Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2065
Gene name	Erb-b2 receptor tyrosine kinase 3
Gene symbol	ERBB3
Synonyms (NCBI Gene)	ErbB-3FERLKHER3LCCS2MDA-BF-1VSCN1c-erbB-3c-erbB3erbB3-Sp180-ErbB3p45-sErbB3p85-sErbB3
Chromosome	12
Chromosome location	12q13.2
Summary	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey th

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SNP ID	Visualize variation	Clinical significance	Consequence
rs755855285	G>A	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs931676601	A>G,T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1057519169	G>A	Likely-pathogenic	Splice donor variant, genic downstream transcript variant
rs1057519803	G>A	Likely-pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs1057519817	C>A,G	Likely-pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs1057519891	G>A,T	Likely-pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs1057519892	A>T	Likely-pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs1057519893	G>A,T	Likely-pathogenic	Missense variant, coding sequence variant
rs1592232580	C>T	Likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant

593

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003659	hsa-miR-205-5p	Luciferase reporter assay	19238171
MIRT003659	hsa-miR-205-5p	Review	20026422
MIRT003659	hsa-miR-205-5p	Luciferase reporter assay	20065103
MIRT005117	hsa-miR-125a-5p	Luciferase reporter assayNorthern blotqRT-PCRWestern blot	17110380
MIRT005117	hsa-miR-125a-5p	Luciferase reporter assayNorthern blotqRT-PCRWestern blot	17110380
MIRT002938	hsa-miR-125b-5p	Luciferase reporter assayNorthern blotqRT-PCRWestern blot	17110380
MIRT002938	hsa-miR-125b-5p	Luciferase reporter assayNorthern blotqRT-PCRWestern blot	17110380
MIRT003659	hsa-miR-205-5p	Luciferase reporter assayqRT-PCRWestern blot	19276373
MIRT003659	hsa-miR-205-5p	Luciferase reporter assayqRT-PCRWestern blot	19276373
MIRT005117	hsa-miR-125a-5p	Luciferase reporter assayMicroarrayWestern blot	20864407
MIRT003659	hsa-miR-205-5p	Luciferase reporter assayMicroarrayWestern blot	20864407
MIRT006210	hsa-miR-22-3p	Luciferase reporter assayqRT-PCRWestern blot	22484852
MIRT006210	hsa-miR-22-3p	Luciferase reporter assayqRT-PCRWestern blot	22484852
MIRT006210	hsa-miR-22-3p	Luciferase reporter assayqRT-PCRWestern blot	22484852
MIRT005117	hsa-miR-125a-5p	Western blot	17110380
MIRT005117	hsa-miR-125a-5p	Northern blot	17110380
MIRT003659	hsa-miR-205-5p	Reporter assay;Other	19238171
MIRT030589	hsa-miR-24-3p	Microarray	19748357
MIRT053607	hsa-miR-199a-5p	ImmunoblotImmunohistochemistryLuciferase reporter assayqRT-PCR	23146892
MIRT002938	hsa-miR-125b-5p	ImmunoblotImmunohistochemistryLuciferase reporter assayqRT-PCR	23146892
MIRT053647	hsa-miR-143-3p	Microarray	22942087
MIRT005117	hsa-miR-125a-5p	Western blotqRT-PCR	23519125
MIRT002938	hsa-miR-125b-5p	Western blotqRT-PCR	23519125
MIRT003659	hsa-miR-205-5p	Western blotqRT-PCR	23519125
MIRT719396	hsa-miR-323b-3p	HITS-CLIP	19536157
MIRT719395	hsa-miR-5701	HITS-CLIP	19536157
MIRT719394	hsa-miR-301a-5p	HITS-CLIP	19536157
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	19536157
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	19536157
MIRT615961	hsa-miR-331-3p	HITS-CLIP	19536157
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	19536157
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	19536157
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT630919	hsa-miR-4328	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT030589	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630919	hsa-miR-4328	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT630919	hsa-miR-4328	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT537657	hsa-miR-548e-5p	PAR-CLIP	22012620
MIRT065971	hsa-miR-6507-5p	PAR-CLIP	22012620
MIRT537656	hsa-miR-7109-3p	PAR-CLIP	22012620
MIRT065956	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT537655	hsa-miR-8063	PAR-CLIP	22012620
MIRT065968	hsa-miR-4698	PAR-CLIP	22012620
MIRT537654	hsa-miR-597-5p	PAR-CLIP	22012620
MIRT065961	hsa-miR-592	PAR-CLIP	22012620
MIRT065963	hsa-miR-2113	PAR-CLIP	22012620
MIRT737332	hsa-miR-17-5p	Western blottingImmunoprecipitaion (IP)RNA-seqqRT-PCRIn situ hybridizationELISA	32206115
MIRT737333	hsa-miR-20a-5p	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)RNA-seqqRT-PCRELISA	32206115
MIRT719396	hsa-miR-323b-3p	HITS-CLIP	19536157
MIRT719395	hsa-miR-5701	HITS-CLIP	19536157
MIRT719394	hsa-miR-301a-5p	HITS-CLIP	19536157
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	19536157
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	19536157
MIRT615961	hsa-miR-331-3p	HITS-CLIP	19536157
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	19536157
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	19536157
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT630919	hsa-miR-4328	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT030589	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630919	hsa-miR-4328	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT630919	hsa-miR-4328	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615963	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT615962	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT615961	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT615960	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615959	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615958	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT615957	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT615956	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT537657	hsa-miR-548e-5p	PAR-CLIP	22012620
MIRT065971	hsa-miR-6507-5p	PAR-CLIP	22012620
MIRT537656	hsa-miR-7109-3p	PAR-CLIP	22012620
MIRT065956	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT537655	hsa-miR-8063	PAR-CLIP	22012620
MIRT065968	hsa-miR-4698	PAR-CLIP	22012620
MIRT537654	hsa-miR-597-5p	PAR-CLIP	22012620
MIRT065961	hsa-miR-592	PAR-CLIP	22012620
MIRT065963	hsa-miR-2113	PAR-CLIP	22012620
MIRT967893	hsa-miR-106a	CLIP-seq
MIRT967894	hsa-miR-106b	CLIP-seq
MIRT967895	hsa-miR-1207-3p	CLIP-seq
MIRT967896	hsa-miR-1237	CLIP-seq
MIRT967897	hsa-miR-124	CLIP-seq
MIRT967898	hsa-miR-1248	CLIP-seq
MIRT967899	hsa-miR-1253	CLIP-seq
MIRT967900	hsa-miR-1255a	CLIP-seq
MIRT967901	hsa-miR-1255b	CLIP-seq
MIRT967902	hsa-miR-1257	CLIP-seq
MIRT967903	hsa-miR-125b	CLIP-seq
MIRT967904	hsa-miR-127-5p	CLIP-seq
MIRT967905	hsa-miR-1287	CLIP-seq
MIRT967906	hsa-miR-1290	CLIP-seq
MIRT967907	hsa-miR-1301	CLIP-seq
MIRT967908	hsa-miR-1343	CLIP-seq
MIRT967909	hsa-miR-135a	CLIP-seq
MIRT967910	hsa-miR-135b	CLIP-seq
MIRT967911	hsa-miR-143	CLIP-seq
MIRT967912	hsa-miR-17	CLIP-seq
MIRT967913	hsa-miR-204	CLIP-seq
MIRT967914	hsa-miR-20a	CLIP-seq
MIRT967915	hsa-miR-20b	CLIP-seq
MIRT967916	hsa-miR-211	CLIP-seq
MIRT967917	hsa-miR-2110	CLIP-seq
MIRT967918	hsa-miR-22	CLIP-seq
MIRT967919	hsa-miR-221	CLIP-seq
MIRT967920	hsa-miR-222	CLIP-seq
MIRT967921	hsa-miR-2355-5p	CLIP-seq
MIRT967922	hsa-miR-24	CLIP-seq
MIRT967923	hsa-miR-27a	CLIP-seq
MIRT967924	hsa-miR-27b	CLIP-seq
MIRT967925	hsa-miR-302a	CLIP-seq
MIRT967926	hsa-miR-302b	CLIP-seq
MIRT967927	hsa-miR-302c	CLIP-seq
MIRT967928	hsa-miR-302d	CLIP-seq
MIRT967929	hsa-miR-302e	CLIP-seq
MIRT967930	hsa-miR-3074-5p	CLIP-seq
MIRT967931	hsa-miR-3124-3p	CLIP-seq
MIRT967932	hsa-miR-3135b	CLIP-seq
MIRT967933	hsa-miR-3150a-3p	CLIP-seq
MIRT967934	hsa-miR-3153	CLIP-seq
MIRT967935	hsa-miR-3157-3p	CLIP-seq
MIRT967936	hsa-miR-3170	CLIP-seq
MIRT967937	hsa-miR-320e	CLIP-seq
MIRT967938	hsa-miR-324-5p	CLIP-seq
MIRT967939	hsa-miR-331-5p	CLIP-seq
MIRT967940	hsa-miR-345	CLIP-seq
MIRT967941	hsa-miR-3605-5p	CLIP-seq
MIRT967942	hsa-miR-3611	CLIP-seq
MIRT967943	hsa-miR-362-5p	CLIP-seq
MIRT967944	hsa-miR-3681	CLIP-seq
MIRT967945	hsa-miR-3690	CLIP-seq
MIRT967946	hsa-miR-3691-5p	CLIP-seq
MIRT967947	hsa-miR-372	CLIP-seq
MIRT967948	hsa-miR-373	CLIP-seq
MIRT967949	hsa-miR-3944-5p	CLIP-seq
MIRT967950	hsa-miR-412	CLIP-seq
MIRT967951	hsa-miR-4254	CLIP-seq
MIRT967952	hsa-miR-4256	CLIP-seq
MIRT967953	hsa-miR-4266	CLIP-seq
MIRT967954	hsa-miR-4278	CLIP-seq
MIRT967955	hsa-miR-4290	CLIP-seq
MIRT967956	hsa-miR-4319	CLIP-seq
MIRT967957	hsa-miR-4425	CLIP-seq
MIRT967958	hsa-miR-4438	CLIP-seq
MIRT967959	hsa-miR-4450	CLIP-seq
MIRT967960	hsa-miR-4477b	CLIP-seq
MIRT967961	hsa-miR-4484	CLIP-seq
MIRT967962	hsa-miR-4491	CLIP-seq
MIRT967963	hsa-miR-4503	CLIP-seq
MIRT967964	hsa-miR-4509	CLIP-seq
MIRT967965	hsa-miR-450b-5p	CLIP-seq
MIRT967966	hsa-miR-4640-3p	CLIP-seq
MIRT967967	hsa-miR-4657	CLIP-seq
MIRT967968	hsa-miR-4659a-3p	CLIP-seq
MIRT967969	hsa-miR-4659b-3p	CLIP-seq
MIRT967970	hsa-miR-4660	CLIP-seq
MIRT967971	hsa-miR-4661-5p	CLIP-seq
MIRT967972	hsa-miR-4663	CLIP-seq
MIRT967973	hsa-miR-4668-5p	CLIP-seq
MIRT967974	hsa-miR-4678	CLIP-seq
MIRT967975	hsa-miR-4695-5p	CLIP-seq
MIRT967976	hsa-miR-4699-5p	CLIP-seq
MIRT967977	hsa-miR-4708-5p	CLIP-seq
MIRT967978	hsa-miR-4713-3p	CLIP-seq
MIRT967979	hsa-miR-4716-3p	CLIP-seq
MIRT967980	hsa-miR-4729	CLIP-seq
MIRT967981	hsa-miR-4732-3p	CLIP-seq
MIRT967982	hsa-miR-4744	CLIP-seq
MIRT967983	hsa-miR-4752	CLIP-seq
MIRT967984	hsa-miR-4753-3p	CLIP-seq
MIRT967985	hsa-miR-4755-5p	CLIP-seq
MIRT967986	hsa-miR-4769-3p	CLIP-seq
MIRT967987	hsa-miR-4770	CLIP-seq
MIRT967988	hsa-miR-4779	CLIP-seq
MIRT967989	hsa-miR-4790-3p	CLIP-seq
MIRT967990	hsa-miR-4793-5p	CLIP-seq
MIRT967991	hsa-miR-4794	CLIP-seq
MIRT967992	hsa-miR-4796-3p	CLIP-seq
MIRT967993	hsa-miR-4799-5p	CLIP-seq
MIRT967994	hsa-miR-500b	CLIP-seq
MIRT967995	hsa-miR-5047	CLIP-seq
MIRT967996	hsa-miR-506	CLIP-seq
MIRT967997	hsa-miR-507	CLIP-seq
MIRT967998	hsa-miR-5095	CLIP-seq
MIRT967999	hsa-miR-511	CLIP-seq
MIRT968000	hsa-miR-512-3p	CLIP-seq
MIRT968001	hsa-miR-513a-5p	CLIP-seq
MIRT968002	hsa-miR-519a	CLIP-seq
MIRT968003	hsa-miR-519b-3p	CLIP-seq
MIRT968004	hsa-miR-519c-3p	CLIP-seq
MIRT968005	hsa-miR-519d	CLIP-seq
MIRT968006	hsa-miR-520a-3p	CLIP-seq
MIRT968007	hsa-miR-520b	CLIP-seq
MIRT968008	hsa-miR-520c-3p	CLIP-seq
MIRT968009	hsa-miR-520d-3p	CLIP-seq
MIRT968010	hsa-miR-520e	CLIP-seq
MIRT968011	hsa-miR-548al	CLIP-seq
MIRT968012	hsa-miR-548an	CLIP-seq
MIRT968013	hsa-miR-548n	CLIP-seq
MIRT968014	hsa-miR-548t	CLIP-seq
MIRT968015	hsa-miR-557	CLIP-seq
MIRT968016	hsa-miR-580	CLIP-seq
MIRT968017	hsa-miR-584	CLIP-seq
MIRT968018	hsa-miR-597	CLIP-seq
MIRT968019	hsa-miR-599	CLIP-seq
MIRT968020	hsa-miR-623	CLIP-seq
MIRT968021	hsa-miR-635	CLIP-seq
MIRT968022	hsa-miR-670	CLIP-seq
MIRT968023	hsa-miR-874	CLIP-seq
MIRT968024	hsa-miR-93	CLIP-seq
MIRT1922720	hsa-miR-561	CLIP-seq
MIRT967893	hsa-miR-106a	CLIP-seq
MIRT967894	hsa-miR-106b	CLIP-seq
MIRT1986755	hsa-miR-1200	CLIP-seq
MIRT967896	hsa-miR-1237	CLIP-seq
MIRT1986756	hsa-miR-1238	CLIP-seq
MIRT1986757	hsa-miR-1245	CLIP-seq
MIRT1986758	hsa-miR-1271	CLIP-seq
MIRT1986759	hsa-miR-1285	CLIP-seq
MIRT967906	hsa-miR-1290	CLIP-seq
MIRT967911	hsa-miR-143	CLIP-seq
MIRT1986760	hsa-miR-145	CLIP-seq
MIRT1986761	hsa-miR-150	CLIP-seq
MIRT967912	hsa-miR-17	CLIP-seq
MIRT1986762	hsa-miR-198	CLIP-seq
MIRT967913	hsa-miR-204	CLIP-seq
MIRT1986763	hsa-miR-205	CLIP-seq
MIRT967914	hsa-miR-20a	CLIP-seq
MIRT967915	hsa-miR-20b	CLIP-seq
MIRT967916	hsa-miR-211	CLIP-seq
MIRT1986764	hsa-miR-219-2-3p	CLIP-seq
MIRT967922	hsa-miR-24	CLIP-seq
MIRT967925	hsa-miR-302a	CLIP-seq
MIRT967926	hsa-miR-302b	CLIP-seq
MIRT967927	hsa-miR-302c	CLIP-seq
MIRT967928	hsa-miR-302d	CLIP-seq
MIRT967929	hsa-miR-302e	CLIP-seq
MIRT1986765	hsa-miR-3120-5p	CLIP-seq
MIRT967931	hsa-miR-3124-3p	CLIP-seq
MIRT1986766	hsa-miR-3130-3p	CLIP-seq
MIRT1986767	hsa-miR-3130-5p	CLIP-seq
MIRT967934	hsa-miR-3153	CLIP-seq
MIRT1986768	hsa-miR-3182	CLIP-seq
MIRT1986769	hsa-miR-3187-5p	CLIP-seq
MIRT967938	hsa-miR-324-5p	CLIP-seq
MIRT1986770	hsa-miR-338-5p	CLIP-seq
MIRT1986771	hsa-miR-3675-3p	CLIP-seq
MIRT1986772	hsa-miR-3689a-3p	CLIP-seq
MIRT1986773	hsa-miR-3689c	CLIP-seq
MIRT967945	hsa-miR-3690	CLIP-seq
MIRT967947	hsa-miR-372	CLIP-seq
MIRT967948	hsa-miR-373	CLIP-seq
MIRT1986774	hsa-miR-378g	CLIP-seq
MIRT1986775	hsa-miR-3925-3p	CLIP-seq
MIRT1986776	hsa-miR-4252	CLIP-seq
MIRT967951	hsa-miR-4254	CLIP-seq
MIRT1986777	hsa-miR-4276	CLIP-seq
MIRT1986778	hsa-miR-4277	CLIP-seq
MIRT1986779	hsa-miR-4287	CLIP-seq
MIRT1986780	hsa-miR-4314	CLIP-seq
MIRT1986781	hsa-miR-4324	CLIP-seq
MIRT1986782	hsa-miR-4433	CLIP-seq
MIRT1986783	hsa-miR-4437	CLIP-seq
MIRT967958	hsa-miR-4438	CLIP-seq
MIRT1986784	hsa-miR-4464	CLIP-seq
MIRT967960	hsa-miR-4477b	CLIP-seq
MIRT1986785	hsa-miR-4482	CLIP-seq
MIRT1986786	hsa-miR-4486	CLIP-seq
MIRT1986787	hsa-miR-4502	CLIP-seq
MIRT967963	hsa-miR-4503	CLIP-seq
MIRT967965	hsa-miR-450b-5p	CLIP-seq
MIRT967966	hsa-miR-4640-3p	CLIP-seq
MIRT1986788	hsa-miR-4645-3p	CLIP-seq
MIRT1986789	hsa-miR-4674	CLIP-seq
MIRT1986790	hsa-miR-4685-3p	CLIP-seq
MIRT1986791	hsa-miR-4691-5p	CLIP-seq
MIRT967977	hsa-miR-4708-5p	CLIP-seq
MIRT1986792	hsa-miR-4720-3p	CLIP-seq
MIRT1986793	hsa-miR-4728-5p	CLIP-seq
MIRT1986794	hsa-miR-4735-5p	CLIP-seq
MIRT1986795	hsa-miR-4748	CLIP-seq
MIRT967984	hsa-miR-4753-3p	CLIP-seq
MIRT967985	hsa-miR-4755-5p	CLIP-seq
MIRT967987	hsa-miR-4770	CLIP-seq
MIRT1986796	hsa-miR-4775	CLIP-seq
MIRT1986797	hsa-miR-4778-3p	CLIP-seq
MIRT967990	hsa-miR-4793-5p	CLIP-seq
MIRT1986798	hsa-miR-4804-3p	CLIP-seq
MIRT1986799	hsa-miR-500a	CLIP-seq
MIRT967997	hsa-miR-507	CLIP-seq
MIRT967998	hsa-miR-5095	CLIP-seq
MIRT967999	hsa-miR-511	CLIP-seq
MIRT968000	hsa-miR-512-3p	CLIP-seq
MIRT968002	hsa-miR-519a	CLIP-seq
MIRT968003	hsa-miR-519b-3p	CLIP-seq
MIRT968004	hsa-miR-519c-3p	CLIP-seq
MIRT968005	hsa-miR-519d	CLIP-seq
MIRT968006	hsa-miR-520a-3p	CLIP-seq
MIRT968007	hsa-miR-520b	CLIP-seq
MIRT968008	hsa-miR-520c-3p	CLIP-seq
MIRT968009	hsa-miR-520d-3p	CLIP-seq
MIRT968010	hsa-miR-520e	CLIP-seq
MIRT1986800	hsa-miR-520g	CLIP-seq
MIRT1986801	hsa-miR-520h	CLIP-seq
MIRT1986802	hsa-miR-526b	CLIP-seq
MIRT1986803	hsa-miR-544b	CLIP-seq
MIRT1986804	hsa-miR-548ae	CLIP-seq
MIRT1986805	hsa-miR-548aj	CLIP-seq
MIRT1986806	hsa-miR-548am	CLIP-seq
MIRT1986807	hsa-miR-548x	CLIP-seq
MIRT968015	hsa-miR-557	CLIP-seq
MIRT968019	hsa-miR-599	CLIP-seq
MIRT1986808	hsa-miR-612	CLIP-seq
MIRT1986809	hsa-miR-622	CLIP-seq
MIRT968020	hsa-miR-623	CLIP-seq
MIRT1986810	hsa-miR-665	CLIP-seq
MIRT1986811	hsa-miR-766	CLIP-seq
MIRT968024	hsa-miR-93	CLIP-seq
MIRT1986812	hsa-miR-96	CLIP-seq
MIRT967893	hsa-miR-106a	CLIP-seq
MIRT967894	hsa-miR-106b	CLIP-seq
MIRT967895	hsa-miR-1207-3p	CLIP-seq
MIRT967896	hsa-miR-1237	CLIP-seq
MIRT967897	hsa-miR-124	CLIP-seq
MIRT967898	hsa-miR-1248	CLIP-seq
MIRT967899	hsa-miR-1253	CLIP-seq
MIRT2221329	hsa-miR-1256	CLIP-seq
MIRT1986758	hsa-miR-1271	CLIP-seq
MIRT967906	hsa-miR-1290	CLIP-seq
MIRT967911	hsa-miR-143	CLIP-seq
MIRT1986761	hsa-miR-150	CLIP-seq
MIRT967912	hsa-miR-17	CLIP-seq
MIRT2221330	hsa-miR-185	CLIP-seq
MIRT967913	hsa-miR-204	CLIP-seq
MIRT967914	hsa-miR-20a	CLIP-seq
MIRT967915	hsa-miR-20b	CLIP-seq
MIRT967916	hsa-miR-211	CLIP-seq
MIRT967918	hsa-miR-22	CLIP-seq
MIRT967922	hsa-miR-24	CLIP-seq
MIRT967923	hsa-miR-27a	CLIP-seq
MIRT967924	hsa-miR-27b	CLIP-seq
MIRT2221331	hsa-miR-297	CLIP-seq
MIRT967925	hsa-miR-302a	CLIP-seq
MIRT967926	hsa-miR-302b	CLIP-seq
MIRT967927	hsa-miR-302c	CLIP-seq
MIRT967928	hsa-miR-302d	CLIP-seq
MIRT967929	hsa-miR-302e	CLIP-seq
MIRT967931	hsa-miR-3124-3p	CLIP-seq
MIRT2221332	hsa-miR-3150a-5p	CLIP-seq
MIRT2221333	hsa-miR-3150b-5p	CLIP-seq
MIRT967934	hsa-miR-3153	CLIP-seq
MIRT2221334	hsa-miR-3185	CLIP-seq
MIRT2221335	hsa-miR-3192	CLIP-seq
MIRT2221336	hsa-miR-3199	CLIP-seq
MIRT967938	hsa-miR-324-5p	CLIP-seq
MIRT1986770	hsa-miR-338-5p	CLIP-seq
MIRT967942	hsa-miR-3611	CLIP-seq
MIRT2221337	hsa-miR-3649	CLIP-seq
MIRT2221338	hsa-miR-3661	CLIP-seq
MIRT2221339	hsa-miR-3662	CLIP-seq
MIRT1986772	hsa-miR-3689a-3p	CLIP-seq
MIRT1986773	hsa-miR-3689c	CLIP-seq
MIRT967945	hsa-miR-3690	CLIP-seq
MIRT967947	hsa-miR-372	CLIP-seq
MIRT967948	hsa-miR-373	CLIP-seq
MIRT2221340	hsa-miR-3915	CLIP-seq
MIRT2221341	hsa-miR-3924	CLIP-seq
MIRT2221342	hsa-miR-3928	CLIP-seq
MIRT967950	hsa-miR-412	CLIP-seq
MIRT967951	hsa-miR-4254	CLIP-seq
MIRT2221343	hsa-miR-4261	CLIP-seq
MIRT2221344	hsa-miR-4306	CLIP-seq
MIRT1986782	hsa-miR-4433	CLIP-seq
MIRT967958	hsa-miR-4438	CLIP-seq
MIRT967961	hsa-miR-4484	CLIP-seq
MIRT1986787	hsa-miR-4502	CLIP-seq
MIRT967963	hsa-miR-4503	CLIP-seq
MIRT967964	hsa-miR-4509	CLIP-seq
MIRT967965	hsa-miR-450b-5p	CLIP-seq
MIRT2221345	hsa-miR-4515	CLIP-seq
MIRT2221346	hsa-miR-4517	CLIP-seq
MIRT2221347	hsa-miR-4642	CLIP-seq
MIRT2221348	hsa-miR-4644	CLIP-seq
MIRT2221349	hsa-miR-4646-5p	CLIP-seq
MIRT967968	hsa-miR-4659a-3p	CLIP-seq
MIRT967969	hsa-miR-4659b-3p	CLIP-seq
MIRT967971	hsa-miR-4661-5p	CLIP-seq
MIRT967972	hsa-miR-4663	CLIP-seq
MIRT967973	hsa-miR-4668-5p	CLIP-seq
MIRT967977	hsa-miR-4708-5p	CLIP-seq
MIRT2221350	hsa-miR-4727-5p	CLIP-seq
MIRT1986793	hsa-miR-4728-5p	CLIP-seq
MIRT967982	hsa-miR-4744	CLIP-seq
MIRT967985	hsa-miR-4755-5p	CLIP-seq
MIRT967986	hsa-miR-4769-3p	CLIP-seq
MIRT967987	hsa-miR-4770	CLIP-seq
MIRT2221351	hsa-miR-4789-3p	CLIP-seq
MIRT967990	hsa-miR-4793-5p	CLIP-seq
MIRT2221352	hsa-miR-492	CLIP-seq
MIRT1986799	hsa-miR-500a	CLIP-seq
MIRT967996	hsa-miR-506	CLIP-seq
MIRT967997	hsa-miR-507	CLIP-seq
MIRT967998	hsa-miR-5095	CLIP-seq
MIRT968000	hsa-miR-512-3p	CLIP-seq
MIRT968001	hsa-miR-513a-5p	CLIP-seq
MIRT2221353	hsa-miR-515-3p	CLIP-seq
MIRT968002	hsa-miR-519a	CLIP-seq
MIRT968003	hsa-miR-519b-3p	CLIP-seq
MIRT968004	hsa-miR-519c-3p	CLIP-seq
MIRT968005	hsa-miR-519d	CLIP-seq
MIRT2221354	hsa-miR-519e	CLIP-seq
MIRT968006	hsa-miR-520a-3p	CLIP-seq
MIRT968007	hsa-miR-520b	CLIP-seq
MIRT968008	hsa-miR-520c-3p	CLIP-seq
MIRT968009	hsa-miR-520d-3p	CLIP-seq
MIRT968010	hsa-miR-520e	CLIP-seq
MIRT1986800	hsa-miR-520g	CLIP-seq
MIRT1986801	hsa-miR-520h	CLIP-seq
MIRT1986804	hsa-miR-548ae	CLIP-seq
MIRT1986805	hsa-miR-548aj	CLIP-seq
MIRT1986806	hsa-miR-548am	CLIP-seq
MIRT968012	hsa-miR-548an	CLIP-seq
MIRT1986807	hsa-miR-548x	CLIP-seq
MIRT2221355	hsa-miR-550a	CLIP-seq
MIRT968015	hsa-miR-557	CLIP-seq
MIRT2221356	hsa-miR-567	CLIP-seq
MIRT2221357	hsa-miR-578	CLIP-seq
MIRT968019	hsa-miR-599	CLIP-seq
MIRT2221358	hsa-miR-617	CLIP-seq
MIRT968020	hsa-miR-623	CLIP-seq
MIRT2221359	hsa-miR-631	CLIP-seq
MIRT1986810	hsa-miR-665	CLIP-seq
MIRT968024	hsa-miR-93	CLIP-seq
MIRT1986812	hsa-miR-96	CLIP-seq
MIRT967893	hsa-miR-106a	CLIP-seq
MIRT967894	hsa-miR-106b	CLIP-seq
MIRT967912	hsa-miR-17	CLIP-seq
MIRT967914	hsa-miR-20a	CLIP-seq
MIRT967915	hsa-miR-20b	CLIP-seq
MIRT968005	hsa-miR-519d	CLIP-seq
MIRT968024	hsa-miR-93	CLIP-seq
MIRT1922720	hsa-miR-561	CLIP-seq
MIRT967893	hsa-miR-106a	CLIP-seq
MIRT967894	hsa-miR-106b	CLIP-seq
MIRT967912	hsa-miR-17	CLIP-seq
MIRT967914	hsa-miR-20a	CLIP-seq
MIRT967915	hsa-miR-20b	CLIP-seq
MIRT967925	hsa-miR-302a	CLIP-seq
MIRT967926	hsa-miR-302b	CLIP-seq
MIRT967927	hsa-miR-302c	CLIP-seq
MIRT967928	hsa-miR-302d	CLIP-seq
MIRT967929	hsa-miR-302e	CLIP-seq
MIRT967947	hsa-miR-372	CLIP-seq
MIRT967948	hsa-miR-373	CLIP-seq
MIRT967958	hsa-miR-4438	CLIP-seq
MIRT967972	hsa-miR-4663	CLIP-seq
MIRT967998	hsa-miR-5095	CLIP-seq
MIRT968000	hsa-miR-512-3p	CLIP-seq
MIRT968005	hsa-miR-519d	CLIP-seq
MIRT968006	hsa-miR-520a-3p	CLIP-seq
MIRT968007	hsa-miR-520b	CLIP-seq
MIRT968008	hsa-miR-520c-3p	CLIP-seq
MIRT968009	hsa-miR-520d-3p	CLIP-seq
MIRT968010	hsa-miR-520e	CLIP-seq
MIRT1986800	hsa-miR-520g	CLIP-seq
MIRT1986801	hsa-miR-520h	CLIP-seq
MIRT968024	hsa-miR-93	CLIP-seq
MIRT2524974	hsa-miR-203	CLIP-seq
MIRT2524974	hsa-miR-203	CLIP-seq

Show/Hide all (4)

Transcription factor	Regulation	Reference
AR	Activation	21741601
TWIST1	Repression	19051271
TWIST2	Repression	19051271
YBX1	Activation	19648825

Show/Hide all (75)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003197	Process	Endocardial cushion development	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IDA	7556068
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	ISS	7514177
GO:0005515	Function	Protein binding	IPI	7556068, 7592681, 9516479, 10572067, 15282549, 16273093, 16832058, 16843263, 17148612, 17426253, 19411071, 20007781, 20227043, 21075308, 21203579, 21278786, 22439932, 22733765, 22806884, 22939624, 23436906, 23611113, 23680147, 23688700, 23866081, 24189400, 24557338, 24658140, 252417
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IDA	11389077
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	2687875, 17701904
GO:0007162	Process	Negative regulation of cell adhesion	IDA	7556068
GO:0007165	Process	Signal transduction	IDA	10572067
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IDA	7556068
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	ISS	7514177
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IBA
GO:0007422	Process	Peripheral nervous system development	IEA
GO:0007422	Process	Peripheral nervous system development	ISS
GO:0007507	Process	Heart development	ISS
GO:0009925	Component	Basal plasma membrane	IBA
GO:0009968	Process	Negative regulation of signal transduction	IDA	11389077
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0014037	Process	Schwann cell differentiation	IEA
GO:0014037	Process	Schwann cell differentiation	ISS
GO:0014044	Process	Schwann cell development	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	12646923
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016328	Component	Lateral plasma membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019838	Function	Growth factor binding	IPI	11389077
GO:0019838	Function	Growth factor binding	ISS	7514177
GO:0021545	Process	Cranial nerve development	IEA
GO:0021545	Process	Cranial nerve development	ISS
GO:0030182	Process	Neuron differentiation	IBA
GO:0030296	Function	Protein tyrosine kinase activator activity	IDA	7556068
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	27353365
GO:0038023	Function	Signaling receptor activity	IEA
GO:0038131	Function	Neuregulin receptor activity	IBA
GO:0038131	Function	Neuregulin receptor activity	IEA
GO:0038132	Function	Neuregulin binding	IBA
GO:0038132	Function	Neuregulin binding	IDA	20682778
GO:0038133	Process	ERBB2-ERBB3 signaling pathway	IEA
GO:0038143	Component	ERBB3:ERBB2 complex	IDA	12000754
GO:0042060	Process	Wound healing	NAS	12646923
GO:0042127	Process	Regulation of cell population proliferation	IDA	11389077
GO:0042552	Process	Myelination	IEA
GO:0042802	Function	Identical protein binding	IPI	21575594, 23436906
GO:0043066	Process	Negative regulation of apoptotic process	IBA
GO:0043125	Function	ErbB-3 class receptor binding	IPI	12000754
GO:0043235	Component	Receptor complex	IBA
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0043235	Component	Receptor complex	IEA
GO:0043235	Component	Receptor complex	ISS	7514177
GO:0043410	Process	Positive regulation of MAPK cascade	IBA
GO:0043491	Process	Phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	7556068
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0043524	Process	Negative regulation of neuron apoptotic process	ISS
GO:0046982	Function	Protein heterodimerization activity	IPI	7556068
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IBA
GO:0051048	Process	Negative regulation of secretion	IDA	10559227
GO:0051402	Process	Neuron apoptotic process	IEA
GO:0051402	Process	Neuron apoptotic process	IMP	17701904
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	17701904
GO:0055025	Process	Positive regulation of cardiac muscle tissue development	IEA
GO:0070886	Process	Positive regulation of calcineurin-NFAT signaling cascade	IEA
GO:0097049	Process	Motor neuron apoptotic process	IEA
GO:0097192	Process	Extrinsic apoptotic signaling pathway in absence of ligand	IMP	17701904
GO:2000672	Process	Negative regulation of motor neuron apoptotic process	IEA

MIM	HGNC	e!Ensembl
190151	3431	ENSG00000065361

P21860

Protein name

Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)

Protein function

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with t

PDB

1M6B , 2L9U , 3KEX , 3LMG , 3P11 , 4LEO , 4P59 , 4RIW , 4RIX , 4RIY , 5CUS , 5O4O , 5O7P , 6KBI , 6OP9 , 7BHE , 7BHF , 7D85 , 7MN5 , 7MN6 , 7MN8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01030	Recep_L_domain	55 → 167	Receptor L domain	Repeat
PF00757	Furin-like	169 → 332	Furin-like cysteine rich region	Domain
PF01030	Recep_L_domain	353 → 474	Receptor L domain	Repeat
PF14843	GF_recep_IV	499 → 630	Growth factor receptor domain IV	Domain
PF07714	PK_Tyr_Ser-Thr	709 → 965	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Epithelial tissues and brain.

Sequence

MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM
GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM
LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNG
RSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQD
TDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTS
CVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGN
LDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGG
RSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEE
RLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEP
REFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPI
YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG
GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVF
GTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG
SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNV
LLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVT
VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKE
LANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEED
NLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPR
PVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLL
TPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYM
NRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDY
EYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD
SAFDNPDYWHSRLFPKANAQRT

Sequence length

1342

Interactions

View interactions

	KEGG		Reactome
	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Proteoglycans in cancer MicroRNAs in cancer		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants

Show/Hide Causal Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
ERBB3-related disorder	Likely pathogenic	rs771935902, rs2540758459	RCV003410370 RCV003405841
Lethal congenital contracture syndrome 2	Likely pathogenic	rs1565859132, rs762129530, rs141230043	RCV000013400 RCV003388436 RCV001257435
Malignant tumor of urinary bladder	Pathogenic	rs146486757, rs2136822757, rs2540742315, rs1057519893	RCV003332947 RCV003332948 RCV003332988 RCV003332171
Neoplasm	Pathogenic	rs1057519893	RCV004668943
Visceral neuropathy, familial, 1, autosomal recessive	Pathogenic; Likely pathogenic	rs1869082532, rs2136818517, rs2136822199, rs2136815265, rs766102716	RCV001799810 RCV001799811 RCV001799812 RCV003313825 RCV003313826

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Likely benign	rs78663322, rs56107455	RCV005920796 RCV005933085
Embryonal rhabdomyosarcoma	-	rs1057519803	RCV006254434
Erythroleukemia, familial, susceptibility to	Uncertain significance; Conflicting classifications of pathogenicity	rs56259600, rs755855285, rs56017157	RCV005400504 RCV000239667 RCV005400481
Familial cancer of breast	Likely benign	rs56107455	RCV005933084
Lethal congenital contracture syndrome 1	Uncertain significance	rs780883720	RCV000626162
Lung cancer	Likely benign	rs78663322	RCV005920801
Malignant tumor of esophagus	Likely benign	rs78663322	RCV005920795
Ovarian serous cystadenocarcinoma	Likely benign	rs78663322, rs56107455	RCV005920799 RCV005933086
Prostate cancer	Uncertain significance	rs193920754	RCV000149124
Sarcoma	Likely benign	rs78663322	RCV005920798
Thymoma	Likely benign	rs78663322	RCV005920800
Thyroid cancer, nonmedullary, 1	Likely benign	rs150262923	RCV005933146
Uveal melanoma	Likely benign	rs78663322	RCV005920797
Visceral neuropathy, familial	Benign; Likely benign	rs2292238, rs2271189, rs2271194, rs76079275	RCV001658317 RCV001658384 RCV001661290 RCV001661292

Show/Hide Text Mining Associations (159)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Stimulate	10686540
Adenocarcinoma	Associate	24151090, 27070783, 35581263
Adenocarcinoma Mucinous	Associate	32641744
Adenocarcinoma of Lung	Associate	26254096, 26824984, 29473311, 29858224
Aicardi Syndrome	Associate	26011570
Amblyopia	Associate	31752936
Anemia	Associate	31752936
Arthritis Rheumatoid	Associate	19956108
Asthma	Associate	32700739
Astrocytoma	Associate	19017278
Barrett Esophagus	Associate	35437997
Biliary Tract Neoplasms	Associate	30335866, 37341068
Brain Neoplasms	Associate	20604919, 23224376
Breast Carcinoma In Situ	Associate	31907376, 31932682
Breast Neoplasms	Associate	10473632, 10735500, 11692142, 12853564, 1333787, 14602723, 15084248, 15770691, 16428439, 17110380, 1715580, 17201160, 17376931, 17465220, 17661082 View all (74 more)
Breast Neoplasms Male	Associate	33964913
Calcinosis Cutis	Associate	27618787, 27662660
Cap Myopathy	Associate	29453410
Carcinogenesis	Associate	20462431, 21407808, 35177646, 35484888, 35581263, 37200287
Carcinoma	Associate	27514687
Carcinoma Basal Cell	Associate	18507044, 30173251
Carcinoma Ductal	Stimulate	9823984
Carcinoma Hepatocellular	Associate	11355950, 26000702, 26595522, 26846102, 27514687, 28800792, 32515546, 34400880
Carcinoma in Situ	Associate	29473311
Carcinoma Intraductal Noninfiltrating	Associate	26496879
Carcinoma Intraductal Noninfiltrating	Stimulate	9823984
Carcinoma Lobular	Associate	35477749
Carcinoma Lobular	Stimulate	9823984
Carcinoma Merkel Cell	Associate	18507044
Carcinoma Non Small Cell Lung	Associate	11153605, 16288303, 17202451, 17426253, 19150934, 19648825, 23154546, 25891541, 25993617, 26689995, 26862736, 28144730, 31092882, 31170692, 31790894 View all (8 more)
Carcinoma Ovarian Epithelial	Associate	26482609, 31328457
Carcinoma Pancreatic Ductal	Associate	23918833, 27259358
Carcinoma Renal Cell	Associate	38276060
Carcinoma Squamous Cell	Associate	17465227, 19648825, 28423512
Carcinoma Squamous Cell	Stimulate	18507044
Carcinosarcoma	Associate	37530323
Chemical and Drug Induced Liver Injury	Associate	31752936
Cholangiocarcinoma	Associate	23052372, 24563076, 30335866
Chordoma	Associate	30322893
Colonic Neoplasms	Associate	10686540, 16507107, 35484888
Colorectal Neoplasms	Associate	12571082, 16127743, 1715580, 21212430, 22112971, 23301758, 24205104, 24867101, 24970817, 25915155, 25943333, 26287187, 26367378, 27447549, 27906435 View all (14 more)
Contracture	Associate	31752936
Craniopharyngioma	Associate	25990246
Deglutition Disorders	Associate	34001187
Depressive Disorder	Associate	27044931
Developmental Disabilities	Associate	31752936
Diabetes Mellitus Type 1	Associate	19956108, 20668683, 21270831, 21850031, 21873553, 25422107, 26513234, 28597949, 33083497, 34448034, 35594935, 38453145
Diabetic Retinopathy	Associate	35594935, 39719581
Diarrhea	Associate	27074567, 29254887
Endocrine System Diseases	Associate	22854050, 33086721, 37460683
Endometrial Neoplasms	Associate	18334972, 23028188
Enterocolitis Necrotizing	Associate	22606320
Eosinophilic Esophagitis	Stimulate	35437997
Epstein Barr Virus Infections	Associate	17376931
Exanthema	Associate	27074567
Facial Neoplasms	Associate	28821767
Feeding and Eating Disorders	Associate	31752936
Fibrocystic Breast Disease	Associate	26806567
Fibrosarcoma	Associate	26269601
Gallbladder Neoplasms	Associate	30335866, 33563892
Ganglioneuroblastoma	Associate	23835063
Ganglioneuroma	Associate	23835063
Gastro enteropancreatic neuroendocrine tumor	Associate	26684240
Gastroesophageal Reflux	Associate	27559738
Gastrointestinal Neoplasms	Associate	19331154
Glioblastoma	Associate	20467331, 33892666, 34320350, 35255831
Glioma	Associate	15812817, 26612725, 33892666
Head and Neck Neoplasms	Associate	20443891, 21840482, 26195293, 32381551
Heart Defects Congenital	Associate	31819021
Heart Failure	Associate	28235789
Hereditary Angioedema Type III	Associate	26581908
Hereditary Breast and Ovarian Cancer Syndrome	Associate	18698037, 21622572
Hereditary pancreatitis	Associate	26287187
Hirschsprung Disease	Associate	39199380
Histiocytosis Langerhans Cell	Associate	25202140
Hypoxia	Stimulate	23301758
Hypoxia	Associate	26205780, 26515145, 29603584, 36244759
Idiopathic Pulmonary Fibrosis	Associate	32426915
Immunologic Deficiency Syndromes	Associate	31752936
Insulin Resistance	Associate	11779863
Intestinal Perforation	Associate	22606320
Jeune syndrome	Associate	25996847
Leiomyosarcoma	Associate	26287187
Lethal Congenital Contracture Syndrome 2	Associate	17701904
Leukoplakia	Associate	23492901
Leukoplakia Oral	Associate	23492901
Lung Neoplasms	Associate	17627612, 20351256, 21847121, 24913497, 26689995, 29473311, 32170048, 32535106, 33619172, 34548309, 35302851, 36086904, 37302522, 40174661
Lymphatic Metastasis	Stimulate	1333787
Lymphatic Metastasis	Associate	35902718, 38144565
Lymphoma Large Cell Anaplastic	Associate	36086904
Lymphoma Non Hodgkin	Associate	27559738
Malignant mesenchymal tumor	Associate	32889887
Mammary Neoplasms Animal	Associate	2687875, 8464905
Melanoma	Associate	14632199, 16946712, 18507044, 18698037, 21521745, 23543055, 23890105, 26206558, 26269601, 26967479
Melanoma Cutaneous Malignant	Associate	35420772
Meniere Disease	Associate	38254912
Mesothelioma Malignant	Associate	31752449
Mouth Diseases	Associate	18507044
Multiple Myeloma	Associate	27246973
Multiple Trauma	Associate	27246973
Myopia	Associate	29346494
Nasopharyngeal Carcinoma	Associate	32277654
Nausea	Associate	27074567
Neoplasm Invasiveness	Stimulate	27559738
Neoplasm Invasiveness	Associate	29473311
Neoplasm Metastasis	Stimulate	17634423, 18698037
Neoplasm Metastasis	Associate	18507044, 20604919, 25915155, 25953157, 26254096, 27906435, 29286064, 30621788, 31092882, 35302851
Neoplasms	Associate	10615931, 10686540, 14514775, 15084248, 15480434, 15976335, 16267617, 16288303, 16507107, 16685269, 16690615, 1715580, 17465220, 17634423, 17661082 View all (99 more)
Neoplasms	Stimulate	22222570, 27514687
Neoplasms	Inhibit	25630670
Neurilemmoma	Associate	24558021
Neuroblastoma	Associate	23135478, 36037157
Neurofibroma Plexiform	Associate	15255999
Neurofibrosarcoma	Inhibit	15255999
Nonsyndromic Deafness	Associate	29346494
Nystagmus Pathologic	Associate	31752936
Osteoarthritis	Associate	33021861
Osteogenesis imperfecta type 2B	Associate	17634423
Osteoporosis	Associate	33021861
Osteosarcoma	Associate	24854843
Ovarian Neoplasms	Associate	22841590, 23437196, 24901400, 26205780, 26770651, 28248115, 29286064, 29556616, 31328457, 31836588, 32029900, 35761259, 7710941
Pancreatic Neoplasms	Associate	10615931, 17457047, 20726858, 25564668, 26109364, 27871278, 31911180, 34321959
Pancreatic Neoplasms	Inhibit	19304440
Papillomavirus Infections	Associate	26138066
pediatric multisystem inflammatory disease COVID 19 related	Associate	31752936
Plasmablastic Lymphoma	Associate	34714908
Polycystic Ovary Syndrome	Associate	26416764, 33664499
Prolactinoma	Associate	24287797
Prostate cancer familial	Associate	18829572
Prostatic Neoplasms	Associate	17634423, 17823122, 20159994, 20231295, 20574155, 22684500, 25876877, 34785213, 36095024, 36462326, 37380074
Prostatitis	Associate	11326315, 8650201
Pulmonary Arterial Hypertension	Associate	35594935
Pyruvate Carboxylase Deficiency Disease	Associate	34321959
Rectal Neoplasms	Associate	19368728, 31488078
Retinal Dysplasia	Stimulate	27559738
Retinoblastoma	Associate	17604597
Rhabdomyosarcoma	Associate	23227212
Rhabdomyosarcoma Alveolar	Associate	23227212
Salivary Duct Calculi	Associate	25343854
Sarcoma Clear Cell	Associate	16867224, 36959380
Smoke Inhalation Injury	Stimulate	15563701
Squamous Cell Carcinoma of Head and Neck	Associate	14595263, 21801427, 26138066, 26195293, 28723928, 28939847, 29440293, 29792310, 32381551, 32452220, 34001187, 34167951, 34579737, 35756403
Squamous Intraepithelial Lesions	Stimulate	27559738
Stomach Neoplasms	Associate	23372746, 23680147, 24817940, 25455899, 26287187, 26844548, 28522256, 30621788, 30915908, 31781598, 32641744, 33374770, 35962301, 36916290
Stomach Neoplasms	Stimulate	37537191
Syndrome	Associate	31752936
Tachycardia Atrioventricular Nodal Reentry	Associate	18629779
Tertiary Lymphoid Structures	Stimulate	17634423, 9823984
Thyroid Cancer Papillary	Associate	25922907, 26735176, 28469731
Thyroid Neoplasms	Associate	35045748, 38144565
Tinnitus	Associate	38254912
Triple Negative Breast Neoplasms	Associate	26806567, 31792349, 32080212, 32558176
Triple Negative Breast Neoplasms	Inhibit	30367623
Urethral Neoplasms	Associate	18006009, 26287187, 27044931, 28388586
Urinary Bladder Neoplasms	Associate	15583696, 27906180, 31393349, 35035776, 35501832, 36818940
Uterine Cervical Neoplasms	Associate	18629779, 28112728, 34011535, 35581263
Virus Diseases	Inhibit	27514687
Vitamin D Deficiency	Associate	29254887
Xerostomia	Associate	34001187

ERBB3 (erb-b2 receptor tyrosine kinase 3)