Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
208
Gene name Gene Name - the full gene name approved by the HGNC.
AKT serine/threonine kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AKT2
Synonyms (NCBI Gene) Gene synonyms aliases
HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HIHGHH
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of can
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs121434593 C>T Pathogenic Coding sequence variant, missense variant
rs387906659 C>A,T Pathogenic Stop gained, coding sequence variant, missense variant, 5 prime UTR variant
rs778561687 C>A,T Likely-pathogenic Missense variant, coding sequence variant
rs1057519754 T>C Likely-pathogenic Coding sequence variant, intron variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000425 hsa-miR-184 qRT-PCR, Luciferase reporter assay, Western blot 20409325
MIRT006104 hsa-miR-203a-3p Northern blot, qRT-PCR, Western blot 21354697
MIRT006104 hsa-miR-203a-3p Northern blot, qRT-PCR, Western blot 21354697
MIRT006473 hsa-miR-708-5p PC3 22552290
MIRT006473 hsa-miR-708-5p PC3 22552290
Transcription factors
Transcription factor Regulation Reference
NFKB1 Repression 20514445
PROX1 Repression 22982861
RELA Repression 20514445
TWIST1 Activation 21876555;22982861
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001934 Process Positive regulation of protein phosphorylation ISS
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 10983986, 16540465
GO:0004674 Function Protein serine/threonine kinase activity TAS 21432781
GO:0005515 Function Protein binding IPI 10490823, 10983986, 12434148, 16417406, 16792529, 17030088, 19713527, 20059950, 20856200, 21291857, 21737686, 22939624, 23823123, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
164731 392 ENSG00000105221
Protein
UniProt ID P31751
Protein name RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta)
Protein function Serine/threonine kinase closely related to AKT1 and AKT3. All 3 enzymes, AKT1, AKT2 and AKT3, are collectively known as AKT kinase. AKT regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis, through
PDB 1GZK , 1GZN , 1GZO , 1MRV , 1MRY , 1O6K , 1O6L , 1P6S , 2JDO , 2JDR , 2UW9 , 2X39 , 2XH5 , 3D0E , 3E87 , 3E88 , 3E8D , 8Q61 , 9C1W
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH 6 108 PH domain Domain
PF00069 Pkinase 152 409 Protein kinase domain Domain
PF00433 Pkinase_C 430 475 Protein kinase C terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed in myoblasts (PubMed:17565718). {ECO:0000269|PubMed:17565718}.
Sequence
Sequence length 481
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Neutrophil extracellular trap formation
Toll-like receptor signaling pathway
C-type lectin receptor signaling pathway
JAK-STAT signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Neurotrophin signaling pathway
Cholinergic synapse
Dopaminergic synapse
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Relaxin signaling pathway
GnRH secretion
Insulin resistance
Non-alcoholic fatty liver disease
AGE-RAGE signaling pathway in diabetic complications
Growth hormone synthesis, secretion and action
Alcoholic liver disease
Carbohydrate digestion and absorption
Alzheimer disease
Spinocerebellar ataxia
Shigellosis
Salmonella infection
Yersinia infection
Chagas disease
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Human cytomegalovirus infection
Influenza A
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Proteoglycans in cancer
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Diabetic cardiomyopathy
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Activation of AKT2
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
Regulation of PTEN stability and activity
Regulation of localization of FOXO transcription factors
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast adenocarcinoma Breast adenocarcinoma rs28934874, rs112445441, rs121913279, rs121913286, rs104886003, rs121434592
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
19075277
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
19075277
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
16094359, 25157968
Unknown
Disease term Disease name Evidence References Source
Acanthosis nigricans Acanthosis Nigricans ClinVar
Nasopharyngeal carcinoma Nasopharyngeal carcinoma These data suggest that KAT7 can contribute NPC cell growth and survival through up-regulation of NPC-essential genes. 24952746 ClinVar, CBGDA
Diabetes Mellitus diabetes mellitus, noninsulin-dependent, type 2 diabetes mellitus GenCC
Hypoinsulinemic Hypoglycemia And Hemihypertrophy hypoinsulinemic hypoglycemia and body hemihypertrophy GenCC
Associations from Text Mining
Disease Name Relationship Type References
Acanthosis Nigricans Associate 34673243
Acute Disease Associate 21590431
Acute Pain Stimulate 21590431
Adenocarcinoma of Lung Associate 29200198, 30942957, 32211805
Arthritis Rheumatoid Associate 20419126
Breast Neoplasms Associate 14680486, 19933843, 20471940, 21297943, 22809628, 23305873, 23929892, 24838891, 27097161, 27223437, 28478612, 29667444, 31781306, 32558176, 33378961
View all (2 more)
Calcinosis Cutis Associate 27067543
Carcinogenesis Associate 23449277
Carcinoma Basal Cell Associate 22082146, 23435205
Carcinoma Hepatocellular Associate 22580126, 25424347, 26254095