Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2041
Gene name Gene Name - the full gene name approved by the HGNC.	EPH receptor A1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	EPHA1
Synonyms (NCBI Gene) Gene synonyms aliases	EPH, EPHT, EPHT1
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q34-q35
Summary Summary of gene provided in NCBI Entrez Gene.	This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically ha

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017674	hsa-miR-335-5p	Microarray	18185580
MIRT551885	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT551884	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT551883	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT551882	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT551881	hsa-miR-567	HITS-CLIP	21572407
MIRT551880	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT551879	hsa-miR-520d-5p	HITS-CLIP	21572407
MIRT551878	hsa-miR-524-5p	HITS-CLIP	21572407
MIRT551877	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT551876	hsa-miR-3924	HITS-CLIP	21572407
MIRT551875	hsa-miR-297	HITS-CLIP	21572407
MIRT551885	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT551884	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT551883	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT551882	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551881	hsa-miR-567	PAR-CLIP	21572407
MIRT551880	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT551879	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT551878	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT551877	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT551876	hsa-miR-3924	PAR-CLIP	21572407
MIRT551875	hsa-miR-297	PAR-CLIP	21572407
MIRT551885	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT551884	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT551883	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT551882	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT551881	hsa-miR-567	HITS-CLIP	21572407
MIRT551880	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT551879	hsa-miR-520d-5p	HITS-CLIP	21572407
MIRT551878	hsa-miR-524-5p	HITS-CLIP	21572407
MIRT551877	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT551876	hsa-miR-3924	HITS-CLIP	21572407
MIRT551875	hsa-miR-297	HITS-CLIP	21572407
MIRT551885	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT551884	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT551883	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT551882	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551881	hsa-miR-567	PAR-CLIP	21572407
MIRT551880	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT551879	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT551878	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT551877	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT551876	hsa-miR-3924	PAR-CLIP	21572407
MIRT551875	hsa-miR-297	PAR-CLIP	21572407
MIRT966332	hsa-miR-15a	CLIP-seq
MIRT966333	hsa-miR-15b	CLIP-seq
MIRT966334	hsa-miR-16	CLIP-seq
MIRT966335	hsa-miR-195	CLIP-seq
MIRT966336	hsa-miR-1976	CLIP-seq
MIRT966337	hsa-miR-298	CLIP-seq
MIRT966338	hsa-miR-3065-3p	CLIP-seq
MIRT966339	hsa-miR-3140-5p	CLIP-seq
MIRT966340	hsa-miR-424	CLIP-seq
MIRT966341	hsa-miR-4279	CLIP-seq
MIRT966342	hsa-miR-4699-3p	CLIP-seq
MIRT966343	hsa-miR-4766-5p	CLIP-seq
MIRT966344	hsa-miR-4796-3p	CLIP-seq
MIRT966345	hsa-miR-497	CLIP-seq
MIRT2220837	hsa-miR-1207-5p	CLIP-seq
MIRT2220838	hsa-miR-3128	CLIP-seq
MIRT2220839	hsa-miR-4720-5p	CLIP-seq
MIRT2220840	hsa-miR-4736	CLIP-seq
MIRT2220841	hsa-miR-4763-3p	CLIP-seq
MIRT2220842	hsa-miR-4799-3p	CLIP-seq
MIRT2220843	hsa-miR-657	CLIP-seq

Show/Hide all(36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001525	Process	Angiogenesis	IEA
GO:0001954	Process	Positive regulation of cell-matrix adhesion	IDA	19118217
GO:0001968	Function	Fibronectin binding	IDA	18308734
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IBA
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IEA
GO:0005003	Function	Ephrin receptor activity	IDA	12775584
GO:0005003	Function	Ephrin receptor activity	IEA
GO:0005005	Function	Transmembrane-ephrin receptor activity	IDA	19118217
GO:0005005	Function	Transmembrane-ephrin receptor activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	16862074, 19118217
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IDA	19118217
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019901	Function	Protein kinase binding	IPI	19118217
GO:0030155	Process	Regulation of cell adhesion	IEA
GO:0030335	Process	Positive regulation of cell migration	IMP	20043122
GO:0030336	Process	Negative regulation of cell migration	IDA	19118217
GO:0034446	Process	Substrate adhesion-dependent cell spreading	IDA	19118217
GO:0043235	Component	Receptor complex	IBA
GO:0045766	Process	Positive regulation of angiogenesis	IEA
GO:0045766	Process	Positive regulation of angiogenesis	IMP	20043122
GO:0045766	Process	Positive regulation of angiogenesis	ISS	18308734
GO:0048013	Process	Ephrin receptor signaling pathway	IEA
GO:0051496	Process	Positive regulation of stress fiber assembly	IEA
GO:0051496	Process	Positive regulation of stress fiber assembly	ISS

MIM	HGNC	e!Ensembl
179610	3385	ENSG00000146904

Protein

UniProt ID

P21709

Protein name

Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)

Protein function

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor i

PDB

2K1K , 2K1L , 3HIL , 3KKA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01404	Ephrin_lbd	28 → 204	Ephrin receptor ligand binding domain	Domain
PF00041	fn3	334 → 431	Fibronectin type III domain	Domain
PF14575	EphA2_TM	548 → 621	Ephrin type-A receptor 2 transmembrane domain	Domain
PF07714	PK_Tyr_Ser-Thr	624 → 880	Protein tyrosine and serine/threonine kinase	Domain
PF00536	SAM_1	911 → 975	SAM domain (Sterile alpha motif)	Domain

Tissue specificity

TISSUE SPECIFICITY: Overexpressed in several carcinomas.

Sequence

MERRWPLGLGLVLLLCAPLPPGARAKEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNG
TPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKE
TFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLVSGSVKLNVERCSLGRLTRRG
LYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAGLVEVAGTCLPHARASPR
PSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQ
STAESEGATICTCESGHYRAPGEGPQVACTGPPSAPRNLSFSASGTQLSLRWEPPADTGG
RQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHVNGLEPYANYTFNVE
AQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLT
YELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVS
RGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDRATDVDREDKLWLKPYV
DLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKD
TSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQ
LVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGT
YETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIE
DGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPRM
TLRLPSLSGSDGIPYRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQMGITL
PGHQKRILCSIQGFKD

Sequence length

976

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Colorectal Cancer	Colorectal cancer	EPHA1 suppresses spreading and adhesion of HRT18 colorectal cancer cells through deactivation of ERK and JNK signaling pathways.	26977017	CBGDA
Dementia	Dementia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (48)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	35770949
Alzheimer Disease	Associate	22319180, 22445811, 22482808, 23226438, 25114068, 25189118, 25600633, 26101835, 26519433, 28199971, 29750252, 30859738, 31561366, 31585107, 32072450 View all (4 more)
Atherosclerosis	Associate	21672356
Breast Neoplasms	Associate	21935409, 26870995, 32764731, 33977106, 34949656
Calcinosis Cutis	Associate	21479221
Carcinogenesis	Associate	16862074, 19277044, 21479221, 24040450, 24152675, 24771266, 27887627, 38102712
Carcinoma Basal Cell	Inhibit	16862074
Carcinoma Pancreatic Ductal	Associate	19949912
Carcinoma Renal Cell	Associate	25025847, 26261568
Carcinoma Squamous Cell	Inhibit	16862074
Cardiovascular Diseases	Associate	25600633
Cerebral Infarction	Associate	30859738
Choriocarcinoma	Associate	23429488
Cognition Disorders	Associate	28199971
Cognitive Dysfunction	Associate	25189118
Colitis Ulcerative	Associate	32322884
Colonic Neoplasms	Associate	27273865
Colorectal Neoplasms	Inhibit	19011600
Colorectal Neoplasms	Associate	19277044, 38102712
Craniofrontonasal dysplasia	Associate	28238796
Dementia	Associate	29750252
Disease	Associate	24438528
Gestational Trophoblastic Disease	Associate	23429488
Inflammation	Associate	24022400
Lymphatic Metastasis	Inhibit	19011600
Lymphoma Follicular	Associate	16925574
Medulloblastoma	Associate	22723427
Mental Disorders	Associate	32909371
Mood Disorders	Associate	32909371
Multiple Sclerosis	Associate	15779235
Neoplasm Metastasis	Associate	19011600, 19949912, 21935409, 22723427, 38102712
Neoplasms	Associate	10498621, 16737551, 16862074, 18231102, 19277044, 19949912, 21479221, 21935409, 22184117, 22723427, 23429488, 24152675, 24427352, 25025847, 25120806 View all (9 more)
Neoplasms	Inhibit	23627399
Neoplasms	Stimulate	33977106
Neural Tube Defects	Associate	35741713
Neurodegenerative Diseases	Associate	15779235, 25600633
Ovarian Neoplasms	Associate	16737551
Pancreatic Neoplasms	Associate	19949912, 29074453
Prostatic Neoplasms	Associate	24040450, 32362422, 36806315
Prostatitis	Associate	10660600, 8650201
Rectal Neoplasms	Associate	19011600
Sigmoid Neoplasms	Inhibit	19011600
Skin Diseases	Associate	38003532
Skin Neoplasms	Inhibit	16862074
Squamous Cell Carcinoma of Head and Neck	Associate	24022400
Stomach Neoplasms	Stimulate	30873760
Stomach Neoplasms	Associate	32218416
Thymoma	Associate	30787364

EPHA1 (EPH receptor A1)