Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2206
Gene name Gene Name - the full gene name approved by the HGNC.	Membrane spanning 4-domains A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MS4A2
Synonyms (NCBI Gene) Gene synonyms aliases	APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER
Disease Acronyms (UniProt) Disease acronyms from UniProt database	ATOPY
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q12.1
Summary Summary of gene provided in NCBI Entrez Gene.	The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-l

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SNP ID	Visualize variation	Clinical significance	Consequence
rs569108	A>G	Risk-factor	Missense variant, genic downstream transcript variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017962	hsa-miR-335-5p	Microarray	18185580
MIRT1160980	hsa-miR-122	CLIP-seq
MIRT1160981	hsa-miR-1234	CLIP-seq
MIRT1160982	hsa-miR-125a-3p	CLIP-seq
MIRT1160983	hsa-miR-128	CLIP-seq
MIRT1160984	hsa-miR-129-5p	CLIP-seq
MIRT1160985	hsa-miR-1301	CLIP-seq
MIRT1160986	hsa-miR-134	CLIP-seq
MIRT1160987	hsa-miR-150	CLIP-seq
MIRT1160988	hsa-miR-2355-5p	CLIP-seq
MIRT1160989	hsa-miR-3117-3p	CLIP-seq
MIRT1160990	hsa-miR-3118	CLIP-seq
MIRT1160991	hsa-miR-3135b	CLIP-seq
MIRT1160992	hsa-miR-3149	CLIP-seq
MIRT1160993	hsa-miR-3163	CLIP-seq
MIRT1160994	hsa-miR-3169	CLIP-seq
MIRT1160995	hsa-miR-3652	CLIP-seq
MIRT1160996	hsa-miR-3714	CLIP-seq
MIRT1160997	hsa-miR-411	CLIP-seq
MIRT1160998	hsa-miR-4282	CLIP-seq
MIRT1160999	hsa-miR-4286	CLIP-seq
MIRT1161000	hsa-miR-4430	CLIP-seq
MIRT1161001	hsa-miR-4446-3p	CLIP-seq
MIRT1161002	hsa-miR-4466	CLIP-seq
MIRT1161003	hsa-miR-4492	CLIP-seq
MIRT1161004	hsa-miR-4498	CLIP-seq
MIRT1161005	hsa-miR-4505	CLIP-seq
MIRT1161006	hsa-miR-4659a-5p	CLIP-seq
MIRT1161007	hsa-miR-4659b-5p	CLIP-seq
MIRT1161008	hsa-miR-4660	CLIP-seq
MIRT1161009	hsa-miR-4672	CLIP-seq
MIRT1161010	hsa-miR-4708-5p	CLIP-seq
MIRT1161011	hsa-miR-4715-3p	CLIP-seq
MIRT1161012	hsa-miR-4735-5p	CLIP-seq
MIRT1161013	hsa-miR-4736	CLIP-seq
MIRT1161014	hsa-miR-4759	CLIP-seq
MIRT1161015	hsa-miR-4775	CLIP-seq
MIRT1161016	hsa-miR-483-5p	CLIP-seq
MIRT1161017	hsa-miR-5047	CLIP-seq
MIRT1161018	hsa-miR-548an	CLIP-seq
MIRT1161019	hsa-miR-548q	CLIP-seq
MIRT1161020	hsa-miR-552	CLIP-seq
MIRT1161021	hsa-miR-590-3p	CLIP-seq
MIRT1161022	hsa-miR-675	CLIP-seq
MIRT1161023	hsa-miR-762	CLIP-seq
MIRT1161024	hsa-miR-940	CLIP-seq
MIRT2046200	hsa-miR-127-5p	CLIP-seq
MIRT2046201	hsa-miR-1281	CLIP-seq
MIRT2046202	hsa-miR-147	CLIP-seq
MIRT2046203	hsa-miR-1915	CLIP-seq
MIRT2046204	hsa-miR-1976	CLIP-seq
MIRT2046205	hsa-miR-296-3p	CLIP-seq
MIRT1160992	hsa-miR-3149	CLIP-seq
MIRT1160993	hsa-miR-3163	CLIP-seq
MIRT2046206	hsa-miR-3187-3p	CLIP-seq
MIRT2046207	hsa-miR-3663-5p	CLIP-seq
MIRT2046208	hsa-miR-3686	CLIP-seq
MIRT1160996	hsa-miR-3714	CLIP-seq
MIRT2046209	hsa-miR-371-5p	CLIP-seq
MIRT2046210	hsa-miR-3911	CLIP-seq
MIRT1160997	hsa-miR-411	CLIP-seq
MIRT2046211	hsa-miR-4279	CLIP-seq
MIRT2046212	hsa-miR-4435	CLIP-seq
MIRT2046213	hsa-miR-4652-3p	CLIP-seq
MIRT1161009	hsa-miR-4672	CLIP-seq
MIRT2046214	hsa-miR-4684-5p	CLIP-seq
MIRT2046215	hsa-miR-4701-5p	CLIP-seq
MIRT2046216	hsa-miR-4726-3p	CLIP-seq
MIRT1161013	hsa-miR-4736	CLIP-seq
MIRT2046217	hsa-miR-4742-3p	CLIP-seq
MIRT2046218	hsa-miR-4755-3p	CLIP-seq
MIRT2046219	hsa-miR-4768-5p	CLIP-seq
MIRT2046220	hsa-miR-4781-3p	CLIP-seq
MIRT1161016	hsa-miR-483-5p	CLIP-seq
MIRT2046221	hsa-miR-507	CLIP-seq
MIRT1161018	hsa-miR-548an	CLIP-seq
MIRT2046222	hsa-miR-548s	CLIP-seq
MIRT2046223	hsa-miR-557	CLIP-seq
MIRT2046224	hsa-miR-588	CLIP-seq
MIRT2046225	hsa-miR-606	CLIP-seq
MIRT2046226	hsa-miR-644	CLIP-seq
MIRT2046227	hsa-miR-664	CLIP-seq
MIRT1161024	hsa-miR-940	CLIP-seq
MIRT2275309	hsa-miR-1224-3p	CLIP-seq
MIRT1160981	hsa-miR-1234	CLIP-seq
MIRT2046200	hsa-miR-127-5p	CLIP-seq
MIRT2046201	hsa-miR-1281	CLIP-seq
MIRT1160985	hsa-miR-1301	CLIP-seq
MIRT2275310	hsa-miR-1307	CLIP-seq
MIRT2275311	hsa-miR-145	CLIP-seq
MIRT1160987	hsa-miR-150	CLIP-seq
MIRT2275312	hsa-miR-1913	CLIP-seq
MIRT2046203	hsa-miR-1915	CLIP-seq
MIRT2046204	hsa-miR-1976	CLIP-seq
MIRT1160993	hsa-miR-3163	CLIP-seq
MIRT2275313	hsa-miR-3180-5p	CLIP-seq
MIRT2046206	hsa-miR-3187-3p	CLIP-seq
MIRT2275314	hsa-miR-3199	CLIP-seq
MIRT2275315	hsa-miR-324-3p	CLIP-seq
MIRT2046207	hsa-miR-3663-5p	CLIP-seq
MIRT1160996	hsa-miR-3714	CLIP-seq
MIRT2046209	hsa-miR-371-5p	CLIP-seq
MIRT2275316	hsa-miR-371b-5p	CLIP-seq
MIRT2275317	hsa-miR-3943	CLIP-seq
MIRT1160997	hsa-miR-411	CLIP-seq
MIRT2046211	hsa-miR-4279	CLIP-seq
MIRT2275318	hsa-miR-4323	CLIP-seq
MIRT2046212	hsa-miR-4435	CLIP-seq
MIRT1161002	hsa-miR-4466	CLIP-seq
MIRT2275319	hsa-miR-4638-5p	CLIP-seq
MIRT1161006	hsa-miR-4659a-5p	CLIP-seq
MIRT1161007	hsa-miR-4659b-5p	CLIP-seq
MIRT1161008	hsa-miR-4660	CLIP-seq
MIRT1161009	hsa-miR-4672	CLIP-seq
MIRT2046214	hsa-miR-4684-5p	CLIP-seq
MIRT2046215	hsa-miR-4701-5p	CLIP-seq
MIRT1161010	hsa-miR-4708-5p	CLIP-seq
MIRT2275320	hsa-miR-4712-5p	CLIP-seq
MIRT2275321	hsa-miR-4722-3p	CLIP-seq
MIRT2046216	hsa-miR-4726-3p	CLIP-seq
MIRT1161013	hsa-miR-4736	CLIP-seq
MIRT2046218	hsa-miR-4755-3p	CLIP-seq
MIRT2046219	hsa-miR-4768-5p	CLIP-seq
MIRT2275322	hsa-miR-4772-3p	CLIP-seq
MIRT2046220	hsa-miR-4781-3p	CLIP-seq
MIRT1161016	hsa-miR-483-5p	CLIP-seq
MIRT1161017	hsa-miR-5047	CLIP-seq
MIRT2275323	hsa-miR-513b	CLIP-seq
MIRT1161018	hsa-miR-548an	CLIP-seq
MIRT2046222	hsa-miR-548s	CLIP-seq
MIRT1161020	hsa-miR-552	CLIP-seq
MIRT2275324	hsa-miR-562	CLIP-seq
MIRT2046224	hsa-miR-588	CLIP-seq
MIRT2046225	hsa-miR-606	CLIP-seq
MIRT2275325	hsa-miR-617	CLIP-seq
MIRT2046227	hsa-miR-664	CLIP-seq
MIRT1161022	hsa-miR-675	CLIP-seq
MIRT2275326	hsa-miR-770-5p	CLIP-seq
MIRT1161024	hsa-miR-940	CLIP-seq
MIRT2391090	hsa-miR-1208	CLIP-seq
MIRT2046200	hsa-miR-127-5p	CLIP-seq
MIRT2046201	hsa-miR-1281	CLIP-seq
MIRT1160985	hsa-miR-1301	CLIP-seq
MIRT1160986	hsa-miR-134	CLIP-seq
MIRT2046203	hsa-miR-1915	CLIP-seq
MIRT2046204	hsa-miR-1976	CLIP-seq
MIRT1160990	hsa-miR-3118	CLIP-seq
MIRT2391091	hsa-miR-3138	CLIP-seq
MIRT2391092	hsa-miR-34c-3p	CLIP-seq
MIRT2046211	hsa-miR-4279	CLIP-seq
MIRT2391093	hsa-miR-4318	CLIP-seq
MIRT1161008	hsa-miR-4660	CLIP-seq
MIRT1161009	hsa-miR-4672	CLIP-seq
MIRT2046214	hsa-miR-4684-5p	CLIP-seq
MIRT1161010	hsa-miR-4708-5p	CLIP-seq
MIRT2275321	hsa-miR-4722-3p	CLIP-seq
MIRT2046216	hsa-miR-4726-3p	CLIP-seq
MIRT2046219	hsa-miR-4768-5p	CLIP-seq
MIRT2275322	hsa-miR-4772-3p	CLIP-seq
MIRT2391094	hsa-miR-4800-5p	CLIP-seq
MIRT1161017	hsa-miR-5047	CLIP-seq
MIRT2046200	hsa-miR-127-5p	CLIP-seq
MIRT2046201	hsa-miR-1281	CLIP-seq
MIRT2046203	hsa-miR-1915	CLIP-seq
MIRT2046216	hsa-miR-4726-3p	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
GATA2	Activation	24639354

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	NAS	1535625
GO:0006954	Process	Inflammatory response	IEA
GO:0006955	Process	Immune response	IMP	7920628
GO:0019863	Function	IgE binding	IEA
GO:0032998	Component	Fc-epsilon receptor I complex	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS

MIM	HGNC	e!Ensembl
147138	7316	ENSG00000149534

Protein

UniProt ID

Q01362

Protein name

High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2)

Protein function

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranul

PDB

8YVU , 8YWA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04103	CD20	60 → 204	CD20-like family	Family

Tissue specificity

TISSUE SPECIFICITY: Found on the surface of mast cells and basophils.

Sequence

MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF
LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISER
RNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTE
IVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSP
PIDL

Sequence length

244

Interactions

View interactions

	KEGG		Reactome
	Sphingolipid signaling pathway Phospholipase D signaling pathway Fc epsilon RI signaling pathway Asthma		Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Asthma	Asthma, Asthma, Aspirin-Induced	16502481	ClinVar
Alzheimer disease	Alzheimer disease		GWAS

Show/Hide Text Mining Associations (20)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	28650998
Asthma	Associate	10712341, 16519819, 19862939, 20554927, 21320344, 22432035, 22533235, 24039878, 24838642, 29761786, 33277970, 38049812, 40189906
Asthma Aspirin Induced	Associate	18595682
Cerebral Infarction	Associate	22769019
Dermatitis Atopic 3	Associate	10712341
Drug Hypersensitivity	Associate	23643722, 33277970, 36725846
Eczema	Associate	33277970, 34261469
Ige Responsiveness Atopic	Associate	10712341, 16519819, 24039878, 29761786, 33277970, 34261469
Inflammation	Associate	19514647, 34261469
Lung Diseases	Associate	20554927
Lymphatic Metastasis	Associate	34155937
Mast Cell Activation Disorders	Associate	35008966
Mastocytosis	Associate	20554927
Nasal Polyps	Associate	39828458
Osteophyte	Stimulate	35008966
Pdgfra Associated Chronic Eosinophilic Leukemia	Associate	39828458
Psoriasis	Associate	16519819
Rhinitis Allergic	Associate	26792385
Status Asthmaticus	Associate	29761786
Stomach Neoplasms	Associate	34155937

MS4A2 (membrane spanning 4-domains A2)