FAP (fibroblast activation protein alpha)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2191
Gene name Gene Name - the full gene name approved by the HGNC.
Fibroblast activation protein alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FAP
Synonyms (NCBI Gene) Gene synonyms aliases
DPPIV, FAPA, FAPalpha, SIMP
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q24.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all(41)
miRTarBase ID miRNA Experiments Reference
MIRT756324 hsa-miR-329-5p Luciferase reporter assay, Western blotting, qRT-PCR 38459511
MIRT1548582 hsa-miR-4303 CLIP-seq
MIRT1548583 hsa-miR-4682 CLIP-seq
MIRT2227036 hsa-miR-1911 CLIP-seq
MIRT2227037 hsa-miR-27a CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
EGR1 Activation 20515787
EGR1 Repression 20515787
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all(45)
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0002020 Function Protease binding IPI 17317851
GO:0004175 Function Endopeptidase activity IDA 17317851
GO:0004252 Function Serine-type endopeptidase activity IDA 10593948
GO:0005178 Function Integrin binding IPI 10455171
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
600403 3590 ENSG00000078098
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Q12884
Protein name Prolyl endopeptidase FAP (EC 3.4.21.26) (170 kDa melanoma membrane-bound gelatinase) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine prot
Protein function Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and
PDB 1Z68 , 6Y0F , 9DVQ , 9DVR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00930 DPPIV_N 106 → 473 Dipeptidyl peptidase IV (DPP IV) N-terminal region Family
PF00326 Peptidase_S9 553 → 759 Prolyl oligopeptidase family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like
Sequence
Sequence length 760
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Autoimmune diseases Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 rs869025224 30595370
Show/Hide Unknown Diseases (9)
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Vitiligo Vitiligo GWAS
Hypothyroidism Hypothyroidism GWAS
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Show/Hide Text Mining Associations (107)
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 38614364
Adenocarcinoma Associate 20080664, 32428869, 33706022
Adenocarcinoma of Lung Associate 40453096
Aortic Diseases Stimulate 21292680
Arthritis Associate 21292680, 37325617
Arthritis Psoriatic Associate 17105646
Arthritis Rheumatoid Associate 17105646, 34134455, 34450633
Arthritis Rheumatoid Stimulate 28793332
Atherosclerosis Associate 37325617
Brain Neoplasms Associate 34050405