Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2081
Gene name Gene Name - the full gene name approved by the HGNC.	Endoplasmic reticulum to nucleus signaling 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ERN1
Synonyms (NCBI Gene) Gene synonyms aliases	IRE1, IRE1P, IRE1a, hIRE1p
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of u

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052484	hsa-let-7a-5p	CLASH	23622248
MIRT053104	hsa-miR-199a-5p	Luciferase reporter assay, qRT-PCR, Western blot	23598416
MIRT053105	hsa-miR-1291	GFP reporter assay	23598528
MIRT053105	hsa-miR-1291	GFP reporter assay	23598528
MIRT703869	hsa-miR-3173-3p	HITS-CLIP	23313552
MIRT703868	hsa-miR-6891-5p	HITS-CLIP	23313552
MIRT703867	hsa-miR-302f	HITS-CLIP	23313552
MIRT703866	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT703865	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT703864	hsa-miR-940	HITS-CLIP	23313552
MIRT703863	hsa-miR-3929	HITS-CLIP	23313552
MIRT703862	hsa-miR-4419b	HITS-CLIP	23313552
MIRT703861	hsa-miR-4478	HITS-CLIP	23313552
MIRT703860	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT703859	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT703858	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT441507	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT703857	hsa-miR-1827	HITS-CLIP	23313552
MIRT703856	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT703855	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT703854	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT703853	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT703852	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT703851	hsa-miR-1273e	HITS-CLIP	23313552
MIRT703850	hsa-miR-665	HITS-CLIP	23313552
MIRT615329	hsa-miR-4310	HITS-CLIP	23824327
MIRT615328	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT615327	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT615326	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT615325	hsa-miR-5193	HITS-CLIP	23824327
MIRT615324	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT615323	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT615329	hsa-miR-4310	HITS-CLIP	23824327
MIRT615328	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT615327	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT615326	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT615325	hsa-miR-5193	HITS-CLIP	23824327
MIRT615324	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT615323	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT526817	hsa-miR-490-3p	PAR-CLIP	22012620
MIRT526816	hsa-miR-649	PAR-CLIP	22012620
MIRT526814	hsa-miR-4539	PAR-CLIP	22012620
MIRT526815	hsa-miR-7158-3p	PAR-CLIP	22012620
MIRT441510	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT441509	hsa-miR-451b	PAR-CLIP	22100165
MIRT441508	hsa-miR-1184	PAR-CLIP	22100165
MIRT441507	hsa-miR-219b-3p	PAR-CLIP	22100165
MIRT441506	hsa-miR-103a-3p	PAR-CLIP	22100165
MIRT441505	hsa-miR-107	PAR-CLIP	22100165
MIRT441504	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT703863	hsa-miR-3929	PAR-CLIP	27292025
MIRT703862	hsa-miR-4419b	PAR-CLIP	27292025
MIRT703861	hsa-miR-4478	PAR-CLIP	27292025
MIRT703869	hsa-miR-3173-3p	HITS-CLIP	23313552
MIRT703868	hsa-miR-6891-5p	HITS-CLIP	23313552
MIRT703867	hsa-miR-302f	HITS-CLIP	23313552
MIRT703866	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT703865	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT703864	hsa-miR-940	HITS-CLIP	23313552
MIRT703863	hsa-miR-3929	HITS-CLIP	23313552
MIRT703862	hsa-miR-4419b	HITS-CLIP	23313552
MIRT703861	hsa-miR-4478	HITS-CLIP	23313552
MIRT703860	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT703859	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT703858	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT441507	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT703857	hsa-miR-1827	HITS-CLIP	23313552
MIRT703856	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT703855	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT703854	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT703853	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT703852	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT703851	hsa-miR-1273e	HITS-CLIP	23313552
MIRT703850	hsa-miR-665	HITS-CLIP	23313552
MIRT615329	hsa-miR-4310	HITS-CLIP	23824327
MIRT615328	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT615327	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT615326	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT615325	hsa-miR-5193	HITS-CLIP	23824327
MIRT615324	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT615323	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT615329	hsa-miR-4310	HITS-CLIP	23824327
MIRT615328	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT615327	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT615326	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT615325	hsa-miR-5193	HITS-CLIP	23824327
MIRT615324	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT615323	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT526817	hsa-miR-490-3p	PAR-CLIP	22012620
MIRT526816	hsa-miR-649	PAR-CLIP	22012620
MIRT526814	hsa-miR-4539	PAR-CLIP	22012620
MIRT526815	hsa-miR-7158-3p	PAR-CLIP	22012620
MIRT441510	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT441509	hsa-miR-451b	PAR-CLIP	22100165
MIRT441508	hsa-miR-1184	PAR-CLIP	22100165
MIRT441507	hsa-miR-219b-3p	PAR-CLIP	22100165
MIRT441506	hsa-miR-103a-3p	PAR-CLIP	22100165
MIRT441505	hsa-miR-107	PAR-CLIP	22100165
MIRT441504	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT969644	hsa-miR-1587	CLIP-seq
MIRT969645	hsa-miR-2278	CLIP-seq
MIRT969646	hsa-miR-2467-3p	CLIP-seq
MIRT969647	hsa-miR-3122	CLIP-seq
MIRT969648	hsa-miR-3158-5p	CLIP-seq
MIRT969649	hsa-miR-3614-5p	CLIP-seq
MIRT969650	hsa-miR-3663-5p	CLIP-seq
MIRT969651	hsa-miR-3678-3p	CLIP-seq
MIRT969652	hsa-miR-3909	CLIP-seq
MIRT969653	hsa-miR-3913-5p	CLIP-seq
MIRT969654	hsa-miR-4265	CLIP-seq
MIRT969655	hsa-miR-4296	CLIP-seq
MIRT969656	hsa-miR-4322	CLIP-seq
MIRT969657	hsa-miR-4417	CLIP-seq
MIRT969658	hsa-miR-4492	CLIP-seq
MIRT969659	hsa-miR-4498	CLIP-seq
MIRT969660	hsa-miR-4656	CLIP-seq
MIRT969661	hsa-miR-4675	CLIP-seq
MIRT969662	hsa-miR-4741	CLIP-seq
MIRT969663	hsa-miR-4747-5p	CLIP-seq
MIRT969664	hsa-miR-671-5p	CLIP-seq
MIRT969665	hsa-miR-762	CLIP-seq
MIRT1987436	hsa-miR-3166	CLIP-seq
MIRT1987437	hsa-miR-4731-5p	CLIP-seq
MIRT2221817	hsa-miR-1224-3p	CLIP-seq
MIRT1987436	hsa-miR-3166	CLIP-seq
MIRT2221818	hsa-miR-342-5p	CLIP-seq
MIRT2221819	hsa-miR-3652	CLIP-seq
MIRT2221820	hsa-miR-4430	CLIP-seq
MIRT2221821	hsa-miR-4505	CLIP-seq
MIRT2221822	hsa-miR-4664-5p	CLIP-seq
MIRT1987437	hsa-miR-4731-5p	CLIP-seq
MIRT2221823	hsa-miR-4771	CLIP-seq
MIRT2221824	hsa-miR-637	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
XBP1	Unknown	20513357

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	9637683
GO:0000287	Function	Magnesium ion binding	IEA
GO:0001935	Process	Endothelial cell proliferation	IDA	23529610
GO:0003824	Function	Catalytic activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004521	Function	RNA endonuclease activity	IBA
GO:0004521	Function	RNA endonuclease activity	IDA	9637683, 11779465, 19328063, 20625543, 21317875
GO:0004521	Function	RNA endonuclease activity	IEA
GO:0004540	Function	RNA nuclease activity	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9637683, 21317875
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005161	Function	Platelet-derived growth factor receptor binding	IPI	26315405
GO:0005515	Function	Protein binding	IPI	11278723, 15234121, 18369366, 19135427, 19328063, 20103773, 23529610, 25241761, 25742138, 26551274, 27238082, 28128204, 32814053
GO:0005524	Function	ATP binding	IDA	9637683
GO:0005524	Function	ATP binding	IEA
GO:0005637	Component	Nuclear inner membrane	IEA
GO:0005737	Component	Cytoplasm	IDA	19622636
GO:0005739	Component	Mitochondrion	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	23529610
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	9637683
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0006401	Process	RNA catabolic process	IEA
GO:0006402	Process	MRNA catabolic process	TAS	22013210
GO:0006468	Process	Protein phosphorylation	IDA	9637683
GO:0006915	Process	Apoptotic process	IEA
GO:0006986	Process	Response to unfolded protein	IEA
GO:0010629	Process	Negative regulation of gene expression	IEA
GO:0016020	Component	Membrane	IEA
GO:0016241	Process	Regulation of macroautophagy	TAS	22013210
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019899	Function	Enzyme binding	IPI	23103912
GO:0030544	Function	Hsp70 protein binding	IPI	20625543
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IDA	20625543
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IEA
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0033120	Process	Positive regulation of RNA splicing	IDA	11779464, 19622636
GO:0033120	Process	Positive regulation of RNA splicing	IEA
GO:0034620	Process	Cellular response to unfolded protein	IDA	19328063
GO:0034620	Process	Cellular response to unfolded protein	IMP	20625543, 21317875
GO:0034976	Process	Response to endoplasmic reticulum stress	IDA	10650002
GO:0035924	Process	Cellular response to vascular endothelial growth factor stimulus	IDA	23529610
GO:0036498	Process	IRE1-mediated unfolded protein response	IBA
GO:0036498	Process	IRE1-mediated unfolded protein response	IDA	9637683, 11779465, 19328063, 29198525
GO:0036498	Process	IRE1-mediated unfolded protein response	IEA
GO:0036498	Process	IRE1-mediated unfolded protein response	IMP	28128204
GO:0036498	Process	IRE1-mediated unfolded protein response	TAS	22013210
GO:0042802	Function	Identical protein binding	IPI	12637535, 16973740, 20798350, 21317875
GO:0042803	Function	Protein homodimerization activity	IDA	29198525
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	21317875
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0043531	Function	ADP binding	IDA	21317875
GO:0046330	Process	Positive regulation of JNK cascade	IDA	10650002
GO:0046330	Process	Positive regulation of JNK cascade	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051082	Function	Unfolded protein binding	IBA
GO:0051879	Function	Hsp90 protein binding	IDA	12446770
GO:0070054	Process	MRNA splicing, via endonucleolytic cleavage and ligation	IDA	11779464, 19328063, 19622636, 21317875
GO:0070054	Process	MRNA splicing, via endonucleolytic cleavage and ligation	IMP	20625543, 21317875
GO:0070054	Process	MRNA splicing, via endonucleolytic cleavage and ligation	TAS	22013210
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISS
GO:0070301	Process	Cellular response to hydrogen peroxide	IEA
GO:0071333	Process	Cellular response to glucose stimulus	IDA	20103773
GO:0071333	Process	Cellular response to glucose stimulus	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1900103	Process	Positive regulation of endoplasmic reticulum unfolded protein response	IMP	28128204
GO:1901142	Process	Insulin metabolic process	IDA	20103773
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	IMP	26315405
GO:1905898	Process	Positive regulation of response to endoplasmic reticulum stress	IEA
GO:1990332	Component	Ire1 complex	NAS	19328063
GO:1990597	Component	AIP1-IRE1 complex	IEA
GO:1990604	Component	IRE1-TRAF2-ASK1 complex	IBA
GO:1990604	Component	IRE1-TRAF2-ASK1 complex	IDA	23000344
GO:1990630	Component	IRE1-RACK1-PP2A complex	IDA	20103773

MIM	HGNC	e!Ensembl
604033	3449	ENSG00000178607

Protein

UniProt ID

O75460

Protein name

Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]

Protein function

Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:19328063, PubMed:21317875, PubMed:28128204, P

PDB

2HZ6 , 3P23 , 4U6R , 4YZ9 , 4YZC , 4YZD , 4Z7G , 4Z7H , 5HGI , 6HV0 , 6HX1 , 6SHC , 6URC , 6W39 , 6W3A , 6W3B , 6W3C , 6W3E , 6W3K , 6XDB , 6XDD , 6XDF , 7BMK , 8UVL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	571 → 832	Protein kinase domain	Domain
PF06479	Ribonuc_2-5A	838 → 961	Ribonuclease 2-5A	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. High levels observed in pancreatic tissue. {ECO:0000269|PubMed:9637683}.

Sequence

MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP
VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK
KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF
DYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV
MHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV
HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWL
LIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSR
DVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQ
KELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSG
SSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKR
ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAH
LGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAV
GRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQ
RQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ
FFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL
LRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPY
YFHEPPEPQPPVTPDAL

Sequence length

977

Interactions

View interactions

	KEGG		Reactome
	Autophagy - animal Protein processing in endoplasmic reticulum Apoptosis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Lipid and atherosclerosis		IRE1alpha activates chaperones

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS

Show/Hide Text Mining Associations (100)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acidosis	Stimulate	28134810
Acute Lung Injury	Associate	35812413
Adenocarcinoma of Lung	Associate	28334878, 29676829
Alzheimer Disease	Associate	29725981, 33637690
Amyotrophic Lateral Sclerosis	Associate	29725981
Anophthalmia with pulmonary hypoplasia	Associate	25657029
Arthritis Rheumatoid	Associate	36548354
Autistic Disorder	Associate	29761862
Axial osteomalacia	Associate	34698138
Bipolar Disorder	Associate	39272120
Brain Diseases	Associate	30595371
Breast Neoplasms	Associate	22681620, 32672418, 33291081, 34614512, 36167768
Breast Neoplasms Male	Associate	36167768
Burkitt Lymphoma	Associate	36012375
CADASIL	Associate	36175824
Carcinogenesis	Associate	39352777
Carcinoma Hepatocellular	Associate	20165882, 29921924, 37326827
Carcinoma Non Small Cell Lung	Associate	26549806, 31138775, 32576923
Cardiomegaly	Associate	37219631
Cardiotoxicity	Associate	36111515
Cartilage Diseases	Associate	37907740
Cataract	Stimulate	26091066
Cell Transformation Neoplastic	Stimulate	32418990
Cerebral Small Vessel Diseases	Associate	36175824
Cognitive Dysfunction	Associate	29276149
Colitis Ulcerative	Associate	35185383
Colorectal Neoplasms	Associate	30482246, 31243264, 32323831, 36585626
Cystic Fibrosis	Associate	31428093, 33802742
Death	Associate	23872419, 35367758
Developmental Disabilities	Associate	30595371
Diabetes Mellitus	Associate	33490239
Drug Related Side Effects and Adverse Reactions	Associate	25685256, 31281568, 31524237, 36012375
Drug Related Side Effects and Adverse Reactions	Stimulate	35231164
Glioblastoma	Associate	29311133, 32433555, 32446294, 35367758, 37107600, 37823569, 38563293, 39352777, 39652629, 40073403, 40073406
Glioma	Associate	27560636, 27560795, 28222026, 31734650, 31734653, 32857715, 32857719, 33885249, 33920356, 34020533, 36270342
Glomerulonephritis	Associate	33043579
Graves Ophthalmopathy	Associate	36465658
Hepatitis C	Stimulate	25265476
Hodgkin Disease	Associate	38479365
Holt Oram syndrome	Associate	34818599
Hyperplasia	Associate	19106412
Hypoxia	Associate	27560795, 28222026, 31734650, 32857715, 37107600, 37823569, 38563293, 39352777, 40073403
Hypoxia	Stimulate	28423496
Hypoxia Brain	Associate	27560795, 28222026, 31734650, 37823569, 38563293, 40073403
Idiopathic Pulmonary Fibrosis	Associate	35170357
Immune System Diseases	Associate	31428093
Infections	Stimulate	32418990
Infections	Associate	37306512, 37711626
Inflammation	Associate	31428093, 31793207, 31940218, 33043579, 33802742, 35185383, 35812413, 37654182, 37711626
Inflammation	Stimulate	36835664
Inflammatory Bowel Diseases	Stimulate	22028783
Intervertebral Disc Degeneration	Associate	33833850
Leprosy	Associate	30647798
Leprosy Lepromatous	Associate	30647798
Leprosy Tuberculoid	Stimulate	30647798
Leukemia	Associate	34000298, 34032336
Leukemia Myeloid Acute	Associate	20858700
Liver Cirrhosis	Associate	25265476
Liver Diseases	Stimulate	25265476
Liver Diseases	Associate	36520816
Liver Failure	Associate	29554897
Lymphoma B Cell	Associate	36012375
Lymphoma B Cell Marginal Zone	Associate	35185383
Lymphoma Primary Effusion	Associate	36012375
Melanoma	Associate	25016296, 26018731, 28222747, 30989459
Meningioma	Associate	21317875
Metabolic Diseases	Associate	27560636, 29673059
Mitochondrial Diseases	Associate	24743743, 34895315
Multiple Myeloma	Associate	19755988, 21317875, 21723843, 27634301, 32878237, 36555805, 37566015, 40215234
Myopia	Stimulate	26091066
Myopia	Associate	26351848
Neoplasms	Associate	21746806, 27560636, 27634301, 28222747, 28358375, 29311133, 29440447, 32138264, 32446294, 32576923, 33106375, 34000298, 35253431, 35405004, 36167768, 38479365, 38563293, 40005508 View all (3 more)
Neoplasms	Inhibit	26646564, 36038612
Neurodegenerative Diseases	Associate	30595371, 32531952, 37907740
Non alcoholic Fatty Liver Disease	Associate	29673059
Obesity	Associate	23913943, 37711626
Obesity Maternal	Stimulate	30006153
Oropharyngeal Neoplasms	Associate	30414263, 31187548
Osteoarthritis	Inhibit	27435272
Osteoarthritis	Associate	37907740
Osteoporosis	Stimulate	26091066
Osteoporotic Fractures	Associate	28349059
Ototoxicity	Associate	28388302
Ovarian Neoplasms	Associate	35349489, 35619328
Pancreatic Neoplasms	Associate	37651191
Parkinson Disease	Associate	33637690
Pre Eclampsia	Associate	24931423
Prostatic Neoplasms	Associate	23448667, 28338058
Psychological Distress	Associate	26090483
Pulmonary Fibrosis	Associate	35170357
Respiratory Hypersensitivity	Associate	29467762
Retinitis Pigmentosa	Associate	24664756
Skin Neoplasms	Associate	36167768
Smooth Muscle Tumor	Associate	31940218
Stomach Neoplasms	Associate	37651191
Tooth Loss	Associate	36167768
Triple Negative Breast Neoplasms	Associate	29440447
Urethral Neoplasms	Associate	22438966
Uterine Cervical Neoplasms	Associate	28358375
Zika Virus Infection	Associate	32039055

ERN1 (endoplasmic reticulum to nucleus signaling 1)