F3 (coagulation factor III, tissue factor)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID 2152
Gene name Coagulation factor III, tissue factor
Gene symbol F3
Synonyms (NCBI Gene)
CD142TFTFA
Chromosome 1
Chromosome location 1p21.3
Summary This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provi
miRNA miRNA information provided by mirtarbase database.
777
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all (777)
miRTarBase ID miRNA Experiments Reference
MIRT019927 hsa-miR-375 Microarray 20215506
MIRT020315 hsa-miR-130b-3p Sequencing 20371350
MIRT022817 hsa-miR-124-3p Microarray 18668037
MIRT028146 hsa-miR-93-5p Sequencing 20371350
MIRT029798 hsa-miR-26b-5p Microarray 19088304
Transcription factors Transcription factors information provided by TRRUST V2 database.
7
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
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Transcription factor Regulation Reference
EGR1 Unknown 10707957;8576248
JUN Unknown 11057875
JUND Unknown 11057875
NFKB1 Unknown 11057875;11157486;19167713;9867853
REL Unknown 11057875
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all (34)
GO ID Ontology Definition Evidence Reference
GO:0001938 Process Positive regulation of endothelial cell proliferation IDA 17898544
GO:0002020 Function Protease binding IPI 3455766
GO:0002541 Process Activation of plasma proteins involved in acute inflammatory response IDA 17469850
GO:0002543 Process Activation of blood coagulation via clotting cascade IDA 17469850
GO:0004252 Function Serine-type endopeptidase activity IDA 24998411
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
134390 3541 ENSG00000117525
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P13726
Protein name Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)
Protein function Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly a
PDB 1AHW , 1BOY , 1DAN , 1FAK , 1J9C , 1JPS , 1O5D , 1TFH , 1UJ3 , 1W0Y , 1W2K , 1WQV , 1WSS , 1WTG , 1WUN , 1WV7 , 1Z6J , 2A2Q , 2AEI , 2AER , 2B7D , 2B8O , 2C4F , 2CEF , 2CEH , 2CEZ , 2CFJ , 2EC9 , 2F9B , 2FIR , 2FLB , 2FLR , 2HFT , 2PUQ , 2ZP0 , 2ZWL , 2ZZU , 3ELA , 3TH2 , 3TH3 , 3TH4 , 4IBL , 4M7L , 4YLQ , 4Z6A , 4ZMA , 5W06 , 6R2W , 6Z9W , 8CN9 , 8QOD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01108 Tissue_fac 17 → 118 Tissue factor Family
PF09294 Interfer-bind 138 → 245 Interferon-alpha/beta receptor, fibronectin type III Domain
Tissue specificity TISSUE SPECIFICITY: Lung, placenta and pancreas. {ECO:0000269|PubMed:12652293}.
Sequence
Sequence length 295
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
  KEGG  Reactome
  Complement and coagulation cascades
AGE-RAGE signaling pathway in diabetic complications 		  Extrinsic Pathway of Fibrin Clot Formation
NGF-stimulated transcription