FCGR1A (Fc gamma receptor Ia)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2209
Gene name Gene Name - the full gene name approved by the HGNC.
Fc gamma receptor Ia
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FCGR1A
Synonyms (NCBI Gene) Gene synonyms aliases
CD64, CD64A, FCG1, FCGR1, FCRI, FcgammaRI, IGFR1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
miRTarBase ID miRNA Experiments Reference
MIRT993836 hsa-miR-3120-5p CLIP-seq
MIRT993837 hsa-miR-4311 CLIP-seq
MIRT993838 hsa-miR-4652-3p CLIP-seq
MIRT993839 hsa-miR-4711-3p CLIP-seq
MIRT993840 hsa-miR-4753-3p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
SPI1 Unknown 10820245;14734612
STAT1 Unknown 14734612
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(40)
GO ID Ontology Definition Evidence Reference
GO:0001788 Process Antibody-dependent cellular cytotoxicity IBA
GO:0001788 Process Antibody-dependent cellular cytotoxicity IDA 11711607
GO:0001788 Process Antibody-dependent cellular cytotoxicity IEA
GO:0001788 Process Antibody-dependent cellular cytotoxicity IEA
GO:0001798 Process Positive regulation of type IIa hypersensitivity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
146760 3613 ENSG00000150337
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P12314
Protein name High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
Protein function High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected
PDB 3RJD , 4W4O , 4X4M , 4ZNE , 8DIN , 8DIR , 8DJ7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13927 Ig_3 23 → 87 Domain
PF13895 Ig_2 104 → 185 Immunoglobulin domain Domain
PF00047 ig 195 → 275 Immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Monocyte/macrophage specific.
Sequence
Sequence length 374
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Phagosome
Osteoclast differentiation
Neutrophil extracellular trap formation
Hematopoietic cell lineage
Fc gamma R-mediated phagocytosis
Leishmaniasis
Staphylococcus aureus infection
Tuberculosis
Transcriptional misregulation in cancer
Acute myeloid leukemia
Systemic lupus erythematosus 		  Cross-presentation of soluble exogenous antigens (endosomes)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Interferon gamma signaling
FCGR3A-mediated IL10 synthesis
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Acute Myeloid Leukemia Acute myeloid leukemia FCGR1A (CD64) expression on AML increases its sensitivity to DNTs. 33270841 CBGDA
Show/Hide Text Mining Associations (148)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 10931386
Agammaglobulinemia Associate 26708396
AIDS Associated Nephropathy Associate 23982074
Alzheimer Disease Associate 30193587, 33186918, 34602489
Anaphylaxis Associate 30189430
Anemia Sickle Cell Associate 9414294
Arthritis Associate 22251373
Arthritis Infectious Stimulate 32849606
Arthritis Juvenile Stimulate 30683706
Arthritis Juvenile Associate 32849606