ALDH2 (aldehyde dehydrogenase 2 family member)

Gene

• Entrez ID: 217
• Gene name: Aldehyde dehydrogenase 2 family member
• Gene symbol: ALDH2
• Synonyms (NCBI Gene): ALDH-E2, ALDHI, ALDM
• Chromosome: 12
• Chromosome location: 12q24.12
• Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can b

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs671	G>A	Drug-response, protective, risk-factor	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016754	hsa-miR-335-5p	Microarray	18185580
MIRT023536	hsa-miR-1-3p	Proteomics	18668040
MIRT031438	hsa-miR-16-5p	Proteomics	18668040
MIRT039939	hsa-miR-615-3p	CLASH	23622248
MIRT519128	hsa-miR-1245a	PAR-CLIP	23446348
MIRT519127	hsa-miR-8079	PAR-CLIP	23446348
MIRT519126	hsa-miR-4638-5p	PAR-CLIP	23446348
MIRT519125	hsa-miR-6790-3p	PAR-CLIP	23446348
MIRT519124	hsa-miR-6821-3p	PAR-CLIP	23446348
MIRT519123	hsa-miR-4765	PAR-CLIP	23446348
MIRT519122	hsa-miR-640	PAR-CLIP	23446348
MIRT519128	hsa-miR-1245a	PAR-CLIP	23446348
MIRT519127	hsa-miR-8079	PAR-CLIP	23446348
MIRT519126	hsa-miR-4638-5p	PAR-CLIP	23446348
MIRT519125	hsa-miR-6790-3p	PAR-CLIP	23446348
MIRT519124	hsa-miR-6821-3p	PAR-CLIP	23446348
MIRT519123	hsa-miR-4765	PAR-CLIP	23446348
MIRT519122	hsa-miR-640	PAR-CLIP	23446348
MIRT777131	hsa-miR-30a	CLIP-seq
MIRT777132	hsa-miR-30b	CLIP-seq
MIRT777133	hsa-miR-30c	CLIP-seq
MIRT777134	hsa-miR-30d	CLIP-seq
MIRT777135	hsa-miR-30e	CLIP-seq
MIRT777136	hsa-miR-3689a-5p	CLIP-seq
MIRT777137	hsa-miR-3689b	CLIP-seq
MIRT777138	hsa-miR-3689e	CLIP-seq
MIRT777139	hsa-miR-3689f	CLIP-seq
MIRT777140	hsa-miR-4274	CLIP-seq
MIRT777141	hsa-miR-4423-5p	CLIP-seq
MIRT777142	hsa-miR-4519	CLIP-seq
MIRT2170127	hsa-miR-1185	CLIP-seq
MIRT2170128	hsa-miR-3065-3p	CLIP-seq
MIRT2170129	hsa-miR-3140-5p	CLIP-seq
MIRT2170130	hsa-miR-330-3p	CLIP-seq
MIRT2170131	hsa-miR-3679-5p	CLIP-seq
MIRT777136	hsa-miR-3689a-5p	CLIP-seq
MIRT777137	hsa-miR-3689b	CLIP-seq
MIRT777138	hsa-miR-3689e	CLIP-seq
MIRT777139	hsa-miR-3689f	CLIP-seq
MIRT2170132	hsa-miR-3919	CLIP-seq
MIRT2170133	hsa-miR-3942-3p	CLIP-seq
MIRT777140	hsa-miR-4274	CLIP-seq
MIRT2170134	hsa-miR-4282	CLIP-seq
MIRT2170135	hsa-miR-4291	CLIP-seq
MIRT2170136	hsa-miR-4326	CLIP-seq
MIRT777141	hsa-miR-4423-5p	CLIP-seq
MIRT2170137	hsa-miR-4476	CLIP-seq
MIRT777142	hsa-miR-4519	CLIP-seq
MIRT2170138	hsa-miR-4753-3p	CLIP-seq
MIRT2170139	hsa-miR-4756-3p	CLIP-seq
MIRT2170140	hsa-miR-4766-5p	CLIP-seq
MIRT2170141	hsa-miR-4768-5p	CLIP-seq
MIRT2170142	hsa-miR-4793-5p	CLIP-seq
MIRT2170143	hsa-miR-513a-3p	CLIP-seq
MIRT2170144	hsa-miR-520d-5p	CLIP-seq
MIRT2170145	hsa-miR-524-5p	CLIP-seq
MIRT2170146	hsa-miR-548c-3p	CLIP-seq
MIRT2170147	hsa-miR-621	CLIP-seq
MIRT2384067	hsa-miR-578	CLIP-seq
MIRT2170128	hsa-miR-3065-3p	CLIP-seq
MIRT2473006	hsa-miR-3148	CLIP-seq
MIRT2473007	hsa-miR-3674	CLIP-seq
MIRT2170133	hsa-miR-3942-3p	CLIP-seq
MIRT2170134	hsa-miR-4282	CLIP-seq
MIRT2170135	hsa-miR-4291	CLIP-seq
MIRT2473008	hsa-miR-4496	CLIP-seq
MIRT2170138	hsa-miR-4753-3p	CLIP-seq
MIRT2170141	hsa-miR-4768-5p	CLIP-seq
MIRT2170143	hsa-miR-513a-3p	CLIP-seq
MIRT2170128	hsa-miR-3065-3p	CLIP-seq
MIRT2473006	hsa-miR-3148	CLIP-seq
MIRT2473007	hsa-miR-3674	CLIP-seq
MIRT2170133	hsa-miR-3942-3p	CLIP-seq
MIRT2170134	hsa-miR-4282	CLIP-seq
MIRT2170135	hsa-miR-4291	CLIP-seq
MIRT2473008	hsa-miR-4496	CLIP-seq
MIRT2170138	hsa-miR-4753-3p	CLIP-seq
MIRT2170141	hsa-miR-4768-5p	CLIP-seq
MIRT2170143	hsa-miR-513a-3p	CLIP-seq
MIRT2384067	hsa-miR-578	CLIP-seq
MIRT2674900	hsa-miR-628-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IBA	21873635
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IDA	4015840
GO:0004030	Function	Aldehyde dehydrogenase [NAD(P)+] activity	TAS	8903321
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005975	Process	Carbohydrate metabolic process	TAS	8903321
GO:0006066	Process	Alcohol metabolic process	TAS	1306115
GO:0006068	Process	Ethanol catabolic process	IEA
GO:0006069	Process	Ethanol oxidation	TAS
GO:0009055	Function	Electron transfer activity	TAS	8903321
GO:0022900	Process	Electron transport chain	IEA
GO:0043878	Function	Glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	IEA
GO:0051287	Function	NAD binding	ISS	12693930
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 100650
• HGNC: 404
• e!Ensembl: ENSG00000111275

Protein

• UniProt ID: P05091
• Protein name: Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI)
• Protein function: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.
• PDB: 1CW3, 1NZW, 1NZX, 1NZZ, 1O00, 1O01, 1O02, 1O04, 1O05, 1ZUM, 2ONM, 2ONN, 2ONO, 2ONP, 2VLE, 3INJ, 3INL, 3N80, 3N81, 3N82, 3N83, 3SZ9, 4FQF, 4FR8, 4KWF, 4KWG, 5L13, 8DR9, 8SHS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00171	Aldedh	45 → 508	Aldehyde dehydrogenase family	Family

• Sequence:

  MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
  TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
  ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
  QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
  FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
  DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
  QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
  VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
  PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

• Sequence length: 517

Pathways

KEGG:

Glycolysis / Gluconeogenesis
Ascorbate and aldarate metabolism
Fatty acid degradation
Valine, leucine and isoleucine degradation
Lysine degradation
Arginine and proline metabolism
Histidine metabolism
Tryptophan metabolism
beta-Alanine metabolism
Glycerolipid metabolism
Pyruvate metabolism
Pantothenate and CoA biosynthesis
Metabolic pathways
Biosynthesis of cofactors
Alcoholic liver disease

Reactome:

Metabolism of serotonin
Ethanol oxidation

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Autoimmune diseases	Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2	rs869025224	30595370
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208	16332725
Colorectal neoplasms	Colorectal Neoplasms	rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049, rs63750451, rs121434629, rs63751247, rs63750710, rs63751615, rs63750781, rs63750899, rs63750691, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs63750245, rs193922372, rs63750393, rs63749932, rs193922375, rs193922376, rs193922343, rs397514684, rs397515875, rs267608094, rs587779204, rs267608077, rs587779206, rs63750439, rs63751405, rs63750741, rs63750854, rs63750909, rs587779212, rs587779215, rs587779216, rs587779219, rs63749874, rs267608076, rs587779220, rs267608050, rs63750735, rs63750564, rs71539659, rs267608082, rs63751167, rs267608057, rs587779227, rs267608068, rs63750075, rs587779228, rs63751419, rs587779231, rs587779232, rs267608058, rs63751442, rs63751127, rs63750647, rs63750138, rs587779235, rs267608065, rs63751321, rs587779241, rs587779243, rs63750904, rs63751017, rs587779246, rs267608063, rs63750140, rs63750940, rs63750111, rs587779250, rs63750258, rs63750563, rs267608073, rs63751407, rs267608059, rs63749999, rs267608042, rs63750833, rs587779255, rs587779256, rs63749821, rs63749843, rs63750617, rs267608078, rs587779259, rs267608092, rs587779260, rs267608086, rs1553331676, rs63750356, rs587779263, rs267608098, rs587779264, rs587779267, rs63750194, rs63751327, rs587779269, rs63751328, rs587779274, rs587779279, rs267608111, rs1553332996, rs587779284, rs63749942, rs587779288, rs63751058, rs63750554, rs267608114, rs267608118, rs63750139, rs63751319, rs267608128, rs587779295, rs267608127, rs267608126, rs63750767, rs267608120, rs587779299, rs267608121, rs587779301, rs267608131, rs267608122, rs63749873, rs63751077, rs1800937, rs587779315, rs587779318, rs63750019, rs267608066, rs63749980, rs63750552, rs1553412283, rs146816935, rs587779001, rs63750677, rs63750339, rs63751609, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs587778882, rs587778883, rs63751012, rs63750715, rs63750580, rs587778888, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs587778896, rs63751015, rs267607713, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607837, rs267607836, rs63750028, rs587778930, rs63751277, rs587778933, rs267607843, rs63750192, rs63750300, rs63750193, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs63751608, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750587, rs63749863, rs63749868, rs63750035, rs63750604, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63750152, rs63750850, rs267607867, rs267607869, rs63751632, rs267607871, rs587778956, rs63749792, rs267607875, rs63750610, rs281864938, rs63751465, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs63751662, rs267607884, rs267607883, rs63750639, rs63750206, rs587778967, rs63750663, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs267607717, rs587778973, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs267607888, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63751642, rs63751022, rs587778983, rs587778984, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63749859, rs63750437, rs587778997, rs63749990, rs587778998, rs63750005, rs63750641, rs63751421, rs63750266, rs111052004, rs267607726, rs63750453, rs267607734, rs267607735, rs63751665, rs267607732, rs63749816, rs63750539, rs587779006, rs63751606, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs63750866, rs63750865, rs587779010, rs587779012, rs63750057, rs72481822, rs587779014, rs587779015, rs63751045, rs63749820, rs267607750, rs267607749, rs267607753, rs63750891, rs63749959, rs63749804, rs63750903, rs63750211, rs267607765, rs267607760, rs587779021, rs587779022, rs267607759, rs63750515, rs63750648, rs63751480, rs267607772, rs587779024, rs267607768, rs63751653, rs587779027, rs267607767, rs63750581, rs63750706, rs63750385, rs587779031, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs267607785, rs267607783, rs63750823, rs63750822, rs267607787, rs63750303, rs587779037, rs63750948, rs63749827, rs587779039, rs267607789, rs267607790, rs267607791, rs267607786, rs267607795, rs267607794, rs267607788, rs63750792, rs63749950, rs587779045, rs63750034, rs587779047, rs63750216, rs63750517, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs587779054, rs587779055, rs63751259, rs63749926, rs63750796, rs587779058, rs63751197, rs587779063, rs63750778, rs63751004, rs63751147, rs63751027, rs63750396, rs587779067, rs267607940, rs267607943, rs63751617, rs63750558, rs63750267, rs63749849, rs587779075, rs63750302, rs63750611, rs63750984, rs63750586, rs63751412, rs63751413, rs587779076, rs63751142, rs63750086, rs63750006, rs267607950, rs267607949, rs63751693, rs587779083, rs587779084, rs63750807, rs63749920, rs267607954, rs267607957, rs587779087, rs63750384, rs63750615, rs63750068, rs63749947, rs1114167806, rs63750936, rs267607962, rs587779097, rs63750780, rs63749930, rs63750224, rs63750094, rs63750337, rs63751656, rs267607969, rs267607972, rs63750597, rs267607970, rs267607971, rs587779101, rs587779103, rs63751149, rs63750474, rs587779105, rs63751411, rs587779108, rs267607976, rs63751140, rs587779110, rs267607977, rs63750200, rs63751236, rs267607985, rs63750951, rs587779112, rs63750493, rs267607984, rs63750312, rs63750508, rs63750280, rs63750160, rs63750203, rs63750960, rs63750893, rs63751317, rs587779119, rs267607986, rs267607987, rs587779125, rs267607988, rs267607990, rs63751640, rs63751123, rs587779129, rs587779131, rs267607995, rs63750199, rs587779133, rs63749993, rs63750232, rs63751432, rs267607994, rs63750961, rs63750398, rs587779136, rs267607915, rs267607914, rs267607917, rs587779138, rs63750636, rs63751453, rs587779139, rs63750572, rs267608002, rs267608006, rs267607979, rs267608001, rs63751155, rs63751477, rs63750042, rs63749854, rs587779143, rs63751105, rs63750346, rs63749848, rs63750618, rs63750149, rs63750233, rs63750803, rs63750463, rs63749983, rs63751018, rs63749917, rs267608010, rs267608012, rs63751621, rs63750623, rs63751117, rs63751447, rs587779148, rs63750857, rs587779149, rs63749830, rs63750849, rs63750291, rs63751618, rs267608019, rs267608017, rs63751624, rs267608020, rs587779153, rs63751469, rs267607920, rs63750084, rs63750808, rs63751007, rs63751429, rs63750970, rs63751099, rs63750318, rs587779157, rs63750501, rs63750614, rs587779159, rs63750458, rs267607924, rs267607925, rs63750924, rs63750704, rs63750408, rs63750910, rs63751426, rs63750624, rs63750214, rs63750582, rs587779163, rs63750843, rs63750933, rs63750070, rs587779164, rs63750382, rs63750551, rs63751444, rs63750088, rs587779165, rs63751326, rs63750682, rs63751110, rs63751136, rs587779167, rs63750574, rs63749984, rs63751622, rs63751274, rs267607689, rs587779169, rs267607930, rs267607929, rs63751602, rs587779170, rs63749897, rs63750426, rs281864944, rs63750488, rs63749832, rs63750347, rs267607934, rs587779185, rs63750091, rs63750276, rs63750097, rs587779189, rs587779190, rs587779191, rs63750934, rs63750885, rs63749915, rs63749914, rs63750640, rs587779193, rs587779195, rs12476364, rs587779198, rs63750502, rs63751044, rs63750630, rs63750468, rs63750828, rs267608156, rs587779326, rs587778617, rs587779330, rs267608169, rs63750477, rs63750793, rs63750250, rs63750490, rs63751422, rs201451115, rs587779333, rs267608170, rs267608161, rs267608172, rs63750695, rs587779336, rs267608173, rs267608160, rs1554306445, rs587779338, rs63751029, rs267608148, rs587779343, rs63750261, rs267608147, rs587779344, rs267608149, rs267608151, rs267608154, rs63750246, rs267608153, rs200640585, rs143277125, rs587779347, rs398123231, rs398123232, rs587779778, rs587779254, rs587779914, rs200492211, rs587779936, rs587779941, rs587779950, rs587779964, rs587779979, rs587780059, rs188006077, rs587780062, rs587780064, rs587780538, rs587778618, rs587780683, rs587780724, rs63751427, rs587781317, rs63750119, rs587781339, rs587781372, rs587781395, rs267608064, rs587781462, rs63750737, rs587781544, rs587781554, rs587781626, rs587781691, rs587781716, rs587782074, rs587782111, rs587782277, rs587782326, rs587782336, rs587782561, rs587782593, rs141577476, rs587782659, rs587782704, rs63751604, rs587782710, rs587782712, rs267607712, rs587782787, rs587783056, rs373885654, rs730881775, rs587779166, rs730881774, rs730881816, rs730881825, rs730881827, rs730881829, rs730881830, rs730881734, rs41542214, rs786202037, rs786203424, rs786203604, rs786201066, rs786203036, rs786201590, rs786203704, rs786201042, rs786203597, rs587782281, rs786202848, rs786201049, rs750528093, rs786202363, rs786202108, rs267608083, rs786201050, rs374230313, rs786203924, rs786202842, rs786203331, rs786201084, rs1553333738, rs267607716, rs786202328, rs786203456, rs786201990, rs786201039, rs786201062, rs778531080, rs786203073, rs63751228, rs786201047, rs573125799, rs786203954, rs786202098, rs587779340, rs763308607, rs786204082, rs786204144, rs786204050, rs786204252, rs786204104, rs786204321, rs869320619, rs863224481, rs863224833, rs863224473, rs863224829, rs863224474, rs863224475, rs863224476, rs863224480, rs63750549, rs863224498, rs863224497, rs863224496, rs267608159, rs863224450, rs863224676, rs863225397, rs863225386, rs863225387, rs267607953, rs863225389, rs863225390, rs370970617, rs759263820, rs863225392, rs863225394, rs863225395, rs863225402, rs863225421, rs863225398, rs863225399, rs863225400, rs863225403, rs863225404, rs863225406, rs587782562, rs863225408, rs863225409, rs863225412, rs863225416, rs863225418, rs863225383, rs863225384, rs863225377, rs863225378, rs863225381, rs864622041, rs63750059, rs1553350680, rs864622183, rs63749991, rs864622340, rs63750330, rs864622436, rs864622121, rs864622435, rs864622153, rs864622257, rs864622585, rs864622607, rs786203968, rs267607744, rs267607823, rs267607832, rs864622457, rs864622600, rs3209663, rs869312768, rs869312769, rs869312770, rs869312767, rs759151952, rs876657701, rs876661033, rs876661205, rs876661025, rs876661193, rs63749919, rs876661073, rs876661222, rs876661171, rs876661159, rs63749818, rs876658915, rs876661113, rs876661203, rs766389591, rs760228510, rs763939668, rs876660480, rs876658996, rs876660655, rs876658918, rs876658223, rs876660711, rs876658211, rs876660095, rs876658296, rs876660549, rs876658881, rs876660630, rs876659189, rs876660283, rs876660943, rs866771359, rs876658817, rs876658962, rs876658339, rs876658657, rs876658821, rs876659068, rs63750217, rs876659681, rs876659608, rs876659480, rs876659900, rs876660459, rs876658862, rs587782898, rs876658964, rs876659736, rs878853815, rs878853824, rs878853802, rs878853809, rs267608041, rs878853702, rs878853709, rs878853711, rs878853718, rs878853721, rs878853729, rs878853736, rs878853739, rs878853742, rs878853745, rs878853792, rs878853794, rs878853777, rs878853778, rs878853780, rs878853785, rs878853787, rs878854037, rs878854060, rs878854059, rs763872353, rs879254025, rs879254104, rs879253899, rs879254234, rs1553640314, rs886039424, rs886039646, rs886039615, rs886044911, rs63750058, rs1057517551, rs1057517541, rs756843954, rs1057517764, rs1057517763, rs1057517801, rs769742496, rs1057520605, rs1057520735, rs1057524433, rs786202083, rs1553350787, rs1060502035, rs267607694, rs1060502039, rs1060502014, rs1060502038, rs1060502032, rs1060502001, rs1060502000, rs1060502885, rs1060502941, rs1060502029, rs775464903, rs1064792951, rs1553413673, rs1060502918, rs1060502876, rs1060502888, rs1060502932, rs1060502901, rs1060502891, rs1060502940, rs1060502937, rs1060502926, rs1060502886, rs1060501993, rs1060501989, rs1060502890, rs1060502027, rs1060502023, rs1060501991, rs1060502903, rs1553333432, rs1060502875, rs1060502946, rs1060502882, rs1060502881, rs1060500689, rs764085979, rs1060500707, rs1064792918, rs1060500698, rs1060500699, rs1060500706, rs63750867, rs1060500688, rs1060500703, rs1060500692, rs1060500687, rs1060503142, rs111466480, rs1060503137, rs746766787, rs758304323, rs764342199, rs876659162, rs1554300763, rs730881920, rs1060503148, rs1060503110, rs1060503138, rs1064794155, rs1064794809, rs1553352505, rs267607939, rs876658187, rs1064793561, rs1064795653, rs1064795329, rs267608011, rs1064794075, rs1553411392, rs1023534466, rs1553412609, rs1064794388, rs1064793600, rs1064795256, rs1064795591, rs1064794055, rs1064794164, rs1553414010, rs1064793671, rs1064794943, rs876660853, rs1064793489, rs1064795629, rs1064794384, rs1553333072, rs1553333078, rs1553333127, rs1553333500, rs1064793895, rs760190301, rs1064795341, rs1064793607, rs587778968, rs1064795441, rs1064794612, rs1064795515, rs1064794267, rs1064793823, rs1064794331, rs63750978, rs1064796500, rs1064794566, rs1064793234, rs757324104, rs1064794905, rs1064795447, rs1064796190, rs1064793868, rs1554304940, rs1064794083, rs1064795705, rs1064794173, rs1064794152, rs1085308057, rs1114167435, rs1114167883, rs1114167831, rs1114167877, rs1114167855, rs587782537, rs1114167814, rs1114167848, rs1114167845, rs979212552, rs1114167809, rs1114167858, rs1553356720, rs1114167833, rs1114167852, rs1114167835, rs1114167854, rs1114167815, rs267607982, rs1114167844, rs1114167805, rs730881762, rs1114167857, rs1114167832, rs1114167826, rs1114167841, rs1114167828, rs1114167818, rs1114167719, rs1114167776, rs1114167689, rs1114167728, rs1114167692, rs1114167725, rs1114167704, rs1114167696, rs1114167748, rs1114167763, rs1114167804, rs1114167731, rs1114167801, rs753796271, rs1114167736, rs1114167756, rs267608055, rs1114167746, rs1114167715, rs587782706, rs1114167750, rs1114167702, rs1114167765, rs587780670, rs1114167766, rs777159874, rs587782638, rs1114167747, rs1114167709, rs1114167694, rs786204048, rs1114167771, rs1114167794, rs1114167714, rs765411990, rs587782862, rs1114167773, rs1114167724, rs1114167707, rs1114167782, rs1114167793, rs1114167767, rs766905993, rs1114167723, rs1114167755, rs752404604, rs1114167706, rs1114167717, rs1114167783, rs1114167760, rs1553333599, rs1553333615, rs1553333644, rs1114167790, rs587779297, rs1553351549, rs753075410, rs63751271, rs371776176, rs63750689, rs1553369164, rs202145681, rs1553370310, rs1230083633, rs1553412966, rs1553413710, rs1348956744, rs1553331290, rs1553333421, rs1553333598, rs1416452389, rs1553333707, rs1553641362, rs63751448, rs1553648058, rs587778937, rs1553662753, rs1554292880, rs988423880, rs1553353114, rs63751119, rs1553647995, rs1553663750, rs1458321358, rs730881919, rs1553413178, rs63750443, rs63751596, rs1554309086, rs1553348794, rs1553348882, rs1553348898, rs1553348901, rs1553370371, rs1553365799, rs1553370431, rs1553366510, rs1553408158, rs1553366680, rs1553370404, rs1553411419, rs1553408136, rs1553412397, rs869040863, rs1553348842, rs1553348904, rs1553413599, rs1553413655, rs1553413732, rs1553414022, rs767021188, rs1553350966, rs1553412409, rs796532309, rs587779064, rs1553365711, rs1553333017, rs1553412649, rs1553333175, rs1553333301, rs1553333605, rs1553369100, rs1553369131, rs1553331722, rs1324100572, rs1553332776, rs761037236, rs1553412755, rs1553333438, rs1553333449, rs1553412835, rs1553412735, rs1553413424, rs1553414131, rs1553331337, rs1553332297, rs773262801, rs1553333185, rs1553331454, rs1553332151, rs1553333530, rs1553333633, rs587779285, rs1553333310, rs1553333321, rs1553333497, rs1553646681, rs1553647894, rs1553648195, rs1553653158, rs550890395, rs1064796057, rs1553651130, rs1553662800, rs1553665467, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1553652930, rs1434898623, rs1553665683, rs1554298087, rs1554295967, rs1554297040, rs1554298741, rs1554294393, rs1554297523, rs1554293920, rs1554301486, rs1554304974, rs1553348896, rs1553368675, rs1203462814, rs1553369665, rs1553350721, rs1553369812, rs1553361261, rs1553370443, rs1553408388, rs1553413717, rs63749973, rs1553412064, rs1553408467, rs267608062, rs765873566, rs730881815, rs1553414578, rs1553331665, rs1553331366, rs1553332166, rs1553413663, rs1553332622, rs1553333164, rs63751137, rs1553642777, rs1553648068, rs1553332733, rs1553644123, rs1553648149, rs1302248679, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664702, rs1553647969, rs1437454428, rs1231406078, rs1554293991, rs1554297488, rs1554297534, rs1064794577, rs1554297764, rs1554298082, rs876661256, rs1554298056, rs1554293810, rs939641251, rs1554304979, rs1554297058, rs1554298067, rs1554306288, rs151244108, rs1553412129, rs1054003194, rs1553412824, rs1553413253, rs1553332671, rs1553333168, rs1553333700, rs63751101, rs1553646764, rs1554300689, rs1554297877, rs1437858319, rs1432436629, rs1553648225, rs1553352462, rs1553332772, rs1553648201, rs1553333635, rs1554297125, rs753256070, rs1553414092, rs587779923, rs1554297962, rs1553361162, rs1554294448, rs1553412495, rs1253275403, rs1553350167, rs267607937, rs1553361231, rs730881755, rs1553408306, rs1553365719, rs1553370366, rs1553370397, rs1553412441, rs1553412960, rs1553411391, rs770110491, rs1553350466, rs1553350758, rs1553413116, rs1553413294, rs1553413074, rs1553361289, rs1553413640, rs1553413784, rs1553414488, rs1553331242, rs1553410300, rs1553414498, rs1553332312, rs1553412502, rs1114167705, rs1553331659, rs1553332768, rs1553414102, rs1553414395, rs1553414519, rs1553331228, rs1553333674, rs1553638868, rs1553663981, rs1553644277, rs1553665866, rs1554297082, rs1554297564, rs1394474494, rs1554293959, rs587782175, rs1554297285, rs1554298786, rs1553356605, rs1553356700, rs1553369034, rs1553370435, rs1553413305, rs1553331304, rs1553652883, rs63751435, rs1553653195, rs1553662622, rs1554293975, rs1554297164, rs1554297342, rs1554297636, rs1461669945, rs1553658104, rs1553350250, rs1553410230, rs1554304745, rs1554298756, rs1553648220, rs1559543768, rs745487791, rs1558438591, rs1558508067, rs1558508343, rs1558645195, rs1558658971, rs1558661368, rs1558663954, rs1558390582, rs1558392228, rs1558461615, rs1558466434, rs1558519611, rs1558521949, rs1558644886, rs587782101, rs1558661380, rs1558662873, rs1558392033, rs1558394093, rs1559544064, rs63750584, rs1558459096, rs1060501994, rs63751667, rs878853704, rs1558665297, rs1558387361, rs1558393006, rs1558394104, rs1559524070, rs1559530646, rs1553645226, rs1559551570, rs1559575107, rs1559597322, rs1558451119, rs1558459882, rs1558478567, rs1562605623, rs1562614946, rs781078805, rs1558644683, rs1558658980, rs1558659056, rs1558659699, rs1558667222, rs1558668156, rs1558668258, rs1558393070, rs1558394336, rs1562626204, rs1562629003, rs1562632035, rs587782602, rs1562634737, rs1562635799, rs1562669585, rs1060500702, rs1559539489, rs1559553501, rs1562616355, rs1562644987, rs764171734, rs1562711587, rs1562598658, rs1562604682, rs1562664845, rs1562678257, rs1558666177, rs1562633172, rs1559558071, rs1261282733, rs63750832, rs587778978, rs1064795063, rs1558511051, rs63751097, rs765763906, rs1562626070, rs1562671039, rs1558518588, rs1558461683, rs63751115, rs1558644995, rs1558659265, rs1558660612, rs1559521039, rs1559574795, rs1562626011, rs1562636427, rs1559578422, rs772491283, rs1573424223, rs730881784, rs1573446614, rs1573451108, rs1558464008, rs1573484655, rs1573566217, rs1573566488, rs1573567212, rs63750078, rs1573567340, rs1573567537, rs1573567630, rs1573569948, rs1573570621, rs1573574086, rs1573578423, rs1573578439, rs1573579206, rs1572698011, rs1572708636, rs1473648816, rs1276159036, rs1572716371, rs1572719776, rs1572719974, rs1572720016, rs1572720562, rs1572720704, rs778555956, rs1553412720, rs1572723270, rs1572723640, rs587779221, rs1572725436, rs1572725803, rs1572726309, rs1572726468, rs63750985, rs1572727440, rs1572727797, rs1572729033, rs367758473, rs587779253, rs1572730002, rs1572730065, rs1315445200, rs1572735072, rs1572735943, rs1572738865, rs1572745157, rs754469538, rs1572746365, rs1572747837, rs1575376458, rs1575376830, rs1575395515, rs63750507, rs1575469070, rs1575481212, rs1575537843, rs1575620443, rs1575621386, rs1575621506, rs63750740, rs1386031101, rs1575640892, rs1583285552, rs1583299686, rs1583318494, rs1583320992, rs1243063129, rs757679199, rs1583375182, rs762387250, rs36038802, rs267608035, rs1572716545, rs1572739097, rs1575628928, rs746306598, rs1572747278, rs1572747685, rs1583374709, rs1572708580, rs1572736122, rs1575414321, rs1573437173, rs1573456772, rs1583316404, rs1583363851, rs1572727176, rs1573423412, rs1573440880, rs1573442100, rs369670665, rs1573451078, rs1573547745, rs1573548065, rs1573553636, rs1573567132, rs63750234, rs63751409, rs138465383, rs1573573619, rs1572720192, rs1572720794, rs1572722737, rs1572723723, rs1572725235, rs745483465, rs1572728039, rs1572728112, rs1572728472, rs1572729161, rs1175196087, rs1572736128, rs1572738533, rs1572739043, rs891318615, rs1572741984, rs1572745084, rs1572746382, rs1572746488, rs1060504739, rs1575414904, rs1575448385, rs1575469505, rs1466223609, rs63750198, rs1575639851, rs1575640960, rs1583269216, rs1583285344, rs1583319050, rs1583334346, rs1562651617, rs1583410315, rs767028531, rs1573566175, rs1572739119, rs1572746025, rs1575449402, rs1325835006, rs1672250353, rs1672664863, rs1672951706, rs1673066717, rs1673067879, rs1673070318, rs1666728055, rs1667076589, rs63751433, rs1667245819, rs1667245915, rs1667313093, rs1667395869, rs1667504677, rs1668118988, rs1668692410, rs587779313, rs1669058948, rs1669059418, rs1669245178, rs1669252923, rs1669287624, rs1007311950, rs1669354866, rs1669364351, rs1669365820, rs41295270, rs1669441162, rs1669445829, rs1669451548, rs1669467747, rs1669486855, rs1669487701, rs1669491751, rs1669493890, rs1669760609, rs1669874125, rs1670044220, rs1670120965, rs2080898853, rs2080899985, rs2081922847, rs2083403132, rs2083405700, rs2085310643, rs2085311497, rs2085415927, rs2085469647, rs1782934080, rs1782947222, rs1782958183, rs1782962828, rs1064793426, rs63750456, rs1783004175, rs1783147885, rs1783516106, rs1344095646, rs1784299649, rs1784536095, rs1784802468, rs1784806713, rs1221485925, rs1299958102, rs1669882321, rs2082517369, rs1673083690, rs1667266283, rs1307026290, rs1672953209, rs1667575488	16332725
Dermatitis	Dermatitis, Occupational	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	16758956
Esophagus neoplasm	Esophageal Neoplasms, Squamous cell carcinoma of esophagus, Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	8850269, 19698717, 20833657, 16639733, 22960999, 21642993
Metabolic syndrome	Metabolic Syndrome X	rs367643250, rs587777380, rs777736953	28371326
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	25854761

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Asthma		11506308, 9600491	ClinVar
Coronary heart disease	Coronary heart disease		21971053	ClinVar
Ischemic stroke	Ischemic stroke		26708676	ClinVar
Nasopharyngeal carcinoma	Nasopharyngeal carcinoma	These data suggest that KAT7 can contribute NPC cell growth and survival through up-regulation of NPC-essential genes.	20512145	ClinVar, CBGDA
Ischemic Stroke	Ischemic Stroke			GWAS
Coronary Heart Disease	Coronary Heart Disease			GWAS
Gout	Gout			GWAS
Intracranial Aneurysm	Intracranial Aneurysm			GWAS
Coronary artery disease	Coronary artery disease			GWAS
Hypertension	Hypertension			GWAS
Epilepsy	Epilepsy			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Myocardial Infarction	Myocardial Infarction			GWAS
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA
Cirrhosis	Cirrhosis			GWAS
Heart Failure	Heart Failure			GWAS
Diabetes	Diabetes			GWAS
Atrial Fibrillation	Atrial Fibrillation			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Achalasia Addisonianism Alacrimia syndrome	Associate	37822152
Acute Coronary Syndrome	Associate	21958412, 29441687, 32160861
Acute Lung Injury	Associate	31209184
Adenocarcinoma	Associate	17559142, 34022841, 36289279
Adenocarcinoma of Lung	Associate	36289279, 37335087, 37589509, 39735553
Adenoma	Associate	16108833
Adenomatous Polyposis Coli	Associate	36923554
Albuminuria	Associate	26599441
Alcohol Related Disorders	Associate	35670037
Alcoholism	Associate	11748356, 15679538, 18322963, 19456322, 20652463, 22155604, 22703580, 23134043, 23134050, 26284938, 26364564, 28158658, 28578603, 29323248, 30629674, 35169188, 37314537, 37378938
Alcoholism	Inhibit	35657923
alpha 1 Antitrypsin Deficiency	Associate	26174136
Alzheimer Disease	Associate	19456322, 27808372, 29425204
Anemia Aplastic	Associate	39726306
Anemia Hemolytic	Associate	27377053
Anemia Macrocytic	Associate	28158658
Angina Pectoris	Associate	10503603
Angina Unstable	Associate	17984618
Anxiety	Associate	37314537
Anxiety Disorders	Associate	29425204
Aortic Aneurysm Abdominal	Inhibit	37822152
Arteriosclerosis	Associate	37355582
Asthma	Associate	11506308
Atherosclerosis	Inhibit	27270535
Atherosclerosis	Associate	30507608, 36411700
Atrial Fibrillation	Associate	27927211, 34827557
Binge Drinking	Associate	22155604, 36028843
Bipolar Disorder	Associate	29425204
Bone Marrow Failure Disorders	Associate	24037726, 27377053, 39726306
Brain Ischemia	Associate	25253673
Breast Neoplasms	Associate	31066241, 32300124, 36200595, 37943872, 38310106
Breast Neoplasms Male	Associate	30850364
Capillary Malformation Arteriovenous Malformation	Associate	24037726
Carcinogenesis	Associate	35102643
Carcinoma Basal Cell	Associate	21672255
Carcinoma Hepatocellular	Associate	12759747, 18439068, 29582627, 29600553, 35855852, 35877121, 38521503, 9575688
Carcinoma Hepatocellular	Inhibit	37335078
Carcinoma Non Small Cell Lung	Associate	35477569, 37395022
Carcinoma Squamous Cell	Associate	18322963, 18429959, 27038040, 29423536, 34010294, 34022841, 36289279, 37395022
Cardiomyopathies	Associate	20467232, 27153870
Cardiovascular Diseases	Associate	27270535, 29441687, 30507608, 33276716, 33349921
Carotid Artery Diseases	Associate	17984618
Carotid Intimal Medial Thickness 1	Associate	27270535
Cerebral Cortical Thinning	Associate	34593890
Cerebral Hemorrhage	Associate	32107439
Cerebral Infarction	Associate	32481290, 34257742, 40026415, 40304040
Cerebral Palsy Ataxic Autosomal Recessive	Associate	19096130
Cerebral Small Vessel Diseases	Associate	40603063
Cerebrovascular Disorders	Associate	33651448
Chemotherapy Related Cognitive Impairment	Associate	36200595
Cognition Disorders	Associate	27453488, 29425204, 34257742, 36200595, 40603063
Cognitive Dysfunction	Associate	27453488
Colorectal Neoplasms	Associate	10470282, 15780035, 18763293, 19456322, 22901167, 24282520, 25573590, 27706775, 33421985, 36426922, 36923554
Colorectal Neoplasms	Inhibit	33421985
Congenital Bone Marrow Failure Syndromes	Associate	33512438
Congenital Hypothyroidism	Associate	30629674
Coronary Aneurysm	Associate	27904031, 32009064
Coronary Artery Disease	Associate	21971053, 25047496, 25253673, 26946290, 29960587, 30261890, 31345174
Coronary Disease	Associate	25591559, 25803854, 29742731
Coronary Vasospasm	Associate	27153870
Coxa Magna	Associate	14768474
Darier Disease	Associate	9529352
Death	Associate	29441687, 33651448, 40603063
Depressive Disorder	Associate	26599441, 37314537
Developmental Defects of Enamel	Associate	27377053
Diabetes Complications	Associate	26599441
Diabetes Mellitus	Associate	17984618, 20700531, 22155604, 26284938, 31345174, 33276716, 33349921, 33651448, 36050775, 9575688
Diabetes Mellitus Type 2	Associate	24028448, 33651448, 40304040
Diabetic Retinopathy	Associate	24028448
Digestive System Neoplasms	Associate	21437268, 37871625
Dizziness	Associate	28578603
DNA Virus Infections	Associate	30065307
Drug Related Side Effects and Adverse Reactions	Associate	23545897
Drug Resistant Epilepsy	Associate	36050775
Dyslipidemias	Associate	29960587
Embolic Stroke	Associate	26708676
Endometrial Neoplasms	Associate	34195683, 34670872
Esophageal Neoplasms	Associate	16127737, 16235983, 16273622, 17963305, 19452585, 19456322, 19472401, 20518787, 20632450, 21672255, 22292652, 22703580, 22930414, 23134043, 26862830, 28158658, 28464297, 29096698, 29423536, 29707772, 32662535, 33132654, 33750341, 35048370, 35670037, 35717470, 36345163, 40156023
Esophageal Squamous Cell Carcinoma	Associate	10896918, 16127737, 16639733, 18322963, 18429959, 19472401, 20128036, 20632450, 21672255, 21926110, 22292652, 23667679, 26873401, 27038040, 28464297, 30639619, 31957322, 33132654, 33826001, 34010294, 36070895, 37943872
Esophageal Squamous Cell Carcinoma	Stimulate	20128036
Esophageal Squamous Cell Carcinoma	Inhibit	21926110
Essential Hypertension	Associate	21476199, 27270535
Fanconi Anemia	Associate	24037726, 32487094, 33512438, 36345163, 39726306
Fetal Growth Retardation	Associate	31138432
Fibrosis	Associate	26284938, 35877121
Flushing	Associate	20518787, 22234728, 27153870, 27904031, 28578603, 29323248, 29707772, 30629674, 33512438, 34680942, 36345163
Folate Malabsorption Hereditary	Associate	28228507
Fowler Christmas Chapple syndrome	Associate	27038040
Fuchs' Endothelial Dystrophy	Associate	31209184
Glaucoma	Associate	33060820
Glaucoma Open Angle	Associate	33060820
Glucose Intolerance	Associate	20700531
Glucosephosphate Dehydrogenase Deficiency	Associate	28464297
Gout	Associate	27181629, 28566767, 28642574, 33858492
Head and Neck Neoplasms	Associate	10896918, 31957322, 33132654
Heart Diseases	Associate	28578603, 38177014
Heart Failure	Associate	38177014
Helicobacter Infections	Associate	14711373
Hematologic Diseases	Associate	39726306
Hepatitis B	Associate	35877121
Hip Fractures	Associate	28348376
Hypertension	Associate	11510748, 22155604, 22839215, 23615284, 26318866, 27270535, 28562329, 28894224, 32141245, 32843694, 32987175, 33276716, 33349921, 34260573, 35346052, 9575688
Hypertension Pulmonary	Associate	38177014
Hypotension	Associate	28578603
Infarction Anterior Cerebral Artery	Associate	26708676
Infections	Inhibit	28578603
Inferior Wall Myocardial Infarction	Associate	28939800
Inflammation	Associate	21958412, 34362382, 39328412
Intellectual Disability	Associate	39726306
Intervertebral disc disease	Associate	30166580
Kidney Failure Chronic	Associate	18974607
Knee Fractures	Associate	34362382
Laryngeal Neoplasms	Associate	28841898
LEOPARD Syndrome	Associate	36050775
Leukemia Myeloid Acute	Associate	33253299, 33893150, 37761947, 39726306
Leukemia T Cell	Associate	27377053
Leukopenia	Associate	28158658
Liver Cirrhosis Alcoholic	Associate	11748356, 16273622, 34033144, 37378938
Liver Diseases	Associate	26599441
Liver Diseases Alcoholic	Associate	19456322, 29582627
Liver Failure	Associate	22155604, 29582627
Lung Diseases	Associate	35048370
Lung Neoplasms	Associate	17559142, 22079344, 30088263, 35477569, 37395022
Lymphatic Metastasis	Associate	35013309
Melanosis	Associate	28218985
Mesothelioma Malignant	Associate	36523602
Metabolic Side Effects of Drugs and Substances	Associate	35102643
Metabolic Syndrome	Associate	26174136, 28371326
Mitochondrial Diseases	Associate	31209184
Multiple Trauma	Associate	10896918
Myelodysplastic Syndromes	Associate	39726306
Myocardial Infarction	Associate	10503603, 12452318, 20467232, 26599441, 27153870, 28056995, 30886860, 34799616, 35787671
Myocardial Ischemia	Associate	20467232, 25253673
Myocardial Stunning	Associate	20467232
N syndrome	Inhibit	36411700
Nasopharyngeal Carcinoma	Associate	34680942
Neoplasm Invasiveness	Associate	35013309
Neoplasm Metastasis	Associate	35477569, 35657923
Neoplasms	Associate	19472401, 20652463, 23106910, 23134043, 26862830, 26992901, 28881356, 29426835, 30088263, 30166580, 31204364, 34022841, 34024796, 35048370, 35169188, 35477569, 35670037, 35717470, 36050775, 36426922, 36776920, 37871625, 37943872, 39328412, 39726306
Neoplasms	Inhibit	33477333
Neoplasms Cystic Mucinous and Serous	Associate	29247577
Neoplasms Squamous Cell	Associate	21672255, 30639619
Neuroaxonal Dystrophies	Associate	37314537
Neurodegenerative Diseases	Associate	36050775
Neurologic Manifestations	Associate	26708676
Neurotoxicity Syndromes	Associate	27453488, 37314537
Non alcoholic Fatty Liver Disease	Associate	27214654, 32987175
Non alcoholic Fatty Liver Disease	Stimulate	29718361
Obesity	Associate	33276716
Oropharyngeal Neoplasms	Associate	28841898, 29206831
Orthostatic Hypotensive Disorder Streeten Type	Associate	26364564
Osteoarthritis Knee	Associate	34362382
Osteoporosis	Associate	28348376, 35657923
Ovarian Neoplasms	Associate	29247577
Pancreatic Neoplasms	Associate	19068087, 35102643
Pancreatitis	Associate	34267279
Pancreatitis Alcoholic	Associate	16273622
Parkinson Disease	Associate	27453488, 27612022, 27706693
Peptic Ulcer	Associate	19469618
Plaque Amyloid	Associate	34593890
Precancerous Conditions	Associate	19472401, 21672255, 32539207, 35102643, 36028843
Pressure Ulcer	Associate	29323248
Prostatic Neoplasms	Associate	36144737
Pulmonary Disease Chronic Obstructive	Associate	24188068
Rectal Neoplasms	Associate	12033531, 25573590
Respiratory Tract Infections	Associate	25408144
Sjogren Larsson Syndrome	Inhibit	10503603
Sjogren Larsson Syndrome	Associate	10503603, 27377053, 28056995
Squamous Cell Carcinoma of Head and Neck	Associate	17033202, 17489985, 21940907, 26804037, 28841898, 34010294, 34546328
ST Elevation Myocardial Infarction	Associate	21958412, 27153870
Stenosis Pulmonary Artery	Associate	38177014
Stomach Neoplasms	Associate	21133627, 23079843, 28002588, 28036260, 29166882, 31957322, 32356421, 32426482, 39328412
Stroke	Associate	22155604, 28056995, 30955975, 34257742
Stroke Lacunar	Associate	35733147
Syncope Vasovagal	Associate	36307771
Syndrome	Associate	39726306
Tricuspid Valve Insufficiency	Associate	38177014
Tuberculosis	Associate	24690209
Urinary Bladder Neoplasms	Associate	24666523, 26992901
Vascular Diseases	Associate	18061070, 40603063
Vascular Remodeling	Associate	38177014
Ventricular Remodeling	Associate	29016726