Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2098
Gene name Gene Name - the full gene name approved by the HGNC.	Esterase D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ESD
Synonyms (NCBI Gene) Gene synonyms aliases	FGH
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q14.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a geneti

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miRTarBase ID	miRNA	Experiments	Reference
MIRT049564	hsa-miR-92a-3p	CLASH	23622248
MIRT045577	hsa-miR-149-5p	CLASH	23622248
MIRT043244	hsa-miR-324-5p	CLASH	23622248
MIRT041306	hsa-miR-193b-3p	CLASH	23622248
MIRT438236	hsa-miR-525-3p	Luciferase reporter assay	24147004
MIRT438236	hsa-miR-525-3p	Luciferase reporter assay	24147004
MIRT438236	hsa-miR-525-3p	Luciferase reporter assay	24147004
MIRT438236	hsa-miR-525-3p	Luciferase reporter assay	24147004
MIRT637108	hsa-miR-3942-5p	HITS-CLIP	23824327
MIRT637107	hsa-miR-4703-5p	HITS-CLIP	23824327
MIRT618713	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT618712	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT618707	hsa-miR-183-3p	HITS-CLIP	23824327
MIRT618706	hsa-miR-4452	HITS-CLIP	23824327
MIRT618705	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT618704	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT618703	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT618715	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT618714	hsa-miR-4307	HITS-CLIP	23824327
MIRT618713	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT618712	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT618711	hsa-miR-2052	HITS-CLIP	23824327
MIRT618710	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT618709	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT618708	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT618707	hsa-miR-183-3p	HITS-CLIP	23824327
MIRT618706	hsa-miR-4452	HITS-CLIP	23824327
MIRT618705	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT618704	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT618703	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT445438	hsa-miR-5571-5p	PAR-CLIP	22100165
MIRT445437	hsa-miR-589-5p	PAR-CLIP	22100165
MIRT445436	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT445435	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT445434	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT445433	hsa-miR-374c-5p	PAR-CLIP	22100165
MIRT445432	hsa-miR-655-3p	PAR-CLIP	22100165
MIRT445431	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445430	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT637108	hsa-miR-3942-5p	HITS-CLIP	23824327
MIRT637107	hsa-miR-4703-5p	HITS-CLIP	23824327
MIRT618713	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT618712	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT618707	hsa-miR-183-3p	HITS-CLIP	23824327
MIRT618706	hsa-miR-4452	HITS-CLIP	23824327
MIRT618705	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT618704	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT618703	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT618715	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT618714	hsa-miR-4307	HITS-CLIP	23824327
MIRT618713	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT618712	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT618711	hsa-miR-2052	HITS-CLIP	23824327
MIRT618710	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT618709	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT618708	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT618707	hsa-miR-183-3p	HITS-CLIP	23824327
MIRT618706	hsa-miR-4452	HITS-CLIP	23824327
MIRT618705	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT618704	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT618703	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT445438	hsa-miR-5571-5p	PAR-CLIP	22100165
MIRT445437	hsa-miR-589-5p	PAR-CLIP	22100165
MIRT445436	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT445435	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT445434	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT445433	hsa-miR-374c-5p	PAR-CLIP	22100165
MIRT445432	hsa-miR-655-3p	PAR-CLIP	22100165
MIRT445431	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445430	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT970209	hsa-miR-4257	CLIP-seq
MIRT970210	hsa-miR-4272	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005829	Component	Cytosol	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016788	Function	Hydrolase activity, acting on ester bonds	IDA	19126594
GO:0016788	Function	Hydrolase activity, acting on ester bonds	IEA
GO:0018738	Function	S-formylglutathione hydrolase activity	IBA
GO:0018738	Function	S-formylglutathione hydrolase activity	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 31515488, 32296183
GO:0046294	Process	Formaldehyde catabolic process	IEA
GO:0047374	Function	Methylumbelliferyl-acetate deacetylase activity	IEA
GO:0052689	Function	Carboxylic ester hydrolase activity	IEA
GO:0052689	Function	Carboxylic ester hydrolase activity	NAS	3164702
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145

MIM	HGNC	e!Ensembl
133280	3465	ENSG00000139684

Protein

UniProt ID

P10768

Protein name

S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56)

Protein function

Serine hydrolase involved in the detoxification of formaldehyde.

PDB

3FCX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00756	Esterase	23 → 275	Putative esterase	Domain

Sequence

MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYLPPKAETGKCPALYWLSGLTCTEQN
FISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRM
YSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVL
CPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFI
AACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHHAKYLNA

Sequence length

282

Interactions

View interactions

	KEGG		Reactome
	Metabolic pathways Carbon metabolism		Glutathione conjugation

ESD (esterase D)