Gene Gene information from NCBI Gene database.
Entrez ID 2115
Gene name ETS variant transcription factor 1
Gene symbol ETV1
Synonyms (NCBI Gene)
ER81
Chromosome 7
Chromosome location 7p21.2
Summary This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS prot
miRNA miRNA information provided by mirtarbase database.
331
miRTarBase ID miRNA Experiments Reference
MIRT017630 hsa-miR-335-5p Microarray 18185580
MIRT438055 hsa-miR-17-5p Luciferase reporter assayqRT-PCRmicroarrayWestern blotting 23969726
MIRT438054 hsa-miR-20a-5p Luciferase reporter assayqRT-PCRmicroarrayWestern blotting 23969726
MIRT438055 hsa-miR-17-5p Luciferase reporter assayqRT-PCRmicroarrayWestern blotting 23969726
MIRT438054 hsa-miR-20a-5p Luciferase reporter assayqRT-PCRmicroarrayWestern blotting 23969726
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
AR Activation 19789348
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 12750007
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IDA 12750007
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600541 3490 ENSG00000006468
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P50549
Protein name ETS translocation variant 1 (Ets-related protein 81)
Protein function Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase
PDB 4AVP , 4BNC , 5ILS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04621 ETS_PEA3_N 1 333 PEA3 subfamily ETS-domain transcription factor N terminal domain Family
PF00178 Ets 336 415 Ets-domain Domain
Tissue specificity TISSUE SPECIFICITY: Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in pl
Sequence
Sequence length 477
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Transcriptional misregulation in cancer