Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	2199
Gene name	Fibulin 2
Gene symbol	FBLN2
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3p25.1
Summary	This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal

Show/Hide all (90)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002753	hsa-miR-1-3p	Microarray	15685193
MIRT018315	hsa-miR-335-5p	Microarray	18185580
MIRT002753	hsa-miR-1-3p	Microarray;Other	15685193
MIRT527285	hsa-miR-548ac	PAR-CLIP	22012620
MIRT527284	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT527283	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT527282	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT527281	hsa-miR-548z	PAR-CLIP	22012620
MIRT527280	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT527279	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT527278	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT527277	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT527276	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT527275	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT527274	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT527273	hsa-miR-548aa	PAR-CLIP	22012620
MIRT527272	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT527271	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT527270	hsa-miR-497-3p	PAR-CLIP	22012620
MIRT527269	hsa-miR-548at-5p	PAR-CLIP	22012620
MIRT527268	hsa-miR-32-3p	PAR-CLIP	22012620
MIRT527267	hsa-miR-4775	PAR-CLIP	22012620
MIRT527266	hsa-miR-520d-5p	PAR-CLIP	22012620
MIRT527265	hsa-miR-524-5p	PAR-CLIP	22012620
MIRT527285	hsa-miR-548ac	PAR-CLIP	22012620
MIRT527284	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT527283	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT527282	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT527281	hsa-miR-548z	PAR-CLIP	22012620
MIRT527280	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT527279	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT527278	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT527277	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT527276	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT527275	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT527274	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT527273	hsa-miR-548aa	PAR-CLIP	22012620
MIRT527272	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT527271	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT527270	hsa-miR-497-3p	PAR-CLIP	22012620
MIRT527269	hsa-miR-548at-5p	PAR-CLIP	22012620
MIRT527268	hsa-miR-32-3p	PAR-CLIP	22012620
MIRT527267	hsa-miR-4775	PAR-CLIP	22012620
MIRT527266	hsa-miR-520d-5p	PAR-CLIP	22012620
MIRT527265	hsa-miR-524-5p	PAR-CLIP	22012620
MIRT990052	hsa-miR-1	CLIP-seq
MIRT990053	hsa-miR-1204	CLIP-seq
MIRT990054	hsa-miR-206	CLIP-seq
MIRT990055	hsa-miR-2110	CLIP-seq
MIRT990056	hsa-miR-3136-3p	CLIP-seq
MIRT990057	hsa-miR-3144-5p	CLIP-seq
MIRT990058	hsa-miR-3150a-3p	CLIP-seq
MIRT990059	hsa-miR-3191	CLIP-seq
MIRT990060	hsa-miR-3673	CLIP-seq
MIRT990061	hsa-miR-4258	CLIP-seq
MIRT990062	hsa-miR-4260	CLIP-seq
MIRT990063	hsa-miR-4652-5p	CLIP-seq
MIRT990064	hsa-miR-4694-3p	CLIP-seq
MIRT990065	hsa-miR-505	CLIP-seq
MIRT990066	hsa-miR-613	CLIP-seq
MIRT990067	hsa-miR-663b	CLIP-seq
MIRT990068	hsa-miR-3130-5p	CLIP-seq
MIRT990069	hsa-miR-3662	CLIP-seq
MIRT990070	hsa-miR-4482	CLIP-seq
MIRT990071	hsa-miR-548ae	CLIP-seq
MIRT990072	hsa-miR-548aj	CLIP-seq
MIRT990073	hsa-miR-548am	CLIP-seq
MIRT990074	hsa-miR-548x	CLIP-seq
MIRT990075	hsa-miR-128	CLIP-seq
MIRT990076	hsa-miR-186	CLIP-seq
MIRT990077	hsa-miR-27a	CLIP-seq
MIRT990078	hsa-miR-27b	CLIP-seq
MIRT990079	hsa-miR-34b	CLIP-seq
MIRT2531209	hsa-miR-1539	CLIP-seq
MIRT2531210	hsa-miR-1976	CLIP-seq
MIRT2531211	hsa-miR-3193	CLIP-seq
MIRT2531212	hsa-miR-4691-5p	CLIP-seq
MIRT2531213	hsa-miR-4706	CLIP-seq
MIRT2531214	hsa-miR-4734	CLIP-seq
MIRT2531215	hsa-miR-4749-5p	CLIP-seq
MIRT2531216	hsa-miR-744	CLIP-seq
MIRT2680820	hsa-miR-198	CLIP-seq
MIRT2680821	hsa-miR-2467-3p	CLIP-seq
MIRT2531213	hsa-miR-4706	CLIP-seq
MIRT2531214	hsa-miR-4734	CLIP-seq
MIRT2531215	hsa-miR-4749-5p	CLIP-seq
MIRT2680822	hsa-miR-4779	CLIP-seq
MIRT2680823	hsa-miR-486-3p	CLIP-seq
MIRT2680824	hsa-miR-615-5p	CLIP-seq
MIRT2531216	hsa-miR-744	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005201	Function	Extracellular matrix structural constituent	IBA
GO:0005201	Function	Extracellular matrix structural constituent	RCA	25037231
GO:0005201	Function	Extracellular matrix structural constituent	TAS	7806230
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	TAS	7806230
GO:0005515	Function	Protein binding	IPI	19349279, 32296183
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IBA
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IEA
GO:0030023	Function	Extracellular matrix constituent conferring elasticity	ISS
GO:0030023	Function	Extracellular matrix constituent conferring elasticity	RCA	27559042, 28327460
GO:0031012	Component	Extracellular matrix	HDA	23658023, 25037231, 27559042, 28327460
GO:0031012	Component	Extracellular matrix	IBA
GO:0031012	Component	Extracellular matrix	IEA
GO:0031012	Component	Extracellular matrix	ISS	22261194
GO:0031012	Component	Extracellular matrix	TAS	7806230
GO:0050840	Function	Extracellular matrix binding	IBA
GO:0050840	Function	Extracellular matrix binding	IEA
GO:1903561	Component	Extracellular vesicle	HDA	24769233

MIM	HGNC	e!Ensembl
135821	3601	ENSG00000163520

P98095

Protein name

Fibulin-2 (FIBL-2)

Protein function

Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01821	ANATO	445 → 480	Anaphylotoxin-like domain	Domain
PF14670	FXa_inhibition	608 → 644		Domain
PF07645	EGF_CA	719 → 762	Calcium-binding EGF domain	Domain
PF07645	EGF_CA	764 → 808	Calcium-binding EGF domain	Domain
PF07645	EGF_CA	810 → 856	Calcium-binding EGF domain	Domain
PF07645	EGF_CA	858 → 899	Calcium-binding EGF domain	Domain
PF12662	cEGF	923 → 946	Complement Clr-like EGF-like	Domain
PF12662	cEGF	962 → 985	Complement Clr-like EGF-like	Domain
PF07645	EGF_CA	1025 → 1073	Calcium-binding EGF domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary.

Sequence

MVLLWEPAGAWLALGLALALGPSVAAAAPRQDCTGVECPPLENCIEEALEPGACCATCVQ
QGCACEGYQYYDCLQGGFVRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLCPELPPN
CIEAVVVADSCPQCGQVGCVHAGHKYAAGHTVHLPPCRACHCPDAGGELICYQLPGCHGN
FSDAEEGDPERHYEDPYSYDQEVAEVEAATALGGEVQAGAVQAGAGGPPAALGGGSQPLS
TIQAPPWPAVLPRPTAAAALGPPAPVQAKARRVTEDSEEEEEEEEEREEMAVTEQLAAGG
HRGLDGLPTTAPAGPSLPIQEERAEAGARAEAGARPEENLILDAQATSRSTGPEGVTHAP
SLGKAALVPTQAVPGSPRDPVKPSPHNILSTSLPDAAWIPPTREVPRKPQVLPHSHVEED
TDPNSVHSIPRSSPEGSTKDLIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCC
VSYLQEKSCMAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPN
LGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSL
PGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPA
LKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDI
NECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFL
CQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNP
LICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI
DVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIY
GSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANG
RSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQ
NSPARITHYQLNFQTGLLVPAHIFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTG
VVYLQRAVLEPRDFALDVEMKLWRQGSVTTFLAKMHIFFTTFAL

Sequence length

1184

Interactions

View interactions

	KEGG		Reactome
	Cytoskeleton in muscle cells		Molecules associated with elastic fibres

FBLN2 (fibulin 2)