Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
221078
Gene name Gene Name - the full gene name approved by the HGNC.
NOP2/Sun RNA methyltransferase 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NSUN6
Synonyms (NCBI Gene) Gene synonyms aliases
4933414E04Rik, ARL5B-AS1, MRT82, NOPD1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
MRT82
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p12.31
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1195533 hsa-miR-1324 CLIP-seq
MIRT1195534 hsa-miR-140-3p CLIP-seq
MIRT1195535 hsa-miR-151-3p CLIP-seq
MIRT1195536 hsa-miR-3120-3p CLIP-seq
MIRT1195537 hsa-miR-34c-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000049 Function TRNA binding IDA 26160102, 28531330
GO:0001510 Process RNA methylation IBA 21873635
GO:0002946 Process TRNA C5-cytosine methylation IDA 26160102
GO:0005737 Component Cytoplasm IDA 26160102
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
617199 23529 ENSG00000241058
Protein
UniProt ID Q8TEA1
Protein name tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (EC 2.1.1.-) (NOL1/NOP2/Sun and PUA domain-containing protein 1) (NOL1/NOP2/Sun domain family member 6)
Protein function S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA) (PubMed:26160102, PubMed:27703015, PubMed:28531330). In vitro also methylates tRNA(Thr)(AGT) (Pu
PDB 5WWQ , 5WWR , 5WWS , 5WWT , 9IMB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01189 Methyltr_RsmB-F 227 464 16S rRNA methyltransferase RsmB/F Family
Sequence
MSIFPKISLRPEVENYLKEGFMNKEIVTALGKQEAERKFETLLKHLSHPPSFTTVRVNTH
LASVQHVKNLLLDELQKQFNGLSVPILQHPDLQDVLLIPVIGPRKNIKKQQCEAIVGAQC
GNAVLRGAHVYAPGIVSASQFMKAGDVISVYSDIKGKCKKGAKEFDGTKVFLGNGISELS
RKEIFSGLPELKGMGIRMTEPVYLSPSFDSVLPRYLFLQNLPSALVSHVLNPQPGEKILD
LCAAPGGKTTHIAALMHDQGEVIALDKIFNKVEKIKQNALLLGLNSIRAFCFDGTKAVKL
DMVEDTEGEPPFLPESFDRILLDAPCSGMGQRPNMACTWSVKEVASYQPLQRKLFTAAVQ
LLKPEGVLVYSTCTITLAENEEQVAWALTKFPCLQLQPQEPQIGGEGMRGAGLSCEQLKQ
LQRFDPSAVPLPDTDMDSLREARREDMLRLANKDSIGFFIAKFV
KCKST
Sequence length 469
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    tRNA modification in the nucleus and cytosol
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
28114269
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
28114269
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
28114269
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
30285260
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Stimulate 40640303
Alzheimer Disease Associate 36646969
Brain Injuries Traumatic Associate 36646969
Carcinoma Renal Cell Associate 40640303
Cholangiocarcinoma Inhibit 40640303
Colorectal Neoplasms Associate 35212022
Glioblastoma Associate 34705606
Glioma Inhibit 40561176
Glioma of Brain Familial Associate 40640303
Neoplasms Associate 34705606