-miR-378h	CLIP-seq
MIRT1195774	hsa-miR-378i	CLIP-seq
MIRT1195775	hsa-miR-3914	CLIP-seq
MIRT1195776	hsa-miR-422a	CLIP-seq
MIRT740174	hsa-miR-4326	CLIP-seq
MIRT1195777	hsa-miR-4452	CLIP-seq
MIRT1195778	hsa-miR-4480	CLIP-seq
MIRT1195779	hsa-miR-4676-5p	CLIP-seq
MIRT1195780	hsa-miR-4719	CLIP-seq
MIRT1195781	hsa-miR-4791	CLIP-seq
MIRT1195782	hsa-miR-516b	CLIP-seq
MIRT1195783	hsa-miR-548o	CLIP-seq
MIRT1195784	hsa-miR-548u	CLIP-seq
MIRT1195785	hsa-miR-575	CLIP-seq
MIRT1195786	hsa-miR-576-5p	CLIP-seq
MIRT1195787	hsa-miR-579	CLIP-seq
MIRT1195788	hsa-miR-580	CLIP-seq
MIRT1195789	hsa-miR-582-5p	CLIP-seq
MIRT1195790	hsa-miR-589	CLIP-seq
MIRT1195791	hsa-miR-593	CLIP-seq
MIRT1195792	hsa-miR-606	CLIP-seq
MIRT1195793	hsa-miR-765	CLIP-seq
MIRT1195794	hsa-miR-873	CLIP-seq
MIRT2056810	hsa-miR-155	CLIP-seq
MIRT2056811	hsa-miR-4720-3p	CLIP-seq
MIRT2056812	hsa-miR-4804-3p	CLIP-seq
MIRT2056813	hsa-miR-561	CLIP-seq
MIRT2285286	hsa-miR-200b	CLIP-seq
MIRT2285287	hsa-miR-200c	CLIP-seq
MIRT2285288	hsa-miR-429	CLIP-seq
MIRT2285289	hsa-miR-4659a-3p	CLIP-seq
MIRT2285290	hsa-miR-4659b-3p	CLIP-seq
MIRT2285291	hsa-miR-513a-3p	CLIP-seq
MIRT1195786	hsa-miR-576-5p	CLIP-seq
MIRT1195792	hsa-miR-606	CLIP-seq
MIRT1195775	hsa-miR-3914	CLIP-seq
MIRT1195779	hsa-miR-4676-5p	CLIP-seq
MIRT1195785	hsa-miR-575	CLIP-seq
MIRT1195794	hsa-miR-873	CLIP-seq
MIRT1195751	hsa-miR-1185	CLIP-seq
MIRT1195758	hsa-miR-190	CLIP-seq
MIRT1195759	hsa-miR-190b	CLIP-seq
MIRT2686639	hsa-miR-2053	CLIP-seq
MIRT1195760	hsa-miR-3201	CLIP-seq
MIRT1195761	hsa-miR-326	CLIP-seq
MIRT1195762	hsa-miR-330-5p	CLIP-seq
MIRT1195765	hsa-miR-3679-5p	CLIP-seq
MIRT1195766	hsa-miR-3691-3p	CLIP-seq
MIRT2686640	hsa-miR-369-3p	CLIP-seq
MIRT2686641	hsa-miR-374a	CLIP-seq
MIRT2686642	hsa-miR-374b	CLIP-seq
MIRT2686643	hsa-miR-4428	CLIP-seq
MIRT1195778	hsa-miR-4480	CLIP-seq
MIRT1195781	hsa-miR-4791	CLIP-seq
MIRT1195782	hsa-miR-516b	CLIP-seq
MIRT1195791	hsa-miR-593	CLIP-seq
MIRT1195793	hsa-miR-765	CLIP-seq
MIRT2686644	hsa-miR-769-5p	CLIP-seq
MIRT2686645	hsa-miR-889	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0008253	Function	5'-nucleotidase activity	IBA	21873635
GO:0016311	Process	Dephosphorylation	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 621076
• HGNC: 21556
• e!Ensembl: ENSG00000178425

Protein

• UniProt ID: Q5TFE4
• Protein name: 5'-nucleotidase domain-containing protein 1 (EC 3.1.3.-)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05761	5_nucleotid	1 → 377		Family

• Sequence:

  MAQHFSLAACDVVGFDLDHTLCRYNLPESAPLIYNSFAQFLVKEKGYDKELLNVTPEDWD
  FCCKGLALDLEDGNFLKLANNGTVLRASHGTKMMTPEVLAEAYGKKEWKHFLSDTGMACR
  SGKYYFYDNYFDLPGALLCARVVDYLTKLNNGQKTFDFWKDIVAAIQHNYKMSAFKENCG
  IYFPEIKRDPGRYLHSCPESVKKWLRQLKNAGKILLLITSSHSDYCRLLCEYILGNDFTD
  LFDIVITNALKPGFFSHLPSQRPFRTLENDEEQEALPSLDKPGWYSQGNAVHLYELLKKM
  TGKPEPKVVYFGDSMHSDIFPARHYSNWETVLILEELRGDEGTRSQRPEESEPLEKKGKY
  EGPKAKPLNTSSKKWGSFFIDSVLGLENTEDSLVYTWSCKRISTYSTIAIPSIEAIAELP
  LDYKFTRFSSSNSKTAGYYPNPPLVLSSDETLISK

• Sequence length: 455

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Age-related macular degeneration	Age related macular degeneration	rs199474657, rs61750120, rs1800728, rs62654397, rs61749423, rs61751412, rs61749439, rs61751398, rs61752417, rs62645946, rs1801269, rs62646860, rs61750142, rs61750145, rs61750152, rs61751377, rs61753029, rs61751407, rs61751389, rs61750645, rs61750648, rs879255520, rs752147871, rs886044750, rs886044749, rs746541266, rs756840095, rs886044725, rs749526785, rs1057518955, rs1057518767, rs371489809, rs1064793014, rs1571264574, rs1659524475	23455636
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22535842
Metaphyseal chondrodysplasia	Metaphyseal chondrodysplasia Schmid type	rs121909500, rs121434597, rs121434598, rs121434600, rs121434602, rs199476103, rs727502774, rs1554651507, rs727502776, rs1554651446, rs727502778, rs1554651469, rs878853178, rs796065036, rs111033544, rs111033545, rs111033546, rs1562122372, rs111033543, rs111033547, rs111033549, rs111033550, rs111033551, rs111033552, rs111033548, rs111033553, rs111033554, rs111033556, rs2114276588, rs140059558, rs369083541, rs786204684, rs1554651506, rs753874439, rs1554651455, rs1085307765, rs1131691804, rs1383432106, rs1554651508, rs1340624774, rs751921616, rs551450545, rs752934195, rs549085067, rs1156413585, rs772443941, rs1554651395, rs1554651397, rs1554651396, rs1554651403, rs1554651424, rs1554651427, rs727502777, rs1230629953, rs1554651481, rs1554651491, rs1554651503, rs1554651532, rs1554651544, rs1554651365, rs1218494857, rs1587919129, rs1554651422, rs1554651428, rs1554651486, rs1554651489, rs1554651526, rs1554651405, rs1554651400, rs1587919165, rs1554651404, rs1554651411, rs1554651461, rs1554651471, rs1554651473, rs1554651505, rs781730798, rs1554651513, rs1554651153, rs759665242, rs1554651368, rs1554651382, rs1554651418, rs1554651413, rs1554651425, rs1554651451, rs1554651453, rs1554651462, rs1554651466, rs920074067, rs1554651499, rs1554651512, rs1554651524, rs1554651543, rs936059863, rs749667892, rs769180471, rs192060920, rs948931144, rs1554651373, rs1563907881, rs1563907883, rs1563907946, rs1563908212, rs1563908167, rs1582811858, rs1554651445
Myopia	Myopia	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805, rs782555528, rs1554862601, rs1586620121, rs1387950081, rs2051026773, rs1422332023	27182965
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137

Unknown
Disease term	Disease name	Evidence	References	Source
Gout	Gout			GWAS
Dental caries	Dental caries			GWAS
Carpal Tunnel Syndrome	Carpal Tunnel Syndrome			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
AIDS Associated Nephropathy	Associate	23982958
Attention Deficit Disorder with Hyperactivity	Associate	27754487
Breast Neoplasms	Associate	36820551
Cognition Disorders	Associate	23982958
HIV Infections	Associate	23982958