AMER2 (APC membrane recruitment protein 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
219287
Gene name Gene Name - the full gene name approved by the HGNC.
APC membrane recruitment protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AMER2
Synonyms (NCBI Gene) Gene synonyms aliases
FAM123A
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q12.13
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(32)
miRTarBase ID miRNA Experiments Reference
MIRT660713 hsa-miR-551b-5p HITS-CLIP 23824327
MIRT660711 hsa-miR-651-3p HITS-CLIP 23824327
MIRT660710 hsa-miR-6830-5p HITS-CLIP 23824327
MIRT572845 hsa-miR-3912-3p PAR-CLIP 20371350
MIRT572844 hsa-miR-5197-5p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(13)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 22128170
GO:0005546 Function Phosphatidylinositol-4,5-bisphosphate binding IBA
GO:0005546 Function Phosphatidylinositol-4,5-bisphosphate binding IDA 22128170
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA 22128170
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
614659 26360 ENSG00000165566
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q8N7J2
Protein name APC membrane recruitment protein 2 (Amer2) (Protein FAM123A)
Protein function Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key reg
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09422 WTX 99 → 590 WTX protein Family
Sequence
Sequence length 671
Interactions View interactions
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Intracranial Aneurysm Intracranial aneurysm N/A N/A GWAS
Show/Hide Text Mining Associations (2)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Colorectal Neoplasms Associate 35202405
Neoplasms Associate 25740824