OTUD1 (OTU deubiquitinase 1)

Gene

• Entrez ID: 220213
• Gene name: OTU deubiquitinase 1
• Gene symbol: OTUD1
• Synonyms (NCBI Gene): DUBA7, OTDC1
• Chromosome: 10
• Chromosome location: 10p12.2
• Summary: Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019208	hsa-miR-335-5p	Microarray	18185580
MIRT019636	hsa-miR-340-5p	Sequencing	20371350
MIRT025128	hsa-miR-181a-5p	Microarray	17612493
MIRT026901	hsa-miR-192-5p	Microarray	19074876
MIRT031292	hsa-miR-19b-3p	Sequencing	20371350
MIRT050474	hsa-miR-21-5p	CLASH	23622248
MIRT044547	hsa-miR-320a	CLASH	23622248
MIRT039378	hsa-miR-421	CLASH	23622248
MIRT230382	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT230381	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT230381	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT056155	hsa-miR-543	PAR-CLIP	20371350
MIRT230383	hsa-miR-3714	PAR-CLIP	20371350
MIRT230384	hsa-miR-3910	PAR-CLIP	20371350
MIRT025128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT056150	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT056151	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT056152	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT056158	hsa-miR-4262	PAR-CLIP	20371350
MIRT056179	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT056156	hsa-miR-4251	PAR-CLIP	20371350
MIRT566578	hsa-miR-4329	PAR-CLIP	20371350
MIRT566577	hsa-miR-6761-5p	PAR-CLIP	20371350
MIRT056153	hsa-miR-570-3p	PAR-CLIP	20371350
MIRT126502	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT056174	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT031292	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT262152	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT262153	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT230382	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT230381	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT230381	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT056155	hsa-miR-543	PAR-CLIP	20371350
MIRT230383	hsa-miR-3714	PAR-CLIP	20371350
MIRT230384	hsa-miR-3910	PAR-CLIP	20371350
MIRT025128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT056150	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT056151	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT056152	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT056158	hsa-miR-4262	PAR-CLIP	20371350
MIRT056179	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT056156	hsa-miR-4251	PAR-CLIP	20371350
MIRT566578	hsa-miR-4329	PAR-CLIP	20371350
MIRT566577	hsa-miR-6761-5p	PAR-CLIP	20371350
MIRT056153	hsa-miR-570-3p	PAR-CLIP	20371350
MIRT126502	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT1207391	hsa-miR-106a	CLIP-seq
MIRT1207392	hsa-miR-106b	CLIP-seq
MIRT1207393	hsa-miR-1178	CLIP-seq
MIRT1207394	hsa-miR-1256	CLIP-seq
MIRT1207395	hsa-miR-1283	CLIP-seq
MIRT1207396	hsa-miR-1297	CLIP-seq
MIRT1207397	hsa-miR-1298	CLIP-seq
MIRT1207398	hsa-miR-155	CLIP-seq
MIRT1207399	hsa-miR-17	CLIP-seq
MIRT1207400	hsa-miR-20a	CLIP-seq
MIRT1207401	hsa-miR-20b	CLIP-seq
MIRT1207402	hsa-miR-26a	CLIP-seq
MIRT1207403	hsa-miR-26b	CLIP-seq
MIRT1207404	hsa-miR-300	CLIP-seq
MIRT1207405	hsa-miR-302a	CLIP-seq
MIRT1207406	hsa-miR-302b	CLIP-seq
MIRT1207407	hsa-miR-302c	CLIP-seq
MIRT1207408	hsa-miR-302d	CLIP-seq
MIRT1207409	hsa-miR-302e	CLIP-seq
MIRT1207410	hsa-miR-3074-3p	CLIP-seq
MIRT1207411	hsa-miR-320b	CLIP-seq
MIRT1207412	hsa-miR-320c	CLIP-seq
MIRT1207413	hsa-miR-320d	CLIP-seq
MIRT1207414	hsa-miR-33a	CLIP-seq
MIRT1207415	hsa-miR-33b	CLIP-seq
MIRT1207416	hsa-miR-361-5p	CLIP-seq
MIRT1207417	hsa-miR-372	CLIP-seq
MIRT1207418	hsa-miR-373	CLIP-seq
MIRT1207419	hsa-miR-381	CLIP-seq
MIRT1207420	hsa-miR-382	CLIP-seq
MIRT1207421	hsa-miR-3978	CLIP-seq
MIRT1207422	hsa-miR-4261	CLIP-seq
MIRT1207423	hsa-miR-4429	CLIP-seq
MIRT1207424	hsa-miR-4465	CLIP-seq
MIRT1207425	hsa-miR-4494	CLIP-seq
MIRT1207426	hsa-miR-450b-5p	CLIP-seq
MIRT1207427	hsa-miR-451b	CLIP-seq
MIRT1207428	hsa-miR-4694-3p	CLIP-seq
MIRT1207429	hsa-miR-4698	CLIP-seq
MIRT1207430	hsa-miR-4727-5p	CLIP-seq
MIRT1207431	hsa-miR-4766-5p	CLIP-seq
MIRT1207432	hsa-miR-4769-3p	CLIP-seq
MIRT1207433	hsa-miR-4775	CLIP-seq
MIRT1207434	hsa-miR-488	CLIP-seq
MIRT1207435	hsa-miR-494	CLIP-seq
MIRT1207436	hsa-miR-499-3p	CLIP-seq
MIRT1207437	hsa-miR-499a-3p	CLIP-seq
MIRT1207438	hsa-miR-499a-5p	CLIP-seq
MIRT1207439	hsa-miR-507	CLIP-seq
MIRT1207440	hsa-miR-519d	CLIP-seq
MIRT1207441	hsa-miR-520a-3p	CLIP-seq
MIRT1207442	hsa-miR-520b	CLIP-seq
MIRT1207443	hsa-miR-520c-3p	CLIP-seq
MIRT1207444	hsa-miR-520d-3p	CLIP-seq
MIRT1207445	hsa-miR-520e	CLIP-seq
MIRT1207446	hsa-miR-545	CLIP-seq
MIRT1207447	hsa-miR-548aa	CLIP-seq
MIRT1207448	hsa-miR-548ac	CLIP-seq
MIRT1207449	hsa-miR-548ae	CLIP-seq
MIRT1207450	hsa-miR-548aj	CLIP-seq
MIRT1207451	hsa-miR-548am	CLIP-seq
MIRT1207452	hsa-miR-548an	CLIP-seq
MIRT1207453	hsa-miR-548d-3p	CLIP-seq
MIRT1207454	hsa-miR-548l	CLIP-seq
MIRT1207455	hsa-miR-548n	CLIP-seq
MIRT1207456	hsa-miR-548t	CLIP-seq
MIRT1207457	hsa-miR-548x	CLIP-seq
MIRT1207458	hsa-miR-548z	CLIP-seq
MIRT1207459	hsa-miR-556-3p	CLIP-seq
MIRT1207460	hsa-miR-557	CLIP-seq
MIRT1207461	hsa-miR-590-3p	CLIP-seq
MIRT1207462	hsa-miR-664	CLIP-seq
MIRT1207463	hsa-miR-93	CLIP-seq
MIRT1207397	hsa-miR-1298	CLIP-seq
MIRT1207393	hsa-miR-1178	CLIP-seq
MIRT2059615	hsa-miR-1207-3p	CLIP-seq
MIRT2059616	hsa-miR-124	CLIP-seq
MIRT1207395	hsa-miR-1283	CLIP-seq
MIRT1207397	hsa-miR-1298	CLIP-seq
MIRT2059617	hsa-miR-142-5p	CLIP-seq
MIRT1207398	hsa-miR-155	CLIP-seq
MIRT2059618	hsa-miR-2964a-3p	CLIP-seq
MIRT2059619	hsa-miR-29a	CLIP-seq
MIRT2059620	hsa-miR-29b	CLIP-seq
MIRT2059621	hsa-miR-29c	CLIP-seq
MIRT2059622	hsa-miR-302f	CLIP-seq
MIRT2059623	hsa-miR-3120-3p	CLIP-seq
MIRT2059624	hsa-miR-3121-3p	CLIP-seq
MIRT2059625	hsa-miR-3143	CLIP-seq
MIRT2059626	hsa-miR-340	CLIP-seq
MIRT2059627	hsa-miR-3663-3p	CLIP-seq
MIRT2059628	hsa-miR-3685	CLIP-seq
MIRT2059629	hsa-miR-4274	CLIP-seq
MIRT2059630	hsa-miR-4328	CLIP-seq
MIRT2059631	hsa-miR-4422	CLIP-seq
MIRT2059632	hsa-miR-4495	CLIP-seq
MIRT2059633	hsa-miR-4519	CLIP-seq
MIRT2059634	hsa-miR-4646-5p	CLIP-seq
MIRT2059635	hsa-miR-4668-3p	CLIP-seq
MIRT2059636	hsa-miR-4677-3p	CLIP-seq
MIRT1207429	hsa-miR-4698	CLIP-seq
MIRT2059637	hsa-miR-4789-5p	CLIP-seq
MIRT1207436	hsa-miR-499-3p	CLIP-seq
MIRT1207437	hsa-miR-499a-3p	CLIP-seq
MIRT2059638	hsa-miR-506	CLIP-seq
MIRT2059639	hsa-miR-518a-5p	CLIP-seq
MIRT2059640	hsa-miR-527	CLIP-seq
MIRT2059641	hsa-miR-539	CLIP-seq
MIRT1207446	hsa-miR-545	CLIP-seq
MIRT2059642	hsa-miR-582-5p	CLIP-seq
MIRT1207462	hsa-miR-664	CLIP-seq
MIRT2059615	hsa-miR-1207-3p	CLIP-seq
MIRT2288035	hsa-miR-1290	CLIP-seq
MIRT1207397	hsa-miR-1298	CLIP-seq
MIRT2059617	hsa-miR-142-5p	CLIP-seq
MIRT2059618	hsa-miR-2964a-3p	CLIP-seq
MIRT2059622	hsa-miR-302f	CLIP-seq
MIRT1207410	hsa-miR-3074-3p	CLIP-seq
MIRT2059623	hsa-miR-3120-3p	CLIP-seq
MIRT2288036	hsa-miR-3167	CLIP-seq
MIRT1207411	hsa-miR-320b	CLIP-seq
MIRT1207412	hsa-miR-320c	CLIP-seq
MIRT1207413	hsa-miR-320d	CLIP-seq
MIRT2288037	hsa-miR-326	CLIP-seq
MIRT2288038	hsa-miR-330-5p	CLIP-seq
MIRT2059626	hsa-miR-340	CLIP-seq
MIRT1207416	hsa-miR-361-5p	CLIP-seq
MIRT2059631	hsa-miR-4422	CLIP-seq
MIRT1207423	hsa-miR-4429	CLIP-seq
MIRT1207425	hsa-miR-4494	CLIP-seq
MIRT2059634	hsa-miR-4646-5p	CLIP-seq
MIRT2059636	hsa-miR-4677-3p	CLIP-seq
MIRT1207428	hsa-miR-4694-3p	CLIP-seq
MIRT1207429	hsa-miR-4698	CLIP-seq
MIRT1207430	hsa-miR-4727-5p	CLIP-seq
MIRT1207431	hsa-miR-4766-5p	CLIP-seq
MIRT1207432	hsa-miR-4769-3p	CLIP-seq
MIRT2288039	hsa-miR-4782-5p	CLIP-seq
MIRT2059637	hsa-miR-4789-5p	CLIP-seq
MIRT1207436	hsa-miR-499-3p	CLIP-seq
MIRT1207437	hsa-miR-499a-3p	CLIP-seq
MIRT1207438	hsa-miR-499a-5p	CLIP-seq
MIRT2059641	hsa-miR-539	CLIP-seq
MIRT1207446	hsa-miR-545	CLIP-seq
MIRT1207462	hsa-miR-664	CLIP-seq
MIRT2288040	hsa-miR-876-5p	CLIP-seq
MIRT2288041	hsa-miR-942	CLIP-seq
MIRT2288042	hsa-miR-944	CLIP-seq
MIRT2059624	hsa-miR-3121-3p	CLIP-seq
MIRT2059624	hsa-miR-3121-3p	CLIP-seq
MIRT2586144	hsa-miR-1287	CLIP-seq
MIRT2059617	hsa-miR-142-5p	CLIP-seq
MIRT2586145	hsa-miR-186	CLIP-seq
MIRT2586146	hsa-miR-208a	CLIP-seq
MIRT2586147	hsa-miR-208b	CLIP-seq
MIRT2586148	hsa-miR-2117	CLIP-seq
MIRT2586149	hsa-miR-216b	CLIP-seq
MIRT2586150	hsa-miR-3133	CLIP-seq
MIRT2059625	hsa-miR-3143	CLIP-seq
MIRT2586151	hsa-miR-3144-3p	CLIP-seq
MIRT2586152	hsa-miR-3152-5p	CLIP-seq
MIRT2059626	hsa-miR-340	CLIP-seq
MIRT2586153	hsa-miR-3617	CLIP-seq
MIRT2586154	hsa-miR-410	CLIP-seq
MIRT2586155	hsa-miR-4255	CLIP-seq
MIRT2586156	hsa-miR-4273	CLIP-seq
MIRT2586157	hsa-miR-4279	CLIP-seq
MIRT2586158	hsa-miR-4320	CLIP-seq
MIRT2059631	hsa-miR-4422	CLIP-seq
MIRT2586159	hsa-miR-4459	CLIP-seq
MIRT2586160	hsa-miR-4477a	CLIP-seq
MIRT2586161	hsa-miR-4480	CLIP-seq
MIRT2059632	hsa-miR-4495	CLIP-seq
MIRT2586162	hsa-miR-4633-5p	CLIP-seq
MIRT2586163	hsa-miR-4670-3p	CLIP-seq
MIRT2586164	hsa-miR-4695-5p	CLIP-seq
MIRT2586165	hsa-miR-4716-5p	CLIP-seq
MIRT2586166	hsa-miR-4722-5p	CLIP-seq
MIRT2586167	hsa-miR-4729	CLIP-seq
MIRT2586168	hsa-miR-4774-3p	CLIP-seq
MIRT2586169	hsa-miR-4797-5p	CLIP-seq
MIRT1207434	hsa-miR-488	CLIP-seq
MIRT2586170	hsa-miR-491-3p	CLIP-seq
MIRT1207436	hsa-miR-499-3p	CLIP-seq
MIRT2586171	hsa-miR-499-5p	CLIP-seq
MIRT1207437	hsa-miR-499a-3p	CLIP-seq
MIRT2586172	hsa-miR-641	CLIP-seq
MIRT2586145	hsa-miR-186	CLIP-seq
MIRT2586152	hsa-miR-3152-5p	CLIP-seq
MIRT2059626	hsa-miR-340	CLIP-seq
MIRT2586161	hsa-miR-4480	CLIP-seq
MIRT2586162	hsa-miR-4633-5p	CLIP-seq
MIRT2586167	hsa-miR-4729	CLIP-seq
MIRT2586168	hsa-miR-4774-3p	CLIP-seq
MIRT1207434	hsa-miR-488	CLIP-seq
MIRT2586170	hsa-miR-491-3p	CLIP-seq
MIRT1207436	hsa-miR-499-3p	CLIP-seq
MIRT1207437	hsa-miR-499a-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Cysteine-type deubiquitinase activity	IBA
GO:0004843	Function	Cysteine-type deubiquitinase activity	IDA	23827681, 36445135
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0005515	Function	Protein binding	IPI	38012669
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016579	Process	Protein deubiquitination	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0070536	Process	Protein K63-linked deubiquitination	IDA	23827681

Other IDs

• MIM: 612022
• HGNC: 27346
• e!Ensembl: ENSG00000165312

Protein

• UniProt ID: Q5VV17
• Protein name: OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7)
• Protein function: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin (PubMed:23827681). Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitinatio
• PDB: 4BOP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02338	OTU	315 → 433	OTU-like cysteine protease	Family

• Sequence:

  MQLYSSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAE
  HREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALG
  ADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPA
  GLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERG
  GDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQ
  DKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEG
  DVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRP
  SIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQVQRKRDEELAKSMAISLSKMYIEQNAC
  S

• Sequence length: 481

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
OTUD1-related disorder	Uncertain significance; Benign; Likely benign	rs772000715, rs147006133, rs928035411, rs777457042, rs115994850, rs978602029, rs1384127775, rs139969083, rs574869227, rs1029302545, rs74122449, rs148315007	RCV003906622 RCV003916887 RCV003934071 RCV003943916 RCV003941576 RCV003941625 RCV003937283 RCV003932305 RCV003936971 RCV003976918 RCV003915921 RCV003978281

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Non Small Cell Lung	Inhibit	35098684
Multiple Myeloma	Associate	36357400
Multiple Sclerosis	Associate	39201568
Neoplasms	Associate	24937664, 30008265, 36357400, 37872170
Sarcoidosis	Associate	22972473
Thyroid Neoplasms	Associate	24937664
Thyroid Nodule	Associate	24937664