Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	2114
Gene name	ETS proto-oncogene 2, transcription factor
Gene symbol	ETS2
Synonyms (NCBI Gene)	ETS2IT1
Chromosome	21
Chromosome location	21q22.2
Summary	This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosom

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004398	hsa-miR-199a-5p	MicroarrayNorthern blot	16331254
MIRT000775	hsa-miR-199a-3p	MicroarrayNorthern blot	16331254
MIRT024245	hsa-miR-218-5p	Sequencing	20371350
MIRT050649	hsa-miR-18a-5p	CLASH	23622248
MIRT045544	hsa-miR-149-5p	CLASH	23622248
MIRT037225	hsa-miR-877-5p	CLASH	23622248
MIRT053485	hsa-miR-196b-5p	ChIP-seqLuciferase reporter assayqRT-PCRWestern blot	22298639
MIRT298550	hsa-miR-944	PAR-CLIP	20371350
MIRT563639	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT298547	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT563638	hsa-miR-205-3p	PAR-CLIP	20371350
MIRT298548	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT563637	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT563636	hsa-miR-3671	PAR-CLIP	20371350
MIRT563635	hsa-miR-607	PAR-CLIP	20371350
MIRT085405	hsa-miR-548aa	PAR-CLIP	21572407
MIRT085407	hsa-miR-548ap-3p	PAR-CLIP	21572407
MIRT085401	hsa-miR-548t-3p	PAR-CLIP	21572407
MIRT085408	hsa-miR-548as-3p	PAR-CLIP	21572407
MIRT085409	hsa-miR-548at-3p	PAR-CLIP	21572407
MIRT085410	hsa-miR-548ay-3p	PAR-CLIP	21572407
MIRT085404	hsa-miR-3662	PAR-CLIP	21572407
MIRT085403	hsa-miR-3646	PAR-CLIP	21572407
MIRT085400	hsa-miR-455-5p	PAR-CLIP	21572407
MIRT254150	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT254147	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT254148	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT254149	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT254145	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT254152	hsa-miR-548aw	PAR-CLIP	21572407
MIRT254144	hsa-miR-587	PAR-CLIP	21572407
MIRT298550	hsa-miR-944	PAR-CLIP	20371350
MIRT563639	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT298547	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT563638	hsa-miR-205-3p	PAR-CLIP	20371350
MIRT298548	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT563637	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT563636	hsa-miR-3671	PAR-CLIP	20371350
MIRT563635	hsa-miR-607	PAR-CLIP	20371350
MIRT085405	hsa-miR-548aa	PAR-CLIP	21572407
MIRT085407	hsa-miR-548ap-3p	PAR-CLIP	21572407
MIRT085401	hsa-miR-548t-3p	PAR-CLIP	21572407
MIRT085408	hsa-miR-548as-3p	PAR-CLIP	21572407
MIRT085409	hsa-miR-548at-3p	PAR-CLIP	21572407
MIRT085410	hsa-miR-548ay-3p	PAR-CLIP	21572407
MIRT085404	hsa-miR-3662	PAR-CLIP	21572407
MIRT085403	hsa-miR-3646	PAR-CLIP	21572407
MIRT085400	hsa-miR-455-5p	PAR-CLIP	21572407
MIRT254150	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT254147	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT254148	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT254149	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT254145	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT254152	hsa-miR-548aw	PAR-CLIP	21572407
MIRT254144	hsa-miR-587	PAR-CLIP	21572407
MIRT971887	hsa-miR-1224-3p	CLIP-seq
MIRT971888	hsa-miR-1245b-5p	CLIP-seq
MIRT971889	hsa-miR-1260	CLIP-seq
MIRT971890	hsa-miR-1260b	CLIP-seq
MIRT971891	hsa-miR-1264	CLIP-seq
MIRT971892	hsa-miR-1280	CLIP-seq
MIRT971893	hsa-miR-1283	CLIP-seq
MIRT971894	hsa-miR-136	CLIP-seq
MIRT971895	hsa-miR-188-3p	CLIP-seq
MIRT971896	hsa-miR-188-5p	CLIP-seq
MIRT971897	hsa-miR-203	CLIP-seq
MIRT971898	hsa-miR-300	CLIP-seq
MIRT971899	hsa-miR-3142	CLIP-seq
MIRT971900	hsa-miR-3156-3p	CLIP-seq
MIRT971901	hsa-miR-3187-3p	CLIP-seq
MIRT971902	hsa-miR-323b-5p	CLIP-seq
MIRT971903	hsa-miR-339-5p	CLIP-seq
MIRT971904	hsa-miR-3667-3p	CLIP-seq
MIRT971905	hsa-miR-369-3p	CLIP-seq
MIRT971906	hsa-miR-371-5p	CLIP-seq
MIRT971907	hsa-miR-371b-5p	CLIP-seq
MIRT971908	hsa-miR-374a	CLIP-seq
MIRT971909	hsa-miR-374b	CLIP-seq
MIRT971910	hsa-miR-381	CLIP-seq
MIRT971911	hsa-miR-4252	CLIP-seq
MIRT971912	hsa-miR-4320	CLIP-seq
MIRT971913	hsa-miR-4435	CLIP-seq
MIRT971914	hsa-miR-4475	CLIP-seq
MIRT971915	hsa-miR-450b-5p	CLIP-seq
MIRT971916	hsa-miR-4637	CLIP-seq
MIRT971917	hsa-miR-4640-3p	CLIP-seq
MIRT971918	hsa-miR-4650-5p	CLIP-seq
MIRT971919	hsa-miR-4652-3p	CLIP-seq
MIRT971920	hsa-miR-4666-3p	CLIP-seq
MIRT971921	hsa-miR-4667-3p	CLIP-seq
MIRT971922	hsa-miR-4701-5p	CLIP-seq
MIRT971923	hsa-miR-4717-5p	CLIP-seq
MIRT971924	hsa-miR-4753-3p	CLIP-seq
MIRT971925	hsa-miR-4753-5p	CLIP-seq
MIRT971926	hsa-miR-4766-5p	CLIP-seq
MIRT971927	hsa-miR-518a-5p	CLIP-seq
MIRT971928	hsa-miR-527	CLIP-seq
MIRT971929	hsa-miR-548s	CLIP-seq
MIRT971930	hsa-miR-588	CLIP-seq
MIRT971931	hsa-miR-942	CLIP-seq
MIRT1987949	hsa-miR-101	CLIP-seq
MIRT971889	hsa-miR-1260	CLIP-seq
MIRT971890	hsa-miR-1260b	CLIP-seq
MIRT1987950	hsa-miR-144	CLIP-seq
MIRT1987951	hsa-miR-3138	CLIP-seq
MIRT1987952	hsa-miR-4800-5p	CLIP-seq
MIRT1987953	hsa-miR-598	CLIP-seq
MIRT1987949	hsa-miR-101	CLIP-seq
MIRT1987950	hsa-miR-144	CLIP-seq
MIRT971897	hsa-miR-203	CLIP-seq
MIRT2222364	hsa-miR-205	CLIP-seq
MIRT971902	hsa-miR-323b-5p	CLIP-seq
MIRT2222365	hsa-miR-3922-5p	CLIP-seq
MIRT971916	hsa-miR-4637	CLIP-seq
MIRT971923	hsa-miR-4717-5p	CLIP-seq
MIRT971925	hsa-miR-4753-5p	CLIP-seq
MIRT971926	hsa-miR-4766-5p	CLIP-seq
MIRT2222366	hsa-miR-628-3p	CLIP-seq
MIRT2387548	hsa-miR-1293	CLIP-seq
MIRT2387549	hsa-miR-323-5p	CLIP-seq
MIRT2387550	hsa-miR-4483	CLIP-seq

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Transcription factor	Regulation	Reference
ERF	Repression	7588608
ETV7	Unknown	22615925
JUN	Unknown	22354960

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	12637547
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	12637547
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	12637547
GO:0001501	Process	Skeletal system development	TAS	8596630
GO:0001712	Process	Ectodermal cell fate commitment	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	10918595
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	8596630
GO:0005515	Function	Protein binding	IPI	18242510, 18598946, 25117710, 26331536, 26496610, 32814053, 32911434
GO:0005634	Component	Nucleus	HDA	16780588
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0007498	Process	Mesoderm development	IEA
GO:0019904	Function	Protein domain specific binding	IPI	11583620
GO:0030154	Process	Cell differentiation	IBA
GO:0035259	Function	Nuclear glucocorticoid receptor binding	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	11909962
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IDA	11909962
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	11909962
GO:0090009	Process	Primitive streak formation	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

MIM	HGNC	e!Ensembl
164740	3489	ENSG00000157557

P15036

Protein name

Protein C-ets-2

Protein function

Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.

PDB

4BQA , 4MHV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02198	SAM_PNT	87 → 170	Sterile alpha motif (SAM)/Pointed domain	Domain
PF00178	Ets	364 → 443	Ets-domain	Domain

Sequence

MNDFGIKNMDQVAPVANSYRGTLKRQPAFDTFDGSLFAVFPSLNEEQTLQEVPTGLDSIS
HDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATN
EFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEE
NSHLTSVPHWINSNTLGFGTEQAPYGMQTQNYPKGGLLDSMCPASTPSVLSSEQEFQMFP
KSRLSSVSVTYCSVSQDFPGSNLNLLTNNSGTPKDHDSPENGADSFESSDSLLQSWNSQS
SLLDVQRVPSFESFEDDCSQSLCLNKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGS
GPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRG
LRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED

Sequence length

469

Interactions

View interactions

	KEGG		Reactome
	Ras signaling pathway Human T-cell leukemia virus 1 infection		Oncogene Induced Senescence

ETS2 (ETS proto-oncogene 2, transcription factor)