Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	220002
Gene name	Cytochrome b561 family member A3
Gene symbol	CYB561A3
Synonyms (NCBI Gene)	CYBASC3LCYTB
Chromosome	11
Chromosome location	11q12.2

Show/Hide all (66)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025675	hsa-miR-7-5p	Microarray	19073608
MIRT027100	hsa-miR-103a-3p	Sequencing	20371350
MIRT031578	hsa-miR-16-5p	Sequencing	20371350
MIRT043995	hsa-miR-378a-5p	CLASH	23622248
MIRT711266	hsa-miR-764	HITS-CLIP	19536157
MIRT711265	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT711264	hsa-miR-4487	HITS-CLIP	19536157
MIRT711263	hsa-miR-6131	HITS-CLIP	19536157
MIRT711262	hsa-miR-711	HITS-CLIP	19536157
MIRT711261	hsa-miR-3649	HITS-CLIP	19536157
MIRT664481	hsa-miR-4433b-3p	HITS-CLIP	23824327
MIRT648623	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT648621	hsa-miR-4267	HITS-CLIP	23824327
MIRT648622	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648620	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT648619	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT648618	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT648617	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT648615	hsa-miR-7977	HITS-CLIP	23824327
MIRT648616	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT648614	hsa-miR-627-5p	HITS-CLIP	23824327
MIRT648612	hsa-miR-8081	HITS-CLIP	23824327
MIRT648623	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT648621	hsa-miR-4267	HITS-CLIP	23824327
MIRT648622	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648620	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT648619	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT648618	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT648617	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT648615	hsa-miR-7977	HITS-CLIP	23824327
MIRT648616	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT648614	hsa-miR-627-5p	HITS-CLIP	23824327
MIRT648612	hsa-miR-8081	HITS-CLIP	23824327
MIRT727913	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727912	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT031578	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727911	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT711266	hsa-miR-764	HITS-CLIP	19536157
MIRT711265	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT711264	hsa-miR-4487	HITS-CLIP	19536157
MIRT711263	hsa-miR-6131	HITS-CLIP	19536157
MIRT711262	hsa-miR-711	HITS-CLIP	19536157
MIRT711261	hsa-miR-3649	HITS-CLIP	19536157
MIRT664481	hsa-miR-4433b-3p	HITS-CLIP	23824327
MIRT648623	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT648621	hsa-miR-4267	HITS-CLIP	23824327
MIRT648622	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648620	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT648619	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT648618	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT648617	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT648615	hsa-miR-7977	HITS-CLIP	23824327
MIRT648616	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT648614	hsa-miR-627-5p	HITS-CLIP	23824327
MIRT648612	hsa-miR-8081	HITS-CLIP	23824327
MIRT648623	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT648621	hsa-miR-4267	HITS-CLIP	23824327
MIRT648622	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648620	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT648619	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT648618	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT648617	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT648615	hsa-miR-7977	HITS-CLIP	23824327
MIRT648616	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT648614	hsa-miR-627-5p	HITS-CLIP	23824327
MIRT648612	hsa-miR-8081	HITS-CLIP	23824327

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005730	Component	Nucleolus	IDA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	ISS
GO:0005768	Component	Endosome	IEA
GO:0006879	Process	Intracellular iron ion homeostasis	IEA
GO:0006879	Process	Intracellular iron ion homeostasis	ISS
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IBA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0031902	Component	Late endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0140571	Function	Transmembrane ascorbate ferrireductase activity	IEA
GO:0140571	Function	Transmembrane ascorbate ferrireductase activity	ISS

MIM	HGNC	e!Ensembl
618757	23014	ENSG00000162144

Q8NBI2

Protein name

Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (EC 7.2.1.3) (Cytochrome b ascorbate-dependent protein 3) (Cytochrome b561 family member A3) (Lysosomal cytochrome b) (LCytb)

Protein function

Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extrude

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03188	Cytochrom_B561	46 → 182	Eukaryotic cytochrome b561	Family

Sequence

MVSGRFYLSCLLLGSLGSMCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYG
GASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWL
GITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLF
FSLKNTTRPYHSLPSEAVFANSTGMLVVAFGLLVLYILLASSWKRPEPGILTDRQPLLHD
GE

Sequence length

242

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
FAMILIAL APLASIA OF THE VERMIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Burkitt Lymphoma	Associate	34232987	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Associate	34232987	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pigmentation Disorders	Associate	38200130	★★★★★ ★☆☆☆☆ Found in Text Mining only

CYB561A3 (cytochrome b561 family member A3)