Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2107
Gene name Gene Name - the full gene name approved by the HGNC.
Eukaryotic translation termination factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ETF1
Synonyms (NCBI Gene) Gene synonyms aliases
D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which prom
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT046100 hsa-miR-125b-5p CLASH 23622248
MIRT045869 hsa-miR-128-3p CLASH 23622248
MIRT042497 hsa-miR-423-3p CLASH 23622248
MIRT628249 hsa-miR-1306-5p HITS-CLIP 23824327
MIRT628248 hsa-miR-6832-3p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
SP3 Repression 14563555
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
GO:0002184 Process Cytoplasmic translational termination IBA 21873635
GO:0003723 Function RNA binding HDA 22658674
GO:0003747 Function Translation release factor activity IDA 7990965
GO:0003747 Function Translation release factor activity TAS 15326224
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600285 3477 ENSG00000120705
Protein
UniProt ID P62495
Protein name Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)
Protein function Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793,
PDB 1DT9 , 2HST , 2KTU , 2KTV , 2LGT , 2LLX , 2MQ6 , 2MQ9 , 3E1Y , 3J5Y , 3JAG , 3JAH , 3JAI , 4D5N , 4D61 , 5A8L , 5LZT , 5LZU , 5LZV , 6D90 , 6IP8 , 6XA1 , 6ZME , 8SCB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03463 eRF1_1 18 140 eRF1 domain 1 Domain
PF03464 eRF1_2 145 277 eRF1 domain 2 Domain
PF03465 eRF1_3 280 417 eRF1 domain 3 Domain
Sequence
Sequence length 437
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mRNA surveillance pathway   Eukaryotic Translation Termination
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
31268507, 25056061, 26198764, 28540026, 29483656, 30285260
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Asthma Asthma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Bipolar Disorder Associate 27450446
Carcinoma Hepatocellular Associate 36028814
Communicable Diseases Associate 27387891
Diabetic Nephropathies Associate 29532746
Myasthenia Gravis Associate 27387891