ENO1 (enolase 1)

Gene

• Entrez ID: 2023
• Gene name: Enolase 1
• Gene symbol: ENO1
• Synonyms (NCBI Gene): ENO1-IT1, ENO1L1, HEL-S-17, MPB1, NNE, PPH
• Chromosome: 1
• Chromosome location: 1p36.23
• Summary: This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural l

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049082	hsa-miR-92a-3p	CLASH	23622248
MIRT047021	hsa-miR-204-5p	CLASH	23622248
MIRT046821	hsa-miR-222-3p	CLASH	23622248
MIRT045746	hsa-miR-125a-5p	CLASH	23622248
MIRT043896	hsa-miR-378a-3p	CLASH	23622248
MIRT041760	hsa-miR-484	CLASH	23622248
MIRT041760	hsa-miR-484	CLASH	23622248
MIRT041167	hsa-miR-181d-5p	CLASH	23622248
MIRT040892	hsa-miR-18a-3p	CLASH	23622248
MIRT039693	hsa-miR-615-3p	CLASH	23622248
MIRT039693	hsa-miR-615-3p	CLASH	23622248
MIRT039693	hsa-miR-615-3p	CLASH	23622248
MIRT037729	hsa-miR-744-5p	CLASH	23622248
MIRT052701	hsa-miR-1260b	CLASH	23622248
MIRT052801	hsa-miR-3177-3p	CLASH	23622248
MIRT734972	hsa-miR-330-5p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR, In situ hybridization	33176280
MIRT737241	hsa-miR-22-3p	Immunohistochemistry (IHC), RNA-seq, qRT-PCR	32884340
MIRT737242	hsa-miR-1294	Immunohistochemistry (IHC), RNA-seq, qRT-PCR	32884340
MIRT963554	hsa-miR-2467-5p	CLIP-seq
MIRT963555	hsa-miR-3119	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963557	hsa-miR-3160-3p	CLIP-seq
MIRT963558	hsa-miR-3168	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT963561	hsa-miR-3188	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963563	hsa-miR-3663-3p	CLIP-seq
MIRT963564	hsa-miR-3975	CLIP-seq
MIRT963565	hsa-miR-4263	CLIP-seq
MIRT963566	hsa-miR-4275	CLIP-seq
MIRT963567	hsa-miR-4293	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963569	hsa-miR-4487	CLIP-seq
MIRT963570	hsa-miR-4521	CLIP-seq
MIRT963571	hsa-miR-4640-5p	CLIP-seq
MIRT963572	hsa-miR-4655-5p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963574	hsa-miR-4726-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963576	hsa-miR-485-5p	CLIP-seq
MIRT963577	hsa-miR-518a-5p	CLIP-seq
MIRT963578	hsa-miR-527	CLIP-seq
MIRT963579	hsa-miR-542-5p	CLIP-seq
MIRT963580	hsa-miR-548aa	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963582	hsa-miR-596	CLIP-seq
MIRT963583	hsa-miR-635	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963585	hsa-miR-143	CLIP-seq
MIRT963586	hsa-miR-2276	CLIP-seq
MIRT963554	hsa-miR-2467-5p	CLIP-seq
MIRT963555	hsa-miR-3119	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT963561	hsa-miR-3188	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT963563	hsa-miR-3663-3p	CLIP-seq
MIRT963564	hsa-miR-3975	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT963593	hsa-miR-425	CLIP-seq
MIRT963594	hsa-miR-4284	CLIP-seq
MIRT963567	hsa-miR-4293	CLIP-seq
MIRT963595	hsa-miR-4305	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT963597	hsa-miR-4420	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963598	hsa-miR-4522	CLIP-seq
MIRT963599	hsa-miR-4649-3p	CLIP-seq
MIRT963572	hsa-miR-4655-5p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963600	hsa-miR-4690-5p	CLIP-seq
MIRT963601	hsa-miR-4701-5p	CLIP-seq
MIRT963602	hsa-miR-4717-3p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963604	hsa-miR-4770	CLIP-seq
MIRT963605	hsa-miR-4787-5p	CLIP-seq
MIRT963576	hsa-miR-485-5p	CLIP-seq
MIRT963579	hsa-miR-542-5p	CLIP-seq
MIRT963580	hsa-miR-548aa	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963608	hsa-miR-588	CLIP-seq
MIRT963582	hsa-miR-596	CLIP-seq
MIRT963609	hsa-miR-663b	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963586	hsa-miR-2276	CLIP-seq
MIRT1556306	hsa-miR-3137	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT1556307	hsa-miR-3686	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963605	hsa-miR-4787-5p	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT1985617	hsa-miR-22	CLIP-seq
MIRT963554	hsa-miR-2467-5p	CLIP-seq
MIRT963555	hsa-miR-3119	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963561	hsa-miR-3188	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT963564	hsa-miR-3975	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT1985618	hsa-miR-4270	CLIP-seq
MIRT963566	hsa-miR-4275	CLIP-seq
MIRT963567	hsa-miR-4293	CLIP-seq
MIRT1985619	hsa-miR-4300	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT963597	hsa-miR-4420	CLIP-seq
MIRT1985620	hsa-miR-4441	CLIP-seq
MIRT1985621	hsa-miR-4453	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT1985622	hsa-miR-4538	CLIP-seq
MIRT963571	hsa-miR-4640-5p	CLIP-seq
MIRT963599	hsa-miR-4649-3p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT1985623	hsa-miR-4685-5p	CLIP-seq
MIRT963601	hsa-miR-4701-5p	CLIP-seq
MIRT963574	hsa-miR-4726-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963576	hsa-miR-485-5p	CLIP-seq
MIRT963577	hsa-miR-518a-5p	CLIP-seq
MIRT963578	hsa-miR-527	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963608	hsa-miR-588	CLIP-seq
MIRT963582	hsa-miR-596	CLIP-seq
MIRT963583	hsa-miR-635	CLIP-seq
MIRT963609	hsa-miR-663b	CLIP-seq
MIRT1985624	hsa-miR-920	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT1985617	hsa-miR-22	CLIP-seq
MIRT1556306	hsa-miR-3137	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963557	hsa-miR-3160-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT2220079	hsa-miR-3182	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT1556307	hsa-miR-3686	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT1985618	hsa-miR-4270	CLIP-seq
MIRT963566	hsa-miR-4275	CLIP-seq
MIRT1985619	hsa-miR-4300	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT1985620	hsa-miR-4441	CLIP-seq
MIRT1985621	hsa-miR-4453	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963569	hsa-miR-4487	CLIP-seq
MIRT1985622	hsa-miR-4538	CLIP-seq
MIRT963571	hsa-miR-4640-5p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT1985623	hsa-miR-4685-5p	CLIP-seq
MIRT963600	hsa-miR-4690-5p	CLIP-seq
MIRT963574	hsa-miR-4726-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963577	hsa-miR-518a-5p	CLIP-seq
MIRT963578	hsa-miR-527	CLIP-seq
MIRT963579	hsa-miR-542-5p	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963583	hsa-miR-635	CLIP-seq
MIRT1985624	hsa-miR-920	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963586	hsa-miR-2276	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963557	hsa-miR-3160-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963569	hsa-miR-4487	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963600	hsa-miR-4690-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963605	hsa-miR-4787-5p	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT1985617	hsa-miR-22	CLIP-seq
MIRT963586	hsa-miR-2276	CLIP-seq
MIRT963554	hsa-miR-2467-5p	CLIP-seq
MIRT1556306	hsa-miR-3137	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963558	hsa-miR-3168	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT2220079	hsa-miR-3182	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT1556307	hsa-miR-3686	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT963565	hsa-miR-4263	CLIP-seq
MIRT1985618	hsa-miR-4270	CLIP-seq
MIRT963566	hsa-miR-4275	CLIP-seq
MIRT963594	hsa-miR-4284	CLIP-seq
MIRT1985619	hsa-miR-4300	CLIP-seq
MIRT963595	hsa-miR-4305	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT1985620	hsa-miR-4441	CLIP-seq
MIRT1985621	hsa-miR-4453	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963570	hsa-miR-4521	CLIP-seq
MIRT963598	hsa-miR-4522	CLIP-seq
MIRT1985622	hsa-miR-4538	CLIP-seq
MIRT963571	hsa-miR-4640-5p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT1985623	hsa-miR-4685-5p	CLIP-seq
MIRT963600	hsa-miR-4690-5p	CLIP-seq
MIRT963602	hsa-miR-4717-3p	CLIP-seq
MIRT963574	hsa-miR-4726-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963605	hsa-miR-4787-5p	CLIP-seq
MIRT963577	hsa-miR-518a-5p	CLIP-seq
MIRT963578	hsa-miR-527	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963583	hsa-miR-635	CLIP-seq
MIRT1985624	hsa-miR-920	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT1985617	hsa-miR-22	CLIP-seq
MIRT963586	hsa-miR-2276	CLIP-seq
MIRT963554	hsa-miR-2467-5p	CLIP-seq
MIRT1556306	hsa-miR-3137	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963558	hsa-miR-3168	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT2220079	hsa-miR-3182	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT1556307	hsa-miR-3686	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT963565	hsa-miR-4263	CLIP-seq
MIRT1985618	hsa-miR-4270	CLIP-seq
MIRT963566	hsa-miR-4275	CLIP-seq
MIRT963594	hsa-miR-4284	CLIP-seq
MIRT1985619	hsa-miR-4300	CLIP-seq
MIRT963595	hsa-miR-4305	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT1985620	hsa-miR-4441	CLIP-seq
MIRT1985621	hsa-miR-4453	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963570	hsa-miR-4521	CLIP-seq
MIRT963598	hsa-miR-4522	CLIP-seq
MIRT1985622	hsa-miR-4538	CLIP-seq
MIRT963571	hsa-miR-4640-5p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT1985623	hsa-miR-4685-5p	CLIP-seq
MIRT963600	hsa-miR-4690-5p	CLIP-seq
MIRT963602	hsa-miR-4717-3p	CLIP-seq
MIRT963574	hsa-miR-4726-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963605	hsa-miR-4787-5p	CLIP-seq
MIRT963577	hsa-miR-518a-5p	CLIP-seq
MIRT963578	hsa-miR-527	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963583	hsa-miR-635	CLIP-seq
MIRT1985624	hsa-miR-920	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HIF1A	Activation	8955077

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000015	Component	Phosphopyruvate hydratase complex	IBA
GO:0000015	Component	Phosphopyruvate hydratase complex	IDA	3529090
GO:0000015	Component	Phosphopyruvate hydratase complex	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	2005901
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	2005901
GO:0001222	Function	Transcription corepressor binding	IPI	11134351
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	2005901
GO:0003677	Function	DNA binding	IEA
GO:0003714	Function	Transcription corepressor activity	IDA	11134351
GO:0003723	Function	RNA binding	HDA	22658674
GO:0004634	Function	Phosphopyruvate hydratase activity	IBA
GO:0004634	Function	Phosphopyruvate hydratase activity	IDA	29775581
GO:0004634	Function	Phosphopyruvate hydratase activity	IEA
GO:0004634	Function	Phosphopyruvate hydratase activity	IMP	3529090
GO:0004634	Function	Phosphopyruvate hydratase activity	TAS
GO:0005515	Function	Protein binding	IPI	12666133, 15161933, 17500595, 18194455, 19433310, 20849852, 21274509, 23355646, 23414517, 28514442, 28813417, 32814053, 33961781, 35271311
GO:0005615	Component	Extracellular space	HDA	16502470, 22664934, 23580065
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IC	2005901, 10082554
GO:0005634	Component	Nucleus	IEA
GO:0005640	Component	Nuclear outer membrane	IDA	11134351
GO:0005737	Component	Cytoplasm	IDA	15459207, 25468996
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	12666133, 19433310
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	12666133
GO:0005886	Component	Plasma membrane	IEA
GO:0005938	Component	Cell cortex	IDA	19433310
GO:0006094	Process	Gluconeogenesis	IEA
GO:0006094	Process	Gluconeogenesis	TAS
GO:0006096	Process	Glycolytic process	IBA
GO:0006096	Process	Glycolytic process	IEA
GO:0009615	Process	Response to virus	IEP	16548883
GO:0009986	Component	Cell surface	IDA	12666133, 19433310
GO:0010756	Process	Positive regulation of plasminogen activation	IMP	12666133
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	19433310
GO:0016020	Component	Membrane	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0030308	Process	Negative regulation of cell growth	IDA	10082554
GO:0031430	Component	M band	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	3529090
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	10082554, 11134351
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	10681589
GO:0045933	Process	Positive regulation of muscle contraction	IGI	15459207
GO:0046872	Function	Metal ion binding	IEA
GO:0051020	Function	GTPase binding	IPI	24337748
GO:0061621	Process	Canonical glycolysis	IDA	29775581
GO:0061621	Process	Canonical glycolysis	IEA
GO:0061621	Process	Canonical glycolysis	IMP	3529090
GO:0061621	Process	Canonical glycolysis	TAS
GO:0070062	Component	Extracellular exosome	HDA	11487543, 12519789, 19199708, 20458337, 21362503, 23533145
GO:1903298	Process	Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IDA	15459207
GO:1903298	Process	Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IGI	15459207
GO:2001171	Process	Positive regulation of ATP biosynthetic process	IDA	15459207
GO:2001171	Process	Positive regulation of ATP biosynthetic process	IGI	15459207

Other IDs

• MIM: 172430
• HGNC: 3350
• e!Ensembl: ENSG00000074800

Protein

• UniProt ID: P06733
• Protein name: Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein)
• Protein function: Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic respon
• PDB: 2PSN, 3B97, 5JLZ, 5LAX, 5NI9, 5NIG, 5OCK, 8TRL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03952	Enolase_N	3 → 134	Enolase, N-terminal domain	Domain
  PF00113	Enolase_C	142 → 432	Enolase, C-terminal TIM barrel domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
• Sequence:

  MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGK
  GVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCK
  AGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFRE
  AMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKV
  VIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDD
  WGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLA
  QANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSK
  AKFAGRNFRNPLAK

• Sequence length: 434

Pathways

KEGG:

Glycolysis / Gluconeogenesis
Metabolic pathways
Carbon metabolism
Biosynthesis of amino acids
RNA degradation
HIF-1 signaling pathway
Cytoskeleton in muscle cells

Reactome:

Glycolysis
Gluconeogenesis
Manipulation of host energy metabolism