ESD (esterase D)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2098
Gene name Gene Name - the full gene name approved by the HGNC.
Esterase D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ESD
Synonyms (NCBI Gene) Gene synonyms aliases
FGH
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q14.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a geneti
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(72)
miRTarBase ID miRNA Experiments Reference
MIRT049564 hsa-miR-92a-3p CLASH 23622248
MIRT045577 hsa-miR-149-5p CLASH 23622248
MIRT043244 hsa-miR-324-5p CLASH 23622248
MIRT041306 hsa-miR-193b-3p CLASH 23622248
MIRT438236 hsa-miR-525-3p Luciferase reporter assay 24147004
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(13)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 31515488, 32296183
GO:0005788 Component Endoplasmic reticulum lumen TAS
GO:0005829 Component Cytosol IBA 21873635
GO:0008150 Process Biological_process ND
GO:0016788 Function Hydrolase activity, acting on ester bonds IDA 19126594
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
133280 3465 ENSG00000139684
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P10768
Protein name S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56)
Protein function Serine hydrolase involved in the detoxification of formaldehyde.
PDB 3FCX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00756 Esterase 23 → 275 Putative esterase Domain
Sequence
Sequence length 282
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Metabolic pathways
Carbon metabolism 		  Glutathione conjugation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 18784066
Show/Hide Text Mining Associations (11)
Associations from Text Mining
Disease Name Relationship Type References
Barrett Esophagus Associate 33491460
Central Nervous System Diseases Associate 21474795
Genetic Diseases Inborn Associate 3462698
Hepatolenticular Degeneration Associate 2563776, 3189332, 3456572, 3462698, 3474893, 3856863
Leukemia Myeloid Acute Associate 24085543
Lupus Erythematosus Systemic Associate 21474795
Multiple Myeloma Associate 33531688
Obesity Associate 16355479
Retinoblastoma Associate 2876425, 3456572, 3462698, 3462714, 3462728, 3620311, 3813643, 6716423
Trisomy 13 Syndrome Stimulate 8213811