Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2150
Gene name Gene Name - the full gene name approved by the HGNC.
F2R like trypsin receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
F2RL1
Synonyms (NCBI Gene) Gene synonyms aliases
GPR11, PAR2
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered l
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023577 hsa-miR-1-3p Microarray 18668037
MIRT724017 hsa-miR-483-3p HITS-CLIP 19536157
MIRT724016 hsa-miR-6747-3p HITS-CLIP 19536157
MIRT724015 hsa-miR-1304-3p HITS-CLIP 19536157
MIRT629097 hsa-miR-367-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001965 Function G-protein alpha-subunit binding ISS
GO:0002286 Process T cell activation involved in immune response ISS
GO:0002690 Process Positive regulation of leukocyte chemotaxis IDA 17991872
GO:0002720 Process Positive regulation of cytokine production involved in immune response IDA 11441110
GO:0003104 Process Positive regulation of glomerular filtration ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600933 3538 ENSG00000164251
Protein
UniProt ID P55085
Protein name Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate clea
Protein function Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protei
PDB 5NDD , 5NDZ , 5NJ6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 92 344 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon (PubMed:7556175, PubMed:8615752). Moderate expression is detected in many organs, but none in brain or skeletal muscle (PubM
Sequence
Sequence length 397
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
African trypanosomiasis
  Peptide ligand-binding receptors
G alpha (q) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340
View all (64 more)
17145863
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acne Vulgaris Stimulate 20697725
Acne Vulgaris Associate 25880702
Adenocarcinoma Associate 20838026, 24146905
Adenocarcinoma of Lung Associate 12548614, 30321617, 31558162, 33968158, 37543671
alpha 1 Antitrypsin Deficiency Autosomal Recessive Associate 21072196
Alzheimer Disease Stimulate 25982926
Alzheimer Disease Associate 32858090
Antiphospholipid Syndrome Associate 20131237
Arthritis Psoriatic Associate 33763056
Arthritis Rheumatoid Associate 17328048, 20131259, 24914212, 33763056, 37814309