Gene Gene information from NCBI Gene database.
Entrez ID 2117
Gene name ETS variant transcription factor 3
Gene symbol ETV3
Synonyms (NCBI Gene)
METSPE-1PE1
Chromosome 1
Chromosome location 1q23.1
miRNA miRNA information provided by mirtarbase database.
239
miRTarBase ID miRNA Experiments Reference
MIRT048238 hsa-miR-196a-5p CLASH 23622248
MIRT047196 hsa-miR-182-5p CLASH 23622248
MIRT703849 hsa-miR-204-5p HITS-CLIP 23313552
MIRT703848 hsa-miR-211-5p HITS-CLIP 23313552
MIRT703847 hsa-miR-3675-3p HITS-CLIP 23313552
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
CREB1 Activation 14754893
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin IEA
GO:0000785 Component Chromatin ISA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
164873 3492 ENSG00000117036
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P41162
Protein name ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor)
Protein function Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00178 Ets 36 116 Ets-domain Domain
Sequence
MKAGCSIVEKPEGGGGYQFPDWAYKTESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGE
YGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFN
FNKL
VMPNYPFINIRSSGVVPQSAPPVPTASSRFHFPPLDTHSPTNDVQPGRFSASSLTASGQE
SSNGTDRKTELSELEDGSAADWRRGVDPVSSRNAIGGGGIGHQKRKPDIMLPLFARPGMY
PDPHSPFAVSPIPGRGGVLNVPISPALSLTPTIFSYSPSPGLSPFTSSSCFSFNPEEMKH
YLHSQACSVFNYHLSPRTFPRYPGLMVPPLQCQMHPEESTQFSIKLQPPPVGRKNRERVE
SSEESAPVTTPTMASIPPRIKVEPASEKDPESLRQSAREKEEHTQEEGTVPSRTIEEEKG
TIFARPAAPPIWPSVPISTPSGEPLEVTEDSEDRPGKEPSAPEKKEDALMPPKLRLKRRW
NDDPEARELSKSGKFLWNGSGPQGLATAAADA
Sequence length 512
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEPATITIS VIRUS-RELATED HEPATOCELLULAR CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NASOPHARYNGEAL NEOPLASM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinoma Hepatocellular Associate 33736632
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Associate 35271662
★☆☆☆☆
Found in Text Mining only
Hepatitis B Associate 33736632
★☆☆☆☆
Found in Text Mining only
Histiocytosis Langerhans Cell Associate 29070620
★☆☆☆☆
Found in Text Mining only
Hodgkin Disease Stimulate 37428779
★☆☆☆☆
Found in Text Mining only
Leukemia Lymphocytic Chronic B Cell Associate 20462409
★☆☆☆☆
Found in Text Mining only
Neoplasms Inhibit 20462409
★☆☆☆☆
Found in Text Mining only
Neoplasms Stimulate 28371821
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 32651179
★☆☆☆☆
Found in Text Mining only
Prostatic malacoplakia associated with prostatic abscess Associate 25964175
★☆☆☆☆
Found in Text Mining only