FAAH (fatty acid amide hydrolase)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2166
Gene name Gene Name - the full gene name approved by the HGNC.
Fatty acid amide hydrolase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FAAH
Synonyms (NCBI Gene) Gene synonyms aliases
FAAH-1, FAAH1, PSAB
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(126)
miRTarBase ID miRNA Experiments Reference
MIRT038079 hsa-miR-423-5p CLASH 23622248
MIRT510261 hsa-miR-4695-5p PAR-CLIP 20371350
MIRT510260 hsa-miR-4459 PAR-CLIP 20371350
MIRT510259 hsa-miR-665 PAR-CLIP 20371350
MIRT510258 hsa-miR-6840-3p PAR-CLIP 20371350
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
STAT3 Activation 12556536
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(16)
GO ID Ontology Definition Evidence Reference
GO:0004040 Function Amidase activity IBA 21873635
GO:0005515 Function Protein binding IPI 25416956
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0005856 Component Cytoskeleton IEA
GO:0009062 Process Fatty acid catabolic process IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602935 3553 ENSG00000117480
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O00519
Protein name Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1)
Protein function Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corres
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01425 Amidase 95 → 562 Amidase Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. {ECO:0000269|PubMed:17015445}.
Sequence
Sequence length 579
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Retrograde endocannabinoid signaling   Arachidonic acid metabolism
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Obesity Obesity rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562
View all (27 more)		 20716455, 19103437
Seizure Complex partial seizures, Generalized seizures, Visual seizure, Tonic - clonic seizures, Single Seizure rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061
View all (179 more)		 25933444
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Huntington disease Huntington Disease, Huntington Disease, Late Onset, Juvenile Huntington Disease 20929960 ClinVar
Psoriasis Psoriasis GWAS
Show/Hide Text Mining Associations (65)
Associations from Text Mining
Disease Name Relationship Type References
Abdominal Pain Associate 17962356
Abortion Habitual Associate 11390466
Adenocarcinoma Associate 18566995
Alcoholism Associate 27716956, 28150397
Alzheimer Disease Associate 14657172, 33810505
Alzheimer Disease Stimulate 22720070
Anorexia Nervosa Associate 19659925
Antisocial Personality Disorder Inhibit 33462180
Antisocial Personality Disorder Associate 35064143
Anxiety Associate 19103437, 27005594, 27716956, 31184938, 34496065, 35944262, 37222214