SLC44A5 (solute carrier family 44 member 5)

Gene

• Entrez ID: 204962
• Gene name: Solute carrier family 44 member 5
• Gene symbol: SLC44A5
• Synonyms (NCBI Gene): CTL5
• Chromosome: 1
• Chromosome location: 1p31.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019121	hsa-miR-335-5p	Microarray	18185580
MIRT1364462	hsa-miR-1264	CLIP-seq
MIRT1364463	hsa-miR-224	CLIP-seq
MIRT1364464	hsa-miR-23a	CLIP-seq
MIRT1364465	hsa-miR-23b	CLIP-seq
MIRT1364466	hsa-miR-23c	CLIP-seq
MIRT1364467	hsa-miR-298	CLIP-seq
MIRT1364468	hsa-miR-3121-5p	CLIP-seq
MIRT1364469	hsa-miR-3158-5p	CLIP-seq
MIRT1364470	hsa-miR-3185	CLIP-seq
MIRT1364471	hsa-miR-3682-3p	CLIP-seq
MIRT1364472	hsa-miR-384	CLIP-seq
MIRT1364473	hsa-miR-4446-5p	CLIP-seq
MIRT1364474	hsa-miR-4502	CLIP-seq
MIRT1364475	hsa-miR-4509	CLIP-seq
MIRT1364476	hsa-miR-450b-5p	CLIP-seq
MIRT1364477	hsa-miR-4744	CLIP-seq
MIRT1364478	hsa-miR-4753-3p	CLIP-seq
MIRT1364479	hsa-miR-4755-5p	CLIP-seq
MIRT1364480	hsa-miR-4768-5p	CLIP-seq
MIRT1364481	hsa-miR-670	CLIP-seq
MIRT1364482	hsa-miR-802	CLIP-seq
MIRT1922383	hsa-miR-4775	CLIP-seq
MIRT2331971	hsa-miR-1305	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005886	Component	Plasma membrane	IDA	23651124
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006656	Process	Phosphatidylcholine biosynthetic process	IEA
GO:0006656	Process	Phosphatidylcholine biosynthetic process	TAS
GO:0015220	Function	Choline transmembrane transporter activity	IDA	23651124
GO:0015220	Function	Choline transmembrane transporter activity	IEA
GO:0015220	Function	Choline transmembrane transporter activity	TAS
GO:0015297	Function	Antiporter activity	IEA
GO:0015871	Process	Choline transport	IDA	23651124
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IBA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0055085	Process	Transmembrane transport	IBA
GO:0055085	Process	Transmembrane transport	IEA
GO:0055085	Process	Transmembrane transport	TAS

Other IDs

• MIM: 620329
• HGNC: 28524
• e!Ensembl: ENSG00000137968

Protein

• UniProt ID: Q8NCS7
• Protein name: Choline transporter-like protein 5 (Solute carrier family 44 member 5)
• Protein function: Choline/H+ antiporter.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04515	Choline_transpo	330 → 687	Plasma-membrane choline transporter	Family

• Sequence:

  MNDTEKPADTPSEEEDFGDPRTYDPDFKGPVANRSCTDVLCCMIFLLCIIGYIVLGLVAW
  VHGDPRRAAYPTDSQGHFCGQKGTPNENKTILFYFNLLRCTSPSVLLNLQCPTTQICVSK
  CPEKFLTYVEMQLLYTKDKSYWEDYRQFCKTTAKPVKSLTQLLLDDDCPTAIFPSKPFLQ
  RCFPDFSTKNGTLTIGSKMMFQDGNGGTRSVVELGIAANGINKLLDAKSLGLKVFEDYAR
  TWYWILIGLTIAMVLSWIFLILLRFIAGCLFWVFMIGVIGIIGYGIWHCYQQYTNLQERP
  SSVLTIYDIGIQTNISMYFELQQTWFTFMIILCIIEVIVILMLIFLRNRIRVAIILLKEG
  SKAIGYVPSTLVYPALTFILLSICICYWVVTAVFLATSGVPVYKVIAPGGHCIHENQTCD
  PEIFNTTEIAKACPGALCNFAFYGGKSLYHQYIPTFHVYNLFVFLWLINFVIALGQCALA
  GAFATYYWAMKKPDDIPRYPLFTAFGRAIRYHTGSLAFGSLIIALIQMFKIVLEYLDHRL
  KRTQNTLSKFLQCCLRCCFWCLENAIKFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVL
  KVAVTDEVTYFVLFLGKLLVAGSIGVLAFLFFTQRLPVIAQGPASLNYYWVPLLTVIFGS
  YLIAHGFFSVYAMCVETIFICFCEDLERNDGSTEKPYFVTPNLHGILIKKQLVPQKQKE

• Sequence length: 719

Pathways

KEGG:

Choline metabolism in cancer

Reactome:

Synthesis of PC
Transport of bile salts and organic acids, metal ions and amine compounds