Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2117
Gene name Gene Name - the full gene name approved by the HGNC.	ETS variant transcription factor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ETV3
Synonyms (NCBI Gene) Gene synonyms aliases	METS, PE-1, PE1
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q23.1

Show/Hide all(239)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048238	hsa-miR-196a-5p	CLASH	23622248
MIRT047196	hsa-miR-182-5p	CLASH	23622248
MIRT703849	hsa-miR-204-5p	HITS-CLIP	23313552
MIRT703848	hsa-miR-211-5p	HITS-CLIP	23313552
MIRT703847	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT703845	hsa-miR-511-3p	HITS-CLIP	23313552
MIRT703846	hsa-miR-4714-3p	HITS-CLIP	23313552
MIRT703844	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT703843	hsa-miR-6832-3p	HITS-CLIP	23313552
MIRT703842	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT703841	hsa-miR-938	HITS-CLIP	23313552
MIRT703839	hsa-miR-6886-3p	HITS-CLIP	23313552
MIRT703840	hsa-miR-7158-5p	HITS-CLIP	23313552
MIRT703838	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT703837	hsa-miR-623	HITS-CLIP	23313552
MIRT703836	hsa-miR-4755-5p	HITS-CLIP	23313552
MIRT703835	hsa-miR-5006-3p	HITS-CLIP	23313552
MIRT703834	hsa-miR-4446-5p	HITS-CLIP	23313552
MIRT668496	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT668495	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT668494	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT668493	hsa-miR-1470	HITS-CLIP	23824327
MIRT668492	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT668491	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT668490	hsa-miR-3183	HITS-CLIP	23824327
MIRT668489	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT668488	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT668487	hsa-miR-4682	HITS-CLIP	23824327
MIRT668486	hsa-miR-581	HITS-CLIP	23824327
MIRT668485	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT668484	hsa-miR-4303	HITS-CLIP	23824327
MIRT668483	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT658520	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT658519	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT658518	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT658517	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT658516	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT658515	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT658514	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT658512	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT658513	hsa-miR-4301	HITS-CLIP	23824327
MIRT658511	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT658510	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT658509	hsa-miR-3136-3p	HITS-CLIP	23824327
MIRT658508	hsa-miR-7155-3p	HITS-CLIP	23824327
MIRT658507	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT658506	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT658505	hsa-miR-328-3p	HITS-CLIP	23824327
MIRT658520	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT658519	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT658518	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT658517	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT658516	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT658515	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT658514	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT658512	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT658513	hsa-miR-4301	HITS-CLIP	23824327
MIRT658511	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT658510	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT658509	hsa-miR-3136-3p	HITS-CLIP	23824327
MIRT658508	hsa-miR-7155-3p	HITS-CLIP	23824327
MIRT658507	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT658506	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT658505	hsa-miR-328-3p	HITS-CLIP	23824327
MIRT562371	hsa-miR-548l	PAR-CLIP	20371350
MIRT562370	hsa-miR-7109-3p	PAR-CLIP	20371350
MIRT562369	hsa-miR-502-5p	PAR-CLIP	20371350
MIRT562368	hsa-miR-30c-1-3p	PAR-CLIP	20371350
MIRT562367	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT562366	hsa-miR-6788-5p	PAR-CLIP	20371350
MIRT562365	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT562364	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT562363	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT562362	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT562361	hsa-miR-3689c	PAR-CLIP	20371350
MIRT562360	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT562359	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT562358	hsa-miR-450a-1-3p	PAR-CLIP	20371350
MIRT562357	hsa-miR-3122	PAR-CLIP	20371350
MIRT562356	hsa-miR-3913-5p	PAR-CLIP	20371350
MIRT562355	hsa-miR-887-5p	PAR-CLIP	20371350
MIRT562354	hsa-miR-6513-5p	PAR-CLIP	20371350
MIRT562371	hsa-miR-548l	PAR-CLIP	20371350
MIRT562370	hsa-miR-7109-3p	PAR-CLIP	20371350
MIRT562369	hsa-miR-502-5p	PAR-CLIP	20371350
MIRT562368	hsa-miR-30c-1-3p	PAR-CLIP	20371350
MIRT562367	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT562366	hsa-miR-6788-5p	PAR-CLIP	20371350
MIRT562365	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT562364	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT562363	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT562362	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT562361	hsa-miR-3689c	PAR-CLIP	20371350
MIRT562360	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT562359	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT562358	hsa-miR-450a-1-3p	PAR-CLIP	20371350
MIRT562357	hsa-miR-3122	PAR-CLIP	20371350
MIRT562356	hsa-miR-3913-5p	PAR-CLIP	20371350
MIRT562355	hsa-miR-887-5p	PAR-CLIP	20371350
MIRT562354	hsa-miR-6513-5p	PAR-CLIP	20371350
MIRT548298	hsa-miR-3185	PAR-CLIP	21572407
MIRT548297	hsa-miR-1252-5p	PAR-CLIP	21572407
MIRT548296	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT477223	hsa-miR-8080	PAR-CLIP	23592263
MIRT477222	hsa-miR-6816-3p	PAR-CLIP	23592263
MIRT477221	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT477220	hsa-miR-6741-3p	PAR-CLIP	23592263
MIRT477219	hsa-miR-4742-3p	PAR-CLIP	23592263
MIRT477218	hsa-miR-760	PAR-CLIP	23592263
MIRT477217	hsa-miR-568	PAR-CLIP	23592263
MIRT703849	hsa-miR-204-5p	HITS-CLIP	23313552
MIRT703848	hsa-miR-211-5p	HITS-CLIP	23313552
MIRT703847	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT703845	hsa-miR-511-3p	HITS-CLIP	23313552
MIRT703846	hsa-miR-4714-3p	HITS-CLIP	23313552
MIRT703844	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT703843	hsa-miR-6832-3p	HITS-CLIP	23313552
MIRT703842	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT703841	hsa-miR-938	HITS-CLIP	23313552
MIRT703839	hsa-miR-6886-3p	HITS-CLIP	23313552
MIRT703840	hsa-miR-7158-5p	HITS-CLIP	23313552
MIRT703838	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT703837	hsa-miR-623	HITS-CLIP	23313552
MIRT703836	hsa-miR-4755-5p	HITS-CLIP	23313552
MIRT703835	hsa-miR-5006-3p	HITS-CLIP	23313552
MIRT703834	hsa-miR-4446-5p	HITS-CLIP	23313552
MIRT668496	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT668495	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT668494	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT668493	hsa-miR-1470	HITS-CLIP	23824327
MIRT668492	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT668491	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT668490	hsa-miR-3183	HITS-CLIP	23824327
MIRT668489	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT668488	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT668487	hsa-miR-4682	HITS-CLIP	23824327
MIRT668486	hsa-miR-581	HITS-CLIP	23824327
MIRT668485	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT668484	hsa-miR-4303	HITS-CLIP	23824327
MIRT668483	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT658520	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT658519	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT658518	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT658517	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT658516	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT658515	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT658514	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT658512	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT658513	hsa-miR-4301	HITS-CLIP	23824327
MIRT658511	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT658510	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT658509	hsa-miR-3136-3p	HITS-CLIP	23824327
MIRT658508	hsa-miR-7155-3p	HITS-CLIP	23824327
MIRT658507	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT658506	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT658505	hsa-miR-328-3p	HITS-CLIP	23824327
MIRT658520	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT658519	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT658518	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT658517	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT658516	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT658515	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT658514	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT658512	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT658513	hsa-miR-4301	HITS-CLIP	23824327
MIRT658511	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT658510	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT658509	hsa-miR-3136-3p	HITS-CLIP	23824327
MIRT658508	hsa-miR-7155-3p	HITS-CLIP	23824327
MIRT658507	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT658506	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT658505	hsa-miR-328-3p	HITS-CLIP	23824327
MIRT562371	hsa-miR-548l	PAR-CLIP	20371350
MIRT562370	hsa-miR-7109-3p	PAR-CLIP	20371350
MIRT562369	hsa-miR-502-5p	PAR-CLIP	20371350
MIRT562368	hsa-miR-30c-1-3p	PAR-CLIP	20371350
MIRT562367	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT562366	hsa-miR-6788-5p	PAR-CLIP	20371350
MIRT562365	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT562364	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT562363	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT562362	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT562361	hsa-miR-3689c	PAR-CLIP	20371350
MIRT562360	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT562359	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT562358	hsa-miR-450a-1-3p	PAR-CLIP	20371350
MIRT562357	hsa-miR-3122	PAR-CLIP	20371350
MIRT562356	hsa-miR-3913-5p	PAR-CLIP	20371350
MIRT562355	hsa-miR-887-5p	PAR-CLIP	20371350
MIRT562354	hsa-miR-6513-5p	PAR-CLIP	20371350
MIRT562371	hsa-miR-548l	PAR-CLIP	20371350
MIRT562370	hsa-miR-7109-3p	PAR-CLIP	20371350
MIRT562369	hsa-miR-502-5p	PAR-CLIP	20371350
MIRT562368	hsa-miR-30c-1-3p	PAR-CLIP	20371350
MIRT562367	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT562366	hsa-miR-6788-5p	PAR-CLIP	20371350
MIRT562365	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT562364	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT562363	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT562362	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT562361	hsa-miR-3689c	PAR-CLIP	20371350
MIRT562360	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT562359	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT562358	hsa-miR-450a-1-3p	PAR-CLIP	20371350
MIRT562357	hsa-miR-3122	PAR-CLIP	20371350
MIRT562356	hsa-miR-3913-5p	PAR-CLIP	20371350
MIRT562355	hsa-miR-887-5p	PAR-CLIP	20371350
MIRT562354	hsa-miR-6513-5p	PAR-CLIP	20371350
MIRT548298	hsa-miR-3185	PAR-CLIP	21572407
MIRT548297	hsa-miR-1252-5p	PAR-CLIP	21572407
MIRT548296	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT477223	hsa-miR-8080	PAR-CLIP	23592263
MIRT477222	hsa-miR-6816-3p	PAR-CLIP	23592263
MIRT477221	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT477220	hsa-miR-6741-3p	PAR-CLIP	23592263
MIRT477219	hsa-miR-4742-3p	PAR-CLIP	23592263
MIRT477218	hsa-miR-760	PAR-CLIP	23592263
MIRT477217	hsa-miR-568	PAR-CLIP	23592263
MIRT971972	hsa-miR-1273f	CLIP-seq
MIRT971973	hsa-miR-143	CLIP-seq
MIRT971974	hsa-miR-4511	CLIP-seq
MIRT971975	hsa-miR-4708-5p	CLIP-seq
MIRT971976	hsa-miR-4770	CLIP-seq
MIRT971977	hsa-miR-548b-3p	CLIP-seq
MIRT971978	hsa-miR-618	CLIP-seq
MIRT1987960	hsa-miR-216a	CLIP-seq
MIRT1987961	hsa-miR-216b	CLIP-seq
MIRT1987962	hsa-miR-616	CLIP-seq
MIRT2222376	hsa-miR-1185	CLIP-seq
MIRT2222377	hsa-miR-3605-5p	CLIP-seq
MIRT2222378	hsa-miR-3678-3p	CLIP-seq
MIRT2222379	hsa-miR-3679-5p	CLIP-seq
MIRT2222380	hsa-miR-3921	CLIP-seq
MIRT2222381	hsa-miR-4649-3p	CLIP-seq
MIRT2222382	hsa-miR-4653-5p	CLIP-seq
MIRT2222383	hsa-miR-4684-3p	CLIP-seq
MIRT2465235	hsa-miR-298	CLIP-seq
MIRT2465236	hsa-miR-338-5p	CLIP-seq
MIRT2525878	hsa-miR-4475	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
CREB1	Activation	14754893

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0008150	Process	Biological_process	ND
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0017151	Function	DEAD/H-box RNA helicase binding	IEA
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0090571	Component	RNA polymerase II transcription repressor complex	IEA
GO:0097011	Process	Cellular response to granulocyte macrophage colony-stimulating factor stimulus	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
164873	3492	ENSG00000117036

Protein

UniProt ID

P41162

Protein name

ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor)

Protein function

Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00178	Ets	36 → 116	Ets-domain	Domain

Sequence

MKAGCSIVEKPEGGGGYQFPDWAYKTESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGE
YGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKL
VMPNYPFINIRSSGVVPQSAPPVPTASSRFHFPPLDTHSPTNDVQPGRFSASSLTASGQE
SSNGTDRKTELSELEDGSAADWRRGVDPVSSRNAIGGGGIGHQKRKPDIMLPLFARPGMY
PDPHSPFAVSPIPGRGGVLNVPISPALSLTPTIFSYSPSPGLSPFTSSSCFSFNPEEMKH
YLHSQACSVFNYHLSPRTFPRYPGLMVPPLQCQMHPEESTQFSIKLQPPPVGRKNRERVE
SSEESAPVTTPTMASIPPRIKVEPASEKDPESLRQSAREKEEHTQEEGTVPSRTIEEEKG
TIFARPAAPPIWPSVPISTPSGEPLEVTEDSEDRPGKEPSAPEKKEDALMPPKLRLKRRW
NDDPEARELSKSGKFLWNGSGPQGLATAAADA

Sequence length

512

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Multiple Sclerosis	Multiple Sclerosis	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	GWAS

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Hepatocellular	Associate	33736632
Diabetes Mellitus Type 2	Associate	35271662
Hepatitis B	Associate	33736632
Histiocytosis Langerhans Cell	Associate	29070620
Hodgkin Disease	Stimulate	37428779
Leukemia Lymphocytic Chronic B Cell	Associate	20462409
Neoplasms	Inhibit	20462409
Neoplasms	Stimulate	28371821
Neoplasms	Associate	32651179
Prostatic malacoplakia associated with prostatic abscess	Associate	25964175
Sarcopenia	Associate	35271662

ETV3 (ETS variant transcription factor 3)