AMER2 (APC membrane recruitment protein 2)

Gene

• Entrez ID: 219287
• Gene name: APC membrane recruitment protein 2
• Gene symbol: AMER2
• Synonyms (NCBI Gene): FAM123A
• Chromosome: 13
• Chromosome location: 13q12.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT660713	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT660711	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT660710	hsa-miR-6830-5p	HITS-CLIP	23824327
MIRT572845	hsa-miR-3912-3p	PAR-CLIP	20371350
MIRT572844	hsa-miR-5197-5p	PAR-CLIP	20371350
MIRT572843	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT572842	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT572841	hsa-miR-4736	PAR-CLIP	20371350
MIRT572840	hsa-miR-3907	PAR-CLIP	20371350
MIRT572839	hsa-miR-7150	PAR-CLIP	20371350
MIRT449023	hsa-miR-4496	PAR-CLIP	22100165
MIRT449022	hsa-miR-4635	PAR-CLIP	22100165
MIRT449021	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT449023	hsa-miR-4496	PAR-CLIP	22100165
MIRT449022	hsa-miR-4635	PAR-CLIP	22100165
MIRT449021	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT660713	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT660711	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT660710	hsa-miR-6830-5p	HITS-CLIP	23824327
MIRT572845	hsa-miR-3912-3p	PAR-CLIP	20371350
MIRT572844	hsa-miR-5197-5p	PAR-CLIP	20371350
MIRT572843	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT572842	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT572841	hsa-miR-4736	PAR-CLIP	20371350
MIRT572840	hsa-miR-3907	PAR-CLIP	20371350
MIRT572839	hsa-miR-7150	PAR-CLIP	20371350
MIRT449023	hsa-miR-4496	PAR-CLIP	22100165
MIRT449022	hsa-miR-4635	PAR-CLIP	22100165
MIRT449021	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT449023	hsa-miR-4496	PAR-CLIP	22100165
MIRT449022	hsa-miR-4635	PAR-CLIP	22100165
MIRT449021	hsa-miR-526b-5p	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22128170
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IBA
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IDA	22128170
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22128170
GO:0005886	Component	Plasma membrane	IEA
GO:0007398	Process	Ectoderm development	ISS
GO:0008013	Function	Beta-catenin binding	IBA
GO:0008289	Function	Lipid binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0060828	Process	Regulation of canonical Wnt signaling pathway	IBA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IMP	22128170

Other IDs

• MIM: 614659
• HGNC: 26360
• e!Ensembl: ENSG00000165566

Protein

• UniProt ID: Q8N7J2
• Protein name: APC membrane recruitment protein 2 (Amer2) (Protein FAM123A)
• Protein function: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key reg
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09422	WTX	99 → 590	WTX protein	Family

• Sequence:

  METSRSRGGGGAVSERGGAGASVGVCRRKAEAGAGTGTLAADMDLHCDCAAETPAAEPPS
  GKINKAAFKLFKKRKSGGTMPSIFGVKNKGDGKSSGPTGLVRSRTHDGLAEVLVLESGRK
  EEPRGGGDSGGGGGGRPNPGPPRAAGPGGGSLASSSVAKSHSFFSLLKKNGRSENGKGEP
  VDASKAGGKQKRGLRGLFSGMRWHRKDKRAKAEAAEGRAPGGGLILPGSLTASLECVKEE
  TPRAAREPEEPSQDAPRDPAGEPAGGEEVPAPADRAPARSCREAEGLAHPGDTGARGEDA
  AGHRRAEPGPGEVRTAEDASRTGAVPVKTVPLVDSEGGSGRAPAAPDPASVDPPSDPSAD
  RICLMFSDVTSLKSFDSLTGCGDIIADQEEEAGPSCDKHVPGPGKPALSKKNPGVVAYQG
  GGEEMASPDEVDDTYLQEFWDMLSQTEEQGPEPQEGAAKVAAALETKVVPETPKDTRCVE
  AAKDASSVKRRRLNRIPIEPHPKEEPKHPEKEQQEGVPNSDEGYWDSTTPGPEEDSSSSG
  KKAGIPRDSYSGDALYDLYADPDGSPATLPGGKDNEETSSLSRLKPVSPGTITCPLRTPG
  SLLKDSKIPISIKHLTNLPSSHPVVHQQPSRSEMPRTKIPVSKVLVRRVSNRGLAGTTIR
  ATACHDSAKKL

• Sequence length: 671