FABP4 (fatty acid binding protein 4)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2167
Gene name Gene Name - the full gene name approved by the HGNC.
Fatty acid binding protein 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FABP4
Synonyms (NCBI Gene) Gene synonyms aliases
A-FABP, AFABP, ALBP, HEL-S-104, aP2
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q21.13
Summary Summary of gene provided in NCBI Entrez Gene.
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles inc
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
miRTarBase ID miRNA Experiments Reference
MIRT005490 hsa-miR-138-5p qRT-PCR 20486779
MIRT005959 hsa-miR-369-5p Luciferase reporter assay 21660946
MIRT019040 hsa-miR-335-5p Microarray 18185580
MIRT005959 hsa-miR-369-5p Reporter assay 21660946
MIRT736118 hsa-miR-455-3p Luciferase reporter assay, Western blotting, qRT-PCR 31638263
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
ASXL1 Unknown 21047783
FOXO1 Activation 20102700
PPARA Unknown 19717768
PPARG Activation 11574398
PPARG Unknown 17322100;21047783
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005324 Function Long-chain fatty acid transporter activity ISS
GO:0005504 Function Fatty acid binding TAS 2481498
GO:0005634 Component Nucleus ISS
GO:0005737 Component Cytoplasm ISS
GO:0005737 Component Cytoplasm TAS 16130169
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600434 3559 ENSG00000170323
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P15090
Protein name Fatty acid-binding protein, adipocyte (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)
Protein function Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
PDB 1TOU , 1TOW , 2HNX , 2NNQ , 3FR2 , 3FR4 , 3FR5 , 3P6C , 3P6D , 3P6E , 3P6F , 3P6G , 3P6H , 3Q6L , 3RZY , 4NNS , 4NNT , 5D45 , 5D47 , 5D48 , 5D4A , 5EDB , 5EDC , 5HZ6 , 5HZ8 , 5Y0F , 5Y0G , 5Y0X , 5Y12 , 5Y13 , 6AYL , 6LJS , 6LJT , 6LJU , 6LJV , 6LJW , 6LJX , 7FVU , 7FVV , 7FVW , 7FVX , 7FVY , 7FVZ , 7FW0 , 7FW1 , 7FW2 , 7FW3 , 7FW4 , 7FW5 , 7FW6 , 7FW7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 6 → 132 Lipocalin / cytosolic fatty-acid binding protein family Domain
Sequence
Sequence length 132
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  PPAR signaling pathway
Regulation of lipolysis in adipocytes 		  Triglyceride catabolism
Transcriptional regulation of white adipocyte differentiation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (4)
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Carcinoma Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 16316942
Dermatitis Contact Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 25724174
Kidney disease Kidney Diseases rs74315342, rs749740335, rs757649673, rs112417755, rs35138315 30215792
Show/Hide Text Mining Associations (144)
Associations from Text Mining
Disease Name Relationship Type References
Acth Independent Macronodular Adrenal Hyperplasia Inhibit 38098864
Acute Coronary Syndrome Stimulate 26069234
Adenocarcinoma of Lung Associate 31698633
Albuminuria Associate 25506691
Angina Stable Associate 31234795
Aortic Valve Stenosis Associate 35955575
Arteriosclerosis Associate 30142969
Arthritis Psoriatic Stimulate 27864793
Arthritis Rheumatoid Stimulate 16778393
Atherosclerosis Associate 20111020, 21600061, 22174896, 23122912, 24939870, 29441065, 32539832, 33287461, 33725567, 35955575, 37978381