RTKN2 (rhotekin 2)

Gene

• Entrez ID: 219790
• Gene name: Rhotekin 2
• Gene symbol: RTKN2
• Synonyms (NCBI Gene): PLEKHK1, bA531F24.1
• Chromosome: 10
• Chromosome location: 10q21.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016449	hsa-miR-193b-3p	Microarray	20304954
MIRT024839	hsa-miR-215-5p	Microarray	19074876
MIRT026703	hsa-miR-192-5p	Microarray	19074876
MIRT047538	hsa-miR-10a-5p	CLASH	23622248
MIRT047409	hsa-miR-10b-5p	CLASH	23622248
MIRT040583	hsa-miR-92b-3p	CLASH	23622248
MIRT1321795	hsa-miR-1184	CLIP-seq
MIRT1321796	hsa-miR-1202	CLIP-seq
MIRT1321797	hsa-miR-1205	CLIP-seq
MIRT1321798	hsa-miR-1244	CLIP-seq
MIRT1321799	hsa-miR-1252	CLIP-seq
MIRT1321800	hsa-miR-1278	CLIP-seq
MIRT1321801	hsa-miR-128	CLIP-seq
MIRT1321802	hsa-miR-1286	CLIP-seq
MIRT1321803	hsa-miR-1324	CLIP-seq
MIRT1321804	hsa-miR-142-5p	CLIP-seq
MIRT1321805	hsa-miR-185	CLIP-seq
MIRT1321806	hsa-miR-186	CLIP-seq
MIRT1321807	hsa-miR-199a-3p	CLIP-seq
MIRT1321808	hsa-miR-199b-3p	CLIP-seq
MIRT1321809	hsa-miR-2053	CLIP-seq
MIRT1321810	hsa-miR-2054	CLIP-seq
MIRT1321811	hsa-miR-2355-5p	CLIP-seq
MIRT1321812	hsa-miR-23a	CLIP-seq
MIRT1321813	hsa-miR-23b	CLIP-seq
MIRT1321814	hsa-miR-23c	CLIP-seq
MIRT1321815	hsa-miR-27a	CLIP-seq
MIRT1321816	hsa-miR-27b	CLIP-seq
MIRT1321817	hsa-miR-3124-3p	CLIP-seq
MIRT1321818	hsa-miR-3129-3p	CLIP-seq
MIRT1321819	hsa-miR-3129-5p	CLIP-seq
MIRT1321820	hsa-miR-3148	CLIP-seq
MIRT1321821	hsa-miR-3158-5p	CLIP-seq
MIRT1321822	hsa-miR-3159	CLIP-seq
MIRT1321823	hsa-miR-3163	CLIP-seq
MIRT1321824	hsa-miR-3166	CLIP-seq
MIRT1321825	hsa-miR-3194-3p	CLIP-seq
MIRT1321826	hsa-miR-3194-5p	CLIP-seq
MIRT1321827	hsa-miR-3197	CLIP-seq
MIRT1321828	hsa-miR-323-3p	CLIP-seq
MIRT1321829	hsa-miR-335	CLIP-seq
MIRT1321830	hsa-miR-340	CLIP-seq
MIRT1321831	hsa-miR-365	CLIP-seq
MIRT1321832	hsa-miR-3653	CLIP-seq
MIRT1321833	hsa-miR-3658	CLIP-seq
MIRT1321834	hsa-miR-3662	CLIP-seq
MIRT1321835	hsa-miR-3679-3p	CLIP-seq
MIRT1321836	hsa-miR-3686	CLIP-seq
MIRT1321837	hsa-miR-3692	CLIP-seq
MIRT1321838	hsa-miR-3910	CLIP-seq
MIRT1321839	hsa-miR-3915	CLIP-seq
MIRT1321840	hsa-miR-3921	CLIP-seq
MIRT1321841	hsa-miR-3928	CLIP-seq
MIRT1321842	hsa-miR-3972	CLIP-seq
MIRT1321843	hsa-miR-4264	CLIP-seq
MIRT1321844	hsa-miR-4278	CLIP-seq
MIRT1321845	hsa-miR-4286	CLIP-seq
MIRT1321846	hsa-miR-4306	CLIP-seq
MIRT1321847	hsa-miR-4418	CLIP-seq
MIRT1321848	hsa-miR-4424	CLIP-seq
MIRT1321849	hsa-miR-4427	CLIP-seq
MIRT1321850	hsa-miR-4428	CLIP-seq
MIRT1321851	hsa-miR-4436b-3p	CLIP-seq
MIRT1321852	hsa-miR-4436b-5p	CLIP-seq
MIRT1321853	hsa-miR-4496	CLIP-seq
MIRT1321854	hsa-miR-4528	CLIP-seq
MIRT1321855	hsa-miR-4644	CLIP-seq
MIRT1321856	hsa-miR-4649-3p	CLIP-seq
MIRT1321857	hsa-miR-4652-3p	CLIP-seq
MIRT1321858	hsa-miR-4653-5p	CLIP-seq
MIRT1321859	hsa-miR-4672	CLIP-seq
MIRT1321860	hsa-miR-4680-3p	CLIP-seq
MIRT1321861	hsa-miR-4714-5p	CLIP-seq
MIRT1321862	hsa-miR-4716-3p	CLIP-seq
MIRT1321863	hsa-miR-4722-5p	CLIP-seq
MIRT1321864	hsa-miR-4742-3p	CLIP-seq
MIRT1321865	hsa-miR-4771	CLIP-seq
MIRT1321866	hsa-miR-4778-3p	CLIP-seq
MIRT1321867	hsa-miR-4778-5p	CLIP-seq
MIRT1321868	hsa-miR-4789-5p	CLIP-seq
MIRT1321869	hsa-miR-4796-3p	CLIP-seq
MIRT1321870	hsa-miR-4797-3p	CLIP-seq
MIRT1321871	hsa-miR-509-3-5p	CLIP-seq
MIRT1321872	hsa-miR-509-5p	CLIP-seq
MIRT1321873	hsa-miR-513a-5p	CLIP-seq
MIRT1321874	hsa-miR-513c	CLIP-seq
MIRT1321875	hsa-miR-514b-5p	CLIP-seq
MIRT1321876	hsa-miR-539	CLIP-seq
MIRT1321877	hsa-miR-548a-5p	CLIP-seq
MIRT1321878	hsa-miR-548ab	CLIP-seq
MIRT1321879	hsa-miR-548ak	CLIP-seq
MIRT1321880	hsa-miR-548b-5p	CLIP-seq
MIRT1321881	hsa-miR-548c-5p	CLIP-seq
MIRT1321882	hsa-miR-548d-5p	CLIP-seq
MIRT1321883	hsa-miR-548h	CLIP-seq
MIRT1321884	hsa-miR-548i	CLIP-seq
MIRT1321885	hsa-miR-548j	CLIP-seq
MIRT1321886	hsa-miR-548k	CLIP-seq
MIRT1321887	hsa-miR-548l	CLIP-seq
MIRT1321888	hsa-miR-548w	CLIP-seq
MIRT1321889	hsa-miR-548y	CLIP-seq
MIRT1321890	hsa-miR-559	CLIP-seq
MIRT1321891	hsa-miR-656	CLIP-seq
MIRT1321892	hsa-miR-936	CLIP-seq
MIRT2095540	hsa-miR-1287	CLIP-seq
MIRT1321805	hsa-miR-185	CLIP-seq
MIRT2095541	hsa-miR-3135b	CLIP-seq
MIRT1321820	hsa-miR-3148	CLIP-seq
MIRT2095542	hsa-miR-3173-3p	CLIP-seq
MIRT2095543	hsa-miR-34b	CLIP-seq
MIRT2095544	hsa-miR-3591-5p	CLIP-seq
MIRT2095545	hsa-miR-3618	CLIP-seq
MIRT1321834	hsa-miR-3662	CLIP-seq
MIRT2095546	hsa-miR-3664-5p	CLIP-seq
MIRT2095547	hsa-miR-3688-3p	CLIP-seq
MIRT1321839	hsa-miR-3915	CLIP-seq
MIRT1321841	hsa-miR-3928	CLIP-seq
MIRT2095548	hsa-miR-3978	CLIP-seq
MIRT2095549	hsa-miR-4261	CLIP-seq
MIRT2095550	hsa-miR-4277	CLIP-seq
MIRT1321846	hsa-miR-4306	CLIP-seq
MIRT1321850	hsa-miR-4428	CLIP-seq
MIRT2095551	hsa-miR-4434	CLIP-seq
MIRT2095552	hsa-miR-4516	CLIP-seq
MIRT2095553	hsa-miR-452	CLIP-seq
MIRT2095554	hsa-miR-4531	CLIP-seq
MIRT1321855	hsa-miR-4644	CLIP-seq
MIRT2095555	hsa-miR-4676-3p	CLIP-seq
MIRT2095556	hsa-miR-4694-3p	CLIP-seq
MIRT2095557	hsa-miR-4705	CLIP-seq
MIRT1321861	hsa-miR-4714-5p	CLIP-seq
MIRT2095558	hsa-miR-4735-5p	CLIP-seq
MIRT2095559	hsa-miR-4738-3p	CLIP-seq
MIRT2095560	hsa-miR-4747-5p	CLIP-seq
MIRT2095561	hsa-miR-4779	CLIP-seq
MIRT2095562	hsa-miR-522	CLIP-seq
MIRT1321876	hsa-miR-539	CLIP-seq
MIRT2095563	hsa-miR-548g	CLIP-seq
MIRT2095564	hsa-miR-576-5p	CLIP-seq
MIRT2095565	hsa-miR-934	CLIP-seq
MIRT2319967	hsa-miR-1276	CLIP-seq
MIRT2095540	hsa-miR-1287	CLIP-seq
MIRT1321803	hsa-miR-1324	CLIP-seq
MIRT2319968	hsa-miR-140-3p	CLIP-seq
MIRT2319969	hsa-miR-181a	CLIP-seq
MIRT2319970	hsa-miR-181b	CLIP-seq
MIRT2319971	hsa-miR-181c	CLIP-seq
MIRT2319972	hsa-miR-181d	CLIP-seq
MIRT1321807	hsa-miR-199a-3p	CLIP-seq
MIRT1321808	hsa-miR-199b-3p	CLIP-seq
MIRT1321810	hsa-miR-2054	CLIP-seq
MIRT2319973	hsa-miR-2276	CLIP-seq
MIRT1321812	hsa-miR-23a	CLIP-seq
MIRT1321813	hsa-miR-23b	CLIP-seq
MIRT1321814	hsa-miR-23c	CLIP-seq
MIRT2319974	hsa-miR-29a	CLIP-seq
MIRT2319975	hsa-miR-29b	CLIP-seq
MIRT2319976	hsa-miR-29c	CLIP-seq
MIRT2319977	hsa-miR-3125	CLIP-seq
MIRT1321819	hsa-miR-3129-5p	CLIP-seq
MIRT2095541	hsa-miR-3135b	CLIP-seq
MIRT2319978	hsa-miR-3145-3p	CLIP-seq
MIRT1321820	hsa-miR-3148	CLIP-seq
MIRT1321821	hsa-miR-3158-5p	CLIP-seq
MIRT2319979	hsa-miR-3161	CLIP-seq
MIRT1321824	hsa-miR-3166	CLIP-seq
MIRT2095542	hsa-miR-3173-3p	CLIP-seq
MIRT2095543	hsa-miR-34b	CLIP-seq
MIRT1321834	hsa-miR-3662	CLIP-seq
MIRT2095547	hsa-miR-3688-3p	CLIP-seq
MIRT1321839	hsa-miR-3915	CLIP-seq
MIRT2319980	hsa-miR-3916	CLIP-seq
MIRT2319981	hsa-miR-3919	CLIP-seq
MIRT1321841	hsa-miR-3928	CLIP-seq
MIRT2095548	hsa-miR-3978	CLIP-seq
MIRT2095549	hsa-miR-4261	CLIP-seq
MIRT2319982	hsa-miR-4262	CLIP-seq
MIRT1321843	hsa-miR-4264	CLIP-seq
MIRT1321844	hsa-miR-4278	CLIP-seq
MIRT2319983	hsa-miR-4311	CLIP-seq
MIRT2319984	hsa-miR-433	CLIP-seq
MIRT1321847	hsa-miR-4418	CLIP-seq
MIRT1321850	hsa-miR-4428	CLIP-seq
MIRT2095551	hsa-miR-4434	CLIP-seq
MIRT2319985	hsa-miR-4477b	CLIP-seq
MIRT2319986	hsa-miR-4495	CLIP-seq
MIRT2095552	hsa-miR-4516	CLIP-seq
MIRT2095553	hsa-miR-452	CLIP-seq
MIRT2095554	hsa-miR-4531	CLIP-seq
MIRT2095555	hsa-miR-4676-3p	CLIP-seq
MIRT2319987	hsa-miR-4699-3p	CLIP-seq
MIRT2095557	hsa-miR-4705	CLIP-seq
MIRT1321862	hsa-miR-4716-3p	CLIP-seq
MIRT2319988	hsa-miR-4724-3p	CLIP-seq
MIRT2095558	hsa-miR-4735-5p	CLIP-seq
MIRT2095559	hsa-miR-4738-3p	CLIP-seq
MIRT2095560	hsa-miR-4747-5p	CLIP-seq
MIRT2319989	hsa-miR-4760-5p	CLIP-seq
MIRT2319990	hsa-miR-4768-5p	CLIP-seq
MIRT1321865	hsa-miR-4771	CLIP-seq
MIRT2319991	hsa-miR-4772-3p	CLIP-seq
MIRT2095561	hsa-miR-4779	CLIP-seq
MIRT1321870	hsa-miR-4797-3p	CLIP-seq
MIRT2319992	hsa-miR-488	CLIP-seq
MIRT2319993	hsa-miR-495	CLIP-seq
MIRT1321871	hsa-miR-509-3-5p	CLIP-seq
MIRT1321872	hsa-miR-509-5p	CLIP-seq
MIRT2319994	hsa-miR-518d-5p	CLIP-seq
MIRT2319995	hsa-miR-519b-5p	CLIP-seq
MIRT2319996	hsa-miR-519c-5p	CLIP-seq
MIRT2319997	hsa-miR-520c-5p	CLIP-seq
MIRT2319998	hsa-miR-526a	CLIP-seq
MIRT1321876	hsa-miR-539	CLIP-seq
MIRT2319999	hsa-miR-544	CLIP-seq
MIRT2095563	hsa-miR-548g	CLIP-seq
MIRT2320000	hsa-miR-548u	CLIP-seq
MIRT2320001	hsa-miR-580	CLIP-seq
MIRT2320002	hsa-miR-583	CLIP-seq
MIRT2320003	hsa-miR-877	CLIP-seq
MIRT1321892	hsa-miR-936	CLIP-seq
MIRT2095547	hsa-miR-3688-3p	CLIP-seq
MIRT2095548	hsa-miR-3978	CLIP-seq
MIRT2095549	hsa-miR-4261	CLIP-seq
MIRT2095553	hsa-miR-452	CLIP-seq
MIRT2095555	hsa-miR-4676-3p	CLIP-seq
MIRT2095559	hsa-miR-4738-3p	CLIP-seq
MIRT2095563	hsa-miR-548g	CLIP-seq
MIRT2442580	hsa-miR-1910	CLIP-seq
MIRT2442581	hsa-miR-3158-3p	CLIP-seq
MIRT2442582	hsa-miR-3973	CLIP-seq
MIRT2442583	hsa-miR-455-3p	CLIP-seq
MIRT2442584	hsa-miR-520g	CLIP-seq
MIRT2442585	hsa-miR-520h	CLIP-seq
MIRT2442586	hsa-miR-607	CLIP-seq
MIRT2615883	hsa-miR-150	CLIP-seq
MIRT1321823	hsa-miR-3163	CLIP-seq
MIRT1321830	hsa-miR-340	CLIP-seq
MIRT1321852	hsa-miR-4436b-5p	CLIP-seq
MIRT1321854	hsa-miR-4528	CLIP-seq
MIRT2615884	hsa-miR-4713-5p	CLIP-seq
MIRT1321866	hsa-miR-4778-3p	CLIP-seq
MIRT2615885	hsa-miR-510	CLIP-seq
MIRT2615886	hsa-miR-512-5p	CLIP-seq
MIRT2615887	hsa-miR-532-3p	CLIP-seq
MIRT1321876	hsa-miR-539	CLIP-seq
MIRT2615883	hsa-miR-150	CLIP-seq
MIRT1321823	hsa-miR-3163	CLIP-seq
MIRT1321830	hsa-miR-340	CLIP-seq
MIRT1321852	hsa-miR-4436b-5p	CLIP-seq
MIRT1321854	hsa-miR-4528	CLIP-seq
MIRT2615884	hsa-miR-4713-5p	CLIP-seq
MIRT1321866	hsa-miR-4778-3p	CLIP-seq
MIRT2615885	hsa-miR-510	CLIP-seq
MIRT2615886	hsa-miR-512-5p	CLIP-seq
MIRT2615887	hsa-miR-532-3p	CLIP-seq
MIRT1321876	hsa-miR-539	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IDA	15504364
GO:0005737	Component	Cytoplasm	IDA	15504364
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0030097	Process	Hemopoiesis	IBA
GO:0030097	Process	Hemopoiesis	IEA
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IMP	26124677
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	IMP	26124677
GO:2001243	Process	Negative regulation of intrinsic apoptotic signaling pathway	IMP	26124677

Other IDs

• MIM: 618450
• HGNC: 19364
• e!Ensembl: ENSG00000182010

Protein

• UniProt ID: Q8IZC4
• Protein name: Rhotekin-2 (Pleckstrin homology domain-containing family K member 1) (PH domain-containing family K member 1)
• Protein function: May play an important role in lymphopoiesis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08174	Anillin	98 → 247	Cell division protein anillin	Domain
  PF00169	PH	288 → 391	PH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in lymphocytes, CD4 positive T-cells and bone marrow-derived cells. Also expressed in lung, colon, thymus and brain. {ECO:0000269|PubMed:15504364}.
• Sequence:

  MEGPSLRGPALRLAGLPTQQDCNIQEKIDLEIRMREGIWKLLSLSTQKDQVLHAVKNLMV
  CNARLMAYTSELQKLEEQIANQTGRCDVKFESKERTACKGKIAISDIRIPLMWKDSDHFS
  NKERSRRYAIFCLFKMGANVFDTDVVNVDKTITDICFENVTIFNEAGPDFQIKVEVYSCC
  TEESSITNTPKKLAKKLKTSISKATGKKISSVLQEEDDEMCLLLSSAVFGVKYNLLAHTT
  LTLESAEDSFKTHNLSINGNEESSFWLPLYGNMCCRLVAQPACMAEDAFAGFLNQQQMVE
  GLISWRRLYCVLRGGKLYCFYSPEEIEAKVEPALVVPINKETRIRAMDKDAKKRIHNFSV
  INPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMSPRKPPLFL
  TKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQM
  VIQKKVLYPASEPLHDEKGKKRQAPLPPSDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSS
  LDTKLSTLMHHLQKPMAAPRKLLPARRNRLSDGEHTDTKTNFEAKPVPAPRQKSIKDILD
  PRSWLQAQV

• Sequence length: 609

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Interstitial lung disease 2	Uncertain significance	rs563733406	RCV000677224

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Inhibit	36952123
Arthritis Rheumatoid	Associate	23028356
Breast Neoplasms	Associate	38155217
Carcinoma Non Small Cell Lung	Associate	34394080
Colorectal Neoplasms	Inhibit	38155217
Idiopathic Interstitial Pneumonias	Associate	26503507
Neoplasms	Inhibit	38155217
Osteosarcoma	Associate	30389712
Stomach Neoplasms	Stimulate	36201856