Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2101
Gene name Gene Name - the full gene name approved by the HGNC.	Estrogen related receptor alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ESRRA
Synonyms (NCBI Gene) Gene synonyms aliases	ERR1, ERRa, ERRalpha, ESRL1, NR3B1
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q13.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate t

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006957	hsa-miR-137	Luciferase reporter assay	22723937
MIRT006957	hsa-miR-137	Luciferase reporter assay	22723937
MIRT016687	hsa-miR-423-3p	Sequencing	20371350
MIRT020579	hsa-miR-155-5p	Proteomics	18668040
MIRT028410	hsa-miR-30a-5p	Proteomics	18668040
MIRT039942	hsa-miR-615-3p	CLASH	23622248
MIRT437906	hsa-miR-125a-5p	Luciferase reporter assay, Western blot	25266720
MIRT732379	hsa-miR-135a-5p	Luciferase reporter assay, qRT-PCR, Western blot	27227989
MIRT732379	hsa-miR-135a-5p	Luciferase reporter assay, qRT-PCR, Western blot	27227989
MIRT970988	hsa-miR-103a	CLIP-seq
MIRT970989	hsa-miR-107	CLIP-seq
MIRT970990	hsa-miR-125b	CLIP-seq
MIRT970991	hsa-miR-1301	CLIP-seq
MIRT970992	hsa-miR-135a	CLIP-seq
MIRT970993	hsa-miR-135b	CLIP-seq
MIRT970994	hsa-miR-1470	CLIP-seq
MIRT970995	hsa-miR-15a	CLIP-seq
MIRT970996	hsa-miR-15b	CLIP-seq
MIRT970997	hsa-miR-16	CLIP-seq
MIRT970998	hsa-miR-195	CLIP-seq
MIRT970999	hsa-miR-1973	CLIP-seq
MIRT971000	hsa-miR-3117-5p	CLIP-seq
MIRT971001	hsa-miR-3127-3p	CLIP-seq
MIRT971002	hsa-miR-3159	CLIP-seq
MIRT971003	hsa-miR-3176	CLIP-seq
MIRT971004	hsa-miR-3192	CLIP-seq
MIRT971005	hsa-miR-323-3p	CLIP-seq
MIRT971006	hsa-miR-324-5p	CLIP-seq
MIRT971007	hsa-miR-365	CLIP-seq
MIRT971008	hsa-miR-3922-3p	CLIP-seq
MIRT971009	hsa-miR-3922-5p	CLIP-seq
MIRT971010	hsa-miR-3943	CLIP-seq
MIRT971011	hsa-miR-3944-5p	CLIP-seq
MIRT971012	hsa-miR-3977	CLIP-seq
MIRT971013	hsa-miR-424	CLIP-seq
MIRT971014	hsa-miR-4267	CLIP-seq
MIRT971015	hsa-miR-4313	CLIP-seq
MIRT971016	hsa-miR-4319	CLIP-seq
MIRT971017	hsa-miR-4324	CLIP-seq
MIRT971018	hsa-miR-4464	CLIP-seq
MIRT971019	hsa-miR-4503	CLIP-seq
MIRT971020	hsa-miR-4522	CLIP-seq
MIRT971021	hsa-miR-4667-3p	CLIP-seq
MIRT971022	hsa-miR-4708-3p	CLIP-seq
MIRT971023	hsa-miR-4727-5p	CLIP-seq
MIRT971024	hsa-miR-4732-3p	CLIP-seq
MIRT971025	hsa-miR-4748	CLIP-seq
MIRT971026	hsa-miR-4753-3p	CLIP-seq
MIRT971027	hsa-miR-4757-5p	CLIP-seq
MIRT971028	hsa-miR-4768-5p	CLIP-seq
MIRT971029	hsa-miR-4798-5p	CLIP-seq
MIRT971030	hsa-miR-497	CLIP-seq
MIRT971031	hsa-miR-5047	CLIP-seq
MIRT971032	hsa-miR-532-3p	CLIP-seq
MIRT971033	hsa-miR-544	CLIP-seq
MIRT971034	hsa-miR-545	CLIP-seq
MIRT971035	hsa-miR-548p	CLIP-seq
MIRT971036	hsa-miR-642a	CLIP-seq
MIRT971037	hsa-miR-662	CLIP-seq
MIRT971038	hsa-miR-670	CLIP-seq
MIRT1987664	hsa-miR-1202	CLIP-seq
MIRT970990	hsa-miR-125b	CLIP-seq
MIRT1987665	hsa-miR-1291	CLIP-seq
MIRT970994	hsa-miR-1470	CLIP-seq
MIRT1987666	hsa-miR-214	CLIP-seq
MIRT1987667	hsa-miR-2861	CLIP-seq
MIRT971001	hsa-miR-3127-3p	CLIP-seq
MIRT1987668	hsa-miR-3150b-3p	CLIP-seq
MIRT1987669	hsa-miR-3173-5p	CLIP-seq
MIRT1987670	hsa-miR-3194-5p	CLIP-seq
MIRT1987671	hsa-miR-3198	CLIP-seq
MIRT1987672	hsa-miR-326	CLIP-seq
MIRT1987673	hsa-miR-330-5p	CLIP-seq
MIRT1987674	hsa-miR-3619-5p	CLIP-seq
MIRT1987675	hsa-miR-3688-5p	CLIP-seq
MIRT1987676	hsa-miR-3972	CLIP-seq
MIRT971014	hsa-miR-4267	CLIP-seq
MIRT1987677	hsa-miR-4309	CLIP-seq
MIRT971015	hsa-miR-4313	CLIP-seq
MIRT971016	hsa-miR-4319	CLIP-seq
MIRT971017	hsa-miR-4324	CLIP-seq
MIRT971018	hsa-miR-4464	CLIP-seq
MIRT1987678	hsa-miR-4530	CLIP-seq
MIRT1987679	hsa-miR-4640-3p	CLIP-seq
MIRT971021	hsa-miR-4667-3p	CLIP-seq
MIRT1987680	hsa-miR-4690-5p	CLIP-seq
MIRT1987681	hsa-miR-4695-5p	CLIP-seq
MIRT1987682	hsa-miR-4722-3p	CLIP-seq
MIRT971024	hsa-miR-4732-3p	CLIP-seq
MIRT971025	hsa-miR-4748	CLIP-seq
MIRT1987683	hsa-miR-4784	CLIP-seq
MIRT971036	hsa-miR-642a	CLIP-seq
MIRT971038	hsa-miR-670	CLIP-seq
MIRT1987684	hsa-miR-761	CLIP-seq
MIRT1987685	hsa-miR-765	CLIP-seq
MIRT970988	hsa-miR-103a	CLIP-seq
MIRT970989	hsa-miR-107	CLIP-seq
MIRT2222082	hsa-miR-1272	CLIP-seq
MIRT2222083	hsa-miR-1285	CLIP-seq
MIRT1987665	hsa-miR-1291	CLIP-seq
MIRT970991	hsa-miR-1301	CLIP-seq
MIRT970992	hsa-miR-135a	CLIP-seq
MIRT970993	hsa-miR-135b	CLIP-seq
MIRT2222084	hsa-miR-1915	CLIP-seq
MIRT1987667	hsa-miR-2861	CLIP-seq
MIRT2222085	hsa-miR-296-5p	CLIP-seq
MIRT971000	hsa-miR-3117-5p	CLIP-seq
MIRT2222086	hsa-miR-3121-3p	CLIP-seq
MIRT2222087	hsa-miR-3121-5p	CLIP-seq
MIRT2222088	hsa-miR-3179	CLIP-seq
MIRT2222089	hsa-miR-3187-5p	CLIP-seq
MIRT2222090	hsa-miR-3189-5p	CLIP-seq
MIRT1987671	hsa-miR-3198	CLIP-seq
MIRT971005	hsa-miR-323-3p	CLIP-seq
MIRT971006	hsa-miR-324-5p	CLIP-seq
MIRT1987672	hsa-miR-326	CLIP-seq
MIRT1987673	hsa-miR-330-5p	CLIP-seq
MIRT2222091	hsa-miR-3622b-5p	CLIP-seq
MIRT971007	hsa-miR-365	CLIP-seq
MIRT2222092	hsa-miR-3691-3p	CLIP-seq
MIRT2222093	hsa-miR-378g	CLIP-seq
MIRT971012	hsa-miR-3977	CLIP-seq
MIRT2222094	hsa-miR-4253	CLIP-seq
MIRT1987677	hsa-miR-4309	CLIP-seq
MIRT971015	hsa-miR-4313	CLIP-seq
MIRT2222095	hsa-miR-432	CLIP-seq
MIRT971017	hsa-miR-4324	CLIP-seq
MIRT2222096	hsa-miR-4327	CLIP-seq
MIRT2222097	hsa-miR-4422	CLIP-seq
MIRT971018	hsa-miR-4464	CLIP-seq
MIRT2222098	hsa-miR-4486	CLIP-seq
MIRT2222099	hsa-miR-4653-3p	CLIP-seq
MIRT2222100	hsa-miR-4688	CLIP-seq
MIRT971022	hsa-miR-4708-3p	CLIP-seq
MIRT2222101	hsa-miR-4712-3p	CLIP-seq
MIRT971023	hsa-miR-4727-5p	CLIP-seq
MIRT971025	hsa-miR-4748	CLIP-seq
MIRT971026	hsa-miR-4753-3p	CLIP-seq
MIRT2222102	hsa-miR-4758-3p	CLIP-seq
MIRT971028	hsa-miR-4768-5p	CLIP-seq
MIRT2222103	hsa-miR-486-3p	CLIP-seq
MIRT971031	hsa-miR-5047	CLIP-seq
MIRT2222104	hsa-miR-515-5p	CLIP-seq
MIRT971032	hsa-miR-532-3p	CLIP-seq
MIRT971033	hsa-miR-544	CLIP-seq
MIRT971034	hsa-miR-545	CLIP-seq
MIRT2222105	hsa-miR-593	CLIP-seq
MIRT2222106	hsa-miR-612	CLIP-seq
MIRT971037	hsa-miR-662	CLIP-seq
MIRT2222107	hsa-miR-760	CLIP-seq
MIRT1987685	hsa-miR-765	CLIP-seq
MIRT1987671	hsa-miR-3198	CLIP-seq
MIRT1987677	hsa-miR-4309	CLIP-seq
MIRT1987669	hsa-miR-3173-5p	CLIP-seq
MIRT1987669	hsa-miR-3173-5p	CLIP-seq
MIRT971018	hsa-miR-4464	CLIP-seq
MIRT971023	hsa-miR-4727-5p	CLIP-seq
MIRT971025	hsa-miR-4748	CLIP-seq
MIRT971032	hsa-miR-532-3p	CLIP-seq
MIRT971033	hsa-miR-544	CLIP-seq
MIRT971037	hsa-miR-662	CLIP-seq
MIRT2680306	hsa-miR-1268	CLIP-seq
MIRT2680307	hsa-miR-1268b	CLIP-seq
MIRT2222084	hsa-miR-1915	CLIP-seq
MIRT1987667	hsa-miR-2861	CLIP-seq
MIRT1987668	hsa-miR-3150b-3p	CLIP-seq
MIRT2680308	hsa-miR-3151	CLIP-seq
MIRT2680309	hsa-miR-4266	CLIP-seq
MIRT971018	hsa-miR-4464	CLIP-seq
MIRT1987679	hsa-miR-4640-3p	CLIP-seq
MIRT2680310	hsa-miR-4656	CLIP-seq
MIRT1987681	hsa-miR-4695-5p	CLIP-seq
MIRT2680311	hsa-miR-4716-3p	CLIP-seq
MIRT2680312	hsa-miR-4723-5p	CLIP-seq
MIRT2680313	hsa-miR-4726-3p	CLIP-seq
MIRT971023	hsa-miR-4727-5p	CLIP-seq
MIRT971025	hsa-miR-4748	CLIP-seq
MIRT2680314	hsa-miR-4779	CLIP-seq
MIRT1987683	hsa-miR-4784	CLIP-seq
MIRT971032	hsa-miR-532-3p	CLIP-seq
MIRT971033	hsa-miR-544	CLIP-seq
MIRT971037	hsa-miR-662	CLIP-seq
MIRT1987685	hsa-miR-765	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
ESR1	Unknown	12960079

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001650	Component	Fibrillar center	IDA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	21190936
GO:0003707	Function	Steroid hormone receptor activity	IEA
GO:0004879	Function	Nuclear receptor activity	IBA	21873635
GO:0005496	Function	Steroid binding	IEA
GO:0005515	Function	Protein binding	IPI	12522104, 15337744, 18063693, 18331830, 18441008, 18509053, 21190936, 21988832, 32296183
GO:0005634	Component	Nucleus	IDA	21190936
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	21190936
GO:0006355	Process	Regulation of transcription, DNA-templated	IMP	23836911
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0007005	Process	Mitochondrion organization	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0019904	Function	Protein domain specific binding	IPI	11984006
GO:0030522	Process	Intracellular receptor signaling pathway	IEA
GO:0043401	Process	Steroid hormone mediated signaling pathway	IEA
GO:0043565	Function	Sequence-specific DNA binding	IDA	23836911
GO:0045171	Component	Intercellular bridge	IDA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
601998	3471	ENSG00000173153

Protein

UniProt ID

P11474

Protein name

Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)

Protein function

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promo

PDB

1XB7 , 2PJL , 3D24 , 3K6P , 7E2E

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00105	zf-C4	77 → 146	Zinc finger, C4 type (two domains)	Domain
PF00104	Hormone_recep	224 → 404	Ligand-binding domain of nuclear hormone receptor	Domain

Sequence

MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAG
PGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNE
CEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGP
LAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTI
SWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAA
GLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALL
EYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEA
MMD

Sequence length

423

Interactions

View interactions

	Reactome
			PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	20961995
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	20961995
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465 View all (942 more)	20961995

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Metabolic diseases	Metabolic Diseases		16515477	ClinVar

Show/Hide Text Mining Associations (67)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	36430689
Adrenal Cortex Diseases	Associate	23123734
Adrenal Gland Neoplasms	Associate	23123734
Adrenocortical Carcinoma	Stimulate	23123734
Androgen Insensitivity Syndrome	Associate	33753865
Arthritis	Associate	21506092
Arthritis Rheumatoid	Associate	29848990
Bantu siderosis	Associate	30920960
Breast Neoplasms	Associate	17259347, 17556356, 17631492, 18174157, 18974123, 19462000, 20211987, 20870744, 21546870, 22014575, 22723937, 23725143, 26542058, 27227989, 27456360 View all (9 more)
Carcinogenesis	Associate	16681769, 26639757, 33197888
Carcinoma Basal Cell	Associate	34003583
Carcinoma Hepatocellular	Associate	29214989
Carcinoma Non Small Cell Lung	Associate	20447055, 36430689
Carcinoma Ovarian Epithelial	Associate	21447778
Carcinoma Renal Cell	Associate	27128972
Colorectal Neoplasms	Associate	23680656, 35048632, 36026615
Crohn Disease	Associate	37347142
Diabetes Mellitus Type 1	Associate	25170024
Diabetes Mellitus Type 2	Associate	22778543, 28346099, 29216352
Disease	Associate	33525981
Endocrine System Diseases	Associate	23680656, 29216352
Endometrial Neoplasms	Associate	16681769, 31040369, 33197888, 33525981
Endometrial Neoplasms	Stimulate	29781387, 36835419
Fatigue Syndrome Chronic	Associate	39394558
Fatty Liver	Associate	40113187
Gallbladder Neoplasms	Associate	34184087
Glioma	Associate	28222026
Granuloma	Associate	37347142
Heart Failure	Associate	19061896
Heart Failure	Inhibit	24825877
Hereditary Breast and Ovarian Cancer Syndrome	Inhibit	18974123
Hereditary Breast and Ovarian Cancer Syndrome	Associate	29216352
Hypoxia	Inhibit	28222026
Hypoxia	Associate	36787804
Immune System Diseases	Associate	25170024
Inflammation	Associate	37347142
Lung Neoplasms	Associate	20447055, 36430689
Lymphatic Metastasis	Inhibit	36430689
Metabolic Diseases	Associate	17556356, 19462000, 28346099
Metabolic Syndrome	Associate	28346099
Mitochondrial Diseases	Associate	19061896
Muscular Disorders Atrophic	Inhibit	21561608
Muscular Dystrophy Duchenne	Associate	15883633
Muscular Dystrophy Facioscapulohumeral	Associate	30462217
Neoplasm Metastasis	Associate	27532429
Neoplasm Metastasis	Stimulate	31427441, 36835419
Neoplasms	Associate	18174157, 19822186, 20128821, 20447055, 20870744, 21546870, 21949640, 22014575, 22723937, 23123734, 23680656, 25912138, 26639757, 27227989, 29216352 View all (9 more)
Neoplasms	Inhibit	33525981, 36430689
Neoplasms	Stimulate	35048632
Neuroblastoma	Associate	25912138
Neurodegenerative Diseases	Associate	32683181
Non alcoholic Fatty Liver Disease	Associate	23931760, 40113187
Obesity	Associate	16286534, 29216352, 33185172
Oropharyngeal Neoplasms	Associate	36134662
Osteoarthritis	Inhibit	21506092
Osteoporosis	Associate	15883633, 17556356, 22957024
Osteosarcoma	Associate	27532429, 35918761
Ovarian Neoplasms	Associate	21949640, 24504521, 27966445, 34089362
Prostatic Neoplasms	Stimulate	18697814
Prostatic Neoplasms	Associate	20128821
Sarcopenia	Associate	31862890
Squamous Cell Carcinoma of Head and Neck	Associate	26639757
Tertiary Lymphoid Structures	Stimulate	35048632
Thyroid Neoplasms	Associate	19536094, 23516535, 27494611
Tn Syndrome	Associate	33753865
Triple Negative Breast Neoplasms	Associate	26542058, 31427441, 32717915, 33753865, 37163498, 37796506
Uterine Cervical Neoplasms	Associate	17504382, 21546870

ESRRA (estrogen related receptor alpha)