Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2119
Gene name Gene Name - the full gene name approved by the HGNC.	ETS variant transcription factor 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ETV5
Synonyms (NCBI Gene) Gene synonyms aliases	ERM
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q27.2

Show/Hide all(250)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017311	hsa-miR-335-5p	Microarray	18185580
MIRT530651	hsa-miR-4453	PAR-CLIP	22012620
MIRT530650	hsa-miR-4538	PAR-CLIP	22012620
MIRT530649	hsa-miR-1539	PAR-CLIP	22012620
MIRT530648	hsa-miR-5689	PAR-CLIP	22012620
MIRT530647	hsa-miR-3173-5p	PAR-CLIP	22012620
MIRT530646	hsa-miR-6799-3p	PAR-CLIP	22012620
MIRT530645	hsa-miR-1291	PAR-CLIP	22012620
MIRT530644	hsa-miR-6775-3p	PAR-CLIP	22012620
MIRT530643	hsa-miR-7150	PAR-CLIP	22012620
MIRT530651	hsa-miR-4453	PAR-CLIP	22012620
MIRT530650	hsa-miR-4538	PAR-CLIP	22012620
MIRT530649	hsa-miR-1539	PAR-CLIP	22012620
MIRT530648	hsa-miR-5689	PAR-CLIP	22012620
MIRT530647	hsa-miR-3173-5p	PAR-CLIP	22012620
MIRT530646	hsa-miR-6799-3p	PAR-CLIP	22012620
MIRT530645	hsa-miR-1291	PAR-CLIP	22012620
MIRT530644	hsa-miR-6775-3p	PAR-CLIP	22012620
MIRT530643	hsa-miR-7150	PAR-CLIP	22012620
MIRT756010	hsa-miR-200c-3p	Luciferase reporter assay, Western blotting, qRT-PCR	34753799
MIRT971999	hsa-miR-125a-3p	CLIP-seq
MIRT972000	hsa-miR-1292	CLIP-seq
MIRT972001	hsa-miR-19a	CLIP-seq
MIRT972002	hsa-miR-19b	CLIP-seq
MIRT972003	hsa-miR-3140-5p	CLIP-seq
MIRT972004	hsa-miR-330-3p	CLIP-seq
MIRT972005	hsa-miR-3934	CLIP-seq
MIRT972006	hsa-miR-4471	CLIP-seq
MIRT972007	hsa-miR-4690-5p	CLIP-seq
MIRT972008	hsa-miR-4742-5p	CLIP-seq
MIRT972009	hsa-miR-4790-3p	CLIP-seq
MIRT972010	hsa-miR-510	CLIP-seq
MIRT972011	hsa-miR-621	CLIP-seq
MIRT972012	hsa-miR-764	CLIP-seq
MIRT1987968	hsa-miR-146b-3p	CLIP-seq
MIRT1987969	hsa-miR-200b	CLIP-seq
MIRT1987970	hsa-miR-200c	CLIP-seq
MIRT1987971	hsa-miR-369-3p	CLIP-seq
MIRT1987972	hsa-miR-3925-3p	CLIP-seq
MIRT1987973	hsa-miR-429	CLIP-seq
MIRT1987974	hsa-miR-515-5p	CLIP-seq
MIRT1987975	hsa-miR-766	CLIP-seq
MIRT1987976	hsa-miR-874	CLIP-seq
MIRT1987977	hsa-miR-888	CLIP-seq
MIRT2222395	hsa-miR-23a	CLIP-seq
MIRT2222396	hsa-miR-23b	CLIP-seq
MIRT2222397	hsa-miR-23c	CLIP-seq
MIRT2387554	hsa-miR-137	CLIP-seq
MIRT2387555	hsa-miR-2115	CLIP-seq
MIRT2387556	hsa-miR-3125	CLIP-seq
MIRT2387557	hsa-miR-3150b-3p	CLIP-seq
MIRT2387558	hsa-miR-323b-3p	CLIP-seq
MIRT2387559	hsa-miR-3916	CLIP-seq
MIRT2387560	hsa-miR-4701-5p	CLIP-seq
MIRT2387561	hsa-miR-4784	CLIP-seq
MIRT2387562	hsa-miR-588	CLIP-seq
MIRT2387563	hsa-miR-877	CLIP-seq
MIRT2435124	hsa-miR-129-5p	CLIP-seq
MIRT2525886	hsa-miR-122	CLIP-seq
MIRT2525887	hsa-miR-1236	CLIP-seq
MIRT2525888	hsa-miR-1284	CLIP-seq
MIRT2525889	hsa-miR-136	CLIP-seq
MIRT2387554	hsa-miR-137	CLIP-seq
MIRT1987968	hsa-miR-146b-3p	CLIP-seq
MIRT2525890	hsa-miR-186	CLIP-seq
MIRT2525891	hsa-miR-198	CLIP-seq
MIRT2525892	hsa-miR-203	CLIP-seq
MIRT2525893	hsa-miR-205	CLIP-seq
MIRT2525894	hsa-miR-2278	CLIP-seq
MIRT2222395	hsa-miR-23a	CLIP-seq
MIRT2222396	hsa-miR-23b	CLIP-seq
MIRT2222397	hsa-miR-23c	CLIP-seq
MIRT2525895	hsa-miR-296-3p	CLIP-seq
MIRT2525896	hsa-miR-3065-3p	CLIP-seq
MIRT2525897	hsa-miR-3120-3p	CLIP-seq
MIRT2525898	hsa-miR-3123	CLIP-seq
MIRT2525899	hsa-miR-3133	CLIP-seq
MIRT2525900	hsa-miR-3160-5p	CLIP-seq
MIRT2525901	hsa-miR-3171	CLIP-seq
MIRT2525902	hsa-miR-3173-3p	CLIP-seq
MIRT2525903	hsa-miR-3180-5p	CLIP-seq
MIRT2387558	hsa-miR-323b-3p	CLIP-seq
MIRT2525904	hsa-miR-323b-5p	CLIP-seq
MIRT2525905	hsa-miR-3606	CLIP-seq
MIRT2525906	hsa-miR-3616-3p	CLIP-seq
MIRT2525907	hsa-miR-3621	CLIP-seq
MIRT2525908	hsa-miR-3656	CLIP-seq
MIRT2525909	hsa-miR-3657	CLIP-seq
MIRT2525910	hsa-miR-3658	CLIP-seq
MIRT2525911	hsa-miR-3672	CLIP-seq
MIRT1987971	hsa-miR-369-3p	CLIP-seq
MIRT2525912	hsa-miR-374a	CLIP-seq
MIRT2525913	hsa-miR-374b	CLIP-seq
MIRT2525914	hsa-miR-374c	CLIP-seq
MIRT2525915	hsa-miR-376c	CLIP-seq
MIRT2525916	hsa-miR-377	CLIP-seq
MIRT2525917	hsa-miR-3908	CLIP-seq
MIRT2525918	hsa-miR-3925-5p	CLIP-seq
MIRT2525919	hsa-miR-3928	CLIP-seq
MIRT2525920	hsa-miR-3936	CLIP-seq
MIRT2525921	hsa-miR-3942-3p	CLIP-seq
MIRT2525922	hsa-miR-3976	CLIP-seq
MIRT2525923	hsa-miR-4253	CLIP-seq
MIRT2525924	hsa-miR-4280	CLIP-seq
MIRT2525925	hsa-miR-4305	CLIP-seq
MIRT2525926	hsa-miR-4313	CLIP-seq
MIRT2525927	hsa-miR-4426	CLIP-seq
MIRT2525928	hsa-miR-4428	CLIP-seq
MIRT2525929	hsa-miR-4449	CLIP-seq
MIRT972006	hsa-miR-4471	CLIP-seq
MIRT2525930	hsa-miR-4502	CLIP-seq
MIRT2525931	hsa-miR-450a	CLIP-seq
MIRT2525932	hsa-miR-4514	CLIP-seq
MIRT2525933	hsa-miR-4530	CLIP-seq
MIRT2525934	hsa-miR-4637	CLIP-seq
MIRT2525935	hsa-miR-4643	CLIP-seq
MIRT2525936	hsa-miR-4645-5p	CLIP-seq
MIRT2525937	hsa-miR-4647	CLIP-seq
MIRT2525938	hsa-miR-4662b	CLIP-seq
MIRT2525939	hsa-miR-4669	CLIP-seq
MIRT2525940	hsa-miR-4673	CLIP-seq
MIRT972007	hsa-miR-4690-5p	CLIP-seq
MIRT2525941	hsa-miR-4692	CLIP-seq
MIRT2525942	hsa-miR-4695-3p	CLIP-seq
MIRT2525943	hsa-miR-4761-3p	CLIP-seq
MIRT2525944	hsa-miR-4777-5p	CLIP-seq
MIRT2525945	hsa-miR-4798-3p	CLIP-seq
MIRT2525946	hsa-miR-4802-5p	CLIP-seq
MIRT2525947	hsa-miR-490-3p	CLIP-seq
MIRT2525948	hsa-miR-495	CLIP-seq
MIRT2525949	hsa-miR-518d-5p	CLIP-seq
MIRT2525950	hsa-miR-519b-5p	CLIP-seq
MIRT2525951	hsa-miR-519c-5p	CLIP-seq
MIRT2525952	hsa-miR-520a-5p	CLIP-seq
MIRT2525953	hsa-miR-520c-5p	CLIP-seq
MIRT2525954	hsa-miR-525-5p	CLIP-seq
MIRT2525955	hsa-miR-526a	CLIP-seq
MIRT2525956	hsa-miR-548a-3p	CLIP-seq
MIRT2525957	hsa-miR-548e	CLIP-seq
MIRT2525958	hsa-miR-548f	CLIP-seq
MIRT2525959	hsa-miR-570	CLIP-seq
MIRT2525960	hsa-miR-580	CLIP-seq
MIRT2525961	hsa-miR-581	CLIP-seq
MIRT2525962	hsa-miR-592	CLIP-seq
MIRT2525963	hsa-miR-595	CLIP-seq
MIRT2525964	hsa-miR-597	CLIP-seq
MIRT2525965	hsa-miR-599	CLIP-seq
MIRT2525966	hsa-miR-602	CLIP-seq
MIRT2525967	hsa-miR-629	CLIP-seq
MIRT2525968	hsa-miR-634	CLIP-seq
MIRT2525969	hsa-miR-642b	CLIP-seq
MIRT2525970	hsa-miR-649	CLIP-seq
MIRT2525971	hsa-miR-655	CLIP-seq
MIRT1987976	hsa-miR-874	CLIP-seq
MIRT2525972	hsa-miR-921	CLIP-seq
MIRT2525973	hsa-miR-922	CLIP-seq
MIRT2525974	hsa-miR-939	CLIP-seq
MIRT2525886	hsa-miR-122	CLIP-seq
MIRT2525887	hsa-miR-1236	CLIP-seq
MIRT2680358	hsa-miR-1238	CLIP-seq
MIRT2525888	hsa-miR-1284	CLIP-seq
MIRT2525889	hsa-miR-136	CLIP-seq
MIRT2387554	hsa-miR-137	CLIP-seq
MIRT1987968	hsa-miR-146b-3p	CLIP-seq
MIRT2525890	hsa-miR-186	CLIP-seq
MIRT2680359	hsa-miR-1915	CLIP-seq
MIRT2525891	hsa-miR-198	CLIP-seq
MIRT2525892	hsa-miR-203	CLIP-seq
MIRT2525893	hsa-miR-205	CLIP-seq
MIRT2525894	hsa-miR-2278	CLIP-seq
MIRT2222395	hsa-miR-23a	CLIP-seq
MIRT2222396	hsa-miR-23b	CLIP-seq
MIRT2222397	hsa-miR-23c	CLIP-seq
MIRT2525895	hsa-miR-296-3p	CLIP-seq
MIRT2525896	hsa-miR-3065-3p	CLIP-seq
MIRT2525898	hsa-miR-3123	CLIP-seq
MIRT2525899	hsa-miR-3133	CLIP-seq
MIRT2525900	hsa-miR-3160-5p	CLIP-seq
MIRT2525901	hsa-miR-3171	CLIP-seq
MIRT2525902	hsa-miR-3173-3p	CLIP-seq
MIRT2525903	hsa-miR-3180-5p	CLIP-seq
MIRT2525905	hsa-miR-3606	CLIP-seq
MIRT2680360	hsa-miR-3613-3p	CLIP-seq
MIRT2525906	hsa-miR-3616-3p	CLIP-seq
MIRT2525907	hsa-miR-3621	CLIP-seq
MIRT2525908	hsa-miR-3656	CLIP-seq
MIRT2525909	hsa-miR-3657	CLIP-seq
MIRT2525910	hsa-miR-3658	CLIP-seq
MIRT2525911	hsa-miR-3672	CLIP-seq
MIRT2680361	hsa-miR-3688-3p	CLIP-seq
MIRT2525915	hsa-miR-376c	CLIP-seq
MIRT2525916	hsa-miR-377	CLIP-seq
MIRT2525918	hsa-miR-3925-5p	CLIP-seq
MIRT2525919	hsa-miR-3928	CLIP-seq
MIRT2525920	hsa-miR-3936	CLIP-seq
MIRT2525921	hsa-miR-3942-3p	CLIP-seq
MIRT2525922	hsa-miR-3976	CLIP-seq
MIRT2525923	hsa-miR-4253	CLIP-seq
MIRT2525924	hsa-miR-4280	CLIP-seq
MIRT2525925	hsa-miR-4305	CLIP-seq
MIRT2525926	hsa-miR-4313	CLIP-seq
MIRT2525927	hsa-miR-4426	CLIP-seq
MIRT2525928	hsa-miR-4428	CLIP-seq
MIRT2525929	hsa-miR-4449	CLIP-seq
MIRT972006	hsa-miR-4471	CLIP-seq
MIRT2525930	hsa-miR-4502	CLIP-seq
MIRT2525931	hsa-miR-450a	CLIP-seq
MIRT2525932	hsa-miR-4514	CLIP-seq
MIRT2525933	hsa-miR-4530	CLIP-seq
MIRT2525934	hsa-miR-4637	CLIP-seq
MIRT2525935	hsa-miR-4643	CLIP-seq
MIRT2525936	hsa-miR-4645-5p	CLIP-seq
MIRT2525937	hsa-miR-4647	CLIP-seq
MIRT2525938	hsa-miR-4662b	CLIP-seq
MIRT2525939	hsa-miR-4669	CLIP-seq
MIRT2525940	hsa-miR-4673	CLIP-seq
MIRT972007	hsa-miR-4690-5p	CLIP-seq
MIRT2525941	hsa-miR-4692	CLIP-seq
MIRT2680362	hsa-miR-4694-3p	CLIP-seq
MIRT2525942	hsa-miR-4695-3p	CLIP-seq
MIRT2680363	hsa-miR-4704-3p	CLIP-seq
MIRT2680364	hsa-miR-4733-5p	CLIP-seq
MIRT2525943	hsa-miR-4761-3p	CLIP-seq
MIRT2525944	hsa-miR-4777-5p	CLIP-seq
MIRT2525945	hsa-miR-4798-3p	CLIP-seq
MIRT2525946	hsa-miR-4802-5p	CLIP-seq
MIRT2525947	hsa-miR-490-3p	CLIP-seq
MIRT2525948	hsa-miR-495	CLIP-seq
MIRT2525949	hsa-miR-518d-5p	CLIP-seq
MIRT2525950	hsa-miR-519b-5p	CLIP-seq
MIRT2525951	hsa-miR-519c-5p	CLIP-seq
MIRT2525952	hsa-miR-520a-5p	CLIP-seq
MIRT2525953	hsa-miR-520c-5p	CLIP-seq
MIRT2525954	hsa-miR-525-5p	CLIP-seq
MIRT2525955	hsa-miR-526a	CLIP-seq
MIRT2525959	hsa-miR-570	CLIP-seq
MIRT2525961	hsa-miR-581	CLIP-seq
MIRT2525962	hsa-miR-592	CLIP-seq
MIRT2525963	hsa-miR-595	CLIP-seq
MIRT2525964	hsa-miR-597	CLIP-seq
MIRT2525965	hsa-miR-599	CLIP-seq
MIRT2525966	hsa-miR-602	CLIP-seq
MIRT2525967	hsa-miR-629	CLIP-seq
MIRT2525968	hsa-miR-634	CLIP-seq
MIRT2525969	hsa-miR-642b	CLIP-seq
MIRT2525970	hsa-miR-649	CLIP-seq
MIRT1987976	hsa-miR-874	CLIP-seq
MIRT2525972	hsa-miR-921	CLIP-seq
MIRT2525973	hsa-miR-922	CLIP-seq
MIRT2525974	hsa-miR-939	CLIP-seq

Show/Hide all(37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	17126306
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	19443906
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP	15857832
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	15857832
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	8152800
GO:0003700	Function	DNA-binding transcription factor activity	IDA	19443906
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	8152800
GO:0005515	Function	Protein binding	IPI	17126306, 33961781, 35140242
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	19443906
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0007274	Process	Neuromuscular synaptic transmission	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0030154	Process	Cell differentiation	IBA
GO:0034599	Process	Cellular response to oxidative stress	IDA	19443906
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045202	Component	Synapse	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	15857832
GO:0048133	Process	Male germ-line stem cell asymmetric division	IEA
GO:0050807	Process	Regulation of synapse organization	IEA
GO:0060252	Process	Positive regulation of glial cell proliferation	IEA
GO:0060762	Process	Regulation of branching involved in mammary gland duct morphogenesis	IEA
GO:0071340	Process	Skeletal muscle acetylcholine-gated channel clustering	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
601600	3494	ENSG00000244405

Protein

UniProt ID

P41161

Protein name

ETS translocation variant 5 (Ets-related protein ERM)

Protein function

Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.

PDB

4UNO , 5ILV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04621	ETS_PEA3_N	1 → 366	PEA3 subfamily ETS-domain transcription factor N terminal domain	Family
PF00178	Ets	369 → 448	Ets-domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MDGFYDQQVPFMVPGKSRSEECRGRPVIDRKRKFLDTDLAHDSEELFQDLSQLQEAWLAE
AQVPDDEQFVPDFQSDNLVLHAPPPTKIKRELHSPSSELSSCSHEQALGANYGEKCLYNY
CAYDRKPPSGFKPLTPPTTPLSPTHQNPLFPPPQATLPTSGHAPAAGPVQGVGPAPAPHS
LPEPGPQQQTFAVPRPPHQPLQMPKMMPENQYPSEQRFQRQLSEPCHPFPPQPGVPGDNR
PSYHRQMSEPIVPAAPPPPQGFKQEYHDPLYEHGVPGMPGPPAHGFQSPMGIKQEPRDYC
VDSEVPNCQSSYMRGGYFSSSHEGFSYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGP
PYQRRGSLQLWQFLVTLLDDPANAHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYD
KLSRSLRYYYEKGIMQKVAGERYVYKFVCDPDALFSMAFPDNQRPFLKAESECHLSEEDT
LPLTHFEDSPAYLLDMDRCSSLPYAEGFAY

Sequence length

510

Interactions

View interactions

	KEGG
	Transcriptional misregulation in cancer Prostate cancer

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Hyperuricemia	Hyperuricemia	N/A	N/A	GWAS
Obesity	Obesity	N/A	N/A	GWAS
Osteoarthritis Of Hip	Osteoarthritis of the hip or knee (with total joint replacement)	N/A	N/A	GWAS

Show/Hide Text Mining Associations (35)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	35396535
Adenocarcinoma of Lung	Associate	31503425
Airway Remodeling	Associate	31443657
Azoospermia Nonobstructive	Associate	22771031
Bipolar Disorder	Associate	31754094
Breast Neoplasms	Associate	34224831, 35317849
Carcinogenesis	Associate	24756106
Carcinoma Endometrioid	Associate	24756106
Carcinoma Intraductal Noninfiltrating	Associate	31162284
Carcinoma Ovarian Epithelial	Associate	22589409
Chondrosarcoma	Associate	22968857
Colorectal Neoplasms	Associate	35860243
COVID 19	Associate	37287057
Desmoplastic Small Round Cell Tumor	Associate	28233365
Esophageal Squamous Cell Carcinoma	Stimulate	35813298
Hemangiosarcoma	Associate	28233365
Infertility Male	Associate	22771031
Leukemia Lymphocytic Chronic B Cell	Associate	12036888
Liposarcoma Myxoid	Associate	27790742
Lymphoma B Cell	Stimulate	12036888
Lymphoma Mantle Cell	Associate	12036888
Melanoma	Associate	21087211, 32413516
Neoplasm Invasiveness	Associate	22968857, 31162284
Neoplasm Metastasis	Associate	22589409, 30265861
Neoplasm Metastasis	Stimulate	35813298
Neoplasms	Stimulate	12036888
Neoplasms	Associate	24756106, 28186998, 28341589, 34736492, 35813298
Obesity	Associate	20520848, 23349760, 23539184, 23950976, 27421018, 31754094
Ovarian Neoplasms	Associate	22589409, 34736492, 34887384
Prostatic Neoplasms	Associate	18794152, 20693979, 20975660, 25203299, 25544710
Prostatitis	Associate	19465903, 23814484, 36125519
Rh Null Regulator Type	Associate	25866208
Sarcoma	Associate	27790742, 36153506
Sertoli Cell Only Syndrome	Associate	22771031
Thyroid Cancer Papillary	Stimulate	30265861

ETV5 (ETS variant transcription factor 5)