Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2063
Gene name Gene Name - the full gene name approved by the HGNC.
Nuclear receptor subfamily 2 group F member 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NR2F6
Synonyms (NCBI Gene) Gene synonyms aliases
EAR-2, EAR2, ERBAL2
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.11
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004232 hsa-miR-346 Microarray 16822819
MIRT018838 hsa-miR-335-5p Microarray 18185580
MIRT027803 hsa-miR-98-5p Microarray 19088304
MIRT049946 hsa-miR-30a-5p CLASH 23622248
MIRT048210 hsa-miR-196a-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
CREB1 Repression 15955695
ESRRA Repression 15955695
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 10644740
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
132880 7977 ENSG00000160113
Protein
UniProt ID P10588
Protein name Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2)
Protein function Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other n
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00105 zf-C4 54 123 Zinc finger, C4 type (two domains) Domain
PF00104 Hormone_recep 195 377 Ligand-binding domain of nuclear hormone receptor Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10713182}.
Sequence
Sequence length 404
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Nuclear Receptor transcription pathway
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
11850205, 20852631
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
11850205
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
11850205
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis 22138541 ClinVar
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Hypogonadism Hypogonadism GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 23292282, 27775588, 34889888
Carcinoma Hepatocellular Associate 35907841
Carcinoma Non Small Cell Lung Associate 28922562
Carcinoma Squamous Cell Associate 27775588
Colorectal Neoplasms Associate 27775588
Endometrial Neoplasms Associate 36884115
Glioma Associate 37575237
Glomerulonephritis Associate 35484716
Inflammation Inhibit 35484716
Kidney Diseases Associate 35484716