Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2078
Gene name Gene Name - the full gene name approved by the HGNC.
ETS transcription factor ERG
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ERG
Synonyms (NCBI Gene) Gene synonyms aliases
LMPHM14, erg-3, p55
Disease Acronyms (UniProt) Disease acronyms from UniProt database
LMPHM14
Chromosome Chromosome number
21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
21q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apo
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007094 hsa-miR-145-5p Luciferase reporter assay 23480797
MIRT016692 hsa-miR-133b Reporter assay 17344217
MIRT053340 hsa-miR-30a-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 23728339
MIRT053340 hsa-miR-30a-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 23728339
MIRT053341 hsa-miR-30b-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 23728339
Transcription factors
Transcription factor Regulation Reference
ERG Activation 21536859
ETS1 Activation 7731694
ETS2 Activation 7731694
FLI1 Activation 21536859
GATA3 Activation 21536859
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 23093599
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IMP 18195090
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
165080 3446 ENSG00000157554
Protein
UniProt ID P11308
Protein name Transcriptional regulator ERG (Transforming protein ERG)
Protein function Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
PDB 1SXE , 4IRG , 4IRH , 4IRI , 5YBC , 5YBD , 6VGE , 6VGG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02198 SAM_PNT 122 205 Sterile alpha motif (SAM)/Pointed domain Domain
PF00178 Ets 319 398 Ets-domain Domain
Sequence
MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQP
PARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTT
NERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLT
PSYNADILLSHLHYLRETPLPHLTS
DDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEA
TQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTS
SRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNM
NYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQA
LQPHPPESSLYKYPSDLPYMGS
YHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY
Sequence length 479
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Transcriptional misregulation in cancer
Prostate cancer
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Aortic aneurysm Aortic Aneurysm, Abdominal rs1555554098, rs267606902, rs121434526, rs121434527, rs121434528, rs387906592, rs387906781, rs387906782, rs397516685, rs397514037, rs112901682, rs397515325, rs397515330, rs794728025, rs112602953
View all (29 more)
27899403
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)
22843504
Leukemia leukemia, Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2) rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 19108891, 19822134
Lymphoblastic leukemia Childhood Acute Lymphoblastic Leukemia, L2 Acute Lymphoblastic Leukemia, Precursor Cell Lymphoblastic Leukemia Lymphoma rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699
View all (13 more)
27776115
Unknown
Disease term Disease name Evidence References Source
Lymphatic Malformation lymphatic malformation 14 GenCC
Multiple Sclerosis Multiple Sclerosis GWAS
Coronary artery disease Coronary artery disease GWAS
Hypertension Hypertension GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Associate 28111453
Adenocarcinoma Associate 19151660, 19734849, 21499236, 21499238, 21677539, 23686669, 24406865, 26178158, 26331372, 27272561, 28155973, 29949537, 30656528, 32639612, 32649013
View all (4 more)
Adenocarcinoma Stimulate 21317715
Adenocarcinoma of Lung Associate 40453647
Allan Herndon Dudley syndrome Associate 26195723
amyloidosis IX Associate 21178509, 30300367
Anemia Associate 39604843
Aneuploidy Associate 18711181
Aneurysm Ascending Aorta Associate 33017217, 36142762
Aortic Aneurysm Abdominal Associate 31691800, 34930827