Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2034
Gene name	Endothelial PAS domain protein 1
Gene symbol	EPAS1
Synonyms (NCBI Gene)	ECYT4HIF2AHLFMOP2PASD2bHLHe73
Chromosome	2
Chromosome location	2p21
Summary	This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in

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SNP ID	Visualize variation	Clinical significance	Consequence
rs137853036	G>A,T	Pathogenic	Coding sequence variant, missense variant
rs137853037	A>G	Pathogenic	Coding sequence variant, missense variant

693

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006962	hsa-miR-185-5p	Luciferase reporter assayqRT-PCR	22745131
MIRT006962	hsa-miR-185-5p	Luciferase reporter assayqRT-PCR	22745131
MIRT053030	hsa-miR-145-5p	Luciferase reporter assayqRT-PCRWestern blot	23222716
MIRT053030	hsa-miR-145-5p	Luciferase reporter assayqRT-PCRWestern blot	23222716
MIRT438161	hsa-miR-17-5p	Luciferase reporter assay	24194900
MIRT438161	hsa-miR-17-5p	Luciferase reporter assay	24194900
MIRT438160	hsa-miR-20a-5p	Luciferase reporter assay	24194900
MIRT438160	hsa-miR-20a-5p	Luciferase reporter assay	24194900
MIRT438160	hsa-miR-20a-5p	Luciferase reporter assay	24194900
MIRT438161	hsa-miR-17-5p	Luciferase reporter assay	24194900
MIRT438161	hsa-miR-17-5p	Luciferase reporter assay	24194900
MIRT438160	hsa-miR-20a-5p	Luciferase reporter assay	24194900
MIRT438160	hsa-miR-20a-5p	Luciferase reporter assay	24194900
MIRT438160	hsa-miR-20a-5p	Luciferase reporter assay	24194900
MIRT500129	hsa-miR-7108-3p	PAR-CLIP	22012620
MIRT500128	hsa-miR-4758-3p	PAR-CLIP	22012620
MIRT500127	hsa-miR-6763-3p	PAR-CLIP	22012620
MIRT500129	hsa-miR-7108-3p	PAR-CLIP	24398324
MIRT500128	hsa-miR-4758-3p	PAR-CLIP	24398324
MIRT500127	hsa-miR-6763-3p	PAR-CLIP	24398324
MIRT735082	hsa-miR-455-3p	Luciferase reporter assayImmunohistochemistry (IHC)qRT-PCR	34230481
MIRT735084	hsa-miR-455-5p	Luciferase reporter assayImmunohistochemistry (IHC)qRT-PCR	34230481
MIRT500129	hsa-miR-7108-3p	PAR-CLIP	22012620
MIRT500128	hsa-miR-4758-3p	PAR-CLIP	22012620
MIRT500127	hsa-miR-6763-3p	PAR-CLIP	22012620
MIRT500129	hsa-miR-7108-3p	PAR-CLIP	24398324
MIRT500128	hsa-miR-4758-3p	PAR-CLIP	24398324
MIRT500127	hsa-miR-6763-3p	PAR-CLIP	24398324
MIRT965300	hsa-miR-106a	CLIP-seq
MIRT965301	hsa-miR-106b	CLIP-seq
MIRT965302	hsa-miR-1264	CLIP-seq
MIRT965303	hsa-miR-1271	CLIP-seq
MIRT965304	hsa-miR-129-5p	CLIP-seq
MIRT965305	hsa-miR-139-3p	CLIP-seq
MIRT965306	hsa-miR-142-5p	CLIP-seq
MIRT965307	hsa-miR-147	CLIP-seq
MIRT965308	hsa-miR-17	CLIP-seq
MIRT965309	hsa-miR-182	CLIP-seq
MIRT965310	hsa-miR-20a	CLIP-seq
MIRT965311	hsa-miR-20b	CLIP-seq
MIRT965312	hsa-miR-2113	CLIP-seq
MIRT965313	hsa-miR-218	CLIP-seq
MIRT965314	hsa-miR-2276	CLIP-seq
MIRT965315	hsa-miR-3121-3p	CLIP-seq
MIRT965316	hsa-miR-3136-3p	CLIP-seq
MIRT965317	hsa-miR-3148	CLIP-seq
MIRT965318	hsa-miR-3154	CLIP-seq
MIRT965319	hsa-miR-3156-5p	CLIP-seq
MIRT965320	hsa-miR-3194-3p	CLIP-seq
MIRT965321	hsa-miR-328	CLIP-seq
MIRT965322	hsa-miR-340	CLIP-seq
MIRT965323	hsa-miR-3591-3p	CLIP-seq
MIRT965324	hsa-miR-3609	CLIP-seq
MIRT965325	hsa-miR-3619-3p	CLIP-seq
MIRT965326	hsa-miR-365	CLIP-seq
MIRT965327	hsa-miR-3662	CLIP-seq
MIRT965328	hsa-miR-378	CLIP-seq
MIRT965329	hsa-miR-378b	CLIP-seq
MIRT965330	hsa-miR-378c	CLIP-seq
MIRT965331	hsa-miR-378d	CLIP-seq
MIRT965332	hsa-miR-378e	CLIP-seq
MIRT965333	hsa-miR-378f	CLIP-seq
MIRT965334	hsa-miR-378h	CLIP-seq
MIRT965335	hsa-miR-378i	CLIP-seq
MIRT965336	hsa-miR-3978	CLIP-seq
MIRT965337	hsa-miR-422a	CLIP-seq
MIRT965338	hsa-miR-4259	CLIP-seq
MIRT965339	hsa-miR-4276	CLIP-seq
MIRT965340	hsa-miR-4302	CLIP-seq
MIRT965341	hsa-miR-4419a	CLIP-seq
MIRT965342	hsa-miR-4453	CLIP-seq
MIRT965343	hsa-miR-4468	CLIP-seq
MIRT965344	hsa-miR-4496	CLIP-seq
MIRT965345	hsa-miR-4510	CLIP-seq
MIRT965346	hsa-miR-4527	CLIP-seq
MIRT965347	hsa-miR-4538	CLIP-seq
MIRT965348	hsa-miR-4638-3p	CLIP-seq
MIRT965349	hsa-miR-4668-5p	CLIP-seq
MIRT965350	hsa-miR-4698	CLIP-seq
MIRT965351	hsa-miR-4708-3p	CLIP-seq
MIRT965352	hsa-miR-4715-5p	CLIP-seq
MIRT965353	hsa-miR-4737	CLIP-seq
MIRT965354	hsa-miR-4773	CLIP-seq
MIRT965355	hsa-miR-4776-5p	CLIP-seq
MIRT965356	hsa-miR-4796-3p	CLIP-seq
MIRT965357	hsa-miR-488	CLIP-seq
MIRT965358	hsa-miR-501-3p	CLIP-seq
MIRT965359	hsa-miR-502-3p	CLIP-seq
MIRT965360	hsa-miR-519d	CLIP-seq
MIRT965361	hsa-miR-548a-3p	CLIP-seq
MIRT965362	hsa-miR-548ah	CLIP-seq
MIRT965363	hsa-miR-548e	CLIP-seq
MIRT965364	hsa-miR-548f	CLIP-seq
MIRT965365	hsa-miR-548p	CLIP-seq
MIRT965366	hsa-miR-561	CLIP-seq
MIRT965367	hsa-miR-582-5p	CLIP-seq
MIRT965368	hsa-miR-599	CLIP-seq
MIRT965369	hsa-miR-636	CLIP-seq
MIRT965370	hsa-miR-651	CLIP-seq
MIRT965371	hsa-miR-758	CLIP-seq
MIRT965372	hsa-miR-760	CLIP-seq
MIRT965373	hsa-miR-767-5p	CLIP-seq
MIRT965374	hsa-miR-93	CLIP-seq
MIRT965375	hsa-miR-938	CLIP-seq
MIRT965376	hsa-miR-96	CLIP-seq
MIRT1548353	hsa-miR-127-5p	CLIP-seq
MIRT1548354	hsa-miR-3177-5p	CLIP-seq
MIRT965326	hsa-miR-365	CLIP-seq
MIRT1548355	hsa-miR-3653	CLIP-seq
MIRT1548356	hsa-miR-3658	CLIP-seq
MIRT965327	hsa-miR-3662	CLIP-seq
MIRT1548357	hsa-miR-3942-3p	CLIP-seq
MIRT1548358	hsa-miR-4511	CLIP-seq
MIRT965354	hsa-miR-4773	CLIP-seq
MIRT1548359	hsa-miR-548b-3p	CLIP-seq
MIRT1548360	hsa-miR-548c-3p	CLIP-seq
MIRT1556308	hsa-miR-1246	CLIP-seq
MIRT1556309	hsa-miR-1261	CLIP-seq
MIRT1556310	hsa-miR-1273d	CLIP-seq
MIRT1556311	hsa-miR-185	CLIP-seq
MIRT1556312	hsa-miR-1912	CLIP-seq
MIRT965317	hsa-miR-3148	CLIP-seq
MIRT1556313	hsa-miR-4279	CLIP-seq
MIRT1556314	hsa-miR-4306	CLIP-seq
MIRT1556315	hsa-miR-4644	CLIP-seq
MIRT1556316	hsa-miR-4668-3p	CLIP-seq
MIRT1556317	hsa-miR-493	CLIP-seq
MIRT1556318	hsa-miR-513a-3p	CLIP-seq
MIRT1548360	hsa-miR-548c-3p	CLIP-seq
MIRT1556319	hsa-miR-616	CLIP-seq
MIRT1986059	hsa-miR-1301	CLIP-seq
MIRT965307	hsa-miR-147	CLIP-seq
MIRT1986060	hsa-miR-148a	CLIP-seq
MIRT1986061	hsa-miR-148b	CLIP-seq
MIRT1986062	hsa-miR-152	CLIP-seq
MIRT1986063	hsa-miR-1973	CLIP-seq
MIRT965326	hsa-miR-365	CLIP-seq
MIRT1986064	hsa-miR-3944-5p	CLIP-seq
MIRT1986065	hsa-miR-4452	CLIP-seq
MIRT1986066	hsa-miR-4517	CLIP-seq
MIRT1986067	hsa-miR-4660	CLIP-seq
MIRT1986068	hsa-miR-5047	CLIP-seq
MIRT1986069	hsa-miR-579	CLIP-seq
MIRT2220456	hsa-miR-105	CLIP-seq
MIRT965300	hsa-miR-106a	CLIP-seq
MIRT965301	hsa-miR-106b	CLIP-seq
MIRT2220457	hsa-miR-1468	CLIP-seq
MIRT1986060	hsa-miR-148a	CLIP-seq
MIRT1986061	hsa-miR-148b	CLIP-seq
MIRT1986062	hsa-miR-152	CLIP-seq
MIRT965308	hsa-miR-17	CLIP-seq
MIRT965310	hsa-miR-20a	CLIP-seq
MIRT965311	hsa-miR-20b	CLIP-seq
MIRT965312	hsa-miR-2113	CLIP-seq
MIRT2220458	hsa-miR-3123	CLIP-seq
MIRT965317	hsa-miR-3148	CLIP-seq
MIRT965319	hsa-miR-3156-5p	CLIP-seq
MIRT965323	hsa-miR-3591-3p	CLIP-seq
MIRT965324	hsa-miR-3609	CLIP-seq
MIRT2220459	hsa-miR-376c	CLIP-seq
MIRT2220460	hsa-miR-3925-5p	CLIP-seq
MIRT2220461	hsa-miR-3976	CLIP-seq
MIRT2220462	hsa-miR-4263	CLIP-seq
MIRT1986065	hsa-miR-4452	CLIP-seq
MIRT965342	hsa-miR-4453	CLIP-seq
MIRT965343	hsa-miR-4468	CLIP-seq
MIRT965347	hsa-miR-4538	CLIP-seq
MIRT1556316	hsa-miR-4668-3p	CLIP-seq
MIRT965349	hsa-miR-4668-5p	CLIP-seq
MIRT2220463	hsa-miR-4706	CLIP-seq
MIRT2220464	hsa-miR-4749-5p	CLIP-seq
MIRT965356	hsa-miR-4796-3p	CLIP-seq
MIRT965360	hsa-miR-519d	CLIP-seq
MIRT965362	hsa-miR-548ah	CLIP-seq
MIRT2220465	hsa-miR-576-5p	CLIP-seq
MIRT1986069	hsa-miR-579	CLIP-seq
MIRT2220466	hsa-miR-625	CLIP-seq
MIRT2220467	hsa-miR-660	CLIP-seq
MIRT2220468	hsa-miR-744	CLIP-seq
MIRT965371	hsa-miR-758	CLIP-seq
MIRT965374	hsa-miR-93	CLIP-seq
MIRT1986065	hsa-miR-4452	CLIP-seq
MIRT1986069	hsa-miR-579	CLIP-seq
MIRT965300	hsa-miR-106a	CLIP-seq
MIRT965301	hsa-miR-106b	CLIP-seq
MIRT2428533	hsa-miR-1184	CLIP-seq
MIRT2428534	hsa-miR-1205	CLIP-seq
MIRT1556308	hsa-miR-1246	CLIP-seq
MIRT2428535	hsa-miR-1253	CLIP-seq
MIRT1556309	hsa-miR-1261	CLIP-seq
MIRT1556310	hsa-miR-1273d	CLIP-seq
MIRT1548353	hsa-miR-127-5p	CLIP-seq
MIRT2428536	hsa-miR-1283	CLIP-seq
MIRT965304	hsa-miR-129-5p	CLIP-seq
MIRT965306	hsa-miR-142-5p	CLIP-seq
MIRT2220457	hsa-miR-1468	CLIP-seq
MIRT965307	hsa-miR-147	CLIP-seq
MIRT965308	hsa-miR-17	CLIP-seq
MIRT1556311	hsa-miR-185	CLIP-seq
MIRT1556312	hsa-miR-1912	CLIP-seq
MIRT2428537	hsa-miR-199a-3p	CLIP-seq
MIRT2428538	hsa-miR-199a-5p	CLIP-seq
MIRT2428539	hsa-miR-199b-3p	CLIP-seq
MIRT2428540	hsa-miR-199b-5p	CLIP-seq
MIRT965310	hsa-miR-20a	CLIP-seq
MIRT965311	hsa-miR-20b	CLIP-seq
MIRT2428541	hsa-miR-223	CLIP-seq
MIRT2428542	hsa-miR-27a	CLIP-seq
MIRT2428543	hsa-miR-27b	CLIP-seq
MIRT2428544	hsa-miR-2861	CLIP-seq
MIRT2428545	hsa-miR-296-3p	CLIP-seq
MIRT2428546	hsa-miR-3129-5p	CLIP-seq
MIRT965317	hsa-miR-3148	CLIP-seq
MIRT2428547	hsa-miR-3150a-3p	CLIP-seq
MIRT2428548	hsa-miR-3157-5p	CLIP-seq
MIRT2428549	hsa-miR-3158-5p	CLIP-seq
MIRT2428550	hsa-miR-3173-3p	CLIP-seq
MIRT2428551	hsa-miR-3175	CLIP-seq
MIRT1548354	hsa-miR-3177-5p	CLIP-seq
MIRT2428552	hsa-miR-3198	CLIP-seq
MIRT2428553	hsa-miR-338-5p	CLIP-seq
MIRT965322	hsa-miR-340	CLIP-seq
MIRT965324	hsa-miR-3609	CLIP-seq
MIRT1548355	hsa-miR-3653	CLIP-seq
MIRT2428554	hsa-miR-3654	CLIP-seq
MIRT1548356	hsa-miR-3658	CLIP-seq
MIRT2428555	hsa-miR-3673	CLIP-seq
MIRT2428556	hsa-miR-369-3p	CLIP-seq
MIRT2428557	hsa-miR-374a	CLIP-seq
MIRT2428558	hsa-miR-374b	CLIP-seq
MIRT2428559	hsa-miR-3918	CLIP-seq
MIRT1548357	hsa-miR-3942-3p	CLIP-seq
MIRT2428560	hsa-miR-3973	CLIP-seq
MIRT2428561	hsa-miR-409-3p	CLIP-seq
MIRT2428562	hsa-miR-4252	CLIP-seq
MIRT2220462	hsa-miR-4263	CLIP-seq
MIRT965339	hsa-miR-4276	CLIP-seq
MIRT2428563	hsa-miR-4282	CLIP-seq
MIRT2428564	hsa-miR-4300	CLIP-seq
MIRT965340	hsa-miR-4302	CLIP-seq
MIRT1556314	hsa-miR-4306	CLIP-seq
MIRT2428565	hsa-miR-4309	CLIP-seq
MIRT2428566	hsa-miR-4330	CLIP-seq
MIRT965341	hsa-miR-4419a	CLIP-seq
MIRT2428567	hsa-miR-4428	CLIP-seq
MIRT2428568	hsa-miR-4434	CLIP-seq
MIRT2428569	hsa-miR-4438	CLIP-seq
MIRT965342	hsa-miR-4453	CLIP-seq
MIRT2428570	hsa-miR-4474-3p	CLIP-seq
MIRT965345	hsa-miR-4510	CLIP-seq
MIRT1548358	hsa-miR-4511	CLIP-seq
MIRT2428571	hsa-miR-4512	CLIP-seq
MIRT2428572	hsa-miR-4516	CLIP-seq
MIRT1986066	hsa-miR-4517	CLIP-seq
MIRT2428573	hsa-miR-4520a-3p	CLIP-seq
MIRT965347	hsa-miR-4538	CLIP-seq
MIRT965348	hsa-miR-4638-3p	CLIP-seq
MIRT1556315	hsa-miR-4644	CLIP-seq
MIRT2428574	hsa-miR-4653-3p	CLIP-seq
MIRT1556316	hsa-miR-4668-3p	CLIP-seq
MIRT2428575	hsa-miR-4685-5p	CLIP-seq
MIRT2428576	hsa-miR-4691-3p	CLIP-seq
MIRT2428577	hsa-miR-4697-3p	CLIP-seq
MIRT965350	hsa-miR-4698	CLIP-seq
MIRT2428578	hsa-miR-4717-5p	CLIP-seq
MIRT2428579	hsa-miR-4725-5p	CLIP-seq
MIRT2428580	hsa-miR-4753-5p	CLIP-seq
MIRT2428581	hsa-miR-4760-5p	CLIP-seq
MIRT965354	hsa-miR-4773	CLIP-seq
MIRT2428582	hsa-miR-4779	CLIP-seq
MIRT965356	hsa-miR-4796-3p	CLIP-seq
MIRT965357	hsa-miR-488	CLIP-seq
MIRT2428583	hsa-miR-491-5p	CLIP-seq
MIRT1556317	hsa-miR-493	CLIP-seq
MIRT965358	hsa-miR-501-3p	CLIP-seq
MIRT965359	hsa-miR-502-3p	CLIP-seq
MIRT2428584	hsa-miR-504	CLIP-seq
MIRT2428585	hsa-miR-5095	CLIP-seq
MIRT1556318	hsa-miR-513a-3p	CLIP-seq
MIRT2428586	hsa-miR-513a-5p	CLIP-seq
MIRT965360	hsa-miR-519d	CLIP-seq
MIRT2428587	hsa-miR-520d-5p	CLIP-seq
MIRT2428588	hsa-miR-524-5p	CLIP-seq
MIRT965362	hsa-miR-548ah	CLIP-seq
MIRT1548359	hsa-miR-548b-3p	CLIP-seq
MIRT1548360	hsa-miR-548c-3p	CLIP-seq
MIRT2428589	hsa-miR-548k	CLIP-seq
MIRT2428590	hsa-miR-551a	CLIP-seq
MIRT2428591	hsa-miR-551b	CLIP-seq
MIRT965366	hsa-miR-561	CLIP-seq
MIRT2220465	hsa-miR-576-5p	CLIP-seq
MIRT965367	hsa-miR-582-5p	CLIP-seq
MIRT2220467	hsa-miR-660	CLIP-seq
MIRT965373	hsa-miR-767-5p	CLIP-seq
MIRT2428592	hsa-miR-769-5p	CLIP-seq
MIRT2428593	hsa-miR-889	CLIP-seq
MIRT2428594	hsa-miR-920	CLIP-seq
MIRT965374	hsa-miR-93	CLIP-seq
MIRT2428595	hsa-miR-936	CLIP-seq
MIRT2428596	hsa-miR-939	CLIP-seq
MIRT2436965	hsa-miR-10a	CLIP-seq
MIRT2436966	hsa-miR-10b	CLIP-seq
MIRT2428533	hsa-miR-1184	CLIP-seq
MIRT2428534	hsa-miR-1205	CLIP-seq
MIRT2436967	hsa-miR-1228	CLIP-seq
MIRT2436968	hsa-miR-1245b-5p	CLIP-seq
MIRT2436969	hsa-miR-1247	CLIP-seq
MIRT2436970	hsa-miR-128	CLIP-seq
MIRT1986059	hsa-miR-1301	CLIP-seq
MIRT2436971	hsa-miR-1321	CLIP-seq
MIRT965307	hsa-miR-147	CLIP-seq
MIRT2436972	hsa-miR-149	CLIP-seq
MIRT2436973	hsa-miR-183	CLIP-seq
MIRT2436974	hsa-miR-1909	CLIP-seq
MIRT1556312	hsa-miR-1912	CLIP-seq
MIRT1986063	hsa-miR-1973	CLIP-seq
MIRT2436975	hsa-miR-219-5p	CLIP-seq
MIRT2428544	hsa-miR-2861	CLIP-seq
MIRT2436976	hsa-miR-3064-5p	CLIP-seq
MIRT2436977	hsa-miR-3126-3p	CLIP-seq
MIRT2436978	hsa-miR-3142	CLIP-seq
MIRT2436979	hsa-miR-3151	CLIP-seq
MIRT2428548	hsa-miR-3157-5p	CLIP-seq
MIRT2428549	hsa-miR-3158-5p	CLIP-seq
MIRT2436980	hsa-miR-3168	CLIP-seq
MIRT2436981	hsa-miR-3612	CLIP-seq
MIRT965325	hsa-miR-3619-3p	CLIP-seq
MIRT2436982	hsa-miR-3620	CLIP-seq
MIRT965326	hsa-miR-365	CLIP-seq
MIRT2428554	hsa-miR-3654	CLIP-seq
MIRT2436983	hsa-miR-3663-5p	CLIP-seq
MIRT2436984	hsa-miR-3678-5p	CLIP-seq
MIRT2436985	hsa-miR-3692	CLIP-seq
MIRT965328	hsa-miR-378	CLIP-seq
MIRT965329	hsa-miR-378b	CLIP-seq
MIRT965330	hsa-miR-378c	CLIP-seq
MIRT965331	hsa-miR-378d	CLIP-seq
MIRT965332	hsa-miR-378e	CLIP-seq
MIRT965333	hsa-miR-378f	CLIP-seq
MIRT965334	hsa-miR-378h	CLIP-seq
MIRT965335	hsa-miR-378i	CLIP-seq
MIRT2436986	hsa-miR-3911	CLIP-seq
MIRT2428559	hsa-miR-3918	CLIP-seq
MIRT1986064	hsa-miR-3944-5p	CLIP-seq
MIRT965337	hsa-miR-422a	CLIP-seq
MIRT2436987	hsa-miR-423-3p	CLIP-seq
MIRT2436988	hsa-miR-4254	CLIP-seq
MIRT2436989	hsa-miR-4292	CLIP-seq
MIRT2436990	hsa-miR-4297	CLIP-seq
MIRT2428564	hsa-miR-4300	CLIP-seq
MIRT2436991	hsa-miR-4308	CLIP-seq
MIRT965341	hsa-miR-4419a	CLIP-seq
MIRT2428569	hsa-miR-4438	CLIP-seq
MIRT2436992	hsa-miR-4443	CLIP-seq
MIRT2436993	hsa-miR-4446-3p	CLIP-seq
MIRT2436994	hsa-miR-4447	CLIP-seq
MIRT1986065	hsa-miR-4452	CLIP-seq
MIRT2436995	hsa-miR-4470	CLIP-seq
MIRT2436996	hsa-miR-4472	CLIP-seq
MIRT2428570	hsa-miR-4474-3p	CLIP-seq
MIRT2436997	hsa-miR-4481	CLIP-seq
MIRT2436998	hsa-miR-4488	CLIP-seq
MIRT2436999	hsa-miR-4492	CLIP-seq
MIRT2437000	hsa-miR-4498	CLIP-seq
MIRT965345	hsa-miR-4510	CLIP-seq
MIRT2428571	hsa-miR-4512	CLIP-seq
MIRT965346	hsa-miR-4527	CLIP-seq
MIRT2437001	hsa-miR-4529-5p	CLIP-seq
MIRT965348	hsa-miR-4638-3p	CLIP-seq
MIRT1986067	hsa-miR-4660	CLIP-seq
MIRT2437002	hsa-miR-4669	CLIP-seq
MIRT2428575	hsa-miR-4685-5p	CLIP-seq
MIRT2437003	hsa-miR-4688	CLIP-seq
MIRT2428576	hsa-miR-4691-3p	CLIP-seq
MIRT2437004	hsa-miR-4697-5p	CLIP-seq
MIRT2220463	hsa-miR-4706	CLIP-seq
MIRT2437005	hsa-miR-4715-3p	CLIP-seq
MIRT2437006	hsa-miR-4739	CLIP-seq
MIRT2437007	hsa-miR-4745-5p	CLIP-seq
MIRT2220464	hsa-miR-4749-5p	CLIP-seq
MIRT2437008	hsa-miR-4756-5p	CLIP-seq
MIRT2437009	hsa-miR-4758-5p	CLIP-seq
MIRT965355	hsa-miR-4776-5p	CLIP-seq
MIRT2437010	hsa-miR-4782-3p	CLIP-seq
MIRT2437011	hsa-miR-4794	CLIP-seq
MIRT2428583	hsa-miR-491-5p	CLIP-seq
MIRT1986068	hsa-miR-5047	CLIP-seq
MIRT2428585	hsa-miR-5095	CLIP-seq
MIRT2428590	hsa-miR-551a	CLIP-seq
MIRT2428591	hsa-miR-551b	CLIP-seq
MIRT1986069	hsa-miR-579	CLIP-seq
MIRT2437012	hsa-miR-604	CLIP-seq
MIRT2437013	hsa-miR-644	CLIP-seq
MIRT2437014	hsa-miR-647	CLIP-seq
MIRT2437015	hsa-miR-650	CLIP-seq
MIRT2220468	hsa-miR-744	CLIP-seq
MIRT2437016	hsa-miR-762	CLIP-seq
MIRT2428592	hsa-miR-769-5p	CLIP-seq
MIRT2428594	hsa-miR-920	CLIP-seq
MIRT2436968	hsa-miR-1245b-5p	CLIP-seq
MIRT2436978	hsa-miR-3142	CLIP-seq
MIRT2436965	hsa-miR-10a	CLIP-seq
MIRT2436966	hsa-miR-10b	CLIP-seq
MIRT2428533	hsa-miR-1184	CLIP-seq
MIRT2428534	hsa-miR-1205	CLIP-seq
MIRT2436967	hsa-miR-1228	CLIP-seq
MIRT2436968	hsa-miR-1245b-5p	CLIP-seq
MIRT2436969	hsa-miR-1247	CLIP-seq
MIRT965302	hsa-miR-1264	CLIP-seq
MIRT965303	hsa-miR-1271	CLIP-seq
MIRT1548353	hsa-miR-127-5p	CLIP-seq
MIRT2436970	hsa-miR-128	CLIP-seq
MIRT965304	hsa-miR-129-5p	CLIP-seq
MIRT2524250	hsa-miR-1299	CLIP-seq
MIRT1986059	hsa-miR-1301	CLIP-seq
MIRT2436971	hsa-miR-1321	CLIP-seq
MIRT965307	hsa-miR-147	CLIP-seq
MIRT1986060	hsa-miR-148a	CLIP-seq
MIRT1986061	hsa-miR-148b	CLIP-seq
MIRT2436972	hsa-miR-149	CLIP-seq
MIRT1986062	hsa-miR-152	CLIP-seq
MIRT965309	hsa-miR-182	CLIP-seq
MIRT2436973	hsa-miR-183	CLIP-seq
MIRT2436974	hsa-miR-1909	CLIP-seq
MIRT2524251	hsa-miR-1910	CLIP-seq
MIRT1556312	hsa-miR-1912	CLIP-seq
MIRT1986063	hsa-miR-1973	CLIP-seq
MIRT2436975	hsa-miR-219-5p	CLIP-seq
MIRT965314	hsa-miR-2276	CLIP-seq
MIRT2524252	hsa-miR-2278	CLIP-seq
MIRT2524253	hsa-miR-23a	CLIP-seq
MIRT2524254	hsa-miR-23b	CLIP-seq
MIRT2524255	hsa-miR-23c	CLIP-seq
MIRT2428544	hsa-miR-2861	CLIP-seq
MIRT2428545	hsa-miR-296-3p	CLIP-seq
MIRT2436976	hsa-miR-3064-5p	CLIP-seq
MIRT2524256	hsa-miR-3065-5p	CLIP-seq
MIRT2436977	hsa-miR-3126-3p	CLIP-seq
MIRT2436978	hsa-miR-3142	CLIP-seq
MIRT2436979	hsa-miR-3151	CLIP-seq
MIRT2428548	hsa-miR-3157-5p	CLIP-seq
MIRT2428549	hsa-miR-3158-5p	CLIP-seq
MIRT2436980	hsa-miR-3168	CLIP-seq
MIRT2524257	hsa-miR-3179	CLIP-seq
MIRT965323	hsa-miR-3591-3p	CLIP-seq
MIRT2436981	hsa-miR-3612	CLIP-seq
MIRT965325	hsa-miR-3619-3p	CLIP-seq
MIRT2436982	hsa-miR-3620	CLIP-seq
MIRT965326	hsa-miR-365	CLIP-seq
MIRT1548355	hsa-miR-3653	CLIP-seq
MIRT2428554	hsa-miR-3654	CLIP-seq
MIRT1548356	hsa-miR-3658	CLIP-seq
MIRT965327	hsa-miR-3662	CLIP-seq
MIRT2436983	hsa-miR-3663-5p	CLIP-seq
MIRT2428555	hsa-miR-3673	CLIP-seq
MIRT2436984	hsa-miR-3678-5p	CLIP-seq
MIRT2436985	hsa-miR-3692	CLIP-seq
MIRT2524258	hsa-miR-376a	CLIP-seq
MIRT2524259	hsa-miR-376b	CLIP-seq
MIRT965328	hsa-miR-378	CLIP-seq
MIRT965329	hsa-miR-378b	CLIP-seq
MIRT965330	hsa-miR-378c	CLIP-seq
MIRT965331	hsa-miR-378d	CLIP-seq
MIRT965332	hsa-miR-378e	CLIP-seq
MIRT965333	hsa-miR-378f	CLIP-seq
MIRT965334	hsa-miR-378h	CLIP-seq
MIRT965335	hsa-miR-378i	CLIP-seq
MIRT2436986	hsa-miR-3911	CLIP-seq
MIRT2428559	hsa-miR-3918	CLIP-seq
MIRT1986064	hsa-miR-3944-5p	CLIP-seq
MIRT965337	hsa-miR-422a	CLIP-seq
MIRT2436987	hsa-miR-423-3p	CLIP-seq
MIRT2436988	hsa-miR-4254	CLIP-seq
MIRT2524260	hsa-miR-4264	CLIP-seq
MIRT965339	hsa-miR-4276	CLIP-seq
MIRT2436989	hsa-miR-4292	CLIP-seq
MIRT2436990	hsa-miR-4297	CLIP-seq
MIRT2428564	hsa-miR-4300	CLIP-seq
MIRT965340	hsa-miR-4302	CLIP-seq
MIRT2436991	hsa-miR-4308	CLIP-seq
MIRT2524261	hsa-miR-4325	CLIP-seq
MIRT965341	hsa-miR-4419a	CLIP-seq
MIRT2428569	hsa-miR-4438	CLIP-seq
MIRT2436992	hsa-miR-4443	CLIP-seq
MIRT2436993	hsa-miR-4446-3p	CLIP-seq
MIRT2436994	hsa-miR-4447	CLIP-seq
MIRT1986065	hsa-miR-4452	CLIP-seq
MIRT965342	hsa-miR-4453	CLIP-seq
MIRT2436995	hsa-miR-4470	CLIP-seq
MIRT2436996	hsa-miR-4472	CLIP-seq
MIRT2428570	hsa-miR-4474-3p	CLIP-seq
MIRT2436997	hsa-miR-4481	CLIP-seq
MIRT2436998	hsa-miR-4488	CLIP-seq
MIRT2436999	hsa-miR-4492	CLIP-seq
MIRT2437000	hsa-miR-4498	CLIP-seq
MIRT965345	hsa-miR-4510	CLIP-seq
MIRT2428571	hsa-miR-4512	CLIP-seq
MIRT1986066	hsa-miR-4517	CLIP-seq
MIRT2428573	hsa-miR-4520a-3p	CLIP-seq
MIRT2524262	hsa-miR-4521	CLIP-seq
MIRT965346	hsa-miR-4527	CLIP-seq
MIRT2437001	hsa-miR-4529-5p	CLIP-seq
MIRT965347	hsa-miR-4538	CLIP-seq
MIRT2524263	hsa-miR-4635	CLIP-seq
MIRT965348	hsa-miR-4638-3p	CLIP-seq
MIRT1986067	hsa-miR-4660	CLIP-seq
MIRT2437002	hsa-miR-4669	CLIP-seq
MIRT2428575	hsa-miR-4685-5p	CLIP-seq
MIRT2437003	hsa-miR-4688	CLIP-seq
MIRT2428576	hsa-miR-4691-3p	CLIP-seq
MIRT2437004	hsa-miR-4697-5p	CLIP-seq
MIRT2220463	hsa-miR-4706	CLIP-seq
MIRT965351	hsa-miR-4708-3p	CLIP-seq
MIRT2437005	hsa-miR-4715-3p	CLIP-seq
MIRT2428579	hsa-miR-4725-5p	CLIP-seq
MIRT2437006	hsa-miR-4739	CLIP-seq
MIRT2437007	hsa-miR-4745-5p	CLIP-seq
MIRT2220464	hsa-miR-4749-5p	CLIP-seq
MIRT2437008	hsa-miR-4756-5p	CLIP-seq
MIRT2437009	hsa-miR-4758-5p	CLIP-seq
MIRT965355	hsa-miR-4776-5p	CLIP-seq
MIRT2437010	hsa-miR-4782-3p	CLIP-seq
MIRT2524264	hsa-miR-4782-5p	CLIP-seq
MIRT2437011	hsa-miR-4794	CLIP-seq
MIRT965357	hsa-miR-488	CLIP-seq
MIRT2428583	hsa-miR-491-5p	CLIP-seq
MIRT965358	hsa-miR-501-3p	CLIP-seq
MIRT965359	hsa-miR-502-3p	CLIP-seq
MIRT2428584	hsa-miR-504	CLIP-seq
MIRT1986068	hsa-miR-5047	CLIP-seq
MIRT2428585	hsa-miR-5095	CLIP-seq
MIRT1556318	hsa-miR-513a-3p	CLIP-seq
MIRT2524265	hsa-miR-516b	CLIP-seq
MIRT965361	hsa-miR-548a-3p	CLIP-seq
MIRT965363	hsa-miR-548e	CLIP-seq
MIRT965364	hsa-miR-548f	CLIP-seq
MIRT2428590	hsa-miR-551a	CLIP-seq
MIRT2428591	hsa-miR-551b	CLIP-seq
MIRT1986069	hsa-miR-579	CLIP-seq
MIRT2437012	hsa-miR-604	CLIP-seq
MIRT2524266	hsa-miR-621	CLIP-seq
MIRT2437013	hsa-miR-644	CLIP-seq
MIRT2437014	hsa-miR-647	CLIP-seq
MIRT2437015	hsa-miR-650	CLIP-seq
MIRT2220468	hsa-miR-744	CLIP-seq
MIRT2437016	hsa-miR-762	CLIP-seq
MIRT965373	hsa-miR-767-5p	CLIP-seq
MIRT2428592	hsa-miR-769-5p	CLIP-seq
MIRT2524267	hsa-miR-875-3p	CLIP-seq
MIRT2428593	hsa-miR-889	CLIP-seq
MIRT2428594	hsa-miR-920	CLIP-seq
MIRT965376	hsa-miR-96	CLIP-seq
MIRT2436965	hsa-miR-10a	CLIP-seq
MIRT2436966	hsa-miR-10b	CLIP-seq
MIRT2428533	hsa-miR-1184	CLIP-seq
MIRT2428534	hsa-miR-1205	CLIP-seq
MIRT2436967	hsa-miR-1228	CLIP-seq
MIRT2436968	hsa-miR-1245b-5p	CLIP-seq
MIRT2436969	hsa-miR-1247	CLIP-seq
MIRT965302	hsa-miR-1264	CLIP-seq
MIRT965303	hsa-miR-1271	CLIP-seq
MIRT1548353	hsa-miR-127-5p	CLIP-seq
MIRT2436970	hsa-miR-128	CLIP-seq
MIRT965304	hsa-miR-129-5p	CLIP-seq
MIRT2524250	hsa-miR-1299	CLIP-seq
MIRT1986059	hsa-miR-1301	CLIP-seq
MIRT2436971	hsa-miR-1321	CLIP-seq
MIRT965307	hsa-miR-147	CLIP-seq
MIRT1986060	hsa-miR-148a	CLIP-seq
MIRT1986061	hsa-miR-148b	CLIP-seq
MIRT2436972	hsa-miR-149	CLIP-seq
MIRT1986062	hsa-miR-152	CLIP-seq
MIRT965309	hsa-miR-182	CLIP-seq
MIRT2436973	hsa-miR-183	CLIP-seq
MIRT2436974	hsa-miR-1909	CLIP-seq
MIRT2524251	hsa-miR-1910	CLIP-seq
MIRT1556312	hsa-miR-1912	CLIP-seq
MIRT1986063	hsa-miR-1973	CLIP-seq
MIRT2436975	hsa-miR-219-5p	CLIP-seq
MIRT965314	hsa-miR-2276	CLIP-seq
MIRT2428544	hsa-miR-2861	CLIP-seq
MIRT2428545	hsa-miR-296-3p	CLIP-seq
MIRT2436976	hsa-miR-3064-5p	CLIP-seq
MIRT2524256	hsa-miR-3065-5p	CLIP-seq
MIRT2436977	hsa-miR-3126-3p	CLIP-seq
MIRT2436978	hsa-miR-3142	CLIP-seq
MIRT2436979	hsa-miR-3151	CLIP-seq
MIRT2428548	hsa-miR-3157-5p	CLIP-seq
MIRT2428549	hsa-miR-3158-5p	CLIP-seq
MIRT2436980	hsa-miR-3168	CLIP-seq
MIRT2524257	hsa-miR-3179	CLIP-seq
MIRT965323	hsa-miR-3591-3p	CLIP-seq
MIRT2436981	hsa-miR-3612	CLIP-seq
MIRT965325	hsa-miR-3619-3p	CLIP-seq
MIRT2436982	hsa-miR-3620	CLIP-seq
MIRT965326	hsa-miR-365	CLIP-seq
MIRT1548355	hsa-miR-3653	CLIP-seq
MIRT2428554	hsa-miR-3654	CLIP-seq
MIRT1548356	hsa-miR-3658	CLIP-seq
MIRT965327	hsa-miR-3662	CLIP-seq
MIRT2436983	hsa-miR-3663-5p	CLIP-seq
MIRT2428555	hsa-miR-3673	CLIP-seq
MIRT2436984	hsa-miR-3678-5p	CLIP-seq
MIRT2436985	hsa-miR-3692	CLIP-seq
MIRT2524258	hsa-miR-376a	CLIP-seq
MIRT2524259	hsa-miR-376b	CLIP-seq
MIRT965328	hsa-miR-378	CLIP-seq
MIRT965329	hsa-miR-378b	CLIP-seq
MIRT965330	hsa-miR-378c	CLIP-seq
MIRT965331	hsa-miR-378d	CLIP-seq
MIRT965332	hsa-miR-378e	CLIP-seq
MIRT965333	hsa-miR-378f	CLIP-seq
MIRT965334	hsa-miR-378h	CLIP-seq
MIRT965335	hsa-miR-378i	CLIP-seq
MIRT2436986	hsa-miR-3911	CLIP-seq
MIRT2428559	hsa-miR-3918	CLIP-seq
MIRT1986064	hsa-miR-3944-5p	CLIP-seq
MIRT965337	hsa-miR-422a	CLIP-seq
MIRT2436987	hsa-miR-423-3p	CLIP-seq
MIRT2436988	hsa-miR-4254	CLIP-seq
MIRT2524260	hsa-miR-4264	CLIP-seq
MIRT965339	hsa-miR-4276	CLIP-seq
MIRT2436989	hsa-miR-4292	CLIP-seq
MIRT2436990	hsa-miR-4297	CLIP-seq
MIRT2428564	hsa-miR-4300	CLIP-seq
MIRT965340	hsa-miR-4302	CLIP-seq
MIRT2436991	hsa-miR-4308	CLIP-seq
MIRT2524261	hsa-miR-4325	CLIP-seq
MIRT965341	hsa-miR-4419a	CLIP-seq
MIRT2428569	hsa-miR-4438	CLIP-seq
MIRT2436992	hsa-miR-4443	CLIP-seq
MIRT2436993	hsa-miR-4446-3p	CLIP-seq
MIRT2436994	hsa-miR-4447	CLIP-seq
MIRT1986065	hsa-miR-4452	CLIP-seq
MIRT965342	hsa-miR-4453	CLIP-seq
MIRT2436995	hsa-miR-4470	CLIP-seq
MIRT2436996	hsa-miR-4472	CLIP-seq
MIRT2428570	hsa-miR-4474-3p	CLIP-seq
MIRT2436997	hsa-miR-4481	CLIP-seq
MIRT2436998	hsa-miR-4488	CLIP-seq
MIRT2436999	hsa-miR-4492	CLIP-seq
MIRT2437000	hsa-miR-4498	CLIP-seq
MIRT965345	hsa-miR-4510	CLIP-seq
MIRT2428571	hsa-miR-4512	CLIP-seq
MIRT1986066	hsa-miR-4517	CLIP-seq
MIRT2524262	hsa-miR-4521	CLIP-seq
MIRT965346	hsa-miR-4527	CLIP-seq
MIRT2437001	hsa-miR-4529-5p	CLIP-seq
MIRT965347	hsa-miR-4538	CLIP-seq
MIRT2524263	hsa-miR-4635	CLIP-seq
MIRT965348	hsa-miR-4638-3p	CLIP-seq
MIRT1986067	hsa-miR-4660	CLIP-seq
MIRT2437002	hsa-miR-4669	CLIP-seq
MIRT2428575	hsa-miR-4685-5p	CLIP-seq
MIRT2437003	hsa-miR-4688	CLIP-seq
MIRT2428576	hsa-miR-4691-3p	CLIP-seq
MIRT2437004	hsa-miR-4697-5p	CLIP-seq
MIRT2220463	hsa-miR-4706	CLIP-seq
MIRT965351	hsa-miR-4708-3p	CLIP-seq
MIRT2437005	hsa-miR-4715-3p	CLIP-seq
MIRT2437006	hsa-miR-4739	CLIP-seq
MIRT2437007	hsa-miR-4745-5p	CLIP-seq
MIRT2220464	hsa-miR-4749-5p	CLIP-seq
MIRT2437008	hsa-miR-4756-5p	CLIP-seq
MIRT2437009	hsa-miR-4758-5p	CLIP-seq
MIRT965355	hsa-miR-4776-5p	CLIP-seq
MIRT2437010	hsa-miR-4782-3p	CLIP-seq
MIRT2524264	hsa-miR-4782-5p	CLIP-seq
MIRT2437011	hsa-miR-4794	CLIP-seq
MIRT965357	hsa-miR-488	CLIP-seq
MIRT2428583	hsa-miR-491-5p	CLIP-seq
MIRT1986068	hsa-miR-5047	CLIP-seq
MIRT2428585	hsa-miR-5095	CLIP-seq
MIRT1556318	hsa-miR-513a-3p	CLIP-seq
MIRT2524265	hsa-miR-516b	CLIP-seq
MIRT965361	hsa-miR-548a-3p	CLIP-seq
MIRT965363	hsa-miR-548e	CLIP-seq
MIRT965364	hsa-miR-548f	CLIP-seq
MIRT2428590	hsa-miR-551a	CLIP-seq
MIRT2428591	hsa-miR-551b	CLIP-seq
MIRT1986069	hsa-miR-579	CLIP-seq
MIRT2437012	hsa-miR-604	CLIP-seq
MIRT2524266	hsa-miR-621	CLIP-seq
MIRT2437013	hsa-miR-644	CLIP-seq
MIRT2437014	hsa-miR-647	CLIP-seq
MIRT2437015	hsa-miR-650	CLIP-seq
MIRT2220468	hsa-miR-744	CLIP-seq
MIRT2437016	hsa-miR-762	CLIP-seq
MIRT2428592	hsa-miR-769-5p	CLIP-seq
MIRT2524267	hsa-miR-875-3p	CLIP-seq
MIRT2428593	hsa-miR-889	CLIP-seq
MIRT2428594	hsa-miR-920	CLIP-seq
MIRT965376	hsa-miR-96	CLIP-seq

Show/Hide all (6)

Transcription factor	Regulation	Reference
HIF3A	Unknown	19755485
HOXA1	Unknown	17213808
RELA	Activation	20495570
STAT3	Unknown	23991099
USF2	Unknown	23991099
YY1	Repression	19483472

Show/Hide all (70)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0000987	Function	Cis-regulatory region sequence-specific DNA binding	IEA
GO:0001223	Function	Transcription coactivator binding	IEA
GO:0001223	Function	Transcription coactivator binding	IPI	15261140
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001525	Process	Angiogenesis	IBA
GO:0001525	Process	Angiogenesis	IEA
GO:0001525	Process	Angiogenesis	IEA
GO:0001666	Process	Response to hypoxia	IDA	11782478
GO:0001666	Process	Response to hypoxia	IEA
GO:0001892	Process	Embryonic placenta development	IEA
GO:0001974	Process	Blood vessel remodeling	IBA
GO:0001974	Process	Blood vessel remodeling	IEA
GO:0002027	Process	Regulation of heart rate	IEA
GO:0002070	Process	Epithelial cell maturation	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	11018023, 14668441, 16181639, 17024177, 17324924, 17353276, 17418410, 18000879, 19129502, 19208626, 22678294, 23401859, 23434853, 24378640, 24981860, 25043030, 30487161, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IBA
GO:0005667	Component	Transcription regulator complex	IDA	9000051
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0006979	Process	Response to oxidative stress	IEA
GO:0007005	Process	Mitochondrion organization	IEA
GO:0007165	Process	Signal transduction	TAS	9079689
GO:0007601	Process	Visual perception	IEA
GO:0010467	Process	Gene expression	IEA
GO:0016607	Component	Nuclear speck	IEA
GO:0030097	Process	Hemopoiesis	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030218	Process	Erythrocyte differentiation	IBA
GO:0030218	Process	Erythrocyte differentiation	IEA
GO:0030324	Process	Lung development	IBA
GO:0030324	Process	Lung development	IEA
GO:0032364	Process	Intracellular oxygen homeostasis	IBA
GO:0042415	Process	Norepinephrine metabolic process	IEA
GO:0042789	Process	MRNA transcription by RNA polymerase II	IEA
GO:0043129	Process	Surfactant homeostasis	IEA
GO:0043565	Function	Sequence-specific DNA binding	IDA	9079689
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	11573933
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046982	Function	Protein heterodimerization activity	IDA	16181639
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0046982	Function	Protein heterodimerization activity	IPI	9079689
GO:0046983	Function	Protein dimerization activity	IEA
GO:0048625	Process	Myoblast fate commitment	IEA
GO:0048625	Process	Myoblast fate commitment	ISS
GO:0060586	Process	Multicellular organismal-level iron ion homeostasis	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	9079689
GO:0071456	Process	Cellular response to hypoxia	IBA
GO:0071456	Process	Cellular response to hypoxia	IDA	11573933
GO:0071456	Process	Cellular response to hypoxia	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	26572826
GO:2000434	Process	Regulation of protein neddylation	IEA
GO:2000434	Process	Regulation of protein neddylation	IMP	23401859

MIM	HGNC	e!Ensembl
603349	3374	ENSG00000116016

Q99814

Protein name

Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of P

Protein function

Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulate

PDB

1P97 , 2A24 , 3F1N , 3F1O , 3F1P , 3H7W , 3H82 , 4GHI , 4GS9 , 4PKY , 4XT2 , 5KIZ , 5TBM , 5UFP , 6BVB , 6CZW , 6D09 , 6D0B , 6D0C , 6I7Q , 6I7R , 6X21 , 6X28 , 6X2H , 6X37 , 6X3D , 7Q5V , 7Q5X , 7UJV , 8CK3 , 8CK4 , 8CK8 , 8Q5S , 8Q64 , 8Q6D , 8Q6E , 8RUT , 8RUV , 8RUZ , 8RV1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00989	PAS	85 → 183	PAS fold	Domain
PF08447	PAS_3	254 → 341	PAS fold	Domain
PF11413	HIF-1	517 → 549	Hypoxia-inducible factor-1	Family
PF08778	HIF-1a_CTAD	833 → 869	HIF-1 alpha C terminal transactivation domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.

Sequence

MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG
RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN
FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS
TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF
QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE
FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ
DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL
PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT
RYDCEVNVPVLGSSTLLQGGDLLRALDQAT

Sequence length

870

Interactions

View interactions

	KEGG		Reactome
	HIF-1 signaling pathway Pathways in cancer Renal cell carcinoma		Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells PTK6 Expression Neddylation

247

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Erythrocytosis, familial, 4	Pathogenic; Likely pathogenic	rs2103672173, rs137853036, rs137853037, rs2546476675	RCV002273011 RCV000006841 RCV000006842 RCV000006843 RCV003615814

Show/Hide Unknown Diseases (20)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Asphyxiating thoracic dystrophy 3	Conflicting classifications of pathogenicity	rs752805685	RCV005863688
Cervical cancer	Benign; Likely benign	rs17035085, rs75591953	RCV005919408 RCV005896191
Cholangiocarcinoma	Benign	rs17035085, rs7583392, rs17035079	RCV005919412 RCV005915486 RCV005896202
EPAS1-related disorder	Likely benign; Conflicting classifications of pathogenicity; drug response; Benign	rs141452072, rs149994721, rs7557402, rs35606117, rs1553394876, rs150877473, rs59901247, rs61518065, rs141537861, rs564869067, rs377197070, rs66811540, rs138622780	RCV003971297 RCV003957736 RCV003972423 RCV003912415 RCV003912414 RCV003910298 RCV003969966 RCV003912416 RCV003956518 RCV003959372 RCV003936914 RCV003978945 RCV003950465
Familial erythrocytosis	Benign; Uncertain significance; Likely benign	rs149642079, rs142684263, rs75932330, rs886056094, rs886056096, rs886056097, rs111426869, rs35508970, rs557111154, rs139377540, rs540911183, rs886056075, rs781736017, rs757409274, rs200260946 View all (4 more)	RCV000347255 RCV000295688 RCV000353138 RCV000300618 RCV000361321 RCV000322147 RCV000383658 RCV000393845 RCV000404095 RCV000276622 RCV000264681 RCV000274101 RCV000322848 RCV000377026 RCV000277406 RCV000325547 RCV000359929 RCV000316652 RCV000380886 RCV000337922
Familial pancreatic carcinoma	Benign; Likely benign	rs202210836, rs17035079	RCV005896189 RCV005896198
Gastric cancer	Benign; Likely benign	rs117227021, rs17035085, rs769055855, rs75591953, rs150877473, rs17035079	RCV005916896 RCV005919409 RCV005931853 RCV005896194 RCV005896196 RCV005896200
Hepatocellular carcinoma	drug response; Benign	rs7557402, rs17035079	RCV005896204 RCV005896197
Lung cancer	Benign	rs17035079	RCV005896203
Malignant tumor of esophagus	Benign	rs117227021, rs17035085	RCV005916894 RCV005919407
Ovarian cancer	Benign; Likely benign	rs75591953	RCV005896192
Ovarian serous cystadenocarcinoma	Benign	rs17035085, rs17035079	RCV005919410 RCV005896201
Pancreatic adenocarcinoma	Benign; Likely benign	rs75591953	RCV005896193
Papillary renal cell carcinoma type 1	Likely benign	rs142445582	RCV005907480
Sarcoma	Benign	rs117227021, rs17035079	RCV005916895 RCV005896199
sorafenib response - Toxicity	drug response	rs7557402	RCV003227743
Squamous cell carcinoma of the head and neck	Benign; Likely benign	rs75591953	RCV005896190
Teratoma	Uncertain significance	rs745357489	RCV003221365
Thymoma	Benign	rs17035085	RCV005919411
Uterine corpus endometrial carcinoma	Benign; Likely benign	rs75591953	RCV005896195

Show/Hide Text Mining Associations (159)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	28653893
Adenocarcinoma of Lung	Associate	25436804, 29859855, 31503425, 32708433, 40682067
Altitude Sickness	Associate	26368009, 26625252, 27982053, 32470757, 32478477, 32718338, 39513938
Anemia	Associate	16826581, 36500549
Anemia Sickle Cell	Associate	37285480
Arnold Chiari Malformation	Associate	31185588
Arthritis Juvenile	Associate	18512817
Arthritis Rheumatoid	Associate	12823854, 22488178, 35216458
Axial osteomalacia	Stimulate	34698138
Breast Neoplasms	Associate	21930697, 22452996, 22894905, 23631762, 24535905, 26825173, 26849233, 27001847, 27105516, 27323688, 27465550, 30670058, 31740625, 35301432, 35501580, 39838295 View all (1 more)
Calcinosis Cutis	Inhibit	27244898
Calcinosis Cutis	Associate	34320663, 37285480, 37463949
Carcinogenesis	Associate	19018165, 19483472, 19955413, 21695080, 23331615, 24998849, 25436804, 26846782, 28720067, 28946040, 30104738, 32235007, 32593213, 33591636, 34250767, 34320663, 34965440 View all (2 more)
Carcinoma Ductal Breast	Associate	22452996
Carcinoma Hepatocellular	Associate	14966910, 17589895, 24840636, 25544768, 25719580, 27384772, 28387999, 31796646, 32235007
Carcinoma Hepatocellular	Inhibit	37461802
Carcinoma Non Small Cell Lung	Associate	11556841, 19955413, 25831463, 26263511, 28653893, 29859855, 30642030, 30845377
Carcinoma Renal Cell	Associate	11720477, 16230378, 17140440, 17387348, 17699105, 17898043, 18212329, 18394010, 19061835, 19401348, 19483472, 19920202, 20032376, 20185829, 20813864 View all (45 more)
Carcinoma Renal Cell	Stimulate	33118406
Carcinoma Squamous Cell	Associate	27413748, 29636077
Carcinoma Squamous Cell	Stimulate	28653893
Cardiac Output High	Associate	21389259
Cartilage Diseases	Associate	29263346, 30255592, 36650517
Cell Transformation Neoplastic	Associate	25396735
Clear cell metastatic renal cell carcinoma	Associate	28220024
Colitis Ulcerative	Associate	12610101
Colonic Neoplasms	Associate	18728663, 19843849
Colonic Neoplasms	Inhibit	24825851
Colorectal Neoplasms	Associate	18728663, 19619276, 19843849, 20363910, 21073737, 23071744, 24825851, 25396735, 25726527, 27546461, 27793037, 30985693, 34250767, 37994607, 39179631
COVID 19	Associate	36709793
Crohn Disease	Associate	12610101, 26802079
Diabetes Mellitus Type 2	Associate	22039494
Disease	Associate	30670058, 40084286
Drug Related Side Effects and Adverse Reactions	Associate	32028672
Ductus Arteriosus Patent	Associate	33837257
Endometrial Neoplasms	Associate	12209691
Erythrocytosis Familial 2	Associate	21389259
Eye Abnormalities	Associate	27659016
Familial Primary Pulmonary Hypertension	Associate	20139178
Fetal Growth Retardation	Associate	33371356, 38002309
Fibrosis	Associate	28112200
Gastroesophageal Reflux	Associate	27694141
Gastroesophageal Reflux	Stimulate	30057669
Glaucoma Open Angle	Associate	22876139
Glioblastoma	Associate	19955413, 24481065, 25010988, 25244496, 29492900, 32088728, 33762574, 35054927
Glioma	Associate	17699105, 25805832
Head and Neck Neoplasms	Associate	20395290
Headache	Associate	32718338
Heart Defects Congenital	Associate	30487161
Heart Septal Defects Atrial	Associate	37576964
Hemangioblastoma	Associate	36301191, 36708612, 9665461
Hemangioma capillary infantile	Associate	32094357
Hepatitis B Chronic	Associate	27384772
Hernias Diaphragmatic Congenital	Associate	37605849
Hypertension	Associate	38002309
Hypertension Pulmonary	Associate	21389259, 23492195, 27292716, 27982053
Hypoxia	Stimulate	11336512, 17537234, 19305150, 20010940, 20559021, 20637078, 21179202, 21571835, 22363512, 23331615, 23958427, 24790010, 24825851, 25592037, 25912138 View all (8 more)
Hypoxia	Associate	12209691, 12767996, 16956952, 17403672, 17452775, 17670948, 18283323, 18394010, 18508787, 19619276, 19706526, 20032376, 20395290, 20603601, 21389259 View all (78 more)
Hypoxia	Inhibit	32886165
Hypoxia Brain	Stimulate	11556841, 29656700, 30111297
Hypoxia Brain	Associate	16304044, 18055454, 18319549, 19843849, 21571835, 22402494, 23852087, 24644426, 24825851, 24850901, 26548300, 26849233, 28000962, 28387999, 28463531 View all (11 more)
Idiopathic Pulmonary Fibrosis	Associate	24951777
Infertility	Associate	36157441
Inflammation	Associate	12610101, 20354189, 27694141, 36650517
Inflammatory Bowel Diseases	Associate	12610101
Iron Deficiencies	Inhibit	23993337
Keratoconus	Associate	32886165
Kidney Neoplasms	Associate	18544564, 19018165, 29172931, 30617181, 32123166, 34353313, 34841698, 36097292
Kidney Neoplasms	Stimulate	23940778
Laryngeal Neoplasms	Associate	27075652
Leukemia	Associate	37807875
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	28533480
Leukemia Myeloid Acute	Inhibit	37124944
Leukemia Myeloid Acute	Associate	37807875
Leukemic Infiltration	Stimulate	24859386
Liver Cirrhosis	Associate	27384772, 28112200
Liver Diseases	Associate	27384772
Lung Diseases	Associate	23492195, 33810600
Lung Neoplasms	Associate	19305150, 26548300, 26782458, 28036300, 28720067, 29469087, 36116043
Lymphatic Metastasis	Associate	19305150, 24288553, 26842802, 26846782, 28653893, 36421334
Lymphatic Metastasis	Stimulate	27413748
Lymphoma	Associate	18422776
Lymphoma Follicular	Associate	18422776
Malocclusion Angle Class II	Associate	30135421
Melanoma	Associate	23275444
MELAS Syndrome	Associate	40710331
Mesenchymoma	Associate	18836991
Mesothelioma Malignant	Associate	24790010, 27529370, 30111297
Metabolic Syndrome	Associate	22039494
Mitochondrial Diseases	Associate	37847286
Multiple Myeloma	Associate	29206844, 29656700
Myocardial Infarction	Associate	38253721
Necrosis	Associate	14966910
Neoplasm Invasiveness	Associate	28651487
Neoplasm Metastasis	Associate	14966910, 16929169, 20559021, 23301832, 24535905, 25719580, 34320663, 34353313, 34770976
Neoplasm Metastasis	Inhibit	32586940
Neoplasms	Associate	11556841, 11986208, 12209691, 12368197, 14966910, 15611064, 16929169, 17387348, 17452775, 17589895, 17670948, 18055454, 18283323, 18319549, 18728663 View all (74 more)
Neoplasms	Stimulate	20978319, 33762574, 34841698
Neoplasms	Inhibit	24998849
Neoplastic Syndromes Hereditary	Associate	27659016
Neuroblastoma	Associate	22363512, 25912138, 26057707
Neuroendocrine Tumors	Associate	30135421, 34828399, 36301191
Neurofibrosarcoma	Associate	25833823
Non alcoholic Fatty Liver Disease	Stimulate	31796646
Non Muscle Invasive Bladder Neoplasms	Associate	37240301
Obesity	Associate	20363910
Osteoarthritis	Associate	12823854, 23965235, 26996575, 29263346, 36650517
Osteoarthritis Knee	Associate	26996575
Osteosarcoma	Inhibit	25434862, 30966832
Osteosarcoma	Associate	28259908
Ovarian Neoplasms	Associate	22402494
Pancreatic Neoplasms	Associate	26842802, 28193910, 36708612
Paraganglioma	Associate	22931260, 23090011, 23361906, 23509317, 23539726, 24466223, 27659016, 27679736, 28162975, 28946040, 30644531, 31185588, 33114456, 36700397, 37285480, 37463949, 37576964 View all (2 more)
Paraganglioma Extra Adrenal	Associate	34320663
Peripheral Arterial Disease	Associate	29843956
Peripheral Nervous System Neoplasms	Associate	18319549
Persistent Fetal Circulation Syndrome	Associate	34678164
Personality Disorders	Associate	30617181
Pheochromocytoma	Stimulate	12368197
Pheochromocytoma	Associate	23090011, 23539726, 24466223, 24694336, 28336782, 31185588, 31876082, 33300499, 34320663, 34770976, 36314599, 36700397, 37463949, 40290304
Polycystic Ovary Syndrome	Associate	36157441
Polycythemia	Associate	11986208, 18184961, 18378852, 18508787, 19208626, 20007141, 22367913, 22931260, 23090011, 23361906, 23509317, 23716564, 25760230, 26625252, 27292716 View all (19 more)
Polycythemia primary familial and congenital	Associate	18184961, 18508787, 23090011, 23539726, 23716564, 27292716, 36002380, 36700397
Pre Eclampsia	Stimulate	24644426
Pre Eclampsia	Associate	34665260, 38002309
Prostatic Neoplasms	Associate	19363294, 21372204, 27384993, 33752529, 35536859
Pterygium	Associate	37684398
Pulmonary Disease Chronic Obstructive	Associate	27442627
Pulmonary edema of mountaineers	Associate	19481479
Rectal Neoplasms	Associate	19436307
Respiratory Distress Syndrome	Associate	28613249
Retinal Diseases	Associate	28946040
Retinopathy of Prematurity	Associate	18787502, 40084286
Rh Deficiency Syndrome	Associate	24859386
Rhabdomyosarcoma Embryonal	Associate	37847286
Sarcoma	Associate	34982796
Sarcoma Ewing	Associate	20637078
Sarcoma Kaposi	Associate	23221556
Signs and Symptoms Digestive	Associate	32718338
Skull Base Neoplasms	Associate	31185588
Somatostatinoma	Associate	22931260, 23361906, 23509317, 27659016, 27679736, 28336782, 31185588, 31876082, 33049075, 33300499, 36700397
Squamous Cell Carcinoma of Head and Neck	Associate	28690120
Stomach Diseases	Associate	26810190
Stomach Neoplasms	Associate	18283323, 20559021, 26810190
Syndrome	Associate	31876082, 34818480
Tertiary Lymphoid Structures	Associate	24535905
Thrombosis	Associate	26826018
Thyroid Cancer Papillary	Associate	24288553, 26846782, 36609218
Thyroid Carcinoma Anaplastic	Associate	36609218
Thyroid Diseases	Associate	29084538
Thyroid Neoplasms	Associate	36609218
Urethral Neoplasms	Associate	36421334
Uterine Cervical Neoplasms	Associate	18319549, 29321085
Varicose Veins	Associate	22277691
Ventricular Remodeling	Associate	23492195
Virus Diseases	Associate	40024310
von Hippel Lindau Disease	Associate	15592504, 16230378, 17140440, 28394947, 29172931, 33828526, 34818478, 35671435, 36301191, 36500549, 36708612
von Hippel Lindau Disease	Stimulate	18836991
von Hippel Lindau Disease	Inhibit	19483472, 19920202, 22094876, 32586940

EPAS1 (endothelial PAS domain protein 1)