Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	203447
Gene name Gene Name - the full gene name approved by the HGNC.	Nik related kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NRK
Synonyms (NCBI Gene) Gene synonyms aliases	NESK
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xq22.3
Summary Summary of gene provided in NCBI Entrez Gene.	The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]

Show/Hide all(106)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018046	hsa-miR-335-5p	Microarray	18185580
MIRT1194186	hsa-miR-1183	CLIP-seq
MIRT1194187	hsa-miR-1285	CLIP-seq
MIRT1194188	hsa-miR-130a	CLIP-seq
MIRT1194189	hsa-miR-130b	CLIP-seq
MIRT1194190	hsa-miR-1911	CLIP-seq
MIRT1194191	hsa-miR-219-1-3p	CLIP-seq
MIRT1194192	hsa-miR-301a	CLIP-seq
MIRT1194193	hsa-miR-301b	CLIP-seq
MIRT1194194	hsa-miR-30a	CLIP-seq
MIRT1194195	hsa-miR-30b	CLIP-seq
MIRT1194196	hsa-miR-30c	CLIP-seq
MIRT1194197	hsa-miR-30d	CLIP-seq
MIRT1194198	hsa-miR-30e	CLIP-seq
MIRT1194199	hsa-miR-3187-5p	CLIP-seq
MIRT1194200	hsa-miR-3198	CLIP-seq
MIRT1194201	hsa-miR-326	CLIP-seq
MIRT1194202	hsa-miR-330-5p	CLIP-seq
MIRT1194203	hsa-miR-3616-5p	CLIP-seq
MIRT1194204	hsa-miR-3617	CLIP-seq
MIRT1194205	hsa-miR-3647-5p	CLIP-seq
MIRT1194206	hsa-miR-3665	CLIP-seq
MIRT1194207	hsa-miR-3666	CLIP-seq
MIRT1194208	hsa-miR-378g	CLIP-seq
MIRT1194209	hsa-miR-3945	CLIP-seq
MIRT1194210	hsa-miR-4253	CLIP-seq
MIRT1194211	hsa-miR-4295	CLIP-seq
MIRT1194212	hsa-miR-4309	CLIP-seq
MIRT1194213	hsa-miR-4457	CLIP-seq
MIRT1194214	hsa-miR-4486	CLIP-seq
MIRT1194215	hsa-miR-454	CLIP-seq
MIRT1194216	hsa-miR-4642	CLIP-seq
MIRT1194217	hsa-miR-4643	CLIP-seq
MIRT1194218	hsa-miR-466	CLIP-seq
MIRT1194219	hsa-miR-4709-3p	CLIP-seq
MIRT1194220	hsa-miR-4768-5p	CLIP-seq
MIRT1194221	hsa-miR-4789-3p	CLIP-seq
MIRT1194222	hsa-miR-554	CLIP-seq
MIRT1194223	hsa-miR-556-5p	CLIP-seq
MIRT1194224	hsa-miR-563	CLIP-seq
MIRT1194225	hsa-miR-571	CLIP-seq
MIRT1194226	hsa-miR-573	CLIP-seq
MIRT1194227	hsa-miR-612	CLIP-seq
MIRT1194228	hsa-miR-617	CLIP-seq
MIRT1194229	hsa-miR-641	CLIP-seq
MIRT1194230	hsa-miR-657	CLIP-seq
MIRT2056358	hsa-miR-1207-3p	CLIP-seq
MIRT2056359	hsa-miR-1246	CLIP-seq
MIRT2056360	hsa-miR-3124-3p	CLIP-seq
MIRT2056361	hsa-miR-3134	CLIP-seq
MIRT2056362	hsa-miR-3155	CLIP-seq
MIRT2056363	hsa-miR-3155b	CLIP-seq
MIRT2056364	hsa-miR-3671	CLIP-seq
MIRT2056365	hsa-miR-3685	CLIP-seq
MIRT2056366	hsa-miR-384	CLIP-seq
MIRT2056367	hsa-miR-3915	CLIP-seq
MIRT2056368	hsa-miR-4461	CLIP-seq
MIRT2056369	hsa-miR-4729	CLIP-seq
MIRT2056370	hsa-miR-4766-5p	CLIP-seq
MIRT2056371	hsa-miR-484	CLIP-seq
MIRT2056372	hsa-miR-607	CLIP-seq
MIRT2284890	hsa-miR-1245b-3p	CLIP-seq
MIRT2284891	hsa-miR-2115	CLIP-seq
MIRT2284892	hsa-miR-221	CLIP-seq
MIRT2284893	hsa-miR-222	CLIP-seq
MIRT2284894	hsa-miR-224	CLIP-seq
MIRT2284895	hsa-miR-3182	CLIP-seq
MIRT2284896	hsa-miR-3942-3p	CLIP-seq
MIRT2284897	hsa-miR-4274	CLIP-seq
MIRT2284898	hsa-miR-4283	CLIP-seq
MIRT2284899	hsa-miR-4421	CLIP-seq
MIRT2284900	hsa-miR-4489	CLIP-seq
MIRT2284901	hsa-miR-4492	CLIP-seq
MIRT2284902	hsa-miR-4498	CLIP-seq
MIRT2284903	hsa-miR-4505	CLIP-seq
MIRT2284904	hsa-miR-4519	CLIP-seq
MIRT2284905	hsa-miR-4524	CLIP-seq
MIRT2284906	hsa-miR-4677-3p	CLIP-seq
MIRT2284907	hsa-miR-4679	CLIP-seq
MIRT2284908	hsa-miR-4731-5p	CLIP-seq
MIRT1194221	hsa-miR-4789-3p	CLIP-seq
MIRT2284909	hsa-miR-4796-5p	CLIP-seq
MIRT2284910	hsa-miR-4803	CLIP-seq
MIRT2284911	hsa-miR-494	CLIP-seq
MIRT2284912	hsa-miR-495	CLIP-seq
MIRT2284913	hsa-miR-548ag	CLIP-seq
MIRT2284914	hsa-miR-548ai	CLIP-seq
MIRT2284915	hsa-miR-548v	CLIP-seq
MIRT1194223	hsa-miR-556-5p	CLIP-seq
MIRT2284916	hsa-miR-561	CLIP-seq
MIRT2284917	hsa-miR-624	CLIP-seq
MIRT2284918	hsa-miR-652	CLIP-seq
MIRT2284919	hsa-miR-664	CLIP-seq
MIRT2284920	hsa-miR-762	CLIP-seq
MIRT2455466	hsa-miR-4251	CLIP-seq
MIRT2455467	hsa-miR-4303	CLIP-seq
MIRT2455468	hsa-miR-4329	CLIP-seq
MIRT2455469	hsa-miR-539	CLIP-seq
MIRT2455470	hsa-miR-548aa	CLIP-seq
MIRT2455471	hsa-miR-548ac	CLIP-seq
MIRT2455472	hsa-miR-548d-3p	CLIP-seq
MIRT2455473	hsa-miR-548z	CLIP-seq
MIRT2455471	hsa-miR-548ac	CLIP-seq
MIRT2455472	hsa-miR-548d-3p	CLIP-seq
MIRT2455473	hsa-miR-548z	CLIP-seq
MIRT2686581	hsa-miR-653	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IBA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0046330	Process	Positive regulation of JNK cascade	IBA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
300791	25391	ENSG00000123572

Protein

UniProt ID

Q7Z2Y5

Protein name

Nik-related protein kinase (EC 2.7.11.1)

Protein function

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	25 → 313	Protein kinase domain	Domain
PF00780	CNH	1213 → 1549	CNH domain	Family

Sequence

MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK
TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG
QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG
QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV
WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF
RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR
FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQ
ALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMP
LQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQ
RHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVLL
PLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNSKPLG
PLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDL
EARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHSIQAEVQIEPLKPYISNPK
KIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDIRQRSSQNRQNWLAASESS
SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIF
RNDWLTPAPVIQPPEEDGDYVELYDASADTDGDDDDESNDTFEDTYDHANGNDDLDNQVD
QANDVCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYG
SHTANRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESGALGLNGE
ENCSETDGPGLKRPASQDFEYLQEEPGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQ
SDFSANHSSPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPL
IHMYEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLN
LLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVL
QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQ
AADPVNRFKRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAES
EVMSDVTLPKNPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDI
PSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRN
HHSRVYFMTLGKLEELQSNYDV

Sequence length

1582

Interactions

View interactions

NRK (Nik related kinase)