NRK (Nik related kinase)

Gene

• Entrez ID: 203447
• Gene name: Nik related kinase
• Gene symbol: NRK
• Synonyms (NCBI Gene): NESK
• Chromosome: X
• Chromosome location: Xq22.3
• Summary: The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018046	hsa-miR-335-5p	Microarray	18185580
MIRT1194186	hsa-miR-1183	CLIP-seq
MIRT1194187	hsa-miR-1285	CLIP-seq
MIRT1194188	hsa-miR-130a	CLIP-seq
MIRT1194189	hsa-miR-130b	CLIP-seq
MIRT1194190	hsa-miR-1911	CLIP-seq
MIRT1194191	hsa-miR-219-1-3p	CLIP-seq
MIRT1194192	hsa-miR-301a	CLIP-seq
MIRT1194193	hsa-miR-301b	CLIP-seq
MIRT1194194	hsa-miR-30a	CLIP-seq
MIRT1194195	hsa-miR-30b	CLIP-seq
MIRT1194196	hsa-miR-30c	CLIP-seq
MIRT1194197	hsa-miR-30d	CLIP-seq
MIRT1194198	hsa-miR-30e	CLIP-seq
MIRT1194199	hsa-miR-3187-5p	CLIP-seq
MIRT1194200	hsa-miR-3198	CLIP-seq
MIRT1194201	hsa-miR-326	CLIP-seq
MIRT1194202	hsa-miR-330-5p	CLIP-seq
MIRT1194203	hsa-miR-3616-5p	CLIP-seq
MIRT1194204	hsa-miR-3617	CLIP-seq
MIRT1194205	hsa-miR-3647-5p	CLIP-seq
MIRT1194206	hsa-miR-3665	CLIP-seq
MIRT1194207	hsa-miR-3666	CLIP-seq
MIRT1194208	hsa-miR-378g	CLIP-seq
MIRT1194209	hsa-miR-3945	CLIP-seq
MIRT1194210	hsa-miR-4253	CLIP-seq
MIRT1194211	hsa-miR-4295	CLIP-seq
MIRT1194212	hsa-miR-4309	CLIP-seq
MIRT1194213	hsa-miR-4457	CLIP-seq
MIRT1194214	hsa-miR-4486	CLIP-seq
MIRT1194215	hsa-miR-454	CLIP-seq
MIRT1194216	hsa-miR-4642	CLIP-seq
MIRT1194217	hsa-miR-4643	CLIP-seq
MIRT1194218	hsa-miR-466	CLIP-seq
MIRT1194219	hsa-miR-4709-3p	CLIP-seq
MIRT1194220	hsa-miR-4768-5p	CLIP-seq
MIRT1194221	hsa-miR-4789-3p	CLIP-seq
MIRT1194222	hsa-miR-554	CLIP-seq
MIRT1194223	hsa-miR-556-5p	CLIP-seq
MIRT1194224	hsa-miR-563	CLIP-seq
MIRT1194225	hsa-miR-571	CLIP-seq
MIRT1194226	hsa-miR-573	CLIP-seq
MIRT1194227	hsa-miR-612	CLIP-seq
MIRT1194228	hsa-miR-617	CLIP-seq
MIRT1194229	hsa-miR-641	CLIP-seq
MIRT1194230	hsa-miR-657	CLIP-seq
MIRT2056358	hsa-miR-1207-3p	CLIP-seq
MIRT2056359	hsa-miR-1246	CLIP-seq
MIRT2056360	hsa-miR-3124-3p	CLIP-seq
MIRT2056361	hsa-miR-3134	CLIP-seq
MIRT2056362	hsa-miR-3155	CLIP-seq
MIRT2056363	hsa-miR-3155b	CLIP-seq
MIRT2056364	hsa-miR-3671	CLIP-seq
MIRT2056365	hsa-miR-3685	CLIP-seq
MIRT2056366	hsa-miR-384	CLIP-seq
MIRT2056367	hsa-miR-3915	CLIP-seq
MIRT2056368	hsa-miR-4461	CLIP-seq
MIRT2056369	hsa-miR-4729	CLIP-seq
MIRT2056370	hsa-miR-4766-5p	CLIP-seq
MIRT2056371	hsa-miR-484	CLIP-seq
MIRT2056372	hsa-miR-607	CLIP-seq
MIRT2284890	hsa-miR-1245b-3p	CLIP-seq
MIRT2284891	hsa-miR-2115	CLIP-seq
MIRT2284892	hsa-miR-221	CLIP-seq
MIRT2284893	hsa-miR-222	CLIP-seq
MIRT2284894	hsa-miR-224	CLIP-seq
MIRT2284895	hsa-miR-3182	CLIP-seq
MIRT2284896	hsa-miR-3942-3p	CLIP-seq
MIRT2284897	hsa-miR-4274	CLIP-seq
MIRT2284898	hsa-miR-4283	CLIP-seq
MIRT2284899	hsa-miR-4421	CLIP-seq
MIRT2284900	hsa-miR-4489	CLIP-seq
MIRT2284901	hsa-miR-4492	CLIP-seq
MIRT2284902	hsa-miR-4498	CLIP-seq
MIRT2284903	hsa-miR-4505	CLIP-seq
MIRT2284904	hsa-miR-4519	CLIP-seq
MIRT2284905	hsa-miR-4524	CLIP-seq
MIRT2284906	hsa-miR-4677-3p	CLIP-seq
MIRT2284907	hsa-miR-4679	CLIP-seq
MIRT2284908	hsa-miR-4731-5p	CLIP-seq
MIRT1194221	hsa-miR-4789-3p	CLIP-seq
MIRT2284909	hsa-miR-4796-5p	CLIP-seq
MIRT2284910	hsa-miR-4803	CLIP-seq
MIRT2284911	hsa-miR-494	CLIP-seq
MIRT2284912	hsa-miR-495	CLIP-seq
MIRT2284913	hsa-miR-548ag	CLIP-seq
MIRT2284914	hsa-miR-548ai	CLIP-seq
MIRT2284915	hsa-miR-548v	CLIP-seq
MIRT1194223	hsa-miR-556-5p	CLIP-seq
MIRT2284916	hsa-miR-561	CLIP-seq
MIRT2284917	hsa-miR-624	CLIP-seq
MIRT2284918	hsa-miR-652	CLIP-seq
MIRT2284919	hsa-miR-664	CLIP-seq
MIRT2284920	hsa-miR-762	CLIP-seq
MIRT2455466	hsa-miR-4251	CLIP-seq
MIRT2455467	hsa-miR-4303	CLIP-seq
MIRT2455468	hsa-miR-4329	CLIP-seq
MIRT2455469	hsa-miR-539	CLIP-seq
MIRT2455470	hsa-miR-548aa	CLIP-seq
MIRT2455471	hsa-miR-548ac	CLIP-seq
MIRT2455472	hsa-miR-548d-3p	CLIP-seq
MIRT2455473	hsa-miR-548z	CLIP-seq
MIRT2455471	hsa-miR-548ac	CLIP-seq
MIRT2455472	hsa-miR-548d-3p	CLIP-seq
MIRT2455473	hsa-miR-548z	CLIP-seq
MIRT2686581	hsa-miR-653	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IEA
GO:0031098	Process	Stress-activated protein kinase signaling cascade	IBA	21873635
GO:0031532	Process	Actin cytoskeleton reorganization	IBA	21873635
GO:0032147	Process	Activation of protein kinase activity	IBA	21873635
GO:0048812	Process	Neuron projection morphogenesis	IBA	21873635
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA

Other IDs

• MIM: 300791
• HGNC: 25391
• e!Ensembl: ENSG00000123572

Protein

• UniProt ID: Q7Z2Y5
• Protein name: Nik-related protein kinase (EC 2.7.11.1)
• Protein function: May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	25 → 313	Protein kinase domain	Domain
  PF00780	CNH	1213 → 1549	CNH domain	Family

• Sequence:

  MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK
  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG
  QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG
  QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV
  WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF
  RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR
  FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQ
  ALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMP
  LQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQ
  RHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVLL
  PLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNSKPLG
  PLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDL
  EARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHSIQAEVQIEPLKPYISNPK
  KIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDIRQRSSQNRQNWLAASESS
  SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIF
  RNDWLTPAPVIQPPEEDGDYVELYDASADTDGDDDDESNDTFEDTYDHANGNDDLDNQVD
  QANDVCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYG
  SHTANRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESGALGLNGE
  ENCSETDGPGLKRPASQDFEYLQEEPGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQ
  SDFSANHSSPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPL
  IHMYEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLN
  LLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVL
  QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQ
  AADPVNRFKRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAES
  EVMSDVTLPKNPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDI
  PSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRN
  HHSRVYFMTLGKLEELQSNYDV

• Sequence length: 1582

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Adenocarcinoma of large intestine	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208
Sotos` syndrome	Sotos` syndrome	rs121908067, rs1562213381, rs1562295135, rs1562296511, rs121908068, rs121908069, rs864309639, rs1562099585, rs121908070, rs1562269320, rs1562312238, rs121908071, rs80338957, rs398124379, rs587784068, rs587784071, rs587784073, rs587784076, rs587784077, rs587784078, rs587784079, rs587784080, rs587784081, rs587784082, rs587784084, rs587784085, rs201327209, rs587784086, rs587784087, rs587784088, rs587784089, rs587784092, rs587784093, rs587784094, rs587784095, rs587784096, rs587784097, rs587784098, rs587784099, rs587784100, rs587784101, rs587784103, rs587784104, rs587784105, rs587784107, rs587784109, rs587784110, rs587784111, rs587784112, rs587784114, rs587784115, rs570278338, rs587784117, rs587784118, rs587784119, rs587784121, rs587784122, rs587784123, rs587784124, rs587784125, rs587784126, rs587784127, rs398124378, rs587784128, rs587784132, rs587784131, rs587784133, rs587784135, rs587784137, rs587784138, rs587784139, rs587784140, rs587784141, rs587784142, rs587784143, rs587784144, rs587784145, rs587784146, rs587784147, rs587784148, rs587784149, rs587784150, rs587784151, rs587784152, rs587784153, rs587784154, rs587784155, rs587784156, rs587784157, rs587784158, rs587784160, rs587784162, rs587784163, rs587784164, rs587784165, rs587784166, rs587784167, rs587784168, rs587784169, rs587784170, rs587784171, rs587784173, rs587784174, rs587784176, rs587784177, rs587784178, rs587784179, rs587784180, rs587784183, rs587784184, rs587784185, rs587784186, rs587784187, rs587784188, rs587784189, rs587784191, rs587784192, rs587784193, rs587784196, rs587784197, rs587784198, rs587784199, rs587784200, rs587784201, rs587784202, rs587784204, rs587784206, rs587784207, rs587784208, rs587784209, rs587784210, rs587784211, rs587784214, rs587784219, rs587784220, rs587784221, rs786205576, rs794727176, rs794727930, rs794729232, rs797045057, rs797045058, rs797045804, rs797045805, rs797045807, rs797045808, rs797045809, rs797045810, rs797045811, rs797045812, rs797045813, rs797045814, rs797045815, rs797045816, rs797045817, rs797045819, rs797045820, rs797045821, rs797045823, rs797045824, rs797045825, rs797045826, rs797045827, rs797045828, rs797045829, rs797045830, rs797045831, rs797045832, rs797045833, rs797045834, rs863224905, rs878855075, rs878855077, rs879253860, rs886041219, rs886041218, rs1057516048, rs1057520339, rs1554189490, rs1060501492, rs1060501497, rs1060501490, rs1060501493, rs1064794051, rs1131691754, rs1131692328, rs1554189941, rs1554195815, rs1554204921, rs1554190214, rs1554190247, rs1554204923, rs1554195840, rs1554199368, rs1006906224, rs1554189512, rs1554202205, rs1554207287, rs1286331975, rs1554189482, rs1554189972, rs1554204122, rs1554206783, rs1554206836, rs1554207316, rs1562246533, rs1562292879, rs1562251194, rs1562213553, rs1562305653, rs1581318949, rs1581558015, rs1581321541, rs1581315609, rs1581319715, rs1581468355, rs1581433729, rs1581548112, rs1581407682, rs1581408152, rs1581411423, rs1581527842, rs1581535570, rs1581563059, rs1581319867, rs1581457332, rs1581491984, rs1756522180	21834033

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Inhibit	32162334
Fibrosis	Stimulate	38459501
Hyperplasia	Inhibit	32162334
Prostatic Hyperplasia	Stimulate	38459501
Prostatitis	Associate	38459501
Triple Negative Breast Neoplasms	Associate	30175120