Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	2037
Gene name	Erythrocyte membrane protein band 4.1 like 2
Gene symbol	EPB41L2
Synonyms (NCBI Gene)	4.1-G4.1G
Chromosome	6
Chromosome location	6q23.1-q23.2

137

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021017	hsa-miR-155-5p	Proteomics	18668040
MIRT024109	hsa-miR-1-3p	Proteomics	18668040
MIRT024109	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT025572	hsa-miR-34a-5p	Proteomics	21566225
MIRT050941	hsa-miR-17-5p	CLASH	23622248
MIRT047645	hsa-miR-10a-5p	CLASH	23622248
MIRT046632	hsa-miR-222-3p	CLASH	23622248
MIRT043551	hsa-miR-331-3p	CLASH	23622248
MIRT036304	hsa-miR-1229-3p	CLASH	23622248
MIRT965625	hsa-miR-140-3p	CLIP-seq
MIRT965626	hsa-miR-3591-3p	CLIP-seq
MIRT965627	hsa-miR-3943	CLIP-seq
MIRT965628	hsa-miR-4313	CLIP-seq
MIRT965629	hsa-miR-1182	CLIP-seq
MIRT965630	hsa-miR-1284	CLIP-seq
MIRT965625	hsa-miR-140-3p	CLIP-seq
MIRT965631	hsa-miR-140-5p	CLIP-seq
MIRT965632	hsa-miR-196a	CLIP-seq
MIRT965633	hsa-miR-196b	CLIP-seq
MIRT965634	hsa-miR-224	CLIP-seq
MIRT965635	hsa-miR-3126-3p	CLIP-seq
MIRT965636	hsa-miR-3128	CLIP-seq
MIRT965637	hsa-miR-3148	CLIP-seq
MIRT965638	hsa-miR-3155	CLIP-seq
MIRT965639	hsa-miR-3155b	CLIP-seq
MIRT965640	hsa-miR-3169	CLIP-seq
MIRT965641	hsa-miR-3545-5p	CLIP-seq
MIRT965626	hsa-miR-3591-3p	CLIP-seq
MIRT965642	hsa-miR-3663-5p	CLIP-seq
MIRT965643	hsa-miR-376c	CLIP-seq
MIRT965627	hsa-miR-3943	CLIP-seq
MIRT965644	hsa-miR-3978	CLIP-seq
MIRT965645	hsa-miR-4289	CLIP-seq
MIRT965628	hsa-miR-4313	CLIP-seq
MIRT965646	hsa-miR-4460	CLIP-seq
MIRT965647	hsa-miR-4515	CLIP-seq
MIRT965648	hsa-miR-4642	CLIP-seq
MIRT965649	hsa-miR-4700-3p	CLIP-seq
MIRT965650	hsa-miR-4703-3p	CLIP-seq
MIRT965651	hsa-miR-4720-5p	CLIP-seq
MIRT965652	hsa-miR-4799-3p	CLIP-seq
MIRT965653	hsa-miR-484	CLIP-seq
MIRT965654	hsa-miR-513a-5p	CLIP-seq
MIRT965655	hsa-miR-548an	CLIP-seq
MIRT965656	hsa-miR-616	CLIP-seq
MIRT965657	hsa-miR-639	CLIP-seq
MIRT965658	hsa-miR-875-3p	CLIP-seq
MIRT965638	hsa-miR-3155	CLIP-seq
MIRT965639	hsa-miR-3155b	CLIP-seq
MIRT965642	hsa-miR-3663-5p	CLIP-seq
MIRT965653	hsa-miR-484	CLIP-seq
MIRT2442134	hsa-miR-1271	CLIP-seq
MIRT2442135	hsa-miR-4318	CLIP-seq
MIRT2442136	hsa-miR-4466	CLIP-seq
MIRT2442137	hsa-miR-675	CLIP-seq
MIRT2442138	hsa-miR-96	CLIP-seq
MIRT965629	hsa-miR-1182	CLIP-seq
MIRT2524314	hsa-miR-1207-5p	CLIP-seq
MIRT2442134	hsa-miR-1271	CLIP-seq
MIRT2524315	hsa-miR-128	CLIP-seq
MIRT965631	hsa-miR-140-5p	CLIP-seq
MIRT2524316	hsa-miR-148a	CLIP-seq
MIRT2524317	hsa-miR-148b	CLIP-seq
MIRT2524318	hsa-miR-152	CLIP-seq
MIRT2524319	hsa-miR-198	CLIP-seq
MIRT965634	hsa-miR-224	CLIP-seq
MIRT2524320	hsa-miR-3163	CLIP-seq
MIRT965640	hsa-miR-3169	CLIP-seq
MIRT2524321	hsa-miR-323b-3p	CLIP-seq
MIRT2524322	hsa-miR-340	CLIP-seq
MIRT2524323	hsa-miR-345	CLIP-seq
MIRT2524324	hsa-miR-3925-3p	CLIP-seq
MIRT965644	hsa-miR-3978	CLIP-seq
MIRT2524325	hsa-miR-4256	CLIP-seq
MIRT2524326	hsa-miR-4276	CLIP-seq
MIRT2442135	hsa-miR-4318	CLIP-seq
MIRT2442136	hsa-miR-4466	CLIP-seq
MIRT965647	hsa-miR-4515	CLIP-seq
MIRT2524327	hsa-miR-4522	CLIP-seq
MIRT2524328	hsa-miR-4528	CLIP-seq
MIRT2524329	hsa-miR-455-3p	CLIP-seq
MIRT2524330	hsa-miR-4684-5p	CLIP-seq
MIRT2524331	hsa-miR-4697-3p	CLIP-seq
MIRT965649	hsa-miR-4700-3p	CLIP-seq
MIRT2524332	hsa-miR-4756-3p	CLIP-seq
MIRT2524333	hsa-miR-4763-3p	CLIP-seq
MIRT2524334	hsa-miR-4778-3p	CLIP-seq
MIRT2524335	hsa-miR-4795-5p	CLIP-seq
MIRT965654	hsa-miR-513a-5p	CLIP-seq
MIRT2524336	hsa-miR-515-5p	CLIP-seq
MIRT2524337	hsa-miR-520a-5p	CLIP-seq
MIRT2524338	hsa-miR-525-5p	CLIP-seq
MIRT2524339	hsa-miR-548n	CLIP-seq
MIRT2524340	hsa-miR-548t	CLIP-seq
MIRT2442137	hsa-miR-675	CLIP-seq
MIRT2524341	hsa-miR-766	CLIP-seq
MIRT965658	hsa-miR-875-3p	CLIP-seq
MIRT2442138	hsa-miR-96	CLIP-seq
MIRT965629	hsa-miR-1182	CLIP-seq
MIRT2524314	hsa-miR-1207-5p	CLIP-seq
MIRT2442134	hsa-miR-1271	CLIP-seq
MIRT2524315	hsa-miR-128	CLIP-seq
MIRT2524316	hsa-miR-148a	CLIP-seq
MIRT2524317	hsa-miR-148b	CLIP-seq
MIRT2524318	hsa-miR-152	CLIP-seq
MIRT2524319	hsa-miR-198	CLIP-seq
MIRT965634	hsa-miR-224	CLIP-seq
MIRT2524320	hsa-miR-3163	CLIP-seq
MIRT965640	hsa-miR-3169	CLIP-seq
MIRT2524321	hsa-miR-323b-3p	CLIP-seq
MIRT2524323	hsa-miR-345	CLIP-seq
MIRT2524324	hsa-miR-3925-3p	CLIP-seq
MIRT965644	hsa-miR-3978	CLIP-seq
MIRT2524325	hsa-miR-4256	CLIP-seq
MIRT2524326	hsa-miR-4276	CLIP-seq
MIRT2442135	hsa-miR-4318	CLIP-seq
MIRT2442136	hsa-miR-4466	CLIP-seq
MIRT965647	hsa-miR-4515	CLIP-seq
MIRT2524327	hsa-miR-4522	CLIP-seq
MIRT2524328	hsa-miR-4528	CLIP-seq
MIRT2524329	hsa-miR-455-3p	CLIP-seq
MIRT2524330	hsa-miR-4684-5p	CLIP-seq
MIRT2524331	hsa-miR-4697-3p	CLIP-seq
MIRT965649	hsa-miR-4700-3p	CLIP-seq
MIRT2524332	hsa-miR-4756-3p	CLIP-seq
MIRT2524333	hsa-miR-4763-3p	CLIP-seq
MIRT2524334	hsa-miR-4778-3p	CLIP-seq
MIRT965654	hsa-miR-513a-5p	CLIP-seq
MIRT2524336	hsa-miR-515-5p	CLIP-seq
MIRT2524337	hsa-miR-520a-5p	CLIP-seq
MIRT2524338	hsa-miR-525-5p	CLIP-seq
MIRT2524339	hsa-miR-548n	CLIP-seq
MIRT2524340	hsa-miR-548t	CLIP-seq
MIRT2442137	hsa-miR-675	CLIP-seq
MIRT2524341	hsa-miR-766	CLIP-seq
MIRT965658	hsa-miR-875-3p	CLIP-seq
MIRT2442138	hsa-miR-96	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	20936779, 22003208, 23870127, 24996901, 28514442, 33961781, 36931259, 39251607
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9598318
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005938	Component	Cell cortex	IDA	23870127
GO:0005938	Component	Cell cortex	IEA
GO:0008091	Component	Spectrin	TAS	9598318
GO:0008092	Function	Cytoskeletal protein binding	IEA
GO:0008180	Component	COP9 signalosome	IDA	18850735
GO:0016020	Component	Membrane	IEA
GO:0030054	Component	Cell junction	IDA
GO:0030507	Function	Spectrin binding	IEA
GO:0030866	Process	Cortical actin cytoskeleton organization	IEA
GO:0031032	Process	Actomyosin structure organization	IBA
GO:0042731	Function	PH domain binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1904778	Process	Positive regulation of protein localization to cell cortex	IMP	23870127

MIM	HGNC	e!Ensembl
603237	3379	ENSG00000079819

O43491

Protein name

Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G)

Protein function

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09379	FERM_N	222 → 285	FERM N-terminal domain	Domain
PF00373	FERM_M	300 → 409	FERM central domain	Domain
PF09380	FERM_C	413 → 503	FERM C-terminal PH-like domain	Domain
PF08736	FA	507 → 550	FERM adjacent (FA)	Family
PF04382	SAB	630 → 676	SAB domain	Domain
PF05902	4_1_CTD	892 → 998	4.1 protein C-terminal domain (CTD)	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed.

Sequence

MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR
RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE
EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET
QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG
QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD
PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE
FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK
LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA
AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE
RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT
KAPHLQLIEGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTP
EPRPNEWEKRRITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGP
GEIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEE
PRPAAKVVEREEAVPEASPVTQAGASVITVETVIQENVGAQKIPGEKSVHEGALKQDMGE
EAEEEPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTE
TKTITYESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVI
TGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED

Sequence length

1005

Interactions

View interactions

	Reactome
			Neurexins and neuroligins

EPB41L2 (erythrocyte membrane protein band 4.1 like 2)