Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	216
Gene name	Aldehyde dehydrogenase 1 family member A1
Gene symbol	ALDH1A1
Synonyms (NCBI Gene)	ALDCALDH-E1ALDH1ALDH11HEL-9HEL-S-53eHEL12PUMB1RALDH1
Chromosome	9
Chromosome location	9q21.13
Summary	The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liv

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miRTarBase ID	miRNA	Experiments	Reference
MIRT053112	hsa-miR-140-5p	Luciferase reporter assayWestern blot	23752191
MIRT053112	hsa-miR-140-5p	Luciferase reporter assayWestern blot	23752191
MIRT776938	hsa-miR-1184	CLIP-seq
MIRT776939	hsa-miR-1205	CLIP-seq
MIRT776940	hsa-miR-1283	CLIP-seq
MIRT776941	hsa-miR-3158-5p	CLIP-seq
MIRT776942	hsa-miR-3664-5p	CLIP-seq
MIRT776943	hsa-miR-4699-3p	CLIP-seq
MIRT776944	hsa-miR-4714-5p	CLIP-seq
MIRT776945	hsa-miR-520d-5p	CLIP-seq
MIRT776946	hsa-miR-524-5p	CLIP-seq
MIRT1555915	hsa-miR-562	CLIP-seq
MIRT2170094	hsa-miR-4328	CLIP-seq
MIRT2426186	hsa-miR-1275	CLIP-seq
MIRT2426187	hsa-miR-1305	CLIP-seq
MIRT2426188	hsa-miR-132	CLIP-seq
MIRT2426189	hsa-miR-1323	CLIP-seq
MIRT2426190	hsa-miR-200b	CLIP-seq
MIRT2426191	hsa-miR-200c	CLIP-seq
MIRT2426192	hsa-miR-21	CLIP-seq
MIRT2426193	hsa-miR-212	CLIP-seq
MIRT2426194	hsa-miR-221	CLIP-seq
MIRT2426195	hsa-miR-222	CLIP-seq
MIRT2426196	hsa-miR-23a	CLIP-seq
MIRT2426197	hsa-miR-23b	CLIP-seq
MIRT2426198	hsa-miR-23c	CLIP-seq
MIRT2426199	hsa-miR-297	CLIP-seq
MIRT2426200	hsa-miR-3115	CLIP-seq
MIRT2426201	hsa-miR-3117-3p	CLIP-seq
MIRT2426202	hsa-miR-3132	CLIP-seq
MIRT2426203	hsa-miR-3153	CLIP-seq
MIRT2426204	hsa-miR-3163	CLIP-seq
MIRT2426205	hsa-miR-3169	CLIP-seq
MIRT2426206	hsa-miR-3173-3p	CLIP-seq
MIRT2426207	hsa-miR-3185	CLIP-seq
MIRT2426208	hsa-miR-335	CLIP-seq
MIRT2426209	hsa-miR-374c	CLIP-seq
MIRT2426210	hsa-miR-3913-3p	CLIP-seq
MIRT2426211	hsa-miR-3942-3p	CLIP-seq
MIRT2426212	hsa-miR-4282	CLIP-seq
MIRT2426213	hsa-miR-429	CLIP-seq
MIRT2426214	hsa-miR-4307	CLIP-seq
MIRT2426215	hsa-miR-4326	CLIP-seq
MIRT2170094	hsa-miR-4328	CLIP-seq
MIRT2426216	hsa-miR-4428	CLIP-seq
MIRT2426217	hsa-miR-4475	CLIP-seq
MIRT2426218	hsa-miR-4477a	CLIP-seq
MIRT2426219	hsa-miR-4496	CLIP-seq
MIRT2426220	hsa-miR-4517	CLIP-seq
MIRT2426221	hsa-miR-455-3p	CLIP-seq
MIRT2426222	hsa-miR-4665-5p	CLIP-seq
MIRT2426223	hsa-miR-4666-5p	CLIP-seq
MIRT2426224	hsa-miR-4668-3p	CLIP-seq
MIRT2426225	hsa-miR-4708-5p	CLIP-seq
MIRT2426226	hsa-miR-4709-3p	CLIP-seq
MIRT2426227	hsa-miR-4759	CLIP-seq
MIRT2426228	hsa-miR-4795-3p	CLIP-seq
MIRT2426229	hsa-miR-485-3p	CLIP-seq
MIRT2426230	hsa-miR-487a	CLIP-seq
MIRT2426231	hsa-miR-489	CLIP-seq
MIRT2426232	hsa-miR-5095	CLIP-seq
MIRT2426233	hsa-miR-511	CLIP-seq
MIRT2426234	hsa-miR-514	CLIP-seq
MIRT2426235	hsa-miR-514b-3p	CLIP-seq
MIRT2426236	hsa-miR-548c-3p	CLIP-seq
MIRT2426237	hsa-miR-548o	CLIP-seq
MIRT2426238	hsa-miR-567	CLIP-seq
MIRT2426239	hsa-miR-590-5p	CLIP-seq
MIRT2426240	hsa-miR-607	CLIP-seq
MIRT2426241	hsa-miR-651	CLIP-seq
MIRT2426242	hsa-miR-655	CLIP-seq
MIRT2426243	hsa-miR-891b	CLIP-seq
MIRT2426244	hsa-miR-944	CLIP-seq

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Transcription factor	Regulation	Reference
EZH2	Repression	22144423
TLX1	Unknown	18073142;18082256

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001523	Process	Retinoid metabolic process	ISS
GO:0001758	Function	Retinal dehydrogenase (NAD+) activity	IEA
GO:0001758	Function	Retinal dehydrogenase (NAD+) activity	ISS
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IDA	4015840, 12941160, 23444097, 25450233
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IEA
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IMP	15623782
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	TAS	1709013
GO:0005096	Function	GTPase activator activity	TAS	1709013
GO:0005497	Function	Androgen binding	TAS	1709013
GO:0005515	Function	Protein binding	IPI	32814053, 33495566
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	2987944
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	12941160
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006081	Process	Aldehyde metabolic process	IBA
GO:0006081	Process	Aldehyde metabolic process	TAS	1709013
GO:0006629	Process	Lipid metabolic process	IEA
GO:0009449	Process	Gamma-aminobutyric acid biosynthetic process	ISS
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016620	Function	Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA
GO:0018479	Function	Benzaldehyde dehydrogenase (NAD+) activity	IBA
GO:0018479	Function	Benzaldehyde dehydrogenase (NAD+) activity	IEA
GO:0019145	Function	Aminobutyraldehyde dehydrogenase (NAD+) activity	IEA
GO:0019145	Function	Aminobutyraldehyde dehydrogenase (NAD+) activity	ISS
GO:0030392	Process	Fructosamine catabolic process	IDA	17175089
GO:0030424	Component	Axon	IEA
GO:0030424	Component	Axon	ISS
GO:0036438	Process	Maintenance of lens transparency	ISS
GO:0042572	Process	Retinol metabolic process	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	ISS
GO:0051287	Function	NAD binding	ISS	12693930
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0106373	Function	3-deoxyglucosone dehydrogenase activity	IDA	17175089
GO:0106373	Function	3-deoxyglucosone dehydrogenase activity	IEA
GO:0110095	Process	Cellular detoxification of aldehyde	IMP	15623782
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	22561685
GO:0140087	Function	Acetaldehyde dehydrogenase (NAD+) activity	IEA

MIM	HGNC	e!Ensembl
100640	402	ENSG00000165092

P00352

Protein name

Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalD

Protein function

Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:19296407, PubMed:25450233, PubMed:26373694). Functio

PDB

4WB9 , 4WJ9 , 4WP7 , 4WPN , 4X4L , 5AC2 , 5L2M , 5L2N , 5L2O , 5TEI , 6DUM , 7JWS , 7JWT , 7JWU , 7JWV , 7JWW , 7UM9 , 8D46 , 8DNO , 8ENE , 8PVH , 8T0N , 8T0T , 8WFQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00171	Aldedh	29 → 492	Aldehyde dehydrogenase family	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed by erythrocytes (at protein level). {ECO:0000269|PubMed:17175089}.

Sequence

MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV
DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL
NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI
GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID
KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG
QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES
GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR
ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE
YGFHEYTEVKTVTVKISQKNS

Sequence length

501

Interactions

View interactions

	KEGG		Reactome
	Retinol metabolism Metabolic pathways		RA biosynthesis pathway Fructose catabolism Ethanol oxidation

ALDH1A1 (aldehyde dehydrogenase 1 family member A1)