Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
205
Gene name Gene Name - the full gene name approved by the HGNC.
Adenylate kinase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AK4
Synonyms (NCBI Gene) Gene synonyms aliases
AK 4, AK3, AK3L1, AK3L2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p31.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible trans
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030106 hsa-miR-26b-5p Microarray 19088304
MIRT030613 hsa-miR-24-3p Sequencing 20371350
MIRT508945 hsa-miR-5197-3p PAR-CLIP 20371350
MIRT508946 hsa-miR-3929 PAR-CLIP 20371350
MIRT508944 hsa-miR-4419b PAR-CLIP 20371350
Transcription factors
Transcription factor Regulation Reference
ATF3 Unknown 23002211
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001889 Process Liver development IEA
GO:0002082 Process Regulation of oxidative phosphorylation IMP 26980435
GO:0004017 Function Adenylate kinase activity IDA 19766732
GO:0004017 Function Adenylate kinase activity IDA 11485571
GO:0004550 Function Nucleoside diphosphate kinase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
103030 363 ENSG00000162433
Protein
UniProt ID P27144
Protein name Adenylate kinase 4, mitochondrial (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4)
Protein function Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). Similar to other ad
PDB 2AR7 , 2BBW , 3NDP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00406 ADK 10 190 Domain
PF05191 ADK_lid 126 161 Adenylate kinase, active site lid Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain. {ECO:0000269|PubMed:11485571}.
Sequence
Sequence length 223
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Purine metabolism
Thiamine metabolism
Metabolic pathways
Nucleotide metabolism
Biosynthesis of cofactors
  Interconversion of nucleotide di- and triphosphates
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 18784066
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 37004157
Adenocarcinoma in Situ Associate 37004157
Adenocarcinoma of Lung Associate 31444368, 37004157
Alzheimer Disease Associate 35948448
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis Inhibit 39287711
Breast Neoplasms Associate 32956623
Carcinoma Pancreatic Ductal Associate 35220277
Cognition Disorders Associate 29908079
Cognition Disorders Inhibit 35948448
Glioma Associate 24767988