Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
2107
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Eukaryotic translation termination factor 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
ETF1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1 |
Chromosome
Chromosome number
|
5 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
5q31.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which prom |
UniProt ID |
P62495
|
Protein name |
Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) |
Protein function |
Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793, |
PDB |
1DT9
,
2HST
,
2KTU
,
2KTV
,
2LGT
,
2LLX
,
2MQ6
,
2MQ9
,
3E1Y
,
3J5Y
,
3JAG
,
3JAH
,
3JAI
,
4D5N
,
4D61
,
5A8L
,
5LZT
,
5LZU
,
5LZV
,
6D90
,
6IP8
,
6XA1
,
6ZME
,
8SCB
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF03463
|
eRF1_1 |
18 → 140 |
eRF1 domain 1 |
Domain |
PF03464
|
eRF1_2 |
145 → 277 |
eRF1 domain 2 |
Domain |
PF03465
|
eRF1_3 |
280 → 417 |
eRF1 domain 3 |
Domain |
|
Sequence |
|
Sequence length |
437 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
31268507, 25056061, 26198764, 28540026, 29483656, 30285260 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Diabetes |
Diabetes |
|
|
GWAS |
Asthma |
Asthma |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Bipolar Disorder |
Associate
|
27450446 |
Carcinoma Hepatocellular |
Associate
|
36028814 |
Communicable Diseases |
Associate
|
27387891 |
Diabetic Nephropathies |
Associate
|
29532746 |
Myasthenia Gravis |
Associate
|
27387891 |
|