Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2072
Gene name	ERCC excision repair 4, endonuclease catalytic subunit
Gene symbol	ERCC4
Synonyms (NCBI Gene)	ERCC11FANCQRAD1XFEPSXPF
Chromosome	16
Chromosome location	16p13.12
Summary	The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5` incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1799802	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	5 prime UTR variant, missense variant, coding sequence variant
rs121913049	C>G,T	Uncertain-significance, pathogenic	Coding sequence variant, missense variant
rs121913050	G>A,C,T	Pathogenic	5 prime UTR variant, missense variant, coding sequence variant, genic upstream transcript variant
rs147105770	C>G,T	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs149364215	C>A,T	Pathogenic	Coding sequence variant, missense variant
rs397509400	CTCAA>-	Pathogenic	Frameshift variant, coding sequence variant
rs397509401	->CTTACACTTCACTTCCCCAGACTACGGA	Pathogenic	Frameshift variant, coding sequence variant
rs397509402	T>C	Pathogenic	Missense variant, 5 prime UTR variant, coding sequence variant, genic upstream transcript variant
rs397509403	T>C	Pathogenic	Missense variant, 5 prime UTR variant, coding sequence variant, genic upstream transcript variant
rs397509404	->A	Pathogenic	Coding sequence variant, stop gained
rs772432152	A>-	Likely-pathogenic	Coding sequence variant, genic upstream transcript variant, frameshift variant, upstream transcript variant
rs869025184	TCTC>-	Pathogenic	Frameshift variant, coding sequence variant
rs1057520104	T>-	Likely-pathogenic	Frameshift variant, 5 prime UTR variant, coding sequence variant, genic upstream transcript variant
rs1555468482	C>-	Pathogenic	Stop gained, coding sequence variant

471

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006456	hsa-miR-192-5p	Luciferase reporter assayqRT-PCRWestern blot	21672525
MIRT006456	hsa-miR-192-5p	Luciferase reporter assayqRT-PCRWestern blot	21672525
MIRT006456	hsa-miR-192-5p	Luciferase reporter assayqRT-PCRWestern blot	21672525
MIRT006456	hsa-miR-192-5p	Luciferase reporter assayqRT-PCRWestern blot	21672525
MIRT006456	hsa-miR-192-5p	Luciferase reporter assayqRT-PCRWestern blot	21672525
MIRT006456	hsa-miR-192-5p	Luciferase reporter assayqRT-PCRWestern blot	21672525
MIRT006456	hsa-miR-192-5p	Microarray	19074876
MIRT073811	hsa-miR-4499	PAR-CLIP	21572407
MIRT504575	hsa-miR-455-5p	PAR-CLIP	21572407
MIRT073810	hsa-miR-4461	PAR-CLIP	21572407
MIRT544923	hsa-miR-873-3p	PAR-CLIP	21572407
MIRT504574	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT504573	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT504572	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT504571	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT504570	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT073803	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT073804	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT073805	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT073816	hsa-miR-548aw	PAR-CLIP	21572407
MIRT073807	hsa-miR-4263	PAR-CLIP	21572407
MIRT073811	hsa-miR-4499	PAR-CLIP	21572407
MIRT504575	hsa-miR-455-5p	PAR-CLIP	21572407
MIRT073810	hsa-miR-4461	PAR-CLIP	21572407
MIRT073809	hsa-miR-4427	PAR-CLIP	21572407
MIRT544923	hsa-miR-873-3p	PAR-CLIP	21572407
MIRT504574	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT504573	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT504572	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT504571	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT504570	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT073803	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT073804	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT073805	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT073816	hsa-miR-548aw	PAR-CLIP	21572407
MIRT073807	hsa-miR-4263	PAR-CLIP	21572407
MIRT073811	hsa-miR-4499	PAR-CLIP	23446348
MIRT504575	hsa-miR-455-5p	PAR-CLIP	23446348
MIRT073810	hsa-miR-4461	PAR-CLIP	23446348
MIRT073809	hsa-miR-4427	PAR-CLIP	23446348
MIRT504574	hsa-miR-548aj-5p	PAR-CLIP	23446348
MIRT504573	hsa-miR-548f-5p	PAR-CLIP	23446348
MIRT504572	hsa-miR-548g-5p	PAR-CLIP	23446348
MIRT504571	hsa-miR-548x-5p	PAR-CLIP	23446348
MIRT504570	hsa-miR-1468-3p	PAR-CLIP	23446348
MIRT073803	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT073804	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT073805	hsa-miR-580-3p	PAR-CLIP	23446348
MIRT073816	hsa-miR-548aw	PAR-CLIP	23446348
MIRT073807	hsa-miR-4263	PAR-CLIP	23446348
MIRT073811	hsa-miR-4499	PAR-CLIP	21572407
MIRT504575	hsa-miR-455-5p	PAR-CLIP	21572407
MIRT073810	hsa-miR-4461	PAR-CLIP	21572407
MIRT544923	hsa-miR-873-3p	PAR-CLIP	21572407
MIRT504574	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT504573	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT504572	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT504571	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT504570	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT073803	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT073804	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT073805	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT073816	hsa-miR-548aw	PAR-CLIP	21572407
MIRT073807	hsa-miR-4263	PAR-CLIP	21572407
MIRT073811	hsa-miR-4499	PAR-CLIP	21572407
MIRT504575	hsa-miR-455-5p	PAR-CLIP	21572407
MIRT073810	hsa-miR-4461	PAR-CLIP	21572407
MIRT073809	hsa-miR-4427	PAR-CLIP	21572407
MIRT544923	hsa-miR-873-3p	PAR-CLIP	21572407
MIRT504574	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT504573	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT504572	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT504571	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT504570	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT073803	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT073804	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT073805	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT073816	hsa-miR-548aw	PAR-CLIP	21572407
MIRT073807	hsa-miR-4263	PAR-CLIP	21572407
MIRT073811	hsa-miR-4499	PAR-CLIP	23446348
MIRT504575	hsa-miR-455-5p	PAR-CLIP	23446348
MIRT073810	hsa-miR-4461	PAR-CLIP	23446348
MIRT073809	hsa-miR-4427	PAR-CLIP	23446348
MIRT504574	hsa-miR-548aj-5p	PAR-CLIP	23446348
MIRT504573	hsa-miR-548f-5p	PAR-CLIP	23446348
MIRT504572	hsa-miR-548g-5p	PAR-CLIP	23446348
MIRT504571	hsa-miR-548x-5p	PAR-CLIP	23446348
MIRT504570	hsa-miR-1468-3p	PAR-CLIP	23446348
MIRT073803	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT073804	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT073805	hsa-miR-580-3p	PAR-CLIP	23446348
MIRT073816	hsa-miR-548aw	PAR-CLIP	23446348
MIRT073807	hsa-miR-4263	PAR-CLIP	23446348
MIRT968400	hsa-miR-1207-3p	CLIP-seq
MIRT968401	hsa-miR-1207-5p	CLIP-seq
MIRT968402	hsa-miR-1228	CLIP-seq
MIRT968403	hsa-miR-1244	CLIP-seq
MIRT968404	hsa-miR-125a-3p	CLIP-seq
MIRT968405	hsa-miR-1262	CLIP-seq
MIRT968406	hsa-miR-1273e	CLIP-seq
MIRT968407	hsa-miR-1285	CLIP-seq
MIRT968408	hsa-miR-1293	CLIP-seq
MIRT968409	hsa-miR-146a	CLIP-seq
MIRT968410	hsa-miR-146b-5p	CLIP-seq
MIRT968411	hsa-miR-1909	CLIP-seq
MIRT968412	hsa-miR-199a-3p	CLIP-seq
MIRT968413	hsa-miR-199b-3p	CLIP-seq
MIRT968414	hsa-miR-205	CLIP-seq
MIRT968415	hsa-miR-300	CLIP-seq
MIRT968416	hsa-miR-3120-5p	CLIP-seq
MIRT968417	hsa-miR-3121-3p	CLIP-seq
MIRT968418	hsa-miR-3125	CLIP-seq
MIRT968419	hsa-miR-3129-5p	CLIP-seq
MIRT968420	hsa-miR-3144-3p	CLIP-seq
MIRT968421	hsa-miR-3145-3p	CLIP-seq
MIRT968422	hsa-miR-3147	CLIP-seq
MIRT968423	hsa-miR-3148	CLIP-seq
MIRT968424	hsa-miR-3162-5p	CLIP-seq
MIRT968425	hsa-miR-3187-5p	CLIP-seq
MIRT968426	hsa-miR-323-5p	CLIP-seq
MIRT968427	hsa-miR-342-5p	CLIP-seq
MIRT968428	hsa-miR-3607-3p	CLIP-seq
MIRT968429	hsa-miR-3613-3p	CLIP-seq
MIRT968430	hsa-miR-3622a-3p	CLIP-seq
MIRT968431	hsa-miR-3622b-3p	CLIP-seq
MIRT968432	hsa-miR-3664-5p	CLIP-seq
MIRT968433	hsa-miR-3665	CLIP-seq
MIRT968434	hsa-miR-3672	CLIP-seq
MIRT968435	hsa-miR-3686	CLIP-seq
MIRT968436	hsa-miR-371-5p	CLIP-seq
MIRT968437	hsa-miR-371b-5p	CLIP-seq
MIRT968438	hsa-miR-378	CLIP-seq
MIRT968439	hsa-miR-378b	CLIP-seq
MIRT968440	hsa-miR-378c	CLIP-seq
MIRT968441	hsa-miR-378d	CLIP-seq
MIRT968442	hsa-miR-378e	CLIP-seq
MIRT968443	hsa-miR-378f	CLIP-seq
MIRT968444	hsa-miR-378h	CLIP-seq
MIRT968445	hsa-miR-378i	CLIP-seq
MIRT968446	hsa-miR-381	CLIP-seq
MIRT968447	hsa-miR-3915	CLIP-seq
MIRT968448	hsa-miR-3916	CLIP-seq
MIRT968449	hsa-miR-3921	CLIP-seq
MIRT968450	hsa-miR-3926	CLIP-seq
MIRT968451	hsa-miR-3928	CLIP-seq
MIRT968452	hsa-miR-422a	CLIP-seq
MIRT968453	hsa-miR-4252	CLIP-seq
MIRT968454	hsa-miR-4266	CLIP-seq
MIRT968455	hsa-miR-4299	CLIP-seq
MIRT968456	hsa-miR-4419a	CLIP-seq
MIRT968457	hsa-miR-4425	CLIP-seq
MIRT968458	hsa-miR-4448	CLIP-seq
MIRT968459	hsa-miR-4456	CLIP-seq
MIRT968460	hsa-miR-4466	CLIP-seq
MIRT968461	hsa-miR-4483	CLIP-seq
MIRT968462	hsa-miR-4510	CLIP-seq
MIRT968463	hsa-miR-4514	CLIP-seq
MIRT968464	hsa-miR-4522	CLIP-seq
MIRT968465	hsa-miR-4530	CLIP-seq
MIRT968466	hsa-miR-4537	CLIP-seq
MIRT968467	hsa-miR-4645-5p	CLIP-seq
MIRT968468	hsa-miR-4653-5p	CLIP-seq
MIRT968469	hsa-miR-4664-5p	CLIP-seq
MIRT968470	hsa-miR-4666-3p	CLIP-seq
MIRT968471	hsa-miR-4673	CLIP-seq
MIRT968472	hsa-miR-4676-5p	CLIP-seq
MIRT968473	hsa-miR-4684-5p	CLIP-seq
MIRT968474	hsa-miR-4692	CLIP-seq
MIRT968475	hsa-miR-4701-3p	CLIP-seq
MIRT968476	hsa-miR-4732-5p	CLIP-seq
MIRT968477	hsa-miR-4736	CLIP-seq
MIRT968478	hsa-miR-4746-3p	CLIP-seq
MIRT968479	hsa-miR-4760-3p	CLIP-seq
MIRT968480	hsa-miR-4763-3p	CLIP-seq
MIRT968481	hsa-miR-4775	CLIP-seq
MIRT968482	hsa-miR-4786-5p	CLIP-seq
MIRT968483	hsa-miR-4789-5p	CLIP-seq
MIRT968484	hsa-miR-4792	CLIP-seq
MIRT968485	hsa-miR-4793-3p	CLIP-seq
MIRT968486	hsa-miR-483-3p	CLIP-seq
MIRT968487	hsa-miR-508-5p	CLIP-seq
MIRT968488	hsa-miR-513a-5p	CLIP-seq
MIRT968489	hsa-miR-544b	CLIP-seq
MIRT968490	hsa-miR-548ae	CLIP-seq
MIRT968491	hsa-miR-548aj	CLIP-seq
MIRT968492	hsa-miR-548am	CLIP-seq
MIRT968493	hsa-miR-548c-3p	CLIP-seq
MIRT968494	hsa-miR-548q	CLIP-seq
MIRT968495	hsa-miR-548s	CLIP-seq
MIRT968496	hsa-miR-548x	CLIP-seq
MIRT968497	hsa-miR-575	CLIP-seq
MIRT968498	hsa-miR-579	CLIP-seq
MIRT968499	hsa-miR-581	CLIP-seq
MIRT968500	hsa-miR-590-3p	CLIP-seq
MIRT968501	hsa-miR-612	CLIP-seq
MIRT968502	hsa-miR-654-3p	CLIP-seq
MIRT968503	hsa-miR-661	CLIP-seq
MIRT968504	hsa-miR-664	CLIP-seq
MIRT968505	hsa-miR-675	CLIP-seq
MIRT968506	hsa-miR-766	CLIP-seq
MIRT968507	hsa-miR-769-5p	CLIP-seq
MIRT968508	hsa-miR-876-3p	CLIP-seq
MIRT968509	hsa-miR-935	CLIP-seq
MIRT968510	hsa-miR-936	CLIP-seq
MIRT968511	hsa-miR-940	CLIP-seq
MIRT968423	hsa-miR-3148	CLIP-seq
MIRT968401	hsa-miR-1207-5p	CLIP-seq
MIRT968403	hsa-miR-1244	CLIP-seq
MIRT1987030	hsa-miR-1270	CLIP-seq
MIRT968407	hsa-miR-1285	CLIP-seq
MIRT968408	hsa-miR-1293	CLIP-seq
MIRT1987031	hsa-miR-185	CLIP-seq
MIRT968411	hsa-miR-1909	CLIP-seq
MIRT968412	hsa-miR-199a-3p	CLIP-seq
MIRT968413	hsa-miR-199b-3p	CLIP-seq
MIRT968415	hsa-miR-300	CLIP-seq
MIRT1987032	hsa-miR-3065-3p	CLIP-seq
MIRT1987033	hsa-miR-3120-3p	CLIP-seq
MIRT968416	hsa-miR-3120-5p	CLIP-seq
MIRT1987034	hsa-miR-3122	CLIP-seq
MIRT968419	hsa-miR-3129-5p	CLIP-seq
MIRT1987035	hsa-miR-3133	CLIP-seq
MIRT1987036	hsa-miR-3145-5p	CLIP-seq
MIRT1987037	hsa-miR-3161	CLIP-seq
MIRT1987038	hsa-miR-3165	CLIP-seq
MIRT968425	hsa-miR-3187-5p	CLIP-seq
MIRT1987039	hsa-miR-335	CLIP-seq
MIRT968427	hsa-miR-342-5p	CLIP-seq
MIRT968430	hsa-miR-3622a-3p	CLIP-seq
MIRT968431	hsa-miR-3622b-3p	CLIP-seq
MIRT968432	hsa-miR-3664-5p	CLIP-seq
MIRT968434	hsa-miR-3672	CLIP-seq
MIRT1987040	hsa-miR-3685	CLIP-seq
MIRT1987041	hsa-miR-3689a-3p	CLIP-seq
MIRT1987042	hsa-miR-3689c	CLIP-seq
MIRT1987043	hsa-miR-369-3p	CLIP-seq
MIRT1987044	hsa-miR-374a	CLIP-seq
MIRT1987045	hsa-miR-374b	CLIP-seq
MIRT968446	hsa-miR-381	CLIP-seq
MIRT1987046	hsa-miR-384	CLIP-seq
MIRT1987047	hsa-miR-3913-5p	CLIP-seq
MIRT968450	hsa-miR-3926	CLIP-seq
MIRT968453	hsa-miR-4252	CLIP-seq
MIRT1987048	hsa-miR-4284	CLIP-seq
MIRT1987049	hsa-miR-4306	CLIP-seq
MIRT1987050	hsa-miR-4321	CLIP-seq
MIRT968456	hsa-miR-4419a	CLIP-seq
MIRT968461	hsa-miR-4483	CLIP-seq
MIRT968462	hsa-miR-4510	CLIP-seq
MIRT968463	hsa-miR-4514	CLIP-seq
MIRT968464	hsa-miR-4522	CLIP-seq
MIRT1987051	hsa-miR-4528	CLIP-seq
MIRT1987052	hsa-miR-4531	CLIP-seq
MIRT968466	hsa-miR-4537	CLIP-seq
MIRT1987053	hsa-miR-4644	CLIP-seq
MIRT968467	hsa-miR-4645-5p	CLIP-seq
MIRT968469	hsa-miR-4664-5p	CLIP-seq
MIRT968471	hsa-miR-4673	CLIP-seq
MIRT968474	hsa-miR-4692	CLIP-seq
MIRT1987054	hsa-miR-4709-3p	CLIP-seq
MIRT1987055	hsa-miR-4728-5p	CLIP-seq
MIRT968478	hsa-miR-4746-3p	CLIP-seq
MIRT1987056	hsa-miR-4761-5p	CLIP-seq
MIRT968480	hsa-miR-4763-3p	CLIP-seq
MIRT1987057	hsa-miR-4773	CLIP-seq
MIRT968481	hsa-miR-4775	CLIP-seq
MIRT968482	hsa-miR-4786-5p	CLIP-seq
MIRT968485	hsa-miR-4793-3p	CLIP-seq
MIRT1987058	hsa-miR-4796-5p	CLIP-seq
MIRT1987059	hsa-miR-499-5p	CLIP-seq
MIRT968487	hsa-miR-508-5p	CLIP-seq
MIRT1987060	hsa-miR-513a-3p	CLIP-seq
MIRT968489	hsa-miR-544b	CLIP-seq
MIRT1987061	hsa-miR-545	CLIP-seq
MIRT968495	hsa-miR-548s	CLIP-seq
MIRT1987062	hsa-miR-563	CLIP-seq
MIRT968500	hsa-miR-590-3p	CLIP-seq
MIRT968501	hsa-miR-612	CLIP-seq
MIRT1987063	hsa-miR-620	CLIP-seq
MIRT968503	hsa-miR-661	CLIP-seq
MIRT968506	hsa-miR-766	CLIP-seq
MIRT968507	hsa-miR-769-5p	CLIP-seq
MIRT1987064	hsa-miR-889	CLIP-seq
MIRT968510	hsa-miR-936	CLIP-seq
MIRT968511	hsa-miR-940	CLIP-seq
MIRT968403	hsa-miR-1244	CLIP-seq
MIRT968404	hsa-miR-125a-3p	CLIP-seq
MIRT2221442	hsa-miR-1276	CLIP-seq
MIRT968407	hsa-miR-1285	CLIP-seq
MIRT968408	hsa-miR-1293	CLIP-seq
MIRT968412	hsa-miR-199a-3p	CLIP-seq
MIRT968413	hsa-miR-199b-3p	CLIP-seq
MIRT2221443	hsa-miR-217	CLIP-seq
MIRT2221444	hsa-miR-2278	CLIP-seq
MIRT2221445	hsa-miR-298	CLIP-seq
MIRT1987032	hsa-miR-3065-3p	CLIP-seq
MIRT1987033	hsa-miR-3120-3p	CLIP-seq
MIRT1987034	hsa-miR-3122	CLIP-seq
MIRT968419	hsa-miR-3129-5p	CLIP-seq
MIRT1987038	hsa-miR-3165	CLIP-seq
MIRT2221446	hsa-miR-3166	CLIP-seq
MIRT968425	hsa-miR-3187-5p	CLIP-seq
MIRT2221447	hsa-miR-338-3p	CLIP-seq
MIRT968430	hsa-miR-3622a-3p	CLIP-seq
MIRT968431	hsa-miR-3622b-3p	CLIP-seq
MIRT2221448	hsa-miR-3622b-5p	CLIP-seq
MIRT968433	hsa-miR-3665	CLIP-seq
MIRT968434	hsa-miR-3672	CLIP-seq
MIRT1987041	hsa-miR-3689a-3p	CLIP-seq
MIRT1987042	hsa-miR-3689c	CLIP-seq
MIRT968436	hsa-miR-371-5p	CLIP-seq
MIRT1987047	hsa-miR-3913-5p	CLIP-seq
MIRT968447	hsa-miR-3915	CLIP-seq
MIRT2221449	hsa-miR-410	CLIP-seq
MIRT968453	hsa-miR-4252	CLIP-seq
MIRT2221450	hsa-miR-4269	CLIP-seq
MIRT1987048	hsa-miR-4284	CLIP-seq
MIRT2221451	hsa-miR-4326	CLIP-seq
MIRT968456	hsa-miR-4419a	CLIP-seq
MIRT2221452	hsa-miR-4438	CLIP-seq
MIRT968460	hsa-miR-4466	CLIP-seq
MIRT2221453	hsa-miR-4476	CLIP-seq
MIRT968461	hsa-miR-4483	CLIP-seq
MIRT968462	hsa-miR-4510	CLIP-seq
MIRT968463	hsa-miR-4514	CLIP-seq
MIRT968465	hsa-miR-4530	CLIP-seq
MIRT968466	hsa-miR-4537	CLIP-seq
MIRT2221454	hsa-miR-4668-3p	CLIP-seq
MIRT2221455	hsa-miR-4690-5p	CLIP-seq
MIRT968474	hsa-miR-4692	CLIP-seq
MIRT2221456	hsa-miR-4698	CLIP-seq
MIRT1987055	hsa-miR-4728-5p	CLIP-seq
MIRT968477	hsa-miR-4736	CLIP-seq
MIRT2221457	hsa-miR-4742-5p	CLIP-seq
MIRT1987056	hsa-miR-4761-5p	CLIP-seq
MIRT2221458	hsa-miR-4762-5p	CLIP-seq
MIRT968482	hsa-miR-4786-5p	CLIP-seq
MIRT968484	hsa-miR-4792	CLIP-seq
MIRT968485	hsa-miR-4793-3p	CLIP-seq
MIRT968487	hsa-miR-508-5p	CLIP-seq
MIRT2221459	hsa-miR-5095	CLIP-seq
MIRT1987060	hsa-miR-513a-3p	CLIP-seq
MIRT968488	hsa-miR-513a-5p	CLIP-seq
MIRT968489	hsa-miR-544b	CLIP-seq
MIRT1987061	hsa-miR-545	CLIP-seq
MIRT2221460	hsa-miR-548k	CLIP-seq
MIRT2221461	hsa-miR-548n	CLIP-seq
MIRT968498	hsa-miR-579	CLIP-seq
MIRT968499	hsa-miR-581	CLIP-seq
MIRT968501	hsa-miR-612	CLIP-seq
MIRT968503	hsa-miR-661	CLIP-seq
MIRT968505	hsa-miR-675	CLIP-seq
MIRT968506	hsa-miR-766	CLIP-seq
MIRT968507	hsa-miR-769-5p	CLIP-seq
MIRT2221462	hsa-miR-922	CLIP-seq
MIRT968510	hsa-miR-936	CLIP-seq
MIRT968511	hsa-miR-940	CLIP-seq
MIRT968403	hsa-miR-1244	CLIP-seq
MIRT2387517	hsa-miR-1272	CLIP-seq
MIRT968408	hsa-miR-1293	CLIP-seq
MIRT2387518	hsa-miR-1322	CLIP-seq
MIRT968412	hsa-miR-199a-3p	CLIP-seq
MIRT968413	hsa-miR-199b-3p	CLIP-seq
MIRT1987034	hsa-miR-3122	CLIP-seq
MIRT968419	hsa-miR-3129-5p	CLIP-seq
MIRT1987038	hsa-miR-3165	CLIP-seq
MIRT968430	hsa-miR-3622a-3p	CLIP-seq
MIRT968431	hsa-miR-3622b-3p	CLIP-seq
MIRT1987041	hsa-miR-3689a-3p	CLIP-seq
MIRT1987042	hsa-miR-3689c	CLIP-seq
MIRT1987047	hsa-miR-3913-5p	CLIP-seq
MIRT968460	hsa-miR-4466	CLIP-seq
MIRT968461	hsa-miR-4483	CLIP-seq
MIRT968463	hsa-miR-4514	CLIP-seq
MIRT968474	hsa-miR-4692	CLIP-seq
MIRT1987055	hsa-miR-4728-5p	CLIP-seq
MIRT1987056	hsa-miR-4761-5p	CLIP-seq
MIRT968489	hsa-miR-544b	CLIP-seq
MIRT968505	hsa-miR-675	CLIP-seq
MIRT968510	hsa-miR-936	CLIP-seq
MIRT968511	hsa-miR-940	CLIP-seq
MIRT2428614	hsa-miR-3607-5p	CLIP-seq
MIRT2428615	hsa-miR-660	CLIP-seq
MIRT2428616	hsa-miR-885-5p	CLIP-seq
MIRT2428617	hsa-miR-888	CLIP-seq
MIRT968407	hsa-miR-1285	CLIP-seq
MIRT968425	hsa-miR-3187-5p	CLIP-seq
MIRT968453	hsa-miR-4252	CLIP-seq
MIRT968455	hsa-miR-4299	CLIP-seq
MIRT968456	hsa-miR-4419a	CLIP-seq
MIRT968459	hsa-miR-4456	CLIP-seq
MIRT968462	hsa-miR-4510	CLIP-seq
MIRT968473	hsa-miR-4684-5p	CLIP-seq
MIRT968485	hsa-miR-4793-3p	CLIP-seq
MIRT968487	hsa-miR-508-5p	CLIP-seq
MIRT968493	hsa-miR-548c-3p	CLIP-seq
MIRT968494	hsa-miR-548q	CLIP-seq
MIRT968501	hsa-miR-612	CLIP-seq
MIRT968503	hsa-miR-661	CLIP-seq
MIRT968506	hsa-miR-766	CLIP-seq
MIRT968407	hsa-miR-1285	CLIP-seq
MIRT968408	hsa-miR-1293	CLIP-seq
MIRT2525069	hsa-miR-1298	CLIP-seq
MIRT968416	hsa-miR-3120-5p	CLIP-seq
MIRT1987034	hsa-miR-3122	CLIP-seq
MIRT968420	hsa-miR-3144-3p	CLIP-seq
MIRT1987038	hsa-miR-3165	CLIP-seq
MIRT968425	hsa-miR-3187-5p	CLIP-seq
MIRT968429	hsa-miR-3613-3p	CLIP-seq
MIRT968430	hsa-miR-3622a-3p	CLIP-seq
MIRT968431	hsa-miR-3622b-3p	CLIP-seq
MIRT968432	hsa-miR-3664-5p	CLIP-seq
MIRT1987041	hsa-miR-3689a-3p	CLIP-seq
MIRT1987042	hsa-miR-3689c	CLIP-seq
MIRT1987043	hsa-miR-369-3p	CLIP-seq
MIRT968436	hsa-miR-371-5p	CLIP-seq
MIRT968437	hsa-miR-371b-5p	CLIP-seq
MIRT1987044	hsa-miR-374a	CLIP-seq
MIRT1987045	hsa-miR-374b	CLIP-seq
MIRT1987047	hsa-miR-3913-5p	CLIP-seq
MIRT968453	hsa-miR-4252	CLIP-seq
MIRT968456	hsa-miR-4419a	CLIP-seq
MIRT968461	hsa-miR-4483	CLIP-seq
MIRT968462	hsa-miR-4510	CLIP-seq
MIRT968464	hsa-miR-4522	CLIP-seq
MIRT1987051	hsa-miR-4528	CLIP-seq
MIRT968473	hsa-miR-4684-5p	CLIP-seq
MIRT2221456	hsa-miR-4698	CLIP-seq
MIRT1987054	hsa-miR-4709-3p	CLIP-seq
MIRT1987055	hsa-miR-4728-5p	CLIP-seq
MIRT968476	hsa-miR-4732-5p	CLIP-seq
MIRT968479	hsa-miR-4760-3p	CLIP-seq
MIRT1987056	hsa-miR-4761-5p	CLIP-seq
MIRT968485	hsa-miR-4793-3p	CLIP-seq
MIRT968487	hsa-miR-508-5p	CLIP-seq
MIRT968489	hsa-miR-544b	CLIP-seq
MIRT968493	hsa-miR-548c-3p	CLIP-seq
MIRT968499	hsa-miR-581	CLIP-seq
MIRT968501	hsa-miR-612	CLIP-seq
MIRT968503	hsa-miR-661	CLIP-seq
MIRT968504	hsa-miR-664	CLIP-seq
MIRT968506	hsa-miR-766	CLIP-seq
MIRT968407	hsa-miR-1285	CLIP-seq
MIRT968416	hsa-miR-3120-5p	CLIP-seq
MIRT968417	hsa-miR-3121-3p	CLIP-seq
MIRT1987034	hsa-miR-3122	CLIP-seq
MIRT968425	hsa-miR-3187-5p	CLIP-seq
MIRT968429	hsa-miR-3613-3p	CLIP-seq
MIRT968432	hsa-miR-3664-5p	CLIP-seq
MIRT1987041	hsa-miR-3689a-3p	CLIP-seq
MIRT1987042	hsa-miR-3689c	CLIP-seq
MIRT1987043	hsa-miR-369-3p	CLIP-seq
MIRT968436	hsa-miR-371-5p	CLIP-seq
MIRT968437	hsa-miR-371b-5p	CLIP-seq
MIRT1987044	hsa-miR-374a	CLIP-seq
MIRT1987045	hsa-miR-374b	CLIP-seq
MIRT1987047	hsa-miR-3913-5p	CLIP-seq
MIRT968453	hsa-miR-4252	CLIP-seq
MIRT968456	hsa-miR-4419a	CLIP-seq
MIRT968462	hsa-miR-4510	CLIP-seq
MIRT968464	hsa-miR-4522	CLIP-seq
MIRT1987051	hsa-miR-4528	CLIP-seq
MIRT1987054	hsa-miR-4709-3p	CLIP-seq
MIRT1987055	hsa-miR-4728-5p	CLIP-seq
MIRT1987056	hsa-miR-4761-5p	CLIP-seq
MIRT968485	hsa-miR-4793-3p	CLIP-seq
MIRT2680254	hsa-miR-494	CLIP-seq
MIRT968487	hsa-miR-508-5p	CLIP-seq
MIRT968501	hsa-miR-612	CLIP-seq
MIRT968503	hsa-miR-661	CLIP-seq
MIRT968506	hsa-miR-766	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
FOS	Activation	20976523

Show/Hide all (57)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000014	Function	Single-stranded DNA endodeoxyribonuclease activity	IBA
GO:0000109	Component	Nucleotide-excision repair complex	IDA	10644440
GO:0000110	Component	Nucleotide-excision repair factor 1 complex	IBA
GO:0000110	Component	Nucleotide-excision repair factor 1 complex	IDA	10413517
GO:0000712	Process	Resolution of meiotic recombination intermediates	IBA
GO:0000723	Process	Telomere maintenance	IGI	17055345
GO:0000723	Process	Telomere maintenance	IMP	14690602
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA
GO:0000724	Process	Double-strand break repair via homologous recombination	IMP	14728600
GO:0000781	Component	Chromosome, telomeric region	IDA	14690602
GO:0001094	Function	TFIID-class transcription factor complex binding	IEA
GO:0003677	Function	DNA binding	IDA	14734547
GO:0003677	Function	DNA binding	IEA
GO:0003684	Function	Damaged DNA binding	IBA
GO:0003684	Function	Damaged DNA binding	IMP	11790111
GO:0003697	Function	Single-stranded DNA binding	IBA
GO:0003697	Function	Single-stranded DNA binding	IDA	10413517
GO:0003697	Function	Single-stranded DNA binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004520	Function	DNA endonuclease activity	IDA	8797827
GO:0004520	Function	DNA endonuclease activity	IDA	10413517, 14734547
GO:0004520	Function	DNA endonuclease activity	IEA
GO:0004520	Function	DNA endonuclease activity	IMP	17055345
GO:0005515	Function	Protein binding	IPI	7559382, 9722633, 12571280, 14690602, 14734547, 16338413, 17055345, 17289582, 18812185, 19595721, 19595722, 19596235, 19596236, 24012755, 24780295, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	12571280
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IGI	17055345
GO:0006281	Process	DNA repair	IMP	19596235
GO:0006289	Process	Nucleotide-excision repair	IDA	10644440
GO:0006289	Process	Nucleotide-excision repair	IDA	10413517, 22547097, 32034146
GO:0006289	Process	Nucleotide-excision repair	IMP	8797827, 11790111, 14728600
GO:0006303	Process	Double-strand break repair via nonhomologous end joining	IMP	14690602
GO:0006974	Process	DNA damage response	IEA
GO:0009411	Process	Response to UV	IEA
GO:0009411	Process	Response to UV	IMP	16678501
GO:0009650	Process	UV protection	IEA
GO:0010506	Process	Regulation of autophagy	IEA
GO:0010521	Function	Telomerase inhibitor activity	IDA	18812185
GO:0016787	Function	Hydrolase activity	IEA
GO:0032205	Process	Negative regulation of telomere maintenance	IMP	17055345
GO:0034644	Process	Cellular response to UV	IDA	32034146
GO:0034644	Process	Cellular response to UV	IGI	17055345
GO:0042802	Function	Identical protein binding	IPI	22483113
GO:0061819	Process	Telomeric DNA-containing double minutes formation	IMP	14690602
GO:0070522	Component	ERCC4-ERCC1 complex	IDA	14690602, 17055345, 32034146
GO:0070522	Component	ERCC4-ERCC1 complex	IPI	16076955
GO:1901255	Process	Nucleotide-excision repair involved in interstrand cross-link repair	IBA
GO:1901255	Process	Nucleotide-excision repair involved in interstrand cross-link repair	IDA	32034146
GO:1904357	Process	Negative regulation of telomere maintenance via telomere lengthening	IDA	18812185
GO:1905765	Process	Negative regulation of protection from non-homologous end joining at telomere	IMP	14690602
GO:1990599	Function	3' overhang single-stranded DNA endodeoxyribonuclease activity	IMP	14690602
GO:1990841	Function	Promoter-specific chromatin binding	IEA

MIM	HGNC	e!Ensembl
133520	3436	ENSG00000175595

Q92889

Protein name

DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein)

Protein function

Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. {ECO:0000269|PubMed:

PDB

1Z00 , 2A1J , 2AQ0 , 2KN7 , 2MUT , 6SXA , 6SXB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02732	ERCC4	686 → 816	ERCC4 domain	Domain

Sequence

MESGQPARRIAMAPLLEYERQLVLELLDTDGLVVCARGLGADRLLYHFLQLHCHPACLVL
VLNTQPAEEEYFINQLKIEGVEHLPRRVTNEITSNSRYEVYTQGGVIFATSRILVVDFLT
DRIPSDLITGILVYRAHRIIESCQEAFILRLFRQKNKRGFIKAFTDNAVAFDTGFCHVER
VMRNLFVRKLYLWPRFHVAVNSFLEQHKPEVVEIHVSMTPTMLAIQTAILDILNACLKEL
KCHNPSLEVEDLSLENAIGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQ
YDCVTFLNLLESLRATEKAFGQNSGWLFLDSSTSMFINARARVYHLPDAKMSKKEKISEK
MEIKEGEETKKELVLESNPKWEALTEVLKEIEAENKESEALGGPGQVLICASDDRTCSQL
RDYITLGAEAFLLRLYRKTFEKDSKAEEVWMKFRKEDSSKRIRKSHKRPKDPQNKERAST
KERTLKKKKRKLTLTQMVGKPEELEEEGDVEEGYRREISSSPESCPEEIKHEEFDVNLSS
DAAFGILKEPLTIIHPLLGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRPG
KPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEEREGRDETNLDLVRGT
ASADVSTDTRKAGGQEQNGTQQSIVVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTP
EMCVERKSISDLIGSLNNGRLYSQCISMSRYYKRPVLLIEFDPSKPFSLTSRGALFQEIS
SNDISSKLTLLTLHFPRLRILWCPSPHATAELFEELKQSKPQPDAATALAITADSETLPE
SEKYNPGPQDFLLKMPGVNAKNCRSLMHHVKNIAELAALSQDELTSILGNAANAKQLYDF
IHTSFAEVVSKGKGKK

Sequence length

916

Interactions

View interactions

	KEGG		Reactome
	Nucleotide excision repair Fanconi anemia pathway		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway

2121

Show/Hide Causal Diseases (13)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Abnormality of blood and blood-forming tissues	Likely pathogenic	rs2141946259	RCV001814342
Autosomal recessive cerebellar ataxia	Likely pathogenic; Pathogenic	rs147105770	RCV005429220
Cockayne syndrome	Likely pathogenic; Pathogenic	rs1314323456, rs774510191, rs779091652, rs753325454, rs762738968, rs1355878901, rs1419167361, rs2543161072, rs900093826, rs1355589374, rs772432152, rs780647908, rs2543161364, rs750971687, rs201179693 View all (12 more)	RCV001377820 RCV001389442 RCV003772149 RCV001869789 RCV001919468 RCV002037756 RCV001917980 RCV003061403 RCV002595685 RCV002909338 RCV001855213 RCV003782518 RCV003797867 RCV003781269 RCV003781677 RCV003780144 RCV003792893 RCV003792676 RCV003817876 RCV000651478 RCV000822020 RCV005213201 RCV001067959 RCV001853034 RCV000700109 RCV001212995 RCV001239295
ERCC4-related disorder	Likely pathogenic; Pathogenic	rs147105770	RCV003415812
ERCC4-Related Disorders	Pathogenic; Likely pathogenic	rs753325454, rs149364215	RCV004782796 RCV004700343
Fanconi anemia complementation group Q	Likely pathogenic; Pathogenic	rs1314323456, rs774510191, rs2141946068, rs779091652, rs753325454, rs587777943, rs762738968, rs1355878901, rs1419167361, rs2543161072, rs900093826, rs1355589374, rs772432152, rs780647908, rs2543161364 View all (16 more)	RCV001377820 RCV001389442 RCV001554280 RCV003772149 RCV001869789 RCV005016423 RCV001919468 RCV002037756 RCV001917980 RCV003061403 RCV002595685 RCV002909338 RCV001855213 RCV003782518 RCV003797867 RCV003781269 RCV003781677 RCV003780144 RCV003792893 RCV003792676 RCV003817876 RCV000651478 RCV000822020 RCV000049244 RCV001067959 RCV000049246 RCV000049247 RCV001853034 RCV000700109 RCV001212995 RCV001239295
Ovarian cancer	Likely pathogenic	rs766652186	RCV003154805
Precursor B-cell acute lymphoblastic leukemia	Pathogenic	rs397509400	RCV000722038
Spastic ataxia	Pathogenic	rs397509404	RCV001646986
Xeroderma pigmentosum	Likely pathogenic; Pathogenic	rs1314323456, rs587777943, rs2543179894, rs2141940032, rs147105770	RCV003226467 RCV002259275 RCV003155758 RCV003226760 RCV002222373
Xeroderma pigmentosum, group F	Likely pathogenic; Pathogenic	rs1314323456, rs774510191, rs779091652, rs753325454, rs587777943, rs762738968, rs1355878901, rs1419167361, rs2543169545, rs2141619663, rs2543161072, rs900093826, rs1355589374, rs772432152, rs780647908 View all (18 more)	RCV001377820 RCV001389442 RCV003772149 RCV001869789 RCV005016423 RCV001919468 RCV002037756 RCV001917980 RCV002288435 RCV002468705 RCV003061403 RCV002595685 RCV002909338 RCV001855213 RCV003782518 RCV003797867 RCV003781269 RCV003781677 RCV003780144 RCV003792893 RCV003792676 RCV003817876 RCV000018047 RCV000651478 RCV000822020 RCV005213201 RCV001067959 RCV001310216 RCV004814985 RCV001853034 RCV000700109 RCV001212995 RCV001239295
Xeroderma pigmentosum, type F/Cockayne syndrome	Likely pathogenic; Pathogenic	rs397509403, rs397509404, rs147105770	RCV000049248 RCV000049249 RCV000049250
XFE progeroid syndrome	Likely pathogenic; Pathogenic	rs587777943, rs772432152, rs780647908, rs201179693, rs1258096180, rs121913050, rs2020959, rs149364215, rs147105770	RCV005016423 RCV005016680 RCV005014968 RCV005014966 RCV005014980 RCV000018049 RCV005021255 RCV005016345 RCV000762956

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Behavioral variant of frontotemporal dementia	Uncertain significance	rs374243778	RCV002508160
Breast carcinoma	Conflicting classifications of pathogenicity	rs121913049	RCV001262417
Carcinoma of pancreas	Conflicting classifications of pathogenicity	rs121913049	RCV001391196
Gastric cancer	Uncertain significance; Benign	rs180919656, rs11075223	RCV005911256 RCV005893425
Growth failure in early childhood	Uncertain significance	rs187435008	RCV006436910
Hepatocellular carcinoma	Uncertain significance	rs148933357	RCV005911022
Hereditary cancer-predisposing syndrome	Benign; Likely benign; Conflicting classifications of pathogenicity	rs1800124, rs4986933, rs1800069, rs1799802, rs146601373, rs41552412, rs1800068, rs201181735	RCV000210773 RCV005251066 RCV005251067 RCV005251068 RCV005251069 RCV005251070 RCV005251071 RCV005251092
Hutchinson-Gilford syndrome	Conflicting classifications of pathogenicity	rs4986933, rs146601373, rs121913049	RCV001034545 RCV001034544 RCV001034542
Malignant tumor of esophagus	-; Conflicting classifications of pathogenicity	rs2543181855, rs145851520	RCV005931090 RCV005896992
Microcephaly	Uncertain significance	rs758565772	RCV001252767
Ovarian serous cystadenocarcinoma	Uncertain significance	rs1261870926	RCV005899861
Sarcoma	Uncertain significance; Benign	rs180919656, rs11075223	RCV005911255 RCV005893424
Uterine carcinosarcoma	Benign	rs11075223	RCV005893426
Uterine corpus endometrial carcinoma	Likely benign	rs112309788	RCV005919317

Show/Hide Text Mining Associations (79)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	29739952, 37006075
Adenocarcinoma of Lung	Associate	19297315
Anemia Hemolytic	Associate	32111838
Atherosclerosis	Associate	36071684
Bovine Respiratory Disease Complex	Associate	30165384
Breast Diseases	Associate	19124519
Breast Neoplasms	Associate	18551366, 18701435, 19124519, 19423537, 19920816, 21622940, 21700777, 23852586, 23909490, 24465539, 31499327, 33067872
Breast Neoplasms	Inhibit	23852586
Carcinoma Acinar Cell	Associate	33202356
Carcinoma Adenoid Cystic	Associate	33202356
Carcinoma Hepatocellular	Associate	26967386
Carcinoma Mucoepidermoid	Associate	33202356
Carcinoma Non Small Cell Lung	Stimulate	17118488
Carcinoma Non Small Cell Lung	Associate	26045829, 33422766, 33827099, 38279246
Carcinoma Non Small Cell Lung	Inhibit	32344513
Carcinoma Pancreatic Ductal	Associate	36409970
Carcinoma Squamous Cell	Associate	32901726
Carotid Stenosis	Associate	36071684
Cockayne Syndrome	Associate	23623389, 29105242, 29325523, 30165384, 30658521, 34096589
Colorectal Neoplasms	Associate	29568775, 31568607
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	30658521
Death	Associate	24793015, 26427666, 37798436
DNA Virus Infections	Associate	30658521
Drug Hypersensitivity	Associate	23982883
Drug Related Side Effects and Adverse Reactions	Associate	20418188, 21452186
Esophageal Neoplasms	Associate	24709955
Esophageal Squamous Cell Carcinoma	Associate	24709955
Fanconi Anemia	Associate	23623386, 23623389, 24351291, 24465539, 29105242, 29325523, 30658521
Gastrointestinal Stromal Tumors	Associate	27460091
Glioma	Associate	23991957, 24634177, 24938470
Granulosa cell tumor of the ovary	Associate	31906898
Head and Neck Neoplasms	Associate	23720401, 24487794, 25019640
Helicobacter Infections	Associate	23679285
Hereditary Sensory and Autonomic Neuropathies	Associate	25340731
Heredodegenerative Disorders Nervous System	Associate	9579555
Hypertension	Associate	31924810
Keratosis Actinic	Associate	24636351
Leukemia Lymphoma Adult T Cell	Associate	33649200
Leukemia Myeloid Acute	Associate	26779634, 32868804
Lung Neoplasms	Associate	19887610, 28464886, 32344513, 37006075
Margins of Excision	Associate	26085086, 30658521, 31499327, 39523403
Melanoma	Associate	23659246, 23982883
Melanoma Cutaneous Malignant	Associate	26427666
Meningioma	Stimulate	20150366
Meningioma	Associate	20150366
Myelodysplastic Syndromes	Associate	28472728
Neoplasms	Associate	18544627, 19124519, 19723666, 21452186, 21677381, 21737503, 22848636, 24318989, 24662920, 24709955, 24793015, 25634215, 26427666, 28878254, 31924810, 32901726, 33422766, 37798436 View all (3 more)
Neoplasms	Stimulate	22460090, 28464886
Neuroblastoma	Associate	29544698
Neurologic Manifestations	Associate	9579555
Neuroma Acoustic	Associate	20150366
Neutropenia	Associate	25340731
Oculocerebral hypopigmentation syndrome type Preus	Associate	14728600
Oculocerebrorenal Syndrome	Associate	26085086
Oropharyngeal Neoplasms	Associate	22848636
Osteogenesis Imperfecta	Associate	35052464
Osteosarcoma	Associate	36271359
Pancreatic Neoplasms	Inhibit	18544627
Pancreatic Neoplasms	Associate	18544627, 39256447
Postoperative Nausea and Vomiting	Associate	37924126
Progeria	Associate	30658521
Progeroid syndrome neonatal	Associate	29105242
Prostatic Neoplasms	Associate	27974699
Q Fever	Associate	24465539
Renal Insufficiency Chronic	Associate	31924810
Salivary Gland Neoplasms	Associate	33202356
Sarcoma	Associate	28878254, 34308104
Small Cell Lung Carcinoma	Associate	37006075
Smoke Inhalation Injury	Associate	23720401
Squamous Cell Carcinoma of Head and Neck	Associate	21737503, 22848636, 24064970, 25019640, 32901726, 40076972
Stomach Neoplasms	Associate	23166636, 23679285, 24318989, 24793015, 27340861, 28415781, 30417012
Sunburn	Associate	30665703
Triple Negative Breast Neoplasms	Associate	21138871
Urinary Bladder Neoplasms	Associate	22460090, 25535740, 27862976
Vomiting	Associate	28686330
Xeroderma Pigmentosum	Associate	18470933, 18927284, 21388382, 23623386, 23623389, 28130555, 29325523, 30165384, 30516811, 30658521, 30665703, 32111838, 37364129, 9579555
Xeroderma Pigmentosum B Cockayne Syndrome	Associate	30658521
Xeroderma Pigmentosum Complementation Group F	Associate	23909490, 26085086, 26681190
XFE Progeroid Syndrome	Associate	23623386, 29105242, 30658521

ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit)