ENO1 (enolase 1)

Gene

• Entrez ID: 2023
• Gene name: Enolase 1
• Gene symbol: ENO1
• Synonyms (NCBI Gene): ENO1-IT1, ENO1L1, HEL-S-17, MPB1, NNE, PPH
• Chromosome: 1
• Chromosome location: 1p36.23
• Summary: This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural l

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049082	hsa-miR-92a-3p	CLASH	23622248
MIRT047021	hsa-miR-204-5p	CLASH	23622248
MIRT046821	hsa-miR-222-3p	CLASH	23622248
MIRT045746	hsa-miR-125a-5p	CLASH	23622248
MIRT043896	hsa-miR-378a-3p	CLASH	23622248
MIRT041760	hsa-miR-484	CLASH	23622248
MIRT041760	hsa-miR-484	CLASH	23622248
MIRT041167	hsa-miR-181d-5p	CLASH	23622248
MIRT040892	hsa-miR-18a-3p	CLASH	23622248
MIRT039693	hsa-miR-615-3p	CLASH	23622248
MIRT039693	hsa-miR-615-3p	CLASH	23622248
MIRT039693	hsa-miR-615-3p	CLASH	23622248
MIRT037729	hsa-miR-744-5p	CLASH	23622248
MIRT052701	hsa-miR-1260b	CLASH	23622248
MIRT052801	hsa-miR-3177-3p	CLASH	23622248
MIRT734972	hsa-miR-330-5p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR, In situ hybridization	33176280
MIRT737241	hsa-miR-22-3p	Immunohistochemistry (IHC), RNA-seq, qRT-PCR	32884340
MIRT737242	hsa-miR-1294	Immunohistochemistry (IHC), RNA-seq, qRT-PCR	32884340
MIRT963554	hsa-miR-2467-5p	CLIP-seq
MIRT963555	hsa-miR-3119	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963557	hsa-miR-3160-3p	CLIP-seq
MIRT963558	hsa-miR-3168	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT963561	hsa-miR-3188	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963563	hsa-miR-3663-3p	CLIP-seq
MIRT963564	hsa-miR-3975	CLIP-seq
MIRT963565	hsa-miR-4263	CLIP-seq
MIRT963566	hsa-miR-4275	CLIP-seq
MIRT963567	hsa-miR-4293	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963569	hsa-miR-4487	CLIP-seq
MIRT963570	hsa-miR-4521	CLIP-seq
MIRT963571	hsa-miR-4640-5p	CLIP-seq
MIRT963572	hsa-miR-4655-5p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963574	hsa-miR-4726-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963576	hsa-miR-485-5p	CLIP-seq
MIRT963577	hsa-miR-518a-5p	CLIP-seq
MIRT963578	hsa-miR-527	CLIP-seq
MIRT963579	hsa-miR-542-5p	CLIP-seq
MIRT963580	hsa-miR-548aa	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963582	hsa-miR-596	CLIP-seq
MIRT963583	hsa-miR-635	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963585	hsa-miR-143	CLIP-seq
MIRT963586	hsa-miR-2276	CLIP-seq
MIRT963554	hsa-miR-2467-5p	CLIP-seq
MIRT963555	hsa-miR-3119	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT963561	hsa-miR-3188	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT963563	hsa-miR-3663-3p	CLIP-seq
MIRT963564	hsa-miR-3975	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT963593	hsa-miR-425	CLIP-seq
MIRT963594	hsa-miR-4284	CLIP-seq
MIRT963567	hsa-miR-4293	CLIP-seq
MIRT963595	hsa-miR-4305	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT963597	hsa-miR-4420	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963598	hsa-miR-4522	CLIP-seq
MIRT963599	hsa-miR-4649-3p	CLIP-seq
MIRT963572	hsa-miR-4655-5p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963600	hsa-miR-4690-5p	CLIP-seq
MIRT963601	hsa-miR-4701-5p	CLIP-seq
MIRT963602	hsa-miR-4717-3p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963604	hsa-miR-4770	CLIP-seq
MIRT963605	hsa-miR-4787-5p	CLIP-seq
MIRT963576	hsa-miR-485-5p	CLIP-seq
MIRT963579	hsa-miR-542-5p	CLIP-seq
MIRT963580	hsa-miR-548aa	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963608	hsa-miR-588	CLIP-seq
MIRT963582	hsa-miR-596	CLIP-seq
MIRT963609	hsa-miR-663b	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963586	hsa-miR-2276	CLIP-seq
MIRT1556306	hsa-miR-3137	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT1556307	hsa-miR-3686	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963605	hsa-miR-4787-5p	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT1985617	hsa-miR-22	CLIP-seq
MIRT963554	hsa-miR-2467-5p	CLIP-seq
MIRT963555	hsa-miR-3119	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963561	hsa-miR-3188	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT963564	hsa-miR-3975	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT1985618	hsa-miR-4270	CLIP-seq
MIRT963566	hsa-miR-4275	CLIP-seq
MIRT963567	hsa-miR-4293	CLIP-seq
MIRT1985619	hsa-miR-4300	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT963597	hsa-miR-4420	CLIP-seq
MIRT1985620	hsa-miR-4441	CLIP-seq
MIRT1985621	hsa-miR-4453	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT1985622	hsa-miR-4538	CLIP-seq
MIRT963571	hsa-miR-4640-5p	CLIP-seq
MIRT963599	hsa-miR-4649-3p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT1985623	hsa-miR-4685-5p	CLIP-seq
MIRT963601	hsa-miR-4701-5p	CLIP-seq
MIRT963574	hsa-miR-4726-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963576	hsa-miR-485-5p	CLIP-seq
MIRT963577	hsa-miR-518a-5p	CLIP-seq
MIRT963578	hsa-miR-527	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963608	hsa-miR-588	CLIP-seq
MIRT963582	hsa-miR-596	CLIP-seq
MIRT963583	hsa-miR-635	CLIP-seq
MIRT963609	hsa-miR-663b	CLIP-seq
MIRT1985624	hsa-miR-920	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT1985617	hsa-miR-22	CLIP-seq
MIRT1556306	hsa-miR-3137	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963557	hsa-miR-3160-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT2220079	hsa-miR-3182	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT1556307	hsa-miR-3686	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT1985618	hsa-miR-4270	CLIP-seq
MIRT963566	hsa-miR-4275	CLIP-seq
MIRT1985619	hsa-miR-4300	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT1985620	hsa-miR-4441	CLIP-seq
MIRT1985621	hsa-miR-4453	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963569	hsa-miR-4487	CLIP-seq
MIRT1985622	hsa-miR-4538	CLIP-seq
MIRT963571	hsa-miR-4640-5p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT1985623	hsa-miR-4685-5p	CLIP-seq
MIRT963600	hsa-miR-4690-5p	CLIP-seq
MIRT963574	hsa-miR-4726-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963577	hsa-miR-518a-5p	CLIP-seq
MIRT963578	hsa-miR-527	CLIP-seq
MIRT963579	hsa-miR-542-5p	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963583	hsa-miR-635	CLIP-seq
MIRT1985624	hsa-miR-920	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT963586	hsa-miR-2276	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963557	hsa-miR-3160-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963569	hsa-miR-4487	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT963600	hsa-miR-4690-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963605	hsa-miR-4787-5p	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT1985617	hsa-miR-22	CLIP-seq
MIRT963586	hsa-miR-2276	CLIP-seq
MIRT963554	hsa-miR-2467-5p	CLIP-seq
MIRT1556306	hsa-miR-3137	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963558	hsa-miR-3168	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT2220079	hsa-miR-3182	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT1556307	hsa-miR-3686	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT963565	hsa-miR-4263	CLIP-seq
MIRT1985618	hsa-miR-4270	CLIP-seq
MIRT963566	hsa-miR-4275	CLIP-seq
MIRT963594	hsa-miR-4284	CLIP-seq
MIRT1985619	hsa-miR-4300	CLIP-seq
MIRT963595	hsa-miR-4305	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT1985620	hsa-miR-4441	CLIP-seq
MIRT1985621	hsa-miR-4453	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963570	hsa-miR-4521	CLIP-seq
MIRT963598	hsa-miR-4522	CLIP-seq
MIRT1985622	hsa-miR-4538	CLIP-seq
MIRT963571	hsa-miR-4640-5p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT1985623	hsa-miR-4685-5p	CLIP-seq
MIRT963600	hsa-miR-4690-5p	CLIP-seq
MIRT963602	hsa-miR-4717-3p	CLIP-seq
MIRT963574	hsa-miR-4726-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963605	hsa-miR-4787-5p	CLIP-seq
MIRT963577	hsa-miR-518a-5p	CLIP-seq
MIRT963578	hsa-miR-527	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963583	hsa-miR-635	CLIP-seq
MIRT1985624	hsa-miR-920	CLIP-seq
MIRT963584	hsa-miR-125a-3p	CLIP-seq
MIRT1985617	hsa-miR-22	CLIP-seq
MIRT963586	hsa-miR-2276	CLIP-seq
MIRT963554	hsa-miR-2467-5p	CLIP-seq
MIRT1556306	hsa-miR-3137	CLIP-seq
MIRT963556	hsa-miR-3151	CLIP-seq
MIRT963587	hsa-miR-3158-3p	CLIP-seq
MIRT963588	hsa-miR-3165	CLIP-seq
MIRT963558	hsa-miR-3168	CLIP-seq
MIRT963559	hsa-miR-3180	CLIP-seq
MIRT963560	hsa-miR-3180-3p	CLIP-seq
MIRT2220079	hsa-miR-3182	CLIP-seq
MIRT963562	hsa-miR-3196	CLIP-seq
MIRT963589	hsa-miR-3197	CLIP-seq
MIRT963590	hsa-miR-3609	CLIP-seq
MIRT963591	hsa-miR-3614-5p	CLIP-seq
MIRT1556307	hsa-miR-3686	CLIP-seq
MIRT963592	hsa-miR-3978	CLIP-seq
MIRT963565	hsa-miR-4263	CLIP-seq
MIRT1985618	hsa-miR-4270	CLIP-seq
MIRT963566	hsa-miR-4275	CLIP-seq
MIRT963594	hsa-miR-4284	CLIP-seq
MIRT1985619	hsa-miR-4300	CLIP-seq
MIRT963595	hsa-miR-4305	CLIP-seq
MIRT963596	hsa-miR-4316	CLIP-seq
MIRT1985620	hsa-miR-4441	CLIP-seq
MIRT1985621	hsa-miR-4453	CLIP-seq
MIRT963568	hsa-miR-4462	CLIP-seq
MIRT963570	hsa-miR-4521	CLIP-seq
MIRT963598	hsa-miR-4522	CLIP-seq
MIRT1985622	hsa-miR-4538	CLIP-seq
MIRT963571	hsa-miR-4640-5p	CLIP-seq
MIRT963573	hsa-miR-4662a-5p	CLIP-seq
MIRT1985623	hsa-miR-4685-5p	CLIP-seq
MIRT963600	hsa-miR-4690-5p	CLIP-seq
MIRT963602	hsa-miR-4717-3p	CLIP-seq
MIRT963574	hsa-miR-4726-5p	CLIP-seq
MIRT963575	hsa-miR-4728-5p	CLIP-seq
MIRT963603	hsa-miR-4763-5p	CLIP-seq
MIRT963605	hsa-miR-4787-5p	CLIP-seq
MIRT963577	hsa-miR-518a-5p	CLIP-seq
MIRT963578	hsa-miR-527	CLIP-seq
MIRT963606	hsa-miR-548ah	CLIP-seq
MIRT963607	hsa-miR-552	CLIP-seq
MIRT963581	hsa-miR-558	CLIP-seq
MIRT963583	hsa-miR-635	CLIP-seq
MIRT1985624	hsa-miR-920	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HIF1A	Activation	8955077

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000015	Component	Phosphopyruvate hydratase complex	IBA	21873635
GO:0000015	Component	Phosphopyruvate hydratase complex	IDA	3529090
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	2005901
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	2005901
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	2005901
GO:0003723	Function	RNA binding	HDA	22658674
GO:0004634	Function	Phosphopyruvate hydratase activity	IBA	21873635
GO:0004634	Function	Phosphopyruvate hydratase activity	IDA	29775581
GO:0004634	Function	Phosphopyruvate hydratase activity	IMP	3529090
GO:0005515	Function	Protein binding	IPI	11134351, 12666133, 15161933, 17500595, 18194455, 19433310, 20849852, 21274509, 23355646, 23414517, 23823123, 28813417, 32814053
GO:0005615	Component	Extracellular space	HDA	16502470, 22664934, 23580065
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IC	2005901, 10082554
GO:0005737	Component	Cytoplasm	IDA	15459207, 25468996
GO:0005829	Component	Cytosol	IDA	12666133, 19433310
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	12666133
GO:0006094	Process	Gluconeogenesis	TAS
GO:0006096	Process	Glycolytic process	IBA	21873635
GO:0009615	Process	Response to virus	IEP	16548883
GO:0009986	Component	Cell surface	IDA	12666133, 19433310
GO:0010756	Process	Positive regulation of plasminogen activation	IMP	12666133
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	19433310
GO:0030308	Process	Negative regulation of cell growth	IDA	10082554
GO:0031430	Component	M band	IEA
GO:0032889	Process	Regulation of vacuole fusion, non-autophagic	IBA	21873635
GO:0042803	Function	Protein homodimerization activity	IDA	3529090
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IDA	10082554
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IMP	10681589
GO:0045933	Process	Positive regulation of muscle contraction	IGI	15459207
GO:0051020	Function	GTPase binding	IPI	24337748
GO:0061621	Process	Canonical glycolysis	IDA	29775581
GO:0061621	Process	Canonical glycolysis	IMP	3529090
GO:0061621	Process	Canonical glycolysis	TAS
GO:0070062	Component	Extracellular exosome	HDA	11487543, 12519789, 19199708, 20458337, 21362503, 23533145
GO:0099738	Component	Cell cortex region	IDA	19433310
GO:1903298	Process	Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IDA	15459207
GO:1903298	Process	Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IGI	15459207
GO:2001171	Process	Positive regulation of ATP biosynthetic process	IDA	15459207
GO:2001171	Process	Positive regulation of ATP biosynthetic process	IGI	15459207

Other IDs

• MIM: 172430
• HGNC: 3350
• e!Ensembl: ENSG00000074800

Protein

• UniProt ID: P06733
• Protein name: Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein)
• Protein function: Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic respon
• PDB: 2PSN, 3B97, 5JLZ, 5LAX, 5NI9, 5NIG, 5OCK, 8TRL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03952	Enolase_N	3 → 134	Enolase, N-terminal domain	Domain
  PF00113	Enolase_C	142 → 432	Enolase, C-terminal TIM barrel domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
• Sequence:

  MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGK
  GVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCK
  AGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFRE
  AMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKV
  VIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDD
  WGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLA
  QANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSK
  AKFAGRNFRNPLAK

• Sequence length: 434

Pathways

KEGG:

Glycolysis / Gluconeogenesis
Metabolic pathways
Carbon metabolism
Biosynthesis of amino acids
RNA degradation
HIF-1 signaling pathway
Cytoskeleton in muscle cells

Reactome:

Glycolysis
Gluconeogenesis
Manipulation of host energy metabolism

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Adenocarcinoma	Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular	rs121913530, rs886039394, rs121913474	15378696
Alzheimer disease	Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	19374891
Arthritis	Degenerative polyarthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	18784066
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243	19655245
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	19655245
Carcinoma	Carcinoma, Squamous cell carcinoma, Carcinoma, Cribriform, Carcinoma, Granular Cell, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	12376462, 15274141, 15378696
Esophagus neoplasm	Esophageal Neoplasms, Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	15986332
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	15378696
Lung carcinoma	Non-Small Cell Lung Carcinoma	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	17094902
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	19381893, 27602772
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465, rs137854466, rs137854467, rs387906547, rs387906548, rs137854469, rs137854473, rs1131692050, rs112989722, rs137854474, rs137854476, rs140593, rs1555395819, rs137854478, rs137854479, rs137854480, rs137854481, rs137854482, rs137854483, rs137854484, rs137854485, rs112289537, rs193922181, rs193922182, rs193922185, rs140603, rs193922187, rs193922188, rs193921256, rs112660651, rs193922193, rs193922194, rs193922197, rs193922198, rs193922199, rs193922203, rs193922204, rs193922205, rs193922206, rs111401431, rs193922207, rs113871094, rs111671429, rs193922216, rs193922219, rs193922220, rs193922223, rs193922224, rs193922225, rs193922226, rs193922227, rs193922228, rs193922230, rs193922235, rs147195031, rs193922236, rs193922239, rs193922240, rs193922241, rs193922246, rs397514558, rs398122934, rs397515753, rs397515754, rs397515755, rs397515756, rs397515757, rs113812345, rs397515758, rs397515759, rs397515762, rs25403, rs397515765, rs397515766, rs397515767, rs397515768, rs397515769, rs397515770, rs397515771, rs25404, rs397515773, rs397515774, rs397515775, rs397515776, rs397515778, rs397515779, rs397515781, rs112202622, rs397515782, rs397515784, rs397515785, rs397515786, rs397515788, rs397515789, rs397515790, rs397515791, rs397515792, rs397515793, rs397515794, rs397515797, rs397515798, rs397515799, rs397515801, rs397515802, rs397515803, rs397515804, rs397515805, rs397515808, rs397515810, rs397515811, rs397515812, rs111231312, rs267606798, rs397515814, rs113905529, rs397515816, rs397515817, rs397515818, rs397515819, rs397515820, rs363853, rs113249837, rs397515821, rs111929350, rs397515823, rs397515824, rs113086760, rs397515825, rs397515826, rs397515827, rs363807, rs397515828, rs397515829, rs397515830, rs397515831, rs397515833, rs111687884, rs113080385, rs397515834, rs397515836, rs113001196, rs397515840, rs397515845, rs397515846, rs397515847, rs397515848, rs397515851, rs397515852, rs397515853, rs397515854, rs111856492, rs397515859, rs397515861, rs397515863, rs397515864, rs397515865, rs397515866, rs397515867, rs137854855, rs199474693, rs587782944, rs587782947, rs587782948, rs672601352, rs876658120, rs727504651, rs727503054, rs727504315, rs727504411, rs727503057, rs727504454, rs200309328, rs363811, rs727504410, rs363821, rs727504347, rs727505006, rs727505110, rs730880356, rs727505269, rs727503058, rs727504421, rs730880107, rs730880104, rs730880103, rs730880102, rs730880101, rs730880106, rs730880100, rs730880105, rs730880099, rs112645512, rs730880108, rs730880098, rs730880097, rs794728321, rs794728283, rs794728280, rs794728336, rs794728272, rs794728160, rs794728271, rs794728270, rs794728319, rs794728262, rs794728251, rs76702162, rs794728335, rs794728334, rs794728246, rs763091520, rs794728333, rs794728237, rs761857514, rs794728234, rs140630, rs794728231, rs794728228, rs794728225, rs794728308, rs794728216, rs794728221, rs763449629, rs201058219, rs794728210, rs794728208, rs794728206, rs794728199, rs794728195, rs794728194, rs794728193, rs794728190, rs1555399381, rs794728176, rs1555399968, rs113422242, rs794728326, rs794728166, rs794728325, rs794728165, rs794728162, rs794728213, rs869025417, rs112642323, rs869025416, rs869025415, rs869025424, rs869025423, rs869025414, rs869025422, rs869025413, rs869025412, rs869025411, rs869025418, rs869025426, rs869025406, rs869025421, rs869025425, rs869025404, rs869025420, rs869025403, rs398122833, rs876657645, rs878853686, rs878853676, rs886038919, rs886038795, rs187553035, rs886038869, rs886038949, rs886038967, rs886038976, rs886038848, rs886038940, rs886038877, rs886039038, rs886038817, rs886038963, rs886039036, rs886038797, rs886039550, rs886041482, rs1057517855, rs1057518912, rs1057518973, rs1057519502, rs1057521100, rs1057521102, rs1057518881, rs1057520617, rs1057521101, rs1555394445, rs369058466, rs1060501069, rs1060501031, rs778966916, rs1060501043, rs1555397663, rs1060501017, rs1060501094, rs1060501065, rs1555393848, rs1555394151, rs1060501051, rs1060501013, rs1060501054, rs1060501048, rs1060501089, rs1060501039, rs1555398160, rs1060501022, rs1060501024, rs1060501086, rs1060501058, rs1060501036, rs1060501100, rs1060501042, rs1060501059, rs1555397743, rs1060501021, rs1060501027, rs1060501096, rs1060501038, rs1060501050, rs1064794130, rs112118237, rs1064793980, rs1064793118, rs1064793636, rs1064794282, rs1064793559, rs1085307921, rs1085308004, rs1085307468, rs112907302, rs1131691479, rs1131691373, rs1131691467, rs1131691938, rs1131691311, rs1131691806, rs1131691317, rs1555393827, rs363804, rs1555397738, rs1555399144, rs1555400274, rs1555394195, rs1555398836, rs113543334, rs1555399825, rs1555394626, rs1555395256, rs1555395257, rs1555396427, rs1555397548, rs1555398173, rs1555404803, rs1232880706, rs1555393825, rs1555394567, rs1555396998, rs1555394928, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555399150, rs1555400373, rs1555405041, rs1555395229, rs1555397671, rs775417975, rs1555398774, rs1555399368, rs1555394904, rs1555395987, rs1555397424, rs1555398377, rs1555398835, rs1555401011, rs1555405043, rs1555394580, rs1555397404, rs1555398511, rs1555395826, rs1555399372, rs1555399821, rs1555399836, rs1555400063, rs363810, rs1555397655, rs1555395756, rs1555395742, rs1555393844, rs112550005, rs1555395002, rs1555395658, rs765387131, rs1555396429, rs1555396835, rs1555397014, rs1555397016, rs778710767, rs1555397557, rs1555397704, rs140648, rs1555398406, rs1555398681, rs1555399257, rs1555399361, rs1555399764, rs1555405056, rs1555393510, rs1555395980, rs1555396789, rs1555399094, rs1555399378, rs1555399816, rs1555395645, rs371097218, rs1555398278, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555405044, rs113544411, rs1555395663, rs1555397216, rs1555398989, rs1555399149, rs1555401670, rs1555395001, rs1445085747, rs1555393538, rs1555393565, rs1404133653, rs1555394450, rs1555394581, rs1555394633, rs1555394900, rs1555395189, rs1555395261, rs1052480459, rs1555395480, rs1555395670, rs363806, rs1555395820, rs1555396419, rs1555396765, rs1296209846, rs794728233, rs1555396853, rs1555396863, rs1555397197, rs1555397204, rs1555397212, rs1555397713, rs1555397736, rs1555398139, rs1555398144, rs1555398409, rs1555398510, rs1555398520, rs1555398524, rs1555398667, rs1555399089, rs1555399482, rs1555399763, rs1555401002, rs794728323, rs1555393508, rs1555393514, rs1555393525, rs1555393532, rs1555393653, rs1555393657, rs1555393824, rs1555393831, rs112196241, rs1555393847, rs1555393862, rs1555393863, rs1555393866, rs113935744, rs1555393882, rs1555393886, rs1555393889, rs1555394138, rs1555394144, rs1555394146, rs1555394148, rs1555394149, rs1555394152, rs1555394153, rs1555394189, rs1555394197, rs1555394206, rs1555394212, rs1555394218, rs1555394220, rs1555394235, rs1555394245, rs1555394246, rs1057520728, rs1555394390, rs1555394391, rs537570299, rs1555394397, rs1555394398, rs1555394399, rs1555394402, rs1555394407, rs1555394412, rs1555394435, rs1555394436, rs1555394441, rs1555394556, rs1555394557, rs1555394559, rs1555394561, rs1555394570, rs397515844, rs1555394571, rs1555394574, rs1555394579, rs1555394582, rs534811966, rs111588631, rs1555394628, rs1555394629, rs1555394630, rs1555394631, rs1555394641, rs1555394644, rs1555394647, rs1555394756, rs886051245, rs1555394775, rs1555394776, rs1555394777, rs1555394779, rs1555394780, rs1555394783, rs1555394901, rs1555394906, rs1555394925, rs794728253, rs886039158, rs1555395013, rs1555395187, rs1555395188, rs1555395203, rs1555395205, rs363815, rs1246984265, rs794728245, rs1555395263, rs1555395267, rs1555395456, rs1555395475, rs1555395482, rs1555395638, rs1555395641, rs1555395648, rs1555395653, rs1555395659, rs111239111, rs1555395745, rs1555395747, rs1555395753, rs1555395757, rs1555395766, rs1555395767, rs1555395843, rs1555395846, rs1555395849, rs1555395978, rs1555395981, rs1555395984, rs1555395989, rs1555395990, rs1260109901, rs1555396186, rs1555396188, rs1555396198, rs1555396199, rs1555396201, rs1555396202, rs1555396205, rs1555396213, rs1555396424, rs1555396426, rs1555396428, rs1555396435, rs1555396630, rs1555396635, rs1555396636, rs1555396639, rs1555396757, rs1555396769, rs1555396838, rs1555396844, rs140627, rs1555396858, rs1555396990, rs1555396991, rs1555396993, rs769588424, rs1555397022, rs1555397024, rs1555397160, rs1555397174, rs1555397176, rs1555397193, rs1555397209, rs1555397210, rs1555397214, rs1060501076, rs113082854, rs113693945, rs111978932, rs1555397403, rs1555397419, rs1555397420, rs1555397421, rs1555397536, rs1555397537, rs1555397540, rs1555397542, rs1555397543, rs1555397545, rs1555397546, rs1555397670, rs1555397692, rs1555397718, rs1555397723, rs1555397744, rs113393517, rs1555398148, rs1555398152, rs1555398174, rs1555398176, rs1555398179, rs1555398282, rs1555398287, rs1555398380, rs1555398394, rs1555398397, rs1555398401, rs1555398404, rs1555398407, rs1555398413, rs1555398501, rs1555398508, rs1555398512, rs1555398513, rs1555398515, rs1555398521, rs794728205, rs1555398527, rs1555398551, rs1060501075, rs1555398566, rs1555398572, rs1555398580, rs1555398582, rs140597, rs1555398622, rs1555398624, rs1555398625, rs112547596, rs1555398627, rs1555398633, rs1555398637, rs1555398642, rs778867355, rs1555398648, rs1555398659, rs1293095681, rs1060501040, rs987202268, rs1555398672, rs1555398673, rs1555398677, rs1555398793, rs1555398803, rs1555398811, rs1555398826, rs1555398833, rs1555398974, rs1555398981, rs778900586, rs1555398988, rs1555398994, rs1555398995, rs1555398996, rs1555399093, rs869025405, rs1555399101, rs1555399146, rs1555399160, rs1555399162, rs1555399164, rs1555399165, rs1555399193, rs1555399195, rs1555399202, rs1555399204, rs1555399206, rs201778577, rs1555399210, rs1555399214, rs1555399270, rs1555399273, rs1555399281, rs1555399371, rs1555399385, rs1555399477, rs1555399484, rs1555399761, rs1555399775, rs1555399802, rs1555399804, rs1555399837, rs1555399840, rs1555399940, rs1555399944, rs1555399949, rs1555399953, rs1555399954, rs1555399955, rs1555399959, rs1555399962, rs1555399963, rs1060501041, rs1555399974, rs1555399976, rs1555399977, rs1555400049, rs794728172, rs1555400062, rs1555400064, rs1555400066, rs1555400267, rs1555400268, rs1555400278, rs794728168, rs1555400279, rs1156747241, rs1555400288, rs1555400371, rs1555400372, rs1555400379, rs1555400385, rs587782943, rs1555400387, rs1555400406, rs1439533354, rs746201757, rs1555400595, rs1555400603, rs1555400604, rs1555400606, rs1555400609, rs752010116, rs1555400612, rs1555400616, rs1555401004, rs1555401005, rs146348130, rs1555401667, rs1555401671, rs1555401676, rs1555401679, rs1555401687, rs1555401689, rs1555401695, rs1555401697, rs1555401701, rs1555404799, rs1555404800, rs200295020, rs1555404810, rs1555404820, rs1555405031, rs1555405039, rs1555405045, rs1555405530, rs794728292, rs1555405533, rs1555405536, rs1555405537, rs111764111, rs1555405658, rs1555405664, rs774371494, rs1555405673, rs1555407399, rs1555407414, rs1555407423, rs1555407429, rs886041536, rs1555404806, rs1566911709, rs1566913974, rs1566894226, rs1566895223, rs1566897376, rs1566902526, rs1566915277, rs1566897374, rs1566897420, rs1566891655, rs1346043320, rs1566922396, rs1566891706, rs1566894783, rs1566913670, rs1555394196, rs1566891454, rs1566891406, rs1566891404, rs1566895262, rs1566891645, rs1566895225, rs1566896114, rs1566898399, rs1566904011, rs1566906537, rs1566908956, rs1566909766, rs1566919599, rs1566937712, rs1566915335, rs1566891675, rs1566904526, rs1566906506, rs1566900540, rs1566894230, rs1555395206, rs1566891797, rs1597512576, rs1597523873, rs1597581001, rs1597516325, rs1057524757, rs1597506641, rs1597520781, rs1597593695, rs1597529829, rs1597520625, rs1597579923, rs1597531796, rs1008275504, rs1597567249, rs1597569265, rs1597652471, rs1597516347, rs1597577114, rs1597633163, rs1597519658, rs1597593852, rs1597516501, rs1566913982, rs1555393859, rs1597513708, rs368978109, rs1480832655, rs1597520683, rs1597522390, rs1597522553, rs1597529748, rs1597533707, rs1597537815, rs1597545309, rs1597545836, rs1597563234, rs1597563280, rs1597564359, rs772108557, rs1597568968, rs1597574236, rs1597574308, rs1597577975, rs193922179, rs1597581005, rs1597593736, rs1597623670, rs1597625734, rs1597631662, rs113604459, rs1597633183, rs1597633219, rs1597518951, rs1555394781, rs1597525871, rs1597526073, rs1597569159, rs1597569536, rs1597563934, rs1597545199, rs1364210063, rs1597552583, rs1597520619, rs1597540854, rs1597591602, rs1597569551, rs1597548716, rs1597553721, rs112728248, rs1597537858, rs1597517935, rs1597540907, rs1597552388, rs1597591643, rs1597529841, rs1597506547, rs1597509836, rs1597529686, rs1566897404, rs1597533713, rs1597543486, rs1597545257, rs1597545345, rs1597548672, rs1597562812, rs1597563287, rs1597571391, rs1555400052, rs1597583989, rs363852, rs1597547226, rs363808, rs974604498, rs2043595650, rs2043526284, rs2042997306, rs1555397195, rs886039054, rs1555397213, rs2042873946	19655245
Osteoporosis	Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287	18924182
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	19898480

Unknown
Disease term	Disease name	Evidence	References	Source
Coronary syndrome	Acute Coronary Syndrome		21751358	ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
Abortion Habitual	Associate	30827932, 37288669
Abortion Spontaneous	Associate	35707546
Adenocarcinoma	Stimulate	27150162, 33628097
Adenocarcinoma	Associate	27767175
Adenocarcinoma of Lung	Associate	29522283, 35635202
Adenocarcinoma of Lung	Stimulate	31767835
Alopecia Areata	Associate	29323127
Alzheimer Disease	Associate	18752637, 19072283
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis	Associate	9649223
Arthritis Rheumatoid	Associate	16277695, 18668562, 20506214, 22661643, 22674012, 24965753, 27145822, 31430907
Asthma	Associate	28951633
Autoimmune Pancreatitis	Associate	19940298
Bantu siderosis	Associate	27742740
Barrett Esophagus	Associate	33628097
Behcet Syndrome	Associate	12847697
Brain Neoplasms	Stimulate	37011206
Breast Neoplasms	Associate	16048908, 20886042, 22734040, 23421821, 26144282, 27110560, 31329371, 31416219, 31428694, 31957838, 37190091
Breast Neoplasms	Stimulate	32521855
Breast Neoplasms	Inhibit	35796020
Burning Mouth Syndrome	Associate	28326926
Carcinogenesis	Associate	17284257, 19846662, 28443473, 28456790, 31416219, 33628097
Carcinogenesis	Inhibit	20849415
Carcinoma Ductal Breast	Associate	20886042
Carcinoma Ductal Breast	Stimulate	25805497
Carcinoma Hepatocellular	Associate	28415822, 30345303, 32084009, 36181125, 38097352, 39457014, 40621461
Carcinoma Non Small Cell Lung	Associate	17506794, 27767175, 28456790
Carcinoma Pancreatic Ductal	Associate	20455595, 26096821
Carcinoma Pancreatic Ductal	Stimulate	37910256
Carcinoma Renal Cell	Associate	23009866, 24504108
Carcinoma Squamous Cell	Associate	17284257, 27767175
Carcinoma Squamous Cell	Stimulate	28443473
Cardiomyopathy Restrictive	Associate	31037987
Cholangiocarcinoma	Associate	22552009
Cholangitis Sclerosing	Associate	9649223
Colonic Neoplasms	Associate	35445138
Colorectal Neoplasms	Associate	18691435, 26097998, 30999858
Congenital contractural arachnodactyly	Associate	22552009
Corneal Dystrophy Crystalline of Schnyder	Associate	16163269
COVID 19	Associate	37291167, 37398658
Craniocerebral Trauma	Stimulate	36295613
Creutzfeldt Jakob Disease Sporadic	Associate	28967811
Delayed Emergence from Anesthesia	Associate	31037987
Dementia	Associate	28967811
Diabetes Mellitus	Associate	29867058
Diabetes Mellitus Type 2	Associate	31076418
Diabetic Foot	Associate	38107519
Drug Related Side Effects and Adverse Reactions	Associate	25944790
Dry Eye Syndromes	Associate	27436115
Endometrial Hyperplasia	Stimulate	23504277
Endometrial Neoplasms	Associate	22415234, 37612452
Endometrial Neoplasms	Stimulate	35805203
Esophageal Neoplasms	Associate	33628097
Esophageal Squamous Cell Carcinoma	Stimulate	33628097
Esophageal Squamous Cell Carcinoma	Associate	34016746
Familial cylindromatosis	Associate	33628097
Genital Neoplasms Female	Associate	23504277
Glioblastoma	Associate	34234410, 36251833, 36494582, 37011206
Glioblastoma	Stimulate	37420311
Glioma	Associate	36251833
Hashimoto's encephalitis	Associate	31585887
Hyperplasia	Associate	35805203
Hypoxia	Stimulate	10848973, 20849415, 27765905
Hypoxia	Associate	18329003, 20412594, 25188299, 26882120, 31416219, 35796020, 36140669, 36181125
Hypoxia Brain	Stimulate	26882120
Inflammation	Associate	16277695
Irritable Bowel Syndrome	Associate	30614852
Keratoconus	Associate	17200661
Kidney Cortex Necrosis	Associate	3766707
Kidney Diseases	Associate	33374003
Leukemia	Associate	27906678, 39380054
Leukemia Lymphocytic Chronic B Cell	Associate	27906678
Leukemia Myeloid Acute	Associate	29286103, 39380054
Liver Neoplasms	Associate	33440265
Lung Neoplasms	Associate	19657000, 24984566, 29538538
Lupus Erythematosus Systemic	Associate	33374003
Lymphatic Metastasis	Stimulate	28824297
Lymphoma B Cell Marginal Zone	Stimulate	28404907
Lymphoma T Cell Peripheral	Associate	30291111
Malformations of Cortical Development	Associate	28967811
Melanoma Cutaneous Malignant	Associate	35925486
Mesothelioma	Associate	27605433
Multiple Myeloma	Stimulate	32024967
Neoplasm Metastasis	Inhibit	19846662, 35796020
Neoplasm Metastasis	Associate	23504277, 27624754, 29522283, 31767835, 32521855, 36361568
Neoplasms	Inhibit	16359544, 19846662, 31416219
Neoplasms	Associate	17506794, 18691435, 19407367, 20412594, 20849415, 20886042, 22552009, 22860099, 23009866, 23902561, 24099319, 25805497, 26097998, 26882120, 27605433, 27624754, 28456790, 28630480, 28824297, 29924389, 30345303, 30967137, 30999858, 31431517, 32521855, 33628097, 35796020, 35836227, 35925486, 36251833, 36295613, 36494582, 36614179, 37011206, 37959729, 39380054
Neoplasms	Stimulate	18401453, 23504277, 24984566, 31767835
Neoplasms Basal Cell	Associate	36494582
Neoplasms Squamous Cell	Associate	12716470
Nerve Degeneration	Stimulate	20583999
Neuroblastoma	Associate	16359544, 27765905
Nonsyndromic Holoprosencephaly	Stimulate	19587696
Osteoarthritis	Associate	37291167
Osteochondrodysplasias	Associate	20498720
Pancreatic Neoplasms	Associate	19940298, 20455595, 26096821, 28824297
Pancreatic Neoplasms	Inhibit	37910256
Phyllodes Tumor	Associate	37240386
Prostatic Neoplasms	Associate	15805119, 22734040, 24391718, 27742740, 35242214
Proteinuria	Associate	33351137
Renal Insufficiency Chronic	Associate	31076418
Retinal Vein Occlusion	Inhibit	33270842
Rheumatic Diseases	Associate	29853344
Severe Acute Respiratory Syndrome	Associate	28951633
Sjogren's Syndrome	Stimulate	20617533, 28404907
Sjogren's Syndrome	Associate	30863411
Small Cell Lung Carcinoma	Associate	8792853
Spondyloepiphyseal Dysplasia Tarda Autosomal Recessive	Associate	20498720
Squamous Cell Carcinoma of Head and Neck	Associate	17284257, 36361568, 36614179, 38102653
Stomach Diseases	Associate	36295613
Stomach Neoplasms	Associate	19846662, 28548950, 29986635, 33067426, 36295613, 37083649, 37334727
Stomach Neoplasms	Inhibit	22860099
Stomach Neoplasms	Stimulate	27624754
Thyroiditis Autoimmune	Associate	35707546
Triple Negative Breast Neoplasms	Associate	34440660
Triple Negative Breast Neoplasms	Stimulate	37190091
Urinary Bladder Neoplasms	Associate	31431517, 33176280
Urinary Bladder Neoplasms	Stimulate	35836227
Uterine Cervical Neoplasms	Associate	34530829
Vitiligo	Associate	19587696
Weight Loss	Associate	31037987