LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing)

Gene

• Entrez ID: 220074
• Gene name: Leucine rich transmembrane and O-methyltransferase domain containing
• Gene symbol: LRTOMT
• Synonyms (NCBI Gene): CFAP111, DFNB63, LRRC51, LRRC51-TOMT, TOMT
• Chromosome: 11
• Chromosome location: 11q13.4
• Summary: This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. The readthrough transcript encodes a fusion protein

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT694485	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT694484	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT694483	hsa-miR-3974	HITS-CLIP	23313552
MIRT694482	hsa-miR-6502-3p	HITS-CLIP	23313552
MIRT694481	hsa-miR-6888-5p	HITS-CLIP	23313552
MIRT694480	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT694479	hsa-miR-4457	HITS-CLIP	23313552
MIRT694478	hsa-miR-125b-2-3p	HITS-CLIP	23313552
MIRT694477	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT694476	hsa-miR-4459	HITS-CLIP	23313552
MIRT694475	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT694474	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT694473	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT694472	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT694471	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT694470	hsa-miR-8073	HITS-CLIP	23313552
MIRT694469	hsa-miR-4794	HITS-CLIP	23313552
MIRT694468	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT694467	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT694466	hsa-miR-1273f	HITS-CLIP	23313552
MIRT694465	hsa-miR-6134	HITS-CLIP	23313552
MIRT694464	hsa-miR-4534	HITS-CLIP	23313552
MIRT694463	hsa-miR-8082	HITS-CLIP	23313552
MIRT694462	hsa-miR-139-3p	HITS-CLIP	23313552
MIRT694461	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT694460	hsa-miR-6745	HITS-CLIP	23313552
MIRT694459	hsa-miR-6756-5p	HITS-CLIP	23313552
MIRT694458	hsa-miR-6766-5p	HITS-CLIP	23313552
MIRT694457	hsa-miR-1293	HITS-CLIP	23313552
MIRT694456	hsa-miR-4483	HITS-CLIP	23313552
MIRT694455	hsa-miR-3165	HITS-CLIP	23313552
MIRT694454	hsa-miR-6769a-5p	HITS-CLIP	23313552
MIRT694453	hsa-miR-6769b-5p	HITS-CLIP	23313552
MIRT694452	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT694451	hsa-miR-513b-5p	HITS-CLIP	23313552
MIRT694450	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT681433	hsa-miR-4537	HITS-CLIP	23706177
MIRT681432	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681431	hsa-miR-4252	HITS-CLIP	23706177
MIRT681430	hsa-miR-25-5p	HITS-CLIP	23706177
MIRT681429	hsa-miR-1227-3p	HITS-CLIP	23706177
MIRT681428	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT681433	hsa-miR-4537	HITS-CLIP	23706177
MIRT681432	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681431	hsa-miR-4252	HITS-CLIP	23706177
MIRT681430	hsa-miR-25-5p	HITS-CLIP	23706177
MIRT681429	hsa-miR-1227-3p	HITS-CLIP	23706177
MIRT681428	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT626332	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT626331	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT626329	hsa-miR-4267	HITS-CLIP	23824327
MIRT626328	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT626327	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT626326	hsa-miR-7155-5p	HITS-CLIP	23824327
MIRT626325	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT626324	hsa-miR-342-5p	HITS-CLIP	23824327
MIRT626323	hsa-miR-4664-5p	HITS-CLIP	23824327
MIRT626322	hsa-miR-4651	HITS-CLIP	23824327
MIRT626321	hsa-miR-608	HITS-CLIP	23824327
MIRT626320	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT626319	hsa-miR-7703	HITS-CLIP	23824327
MIRT626318	hsa-miR-6737-5p	HITS-CLIP	23824327
MIRT626317	hsa-miR-6812-5p	HITS-CLIP	23824327
MIRT626316	hsa-miR-6819-5p	HITS-CLIP	23824327
MIRT694485	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT694484	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT694483	hsa-miR-3974	HITS-CLIP	23313552
MIRT694482	hsa-miR-6502-3p	HITS-CLIP	23313552
MIRT694481	hsa-miR-6888-5p	HITS-CLIP	23313552
MIRT694480	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT694479	hsa-miR-4457	HITS-CLIP	23313552
MIRT694478	hsa-miR-125b-2-3p	HITS-CLIP	23313552
MIRT694477	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT694476	hsa-miR-4459	HITS-CLIP	23313552
MIRT694475	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT694474	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT694473	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT694472	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT694471	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT694470	hsa-miR-8073	HITS-CLIP	23313552
MIRT694469	hsa-miR-4794	HITS-CLIP	23313552
MIRT694468	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT694467	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT694466	hsa-miR-1273f	HITS-CLIP	23313552
MIRT694465	hsa-miR-6134	HITS-CLIP	23313552
MIRT694464	hsa-miR-4534	HITS-CLIP	23313552
MIRT694463	hsa-miR-8082	HITS-CLIP	23313552
MIRT694462	hsa-miR-139-3p	HITS-CLIP	23313552
MIRT694461	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT694460	hsa-miR-6745	HITS-CLIP	23313552
MIRT694459	hsa-miR-6756-5p	HITS-CLIP	23313552
MIRT694458	hsa-miR-6766-5p	HITS-CLIP	23313552
MIRT694457	hsa-miR-1293	HITS-CLIP	23313552
MIRT694456	hsa-miR-4483	HITS-CLIP	23313552
MIRT694455	hsa-miR-3165	HITS-CLIP	23313552
MIRT694454	hsa-miR-6769a-5p	HITS-CLIP	23313552
MIRT694453	hsa-miR-6769b-5p	HITS-CLIP	23313552
MIRT694452	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT694451	hsa-miR-513b-5p	HITS-CLIP	23313552
MIRT694450	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT681433	hsa-miR-4537	HITS-CLIP	23706177
MIRT681432	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681431	hsa-miR-4252	HITS-CLIP	23706177
MIRT681430	hsa-miR-25-5p	HITS-CLIP	23706177
MIRT681429	hsa-miR-1227-3p	HITS-CLIP	23706177
MIRT681428	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT681433	hsa-miR-4537	HITS-CLIP	23706177
MIRT681432	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681431	hsa-miR-4252	HITS-CLIP	23706177
MIRT681430	hsa-miR-25-5p	HITS-CLIP	23706177
MIRT681429	hsa-miR-1227-3p	HITS-CLIP	23706177
MIRT681428	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT626332	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT626331	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT626329	hsa-miR-4267	HITS-CLIP	23824327
MIRT626328	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT626327	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT626326	hsa-miR-7155-5p	HITS-CLIP	23824327
MIRT626325	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT626324	hsa-miR-342-5p	HITS-CLIP	23824327
MIRT626323	hsa-miR-4664-5p	HITS-CLIP	23824327
MIRT626322	hsa-miR-4651	HITS-CLIP	23824327
MIRT626321	hsa-miR-608	HITS-CLIP	23824327
MIRT626320	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT626319	hsa-miR-7703	HITS-CLIP	23824327
MIRT626318	hsa-miR-6737-5p	HITS-CLIP	23824327
MIRT626317	hsa-miR-6812-5p	HITS-CLIP	23824327
MIRT626316	hsa-miR-6819-5p	HITS-CLIP	23824327
MIRT1121206	hsa-miR-3163	CLIP-seq
MIRT1121207	hsa-miR-1253	CLIP-seq
MIRT1121208	hsa-miR-1587	CLIP-seq
MIRT1121209	hsa-miR-3151	CLIP-seq
MIRT1121210	hsa-miR-3157-3p	CLIP-seq
MIRT1121211	hsa-miR-3661	CLIP-seq
MIRT1121212	hsa-miR-3676	CLIP-seq
MIRT1121213	hsa-miR-3938	CLIP-seq
MIRT1121214	hsa-miR-4437	CLIP-seq
MIRT1121215	hsa-miR-4674	CLIP-seq
MIRT1121216	hsa-miR-4699-5p	CLIP-seq
MIRT1121217	hsa-miR-4732-3p	CLIP-seq
MIRT1121218	hsa-miR-4749-3p	CLIP-seq
MIRT1121219	hsa-miR-541	CLIP-seq
MIRT1121220	hsa-miR-631	CLIP-seq
MIRT1121221	hsa-miR-635	CLIP-seq
MIRT1121222	hsa-miR-654-5p	CLIP-seq
MIRT1121223	hsa-miR-890	CLIP-seq
MIRT1121224	hsa-miR-1207-5p	CLIP-seq
MIRT1121225	hsa-miR-1227	CLIP-seq
MIRT1121226	hsa-miR-1827	CLIP-seq
MIRT1121227	hsa-miR-216b	CLIP-seq
MIRT1121228	hsa-miR-3192	CLIP-seq
MIRT1121229	hsa-miR-3202	CLIP-seq
MIRT1121230	hsa-miR-3622a-3p	CLIP-seq
MIRT1121231	hsa-miR-3622b-3p	CLIP-seq
MIRT1121232	hsa-miR-3672	CLIP-seq
MIRT1121233	hsa-miR-3689a-3p	CLIP-seq
MIRT1121234	hsa-miR-3689c	CLIP-seq
MIRT1121235	hsa-miR-3926	CLIP-seq
MIRT1121236	hsa-miR-3929	CLIP-seq
MIRT1121237	hsa-miR-4419b	CLIP-seq
MIRT1121238	hsa-miR-4433	CLIP-seq
MIRT1121239	hsa-miR-4478	CLIP-seq
MIRT1121240	hsa-miR-4504	CLIP-seq
MIRT1121241	hsa-miR-4533	CLIP-seq
MIRT1121242	hsa-miR-4635	CLIP-seq
MIRT1121243	hsa-miR-4649-3p	CLIP-seq
MIRT1121244	hsa-miR-4662a-5p	CLIP-seq
MIRT1121245	hsa-miR-4676-5p	CLIP-seq
MIRT1121246	hsa-miR-4722-5p	CLIP-seq
MIRT1121247	hsa-miR-4728-5p	CLIP-seq
MIRT1121248	hsa-miR-4736	CLIP-seq
MIRT1121249	hsa-miR-4763-3p	CLIP-seq
MIRT1121250	hsa-miR-4797-5p	CLIP-seq
MIRT1121251	hsa-miR-485-5p	CLIP-seq
MIRT1121252	hsa-miR-490-3p	CLIP-seq
MIRT1121219	hsa-miR-541	CLIP-seq
MIRT1121253	hsa-miR-542-3p	CLIP-seq
MIRT1121254	hsa-miR-544b	CLIP-seq
MIRT1121255	hsa-miR-548s	CLIP-seq
MIRT1121256	hsa-miR-566	CLIP-seq
MIRT1121257	hsa-miR-575	CLIP-seq
MIRT1121258	hsa-miR-593	CLIP-seq
MIRT1121259	hsa-miR-619	CLIP-seq
MIRT1121222	hsa-miR-654-5p	CLIP-seq
MIRT1121260	hsa-miR-759	CLIP-seq
MIRT1121261	hsa-miR-766	CLIP-seq
MIRT1121262	hsa-miR-769-5p	CLIP-seq
MIRT1121263	hsa-miR-940	CLIP-seq
MIRT1550952	hsa-miR-1275	CLIP-seq
MIRT1550953	hsa-miR-3675-3p	CLIP-seq
MIRT1121235	hsa-miR-3926	CLIP-seq
MIRT1550954	hsa-miR-4271	CLIP-seq
MIRT1550955	hsa-miR-4525	CLIP-seq
MIRT1550956	hsa-miR-4665-5p	CLIP-seq
MIRT1550957	hsa-miR-4723-5p	CLIP-seq
MIRT1550958	hsa-miR-4725-3p	CLIP-seq
MIRT1121255	hsa-miR-548s	CLIP-seq
MIRT1550959	hsa-miR-625	CLIP-seq
MIRT1550960	hsa-miR-637	CLIP-seq
MIRT1550961	hsa-miR-671-5p	CLIP-seq
MIRT1121243	hsa-miR-4649-3p	CLIP-seq
MIRT2034282	hsa-miR-4656	CLIP-seq
MIRT2034283	hsa-miR-550a	CLIP-seq
MIRT2264772	hsa-miR-4254	CLIP-seq
MIRT2264773	hsa-miR-4640-5p	CLIP-seq
MIRT2264774	hsa-miR-4726-5p	CLIP-seq
MIRT1121218	hsa-miR-4749-3p	CLIP-seq
MIRT2390373	hsa-miR-1825	CLIP-seq
MIRT2390374	hsa-miR-4326	CLIP-seq
MIRT2390375	hsa-miR-515-3p	CLIP-seq
MIRT2390376	hsa-miR-519e	CLIP-seq
MIRT2034283	hsa-miR-550a	CLIP-seq
MIRT2453438	hsa-miR-106a	CLIP-seq
MIRT2453439	hsa-miR-106b	CLIP-seq
MIRT2453440	hsa-miR-1202	CLIP-seq
MIRT2453441	hsa-miR-1343	CLIP-seq
MIRT2453442	hsa-miR-17	CLIP-seq
MIRT2453443	hsa-miR-1915	CLIP-seq
MIRT2453444	hsa-miR-1972	CLIP-seq
MIRT2453445	hsa-miR-203	CLIP-seq
MIRT2453446	hsa-miR-20a	CLIP-seq
MIRT2453447	hsa-miR-20b	CLIP-seq
MIRT2453448	hsa-miR-2355-5p	CLIP-seq
MIRT2453449	hsa-miR-2861	CLIP-seq
MIRT2453450	hsa-miR-3130-3p	CLIP-seq
MIRT2453451	hsa-miR-3145-5p	CLIP-seq
MIRT2453452	hsa-miR-3189-3p	CLIP-seq
MIRT2453453	hsa-miR-328	CLIP-seq
MIRT2453454	hsa-miR-3663-5p	CLIP-seq
MIRT2453455	hsa-miR-3667-3p	CLIP-seq
MIRT2453456	hsa-miR-371b-3p	CLIP-seq
MIRT2453457	hsa-miR-3918	CLIP-seq
MIRT2453458	hsa-miR-3972	CLIP-seq
MIRT2453459	hsa-miR-4325	CLIP-seq
MIRT2453460	hsa-miR-4435	CLIP-seq
MIRT2453461	hsa-miR-4512	CLIP-seq
MIRT2453462	hsa-miR-4529-5p	CLIP-seq
MIRT2453463	hsa-miR-4685-5p	CLIP-seq
MIRT2453464	hsa-miR-4712-5p	CLIP-seq
MIRT2453465	hsa-miR-4726-3p	CLIP-seq
MIRT1121218	hsa-miR-4749-3p	CLIP-seq
MIRT2453466	hsa-miR-4753-3p	CLIP-seq
MIRT2453467	hsa-miR-4755-3p	CLIP-seq
MIRT2453468	hsa-miR-4777-3p	CLIP-seq
MIRT2453469	hsa-miR-4780	CLIP-seq
MIRT2453470	hsa-miR-519d	CLIP-seq
MIRT2453471	hsa-miR-548u	CLIP-seq
MIRT2453472	hsa-miR-601	CLIP-seq
MIRT2453473	hsa-miR-605	CLIP-seq
MIRT2453474	hsa-miR-622	CLIP-seq
MIRT1121221	hsa-miR-635	CLIP-seq
MIRT2453475	hsa-miR-770-5p	CLIP-seq
MIRT2453476	hsa-miR-9	CLIP-seq
MIRT2453477	hsa-miR-93	CLIP-seq
MIRT2453478	hsa-miR-938	CLIP-seq
MIRT2453438	hsa-miR-106a	CLIP-seq
MIRT2453439	hsa-miR-106b	CLIP-seq
MIRT2453440	hsa-miR-1202	CLIP-seq
MIRT2453441	hsa-miR-1343	CLIP-seq
MIRT2453442	hsa-miR-17	CLIP-seq
MIRT2453443	hsa-miR-1915	CLIP-seq
MIRT2453444	hsa-miR-1972	CLIP-seq
MIRT2453445	hsa-miR-203	CLIP-seq
MIRT2453446	hsa-miR-20a	CLIP-seq
MIRT2453447	hsa-miR-20b	CLIP-seq
MIRT2453448	hsa-miR-2355-5p	CLIP-seq
MIRT2453450	hsa-miR-3130-3p	CLIP-seq
MIRT2453451	hsa-miR-3145-5p	CLIP-seq
MIRT2453452	hsa-miR-3189-3p	CLIP-seq
MIRT2453453	hsa-miR-328	CLIP-seq
MIRT2453454	hsa-miR-3663-5p	CLIP-seq
MIRT2453455	hsa-miR-3667-3p	CLIP-seq
MIRT2453456	hsa-miR-371b-3p	CLIP-seq
MIRT2453457	hsa-miR-3918	CLIP-seq
MIRT2453458	hsa-miR-3972	CLIP-seq
MIRT2453459	hsa-miR-4325	CLIP-seq
MIRT2453460	hsa-miR-4435	CLIP-seq
MIRT2453462	hsa-miR-4529-5p	CLIP-seq
MIRT2453463	hsa-miR-4685-5p	CLIP-seq
MIRT2453464	hsa-miR-4712-5p	CLIP-seq
MIRT2453465	hsa-miR-4726-3p	CLIP-seq
MIRT1121218	hsa-miR-4749-3p	CLIP-seq
MIRT2453466	hsa-miR-4753-3p	CLIP-seq
MIRT2453467	hsa-miR-4755-3p	CLIP-seq
MIRT2453468	hsa-miR-4777-3p	CLIP-seq
MIRT2453469	hsa-miR-4780	CLIP-seq
MIRT2453470	hsa-miR-519d	CLIP-seq
MIRT2453471	hsa-miR-548u	CLIP-seq
MIRT2453472	hsa-miR-601	CLIP-seq
MIRT2453473	hsa-miR-605	CLIP-seq
MIRT2453474	hsa-miR-622	CLIP-seq
MIRT1121221	hsa-miR-635	CLIP-seq
MIRT2453475	hsa-miR-770-5p	CLIP-seq
MIRT2453476	hsa-miR-9	CLIP-seq
MIRT2453477	hsa-miR-93	CLIP-seq
MIRT2453478	hsa-miR-938	CLIP-seq
MIRT2453438	hsa-miR-106a	CLIP-seq
MIRT2453439	hsa-miR-106b	CLIP-seq
MIRT2453440	hsa-miR-1202	CLIP-seq
MIRT2453441	hsa-miR-1343	CLIP-seq
MIRT2453442	hsa-miR-17	CLIP-seq
MIRT2453443	hsa-miR-1915	CLIP-seq
MIRT2453444	hsa-miR-1972	CLIP-seq
MIRT2453445	hsa-miR-203	CLIP-seq
MIRT2453446	hsa-miR-20a	CLIP-seq
MIRT2453447	hsa-miR-20b	CLIP-seq
MIRT2453448	hsa-miR-2355-5p	CLIP-seq
MIRT2453450	hsa-miR-3130-3p	CLIP-seq
MIRT2453451	hsa-miR-3145-5p	CLIP-seq
MIRT2453452	hsa-miR-3189-3p	CLIP-seq
MIRT2453453	hsa-miR-328	CLIP-seq
MIRT2453454	hsa-miR-3663-5p	CLIP-seq
MIRT2453455	hsa-miR-3667-3p	CLIP-seq
MIRT2453456	hsa-miR-371b-3p	CLIP-seq
MIRT2453457	hsa-miR-3918	CLIP-seq
MIRT2453458	hsa-miR-3972	CLIP-seq
MIRT2453459	hsa-miR-4325	CLIP-seq
MIRT2453460	hsa-miR-4435	CLIP-seq
MIRT2453462	hsa-miR-4529-5p	CLIP-seq
MIRT2453463	hsa-miR-4685-5p	CLIP-seq
MIRT2453464	hsa-miR-4712-5p	CLIP-seq
MIRT2453465	hsa-miR-4726-3p	CLIP-seq
MIRT1121218	hsa-miR-4749-3p	CLIP-seq
MIRT2453466	hsa-miR-4753-3p	CLIP-seq
MIRT2453467	hsa-miR-4755-3p	CLIP-seq
MIRT2453468	hsa-miR-4777-3p	CLIP-seq
MIRT2453469	hsa-miR-4780	CLIP-seq
MIRT2453470	hsa-miR-519d	CLIP-seq
MIRT2453471	hsa-miR-548u	CLIP-seq
MIRT2453472	hsa-miR-601	CLIP-seq
MIRT2453473	hsa-miR-605	CLIP-seq
MIRT2453474	hsa-miR-622	CLIP-seq
MIRT1121221	hsa-miR-635	CLIP-seq
MIRT2453475	hsa-miR-770-5p	CLIP-seq
MIRT2453476	hsa-miR-9	CLIP-seq
MIRT2453477	hsa-miR-93	CLIP-seq
MIRT2453478	hsa-miR-938	CLIP-seq

Other IDs

• MIM: 612414
• HGNC: 25033
• e!Ensembl: ENSG00000284922

Protein

• UniProt ID: Q8WZ04
• Protein name: Transmembrane O-methyltransferase (EC 2.1.1.6) (Catechol O-methyltransferase 2) (Protein LRTOMT2)
• Protein function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (PubMed:18794526). Component of the cochlear hair cell's mechanotransduction (MET
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01596	Methyltransf_3	96 → 252	O-methyltransferase	Domain

• Sequence:

  MGTPWRKRKGIAGPGLPDLSCALVLQPRAQVGTMSPAIALAFLPLVVTLLVRYRHYFRLL
  VRTVLLRSLRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSRCEYLSHMGPVKG
  QILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAG
  FDEHMVELIVGSSEDVIPCLRTQYQLSRADLVLLAHRPRCYLRDLQLLEAHALLPAGATV
  LADHVLFPGAPRFLQYAKSCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG

• Sequence length: 291

Pathways

KEGG:

Steroid hormone biosynthesis
Tyrosine metabolism
Metabolic pathways
Dopaminergic synapse

Reactome:

Enzymatic degradation of dopamine by COMT

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Autosomal recessive nonsyndromic hearing loss 63	Pathogenic; Likely pathogenic	rs137853185, rs137853186, rs137853187, rs137853188, rs1391956558, rs545947177, rs780468292, rs797044907, rs1565331646, rs1298804148	RCV000000573 RCV000000574 RCV000000575 RCV000000576 RCV002283829 RCV000156590 RCV002471368 RCV001449954 RCV000770827 RCV000779080
Rare genetic deafness	Pathogenic; Likely pathogenic	rs137853185, rs545947177	RCV000603810 RCV000211724

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Hearing impairment	Uncertain significance	rs746981074	RCV001375107
Hearing loss, autosomal recessive	Uncertain significance; Conflicting classifications of pathogenicity; Likely benign; Benign	rs561551303, rs190307646, rs191758747, rs111537544, rs139554095, rs886048628, rs561766061, rs73543612, rs17161980, rs373529881, rs12272086	RCV004577823 RCV004577816 RCV004577819 RCV004577815 RCV004577817 RCV004577818 RCV004577820 RCV004577821 RCV004577822 RCV004577824 RCV004577714
LRTOMT-related disorder	Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	rs530987072, rs570774925, rs76657474, rs556093010, rs537610140, rs1372207779, rs373088272	RCV003973330 RCV003898544 RCV003955254 RCV003897697 RCV003977889 RCV003923877 RCV003910127

Associations from Text Mining
Disease Name	Relationship Type	References
Deafness	Associate	34514748
Deafness Autosomal Recessive	Associate	24926664
Hearing Loss	Associate	28281779, 36928321
Hearing Loss Sensorineural	Associate	31835641
Nonsyndromic Deafness	Associate	31389194, 36928321