Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2026
Gene name Gene Name - the full gene name approved by the HGNC.	Enolase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ENO2
Synonyms (NCBI Gene) Gene synonyms aliases	HEL-S-279, NSE
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p13.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT044208	hsa-miR-99b-5p	CLASH	23622248
MIRT038722	hsa-miR-93-3p	CLASH	23622248
MIRT440723	hsa-miR-382-3p	HITS-CLIP	24374217
MIRT440723	hsa-miR-382-3p	HITS-CLIP	24374217
MIRT732552	hsa-miR-301a-3p	RNA-seq	33037409
MIRT732553	hsa-miR-375	RNA-seq	33037409
MIRT963610	hsa-miR-1266	CLIP-seq
MIRT963611	hsa-miR-139-5p	CLIP-seq
MIRT963612	hsa-miR-24	CLIP-seq
MIRT963613	hsa-miR-3664-3p	CLIP-seq
MIRT963614	hsa-miR-4283	CLIP-seq
MIRT963615	hsa-miR-4437	CLIP-seq
MIRT963616	hsa-miR-4489	CLIP-seq
MIRT963617	hsa-miR-4518	CLIP-seq
MIRT963618	hsa-miR-4640-3p	CLIP-seq
MIRT963619	hsa-miR-4691-3p	CLIP-seq
MIRT963620	hsa-miR-4695-3p	CLIP-seq
MIRT963621	hsa-miR-4728-3p	CLIP-seq
MIRT1985625	hsa-miR-1255a	CLIP-seq
MIRT1985626	hsa-miR-1255b	CLIP-seq
MIRT1985627	hsa-miR-1295	CLIP-seq
MIRT1985628	hsa-miR-1302	CLIP-seq
MIRT1985629	hsa-miR-3126-5p	CLIP-seq
MIRT1985630	hsa-miR-3190	CLIP-seq
MIRT1985631	hsa-miR-335	CLIP-seq
MIRT1985632	hsa-miR-3605-5p	CLIP-seq
MIRT1985633	hsa-miR-3679-3p	CLIP-seq
MIRT1985634	hsa-miR-4257	CLIP-seq
MIRT1985635	hsa-miR-4298	CLIP-seq
MIRT1985636	hsa-miR-4303	CLIP-seq
MIRT1985637	hsa-miR-4311	CLIP-seq
MIRT1985638	hsa-miR-4328	CLIP-seq
MIRT1985639	hsa-miR-4419a	CLIP-seq
MIRT1985640	hsa-miR-4424	CLIP-seq
MIRT1985641	hsa-miR-4459	CLIP-seq
MIRT1985642	hsa-miR-4510	CLIP-seq
MIRT1985643	hsa-miR-4648	CLIP-seq
MIRT1985644	hsa-miR-4649-3p	CLIP-seq
MIRT1985645	hsa-miR-4717-5p	CLIP-seq
MIRT1985646	hsa-miR-4762-3p	CLIP-seq
MIRT1985647	hsa-miR-4796-3p	CLIP-seq
MIRT1985648	hsa-miR-518a-5p	CLIP-seq
MIRT1985649	hsa-miR-520g	CLIP-seq
MIRT1985650	hsa-miR-520h	CLIP-seq
MIRT1985651	hsa-miR-527	CLIP-seq
MIRT1985652	hsa-miR-642b	CLIP-seq
MIRT1985653	hsa-miR-665	CLIP-seq
MIRT1985654	hsa-miR-7	CLIP-seq
MIRT2220080	hsa-miR-3120-3p	CLIP-seq
MIRT1985629	hsa-miR-3126-5p	CLIP-seq
MIRT1985634	hsa-miR-4257	CLIP-seq
MIRT2220081	hsa-miR-4270	CLIP-seq
MIRT1985636	hsa-miR-4303	CLIP-seq
MIRT1985639	hsa-miR-4419a	CLIP-seq
MIRT2220082	hsa-miR-4441	CLIP-seq
MIRT1985642	hsa-miR-4510	CLIP-seq
MIRT1985644	hsa-miR-4649-3p	CLIP-seq
MIRT2220083	hsa-miR-4705	CLIP-seq
MIRT1985646	hsa-miR-4762-3p	CLIP-seq
MIRT2220084	hsa-miR-501-3p	CLIP-seq
MIRT2220085	hsa-miR-502-3p	CLIP-seq
MIRT2220086	hsa-miR-503	CLIP-seq
MIRT2523859	hsa-miR-106a	CLIP-seq
MIRT2523860	hsa-miR-106b	CLIP-seq
MIRT2523861	hsa-miR-1207-3p	CLIP-seq
MIRT2523862	hsa-miR-1224-3p	CLIP-seq
MIRT2523863	hsa-miR-1260	CLIP-seq
MIRT2523864	hsa-miR-1260b	CLIP-seq
MIRT2523865	hsa-miR-1280	CLIP-seq
MIRT1985627	hsa-miR-1295	CLIP-seq
MIRT2523866	hsa-miR-1301	CLIP-seq
MIRT1985628	hsa-miR-1302	CLIP-seq
MIRT963611	hsa-miR-139-5p	CLIP-seq
MIRT2523867	hsa-miR-17	CLIP-seq
MIRT2523868	hsa-miR-185	CLIP-seq
MIRT2523869	hsa-miR-1972	CLIP-seq
MIRT2523870	hsa-miR-20a	CLIP-seq
MIRT2523871	hsa-miR-20b	CLIP-seq
MIRT2523872	hsa-miR-2110	CLIP-seq
MIRT2523873	hsa-miR-23a	CLIP-seq
MIRT2523874	hsa-miR-23b	CLIP-seq
MIRT2523875	hsa-miR-23c	CLIP-seq
MIRT2523876	hsa-miR-296-3p	CLIP-seq
MIRT2523877	hsa-miR-3064-3p	CLIP-seq
MIRT2523878	hsa-miR-3065-3p	CLIP-seq
MIRT2523879	hsa-miR-3115	CLIP-seq
MIRT2220080	hsa-miR-3120-3p	CLIP-seq
MIRT2523880	hsa-miR-3125	CLIP-seq
MIRT1985629	hsa-miR-3126-5p	CLIP-seq
MIRT2523881	hsa-miR-3135b	CLIP-seq
MIRT2523882	hsa-miR-3150a-3p	CLIP-seq
MIRT2523883	hsa-miR-3163	CLIP-seq
MIRT2523884	hsa-miR-3171	CLIP-seq
MIRT2523885	hsa-miR-3173-3p	CLIP-seq
MIRT2523886	hsa-miR-3175	CLIP-seq
MIRT2523887	hsa-miR-3183	CLIP-seq
MIRT2523888	hsa-miR-3185	CLIP-seq
MIRT1985630	hsa-miR-3190	CLIP-seq
MIRT2523889	hsa-miR-3194-3p	CLIP-seq
MIRT2523890	hsa-miR-330-3p	CLIP-seq
MIRT1985631	hsa-miR-335	CLIP-seq
MIRT2523891	hsa-miR-3591-3p	CLIP-seq
MIRT2523892	hsa-miR-361-3p	CLIP-seq
MIRT2523893	hsa-miR-3622b-5p	CLIP-seq
MIRT2523894	hsa-miR-3675-5p	CLIP-seq
MIRT1985633	hsa-miR-3679-3p	CLIP-seq
MIRT2523895	hsa-miR-3688-5p	CLIP-seq
MIRT2523896	hsa-miR-3691-3p	CLIP-seq
MIRT2523897	hsa-miR-369-3p	CLIP-seq
MIRT2523898	hsa-miR-374a	CLIP-seq
MIRT2523899	hsa-miR-374b	CLIP-seq
MIRT2523900	hsa-miR-3916	CLIP-seq
MIRT2523901	hsa-miR-3944-5p	CLIP-seq
MIRT2523902	hsa-miR-3976	CLIP-seq
MIRT2523903	hsa-miR-3978	CLIP-seq
MIRT1985634	hsa-miR-4257	CLIP-seq
MIRT2523904	hsa-miR-4271	CLIP-seq
MIRT2523905	hsa-miR-4281	CLIP-seq
MIRT1985635	hsa-miR-4298	CLIP-seq
MIRT2523906	hsa-miR-4299	CLIP-seq
MIRT1985636	hsa-miR-4303	CLIP-seq
MIRT2523907	hsa-miR-4306	CLIP-seq
MIRT1985637	hsa-miR-4311	CLIP-seq
MIRT2523908	hsa-miR-4318	CLIP-seq
MIRT1985638	hsa-miR-4328	CLIP-seq
MIRT1985639	hsa-miR-4419a	CLIP-seq
MIRT1985640	hsa-miR-4424	CLIP-seq
MIRT2523909	hsa-miR-4436b-3p	CLIP-seq
MIRT2523910	hsa-miR-4456	CLIP-seq
MIRT2523911	hsa-miR-4468	CLIP-seq
MIRT2523912	hsa-miR-4506	CLIP-seq
MIRT2523913	hsa-miR-450b-3p	CLIP-seq
MIRT1985642	hsa-miR-4510	CLIP-seq
MIRT2523914	hsa-miR-451b	CLIP-seq
MIRT963618	hsa-miR-4640-3p	CLIP-seq
MIRT2523915	hsa-miR-4643	CLIP-seq
MIRT2523916	hsa-miR-4644	CLIP-seq
MIRT1985643	hsa-miR-4648	CLIP-seq
MIRT1985644	hsa-miR-4649-3p	CLIP-seq
MIRT2523917	hsa-miR-4649-5p	CLIP-seq
MIRT2523918	hsa-miR-4650-5p	CLIP-seq
MIRT2523919	hsa-miR-4660	CLIP-seq
MIRT2523920	hsa-miR-4662a-5p	CLIP-seq
MIRT2523921	hsa-miR-4676-5p	CLIP-seq
MIRT963619	hsa-miR-4691-3p	CLIP-seq
MIRT2523922	hsa-miR-4696	CLIP-seq
MIRT2523923	hsa-miR-4704-5p	CLIP-seq
MIRT2523924	hsa-miR-4713-3p	CLIP-seq
MIRT2523925	hsa-miR-4717-3p	CLIP-seq
MIRT1985645	hsa-miR-4717-5p	CLIP-seq
MIRT2523926	hsa-miR-4723-3p	CLIP-seq
MIRT2523927	hsa-miR-4725-3p	CLIP-seq
MIRT2523928	hsa-miR-4725-5p	CLIP-seq
MIRT963621	hsa-miR-4728-3p	CLIP-seq
MIRT2523929	hsa-miR-4732-3p	CLIP-seq
MIRT2523930	hsa-miR-4755-3p	CLIP-seq
MIRT2523931	hsa-miR-4761-3p	CLIP-seq
MIRT1985646	hsa-miR-4762-3p	CLIP-seq
MIRT2523932	hsa-miR-4773	CLIP-seq
MIRT2523933	hsa-miR-4779	CLIP-seq
MIRT2523934	hsa-miR-4795-5p	CLIP-seq
MIRT2523935	hsa-miR-500a	CLIP-seq
MIRT2523936	hsa-miR-504	CLIP-seq
MIRT2523937	hsa-miR-5047	CLIP-seq
MIRT2523938	hsa-miR-519d	CLIP-seq
MIRT2523939	hsa-miR-532-3p	CLIP-seq
MIRT2523940	hsa-miR-548q	CLIP-seq
MIRT2523941	hsa-miR-575	CLIP-seq
MIRT2523942	hsa-miR-635	CLIP-seq
MIRT2523943	hsa-miR-638	CLIP-seq
MIRT2523944	hsa-miR-642a	CLIP-seq
MIRT1985652	hsa-miR-642b	CLIP-seq
MIRT2523945	hsa-miR-765	CLIP-seq
MIRT2523946	hsa-miR-769-3p	CLIP-seq
MIRT2523947	hsa-miR-877	CLIP-seq
MIRT2523948	hsa-miR-93	CLIP-seq
MIRT2523949	hsa-miR-939	CLIP-seq
MIRT2523859	hsa-miR-106a	CLIP-seq
MIRT2523860	hsa-miR-106b	CLIP-seq
MIRT2523861	hsa-miR-1207-3p	CLIP-seq
MIRT2523862	hsa-miR-1224-3p	CLIP-seq
MIRT2523863	hsa-miR-1260	CLIP-seq
MIRT2523864	hsa-miR-1260b	CLIP-seq
MIRT2523865	hsa-miR-1280	CLIP-seq
MIRT1985627	hsa-miR-1295	CLIP-seq
MIRT2523866	hsa-miR-1301	CLIP-seq
MIRT1985628	hsa-miR-1302	CLIP-seq
MIRT963611	hsa-miR-139-5p	CLIP-seq
MIRT2523867	hsa-miR-17	CLIP-seq
MIRT2523868	hsa-miR-185	CLIP-seq
MIRT2523869	hsa-miR-1972	CLIP-seq
MIRT2523870	hsa-miR-20a	CLIP-seq
MIRT2523871	hsa-miR-20b	CLIP-seq
MIRT2523872	hsa-miR-2110	CLIP-seq
MIRT2523873	hsa-miR-23a	CLIP-seq
MIRT2523874	hsa-miR-23b	CLIP-seq
MIRT2523875	hsa-miR-23c	CLIP-seq
MIRT2523876	hsa-miR-296-3p	CLIP-seq
MIRT2523877	hsa-miR-3064-3p	CLIP-seq
MIRT2523878	hsa-miR-3065-3p	CLIP-seq
MIRT2523879	hsa-miR-3115	CLIP-seq
MIRT2523880	hsa-miR-3125	CLIP-seq
MIRT1985629	hsa-miR-3126-5p	CLIP-seq
MIRT2523881	hsa-miR-3135b	CLIP-seq
MIRT2523882	hsa-miR-3150a-3p	CLIP-seq
MIRT2523883	hsa-miR-3163	CLIP-seq
MIRT2523884	hsa-miR-3171	CLIP-seq
MIRT2523885	hsa-miR-3173-3p	CLIP-seq
MIRT2523886	hsa-miR-3175	CLIP-seq
MIRT2523887	hsa-miR-3183	CLIP-seq
MIRT2523888	hsa-miR-3185	CLIP-seq
MIRT1985630	hsa-miR-3190	CLIP-seq
MIRT2523889	hsa-miR-3194-3p	CLIP-seq
MIRT2523890	hsa-miR-330-3p	CLIP-seq
MIRT1985631	hsa-miR-335	CLIP-seq
MIRT2523891	hsa-miR-3591-3p	CLIP-seq
MIRT2523892	hsa-miR-361-3p	CLIP-seq
MIRT2523893	hsa-miR-3622b-5p	CLIP-seq
MIRT2523894	hsa-miR-3675-5p	CLIP-seq
MIRT1985633	hsa-miR-3679-3p	CLIP-seq
MIRT2523895	hsa-miR-3688-5p	CLIP-seq
MIRT2523896	hsa-miR-3691-3p	CLIP-seq
MIRT2523897	hsa-miR-369-3p	CLIP-seq
MIRT2523898	hsa-miR-374a	CLIP-seq
MIRT2523899	hsa-miR-374b	CLIP-seq
MIRT2523900	hsa-miR-3916	CLIP-seq
MIRT2523901	hsa-miR-3944-5p	CLIP-seq
MIRT2523902	hsa-miR-3976	CLIP-seq
MIRT2523903	hsa-miR-3978	CLIP-seq
MIRT1985634	hsa-miR-4257	CLIP-seq
MIRT2523904	hsa-miR-4271	CLIP-seq
MIRT2523905	hsa-miR-4281	CLIP-seq
MIRT1985635	hsa-miR-4298	CLIP-seq
MIRT2523906	hsa-miR-4299	CLIP-seq
MIRT1985636	hsa-miR-4303	CLIP-seq
MIRT2523907	hsa-miR-4306	CLIP-seq
MIRT1985637	hsa-miR-4311	CLIP-seq
MIRT2523908	hsa-miR-4318	CLIP-seq
MIRT1985638	hsa-miR-4328	CLIP-seq
MIRT1985639	hsa-miR-4419a	CLIP-seq
MIRT1985640	hsa-miR-4424	CLIP-seq
MIRT2523909	hsa-miR-4436b-3p	CLIP-seq
MIRT2523910	hsa-miR-4456	CLIP-seq
MIRT2523911	hsa-miR-4468	CLIP-seq
MIRT2523912	hsa-miR-4506	CLIP-seq
MIRT2523913	hsa-miR-450b-3p	CLIP-seq
MIRT1985642	hsa-miR-4510	CLIP-seq
MIRT2523914	hsa-miR-451b	CLIP-seq
MIRT963618	hsa-miR-4640-3p	CLIP-seq
MIRT2523915	hsa-miR-4643	CLIP-seq
MIRT2523916	hsa-miR-4644	CLIP-seq
MIRT1985643	hsa-miR-4648	CLIP-seq
MIRT1985644	hsa-miR-4649-3p	CLIP-seq
MIRT2523917	hsa-miR-4649-5p	CLIP-seq
MIRT2523918	hsa-miR-4650-5p	CLIP-seq
MIRT2523919	hsa-miR-4660	CLIP-seq
MIRT2523922	hsa-miR-4696	CLIP-seq
MIRT2523923	hsa-miR-4704-5p	CLIP-seq
MIRT2523924	hsa-miR-4713-3p	CLIP-seq
MIRT2523925	hsa-miR-4717-3p	CLIP-seq
MIRT1985645	hsa-miR-4717-5p	CLIP-seq
MIRT2523926	hsa-miR-4723-3p	CLIP-seq
MIRT2523927	hsa-miR-4725-3p	CLIP-seq
MIRT2523928	hsa-miR-4725-5p	CLIP-seq
MIRT963621	hsa-miR-4728-3p	CLIP-seq
MIRT2523929	hsa-miR-4732-3p	CLIP-seq
MIRT2523931	hsa-miR-4761-3p	CLIP-seq
MIRT1985646	hsa-miR-4762-3p	CLIP-seq
MIRT2523932	hsa-miR-4773	CLIP-seq
MIRT2523933	hsa-miR-4779	CLIP-seq
MIRT2523934	hsa-miR-4795-5p	CLIP-seq
MIRT2523935	hsa-miR-500a	CLIP-seq
MIRT2523936	hsa-miR-504	CLIP-seq
MIRT2523937	hsa-miR-5047	CLIP-seq
MIRT2523938	hsa-miR-519d	CLIP-seq
MIRT2523939	hsa-miR-532-3p	CLIP-seq
MIRT2523940	hsa-miR-548q	CLIP-seq
MIRT2523942	hsa-miR-635	CLIP-seq
MIRT2523943	hsa-miR-638	CLIP-seq
MIRT2523944	hsa-miR-642a	CLIP-seq
MIRT1985652	hsa-miR-642b	CLIP-seq
MIRT2523945	hsa-miR-765	CLIP-seq
MIRT2523946	hsa-miR-769-3p	CLIP-seq
MIRT2523947	hsa-miR-877	CLIP-seq
MIRT2523948	hsa-miR-93	CLIP-seq
MIRT2523949	hsa-miR-939	CLIP-seq

Show/Hide all(39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000015	Component	Phosphopyruvate hydratase complex	IBA
GO:0000015	Component	Phosphopyruvate hydratase complex	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0001917	Component	Photoreceptor inner segment	IEA
GO:0004634	Function	Phosphopyruvate hydratase activity	IBA
GO:0004634	Function	Phosphopyruvate hydratase activity	IEA
GO:0004634	Function	Phosphopyruvate hydratase activity	ISS	22087329
GO:0004634	Function	Phosphopyruvate hydratase activity	TAS	2045099
GO:0005515	Function	Protein binding	IPI	21044950, 28514442, 33961781, 35271311
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005938	Component	Cell cortex	IEA
GO:0006094	Process	Gluconeogenesis	IEA
GO:0006094	Process	Gluconeogenesis	TAS
GO:0006096	Process	Glycolytic process	IBA
GO:0006096	Process	Glycolytic process	IEA
GO:0006096	Process	Glycolytic process	ISS	22087329
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IDA	19433310
GO:0016020	Component	Membrane	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0030426	Component	Growth cone	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045121	Component	Membrane raft	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061621	Process	Canonical glycolysis	IEA
GO:0061621	Process	Canonical glycolysis	TAS
GO:0070062	Component	Extracellular exosome	HDA	20458337, 23533145
GO:0097060	Component	Synaptic membrane	IEA

MIM	HGNC	e!Ensembl
131360	3353	ENSG00000111674

Protein

UniProt ID

P09104

Protein name

Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE)

Protein function

Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).

PDB

1TE6 , 2AKM , 2AKZ , 3UCC , 3UCD , 3UJE , 3UJF , 3UJR , 3UJS , 4ZA0 , 4ZCW , 5EU9 , 5IDZ , 5TD9 , 5TIJ , 7MBH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03952	Enolase_N	3 → 134	Enolase, N-terminal domain	Domain
PF00113	Enolase_C	142 → 432	Enolase, C-terminal TIM barrel domain	Domain

Tissue specificity

TISSUE SPECIFICITY: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

Sequence

MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGK
GVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCK
AGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRD
AMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKI
VIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDD
WAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLA
QENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDE
ARFAGHNFRNPSVL

Sequence length

434

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Metabolic pathways Carbon metabolism Biosynthesis of amino acids RNA degradation HIF-1 signaling pathway Cytoskeleton in muscle cells		Glycolysis Gluconeogenesis

ENO2 (enolase 2)